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Instilling Eye Drops

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81. Corticosteroids - topical (skin), nose, and eyes

% of people, leading to corticosteroid-induced glaucoma. May cause corticosteroid-induced cataract if use is prolonged. Should not be used with soft contact lenses — lenses should be removed before instillation of drops, and not worn during the period of treatment. Have I got the right topic? Have I got the right topic? From birth onwards. This CKS topic covers the management of people receiving topical corticosteroids, intranasal corticosteroids, and corticosteroid eye preparations in primary care (...) -the-counter for the prevention and treatment of seasonal allergic rhinitis in adults 18 years of age and older. [ ] Eye preparations Eye preparations Corticosteroid eye preparations are available as drops, ointments, ophthalmic suspensions, and Minims® (preservative-free, single-use application packs). Some are also available as compound preparations, containing antibacterials. The corticosteroid eye preparations available in the UK include: Betamethasone (drops and ointment). Dexamethasone (drops

2018 NICE Clinical Knowledge Summaries

82. Ocular Tolerability of Voclosporin Ophthalmic Solution Versus Restasis® in Subjects With Dry Eye Disease

excipients), topical anesthetics or vital dyes. Be unable to demonstrate correct instillation of over-the-counter (OTC) ocular lubricant. Report discomfort in both eyes from instillation of OTC ocular lubricant during Visit 2 (based on score of ≥30 on the Drop Discomfort VAS). Have used Restasis® (cyclosporine ophthalmic emulsion) within 30 days prior to Visit 1. Have used Restasis® for more than 1 month (if prior use is reported). Have used Xiidra® (lifitegrast ophthalmic solution) within 14 days prior (...) : Voclosporin Ophthalmic Solution Investigational Drug Other Name: 0.2% VOS Active Comparator: Comparator 0.05% cyclosporine ophthalmic emulsion (Restasis®) BID, both eyes for 28 days Drug: Restasis® Comparator Other Name: RESTASIS® (cyclosporine ophthalmic emulsion) 0.05% Outcome Measures Go to Primary Outcome Measures : Drop Discomfort Assessment Visual Analogue Scale(VAS) [ Time Frame: 1-minute Post-Dose 1 instillation ] VAS scale 0 - 100 - Where 0 is the no discomfort and 100 the worst discomfort

2018 Clinical Trials

83. In suspected corneal foreign body should local anaesthetic be applied before or after eye examination?

Royal Infirmary, Manchester, UK Date Submitted: 9th February 2015 Date Completed: 1st July 2015 Last Modified: 1st July 2015 Status: Green (complete) Three Part Question In [a patient presenting with a suspected corneal foreign body] is [instillation of anaesthetic drops before eye examination better than installation after eye examination] at [allowing identification and removal of any foreign bodies]? Clinical Scenario A 47-year-old man presents complaining of a painful gritty sensation within his (...) left eye. He had been taking down a ceiling in his house and had not been wearing eye protection. You suspect a corneal foreign body. You are about to instil local anaesthetic drops when your registrar suggests that this is not necessary since, if there is a foreign body and it is subtarsal it could be removed without the need for the drops. She points out that installation of local anaesthetic drops is not without risk. You wonder if there is any evidence to support her pragmatic view. Search

2015 BestBETS

84. Post-operative ocular inflammation: A single sub-conjunctival injection of XG-102 compared to dexamethasone drops in a randomized trial. Full Text available with Trip Pro

surgery were eligible to participate. Patients were administered a single subconjunctival injection of 250 μL XG-102 90 μg (n = 47) or 900 μg (n = 48) or placebo (n = 50) at the end of ocular surgery. Subconjunctival injection for each group (XG-102 90 μg, XG-102 900 μg, or placebo) was followed by eye drops instilled 4 times per day for 21 days with placebo, placebo, or dexamethasone solution, respectively. The primary outcome measure was anterior chamber cell grades at day 28 comparing XG-102 900 μg (...) Post-operative ocular inflammation: A single sub-conjunctival injection of XG-102 compared to dexamethasone drops in a randomized trial. To evaluate the efficacy and safety of XG-102 (brimapitide) compared to dexamethasone eye drops in the treatment of postoperative ocular inflammation.Multicenter, randomized, parallel group, double-masked, noninferiority clinical trial.Patients who underwent anterior and posterior segments combined surgery or glaucoma surgery or complex posterior segment

2016 American Journal of Ophthalmology Controlled trial quality: predicted high

85. Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction Full Text available with Trip Pro

, subjects underwent slit-lamp examination and completed MGD symptoms and dry eye-related quality of life score (DEQS) questionnaires. Meibum quality (meibum score) and meibomian gland loss (meiboscore) were evaluated. Tear lipid layer thickness was measured in both eyes with an ocular surface interferometer immediately after clinic arrival and 20 minutes after instillation of one drop of topical diquafosol.Thirteen patients (3 men, 10 women) with a mean age of 69.5±8.3 years completed the 3-month study (...) Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction To prospectively evaluate the effect of topical diquafosol sodium on eyes with dry eye disease (DED) and meibomian gland dysfunction (MGD).The subjects were consecutive patients diagnosed with both DED and MGD at Inouye Eye Hospital between March and September of 2016. The subjects were administered topical 3% diquafosol sodium ophthalmic solution six times a day for 3 months. At each study visit

2017 Clinical ophthalmology (Auckland, N.Z.)

86. Corneal epithelial permeability to fluorescein in humans by a multi-drop method. Full Text available with Trip Pro

for this study. First, a probe-drop of fluorescein (0.35%, 2 μL) was instilled on the conjunctiva. The clearance of the dye from the tears was immediately measured using the fluorometer. Following this, two loading drops (2%; 6 μL each) were administered 10 min apart. Fifteen minutes later, the ocular surface was washed and fluorescence from the stroma Fs was measured. Permeability was calculated using Pdc = (Q x Fs)/ (2 x AUC), where Q is the stromal thickness and AUC is the area under the fluorescence vs (...) Corneal epithelial permeability to fluorescein in humans by a multi-drop method. The permeability of the corneal epithelium to fluorescein Pdc is an indicator of the health of the ocular surface. It can be measured in a clinical setting by determining the accumulation of fluorescein in the stroma following administration of the dye on the ocular surface. Here we demonstrate a new multi-drop method for the measurement of Pdc by a spot fluorometer.Twenty-nine healthy participants were recruited

2018 PLoS ONE

87. The effect of cold tetracaine on the severity of burning sensation upon instillation. Full Text available with Trip Pro

The effect of cold tetracaine on the severity of burning sensation upon instillation. Tetracaine is one of the most common eye drops that are used for analgesia in clinical practice. However, it causes ocular burning sensation when instilled. This study aimed to compare the effects of the cold and room temperature tetracaine on burning sensation.We conducted a prospective, double-blinded, randomized controlled trial at the ophthalmology outpatient clinic, Phramongkutklao Hospital during January (...) 2016-February 2017. In this study, 424 consecutive patients (those with a history of keratopathy or neuropathy were excluded) who received dilated fundus examination were randomized to receive cold tetracaine (4°C) in one eye and room temperature tetracaine (22.5°C) in the other eye. Each patient was asked to answer the questionnaire on the severity of burning sensation using 100 mm visual analog scale.Patients reported less burning sensation on the eye that received cold tetracaine (visual analog

2018 Clinical ophthalmology (Auckland, N.Z.) Controlled trial quality: uncertain

88. Increase in the OCT angiographic peripapillary vessel density by ROCK inhibitor ripasudil instillation: a comparison with brimonidine Full Text available with Trip Pro

the response of optical coherence tomography angiography (OCTA) parameters to drugs in 24 eyes treated with ripasudil and 23 eyes treated with brimonidine at the Sensho-kai Eye Institute. After division by the signal strength (SS), we compared the responses of peripapillary VD/SS and PLFI/unit area (UA)/SS to topical eye drops in eyes with primary open-angle glaucoma (POAG) and ocular hypertension (OH).In the superficial peripapillary retina, VD/SS increased significantly in the ripasudil-treated eyes (...) Increase in the OCT angiographic peripapillary vessel density by ROCK inhibitor ripasudil instillation: a comparison with brimonidine To assess the responses of the superficial peripapillary retinal vessel density (VD) and prelaminar flow index (PLFI) to topical Rho-assisted coiled-coil forming protein kinase (ROCK) inhibitor ripasudil and alpha-2 agonist brimonidine using optical coherence tomography angiography.This is a prospective, non-randomized, comparative cohort study. We studied

2018 Graefe's Archive for Clinical and Experimental Ophthalmology

89. Comparison of 0.05% cyclosporine and 3% diquafosol solution for dry eye patients: a randomized, blinded, multicenter clinical trial. Full Text available with Trip Pro

Comparison of 0.05% cyclosporine and 3% diquafosol solution for dry eye patients: a randomized, blinded, multicenter clinical trial. This study is aim to compare the clinical effectiveness between the two most prominent dry eye disease (DED)-specific eye drops, 0.05% cyclosporine (CN) and 3% diquafosol (DQ).This is a multi-centered, randomized, masked, prospective clinical study. A total of 153 DED patients were randomly allocated to use CN twice per day or DQ six times daily. Cornea (...) and conjunctival staining scores (NEI scale), tear break-up time (TBUT), Schirmer test scores, and ocular surface disease index (OSDI) score were measured at baseline, 4 and 12 weeks after treatment.At 12 weeks after treatment, NEI scaled scores were significantly reduced from the baseline by - 6.60 for CN and - 6.63 for DQ group (all P < 0.0001, P = 0.9739 between groups). TBUT and Schirmer values for CN were significantly improved from the baseline at 4 and 12 weeks (P = 0.0034, P < 0.0001 for TBUT, P

2019 BMC Ophthalmology Controlled trial quality: uncertain

90. Effect of Eye Masks on Neonatal Stress Following Dilated Retinal Examination: The MASK-ROP Randomized Clinical Trial. (Abstract)

in July 2017. Analysis was intention to treat.Patients were randomized to wear a phototherapy mask for a minimum of 4 hours after dilating drop instillation in addition to standard comfort measures.Number of desaturation, bradycardic, or apneic events during the 12-hour postexamination period.Of 51 infants who were examined, 28 (54.9%) were randomized to the treatment group (ie, used a mask) and 23 (45.1%) to the control group. Overall, 10 (35.7%) and 13 infants (56.5%) received ventilator support (...) Effect of Eye Masks on Neonatal Stress Following Dilated Retinal Examination: The MASK-ROP Randomized Clinical Trial. Although screening examinations for retinopathy of prematurity (ROP) prevent blindness, they are physiologically stressful for infants. Photosensitivity during mydriasis may contribute to postexamination stress, and reducing light stimulation may make infants more comfortable.To determine the effect of a phototherapy mask worn during mydriasis on infant stress in the 12-hour

2019 JAMA ophthalmology

91. Efficacy and safety of 0.05% cyclosporine ophthalmic emulsion in treatment of Chinese patients with moderate to severe dry eye disease: A 12-week, multicenter, randomized, double-masked, placebo-controlled phase III clinical study. Full Text available with Trip Pro

Efficacy and safety of 0.05% cyclosporine ophthalmic emulsion in treatment of Chinese patients with moderate to severe dry eye disease: A 12-week, multicenter, randomized, double-masked, placebo-controlled phase III clinical study. Dry eye disease (DED) is a chronic ocular surface disease that affects hundreds of millions of people worldwide. Although 0.05% cyclosporine ophthalmic emulsion (CsA OE) has long been prescribed in the U.S. for the treatment of DED, it is not commercially available (...) in China. Our study aims to compare the efficacy and safety profile of 0.05% CsA OE versus vehicle in Chinese patients with moderate to severe DED.This was a multicenter, randomized, double-masked, 2-parallel-arm, 3-month phase III study. Patients with moderate to severe DED were randomized to receive twice-daily 0.05% CsA OE or its vehicle, along with unpreserved hypromellose eye drops 3 times per day. Patients were followed up at day 7, 28, 56, and 84, as well as 2 weeks after the medications were

2019 Medicine Controlled trial quality: uncertain

92. Tear lipid supplement prophylaxis against dry eye in adverse environments. (Abstract)

containing drop (Systane® Ultra) applied simultaneously to the contralateral eye. Subjects were subsequently exposed to a validated simulated adverse environment model created by a standing fan directed towards the eye, at a distance of 1m, for 2.5min. Low contrast glare acuity, lipid layer grade (LLG), non-invasive tear break-up time (NIBUT), temperature variation factor (TVF), and tear meniscus height (TMH) were evaluated at baseline, following eye drop instillation and following simulated adverse (...) and TMH (all p>0.05). More subjects (67%) reported greater ocular comfort in the eye receiving the lipomimetic.Single application of both lipid and non-lipid containing eye drops conferred protective effects against exposure to adverse environmental conditions in subjects with mild-to-moderate dry eye, although the lipomimetic demonstrated superior prophylactic efficacy.Copyright © 2017 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

2019 Contact lens & anterior eye : the journal of the British Contact Lens Association Controlled trial quality: uncertain

93. Changes in pupil size and intraocular pressure after topical application of 0.5% tropicamide to the eyes of dogs sedated with butorphanol. (Abstract)

) or an equal volume of sterile saline (0.9% NaCl) solution. For each dog, 1 drop of 0.5% tropicamide ophthalmic solution was topically instilled in one eye and 1 drop of artificial tear solution was topically instilled in the other eye 10 minutes after the IM injection and again 5 minutes later. Extent of sedation, pupil size, and IOP were evaluated from 20 minutes before to 80 minutes after the IM injection and compared among treatment combinations.Butorphanol induced mild (n = 9) or moderate (3) sedation (...) Changes in pupil size and intraocular pressure after topical application of 0.5% tropicamide to the eyes of dogs sedated with butorphanol. To assess changes in pupil size and intraocular pressure (IOP) following topical application of a 0.5% tropicamide solution in the eyes of healthy butorphanol-sedated dogs.12 healthy adult Beagles.In a randomized crossover study consisting of 2 treatment periods with a 1-week washout between periods, dogs received an IM injection of butorphanol (0.2 mg/kg

2019 American journal of veterinary research

94. Abusive Head Trauma and the Eye in Infancy

Aims of the guidance 1. To review the literature from the time of the last publications on AHT and the eye. 2. To update the previously published articles 10 3. To identify good practice in the management of cases referred with suspected abusive head trauma and encourage evidence based standardized assessment of such children. 4. To identify new information concerning conditions which may simulate the ocular findings in abusive head trauma in children. 1.4 Scope of guidance This guidance deals (...) JT, Drake J, Dirks P, et al. Ocular manifestations of crush head injury in children. Eye 2007;21(1):5-10. (25) Adamsbaum C, Grabar S, Mejean N, Rey-Salmon C. Abusive head trauma: Judicial admissions highlight violent and repetitive shaking. Pediatrics 2010;126(3):546-55. (26) Binenbaum G, Mirza-George N, Christian CW, Forbes BJ. Odds of abuse associated with retinal hemorrhages in children suspected of child abuse. J AAPOS 2009;13(3):268- 72. (27) Pierre-Kahn V, Roche O, Dureau P, Uteza Y, Renier

2013 Royal College of Ophthalmologists

95. Dry eye syndrome

— for further information, see the CKS topic on . Rosacea — for further information, see the CKS topic on . Sleep apnoea — for further information, see the CKS topic on . Recommend use of tear supplements (sometimes called artificial tears or lubricant eye drops) if lifestyle measures do not relieve symptoms. A large range of tear replacement and ocular lubricant products are available on prescription or over the counter. For a complete list of products available in the UK, see the British National (...) Dry eye syndrome Dry eye syndrome - NICE CKS Share Dry eye syndrome: Summary Dry eye syndrome is a chronic condition characterised by inflammation of the ocular surface and reduction in quality and/or quantity of tears. The tear film covers the cornea and exposed conjunctiva. It contributes to the health of the cornea and conjunctiva by supplying nutrients, flushing away waste products and acting as a protective barrier. Dry eye syndrome is usually categorised into either aqueous or evaporative

2017 NICE Clinical Knowledge Summaries

96. Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops

because the topical corticotherapy leads to ocular complications. The most used immunosuppressant is cyclosporine. Tacrolimus , another immunosuppressant, has been used in treatment of immune and inflammatory ocular diseases.This study describes a prospective controlled double-blinded randomized study of the clinical outcome of SS dry eyes patients treated with 0.03% tacrolimus eye drops. As secondary purposes, outcome of dry eye symptoms and any ocular symptoms of the eye drops were also questioned (...) inflammatory cytokines (eg, IL-3, IL-4, IL-5, IL-8, interferon- ϒ, and tumor necrosis factor - α) . The systemic and topical use of tacrolimus is already well established in ophthalmologic treatments of immune-mediated diseases , uveitis, graft-versus-host disease , corneal transplants and ocular pemphigoid . In veterinary medicine, topical tacrolimus aqueous suspension is well established to treat dry eye in dogs . In humans, tacrolimus eye drops were reported to be effective in treating severe allergic

2013 Clinical Trials

97. Safety and tolerability of lifitegrast ophthalmic solution 5.0%: Pooled analysis of five randomized controlled trials in dry eye disease. Full Text available with Trip Pro

(0-4 scale)). Participants were randomized to lifitegrast ophthalmic solution 5.0% or placebo twice daily for 84 or 360 days. Treatment-emergent adverse events and drop comfort scores were assessed.Overall, 2464 participants (lifitegrast, n = 1287; placebo, n = 1177) were included. Ocular treatment-emergent adverse events occurring in >5% in either group were instillation site irritation (lifitegrast, 15.2%; placebo, 2.8%), instillation site reaction (lifitegrast, 12.3%; placebo, 2.3 (...) %), and instillation site pain (lifitegrast, 9.8%; placebo, 2.1%); the most common (> 5%) nonocular treatment-emergent adverse event was dysgeusia (lifitegrast, 14.5%; placebo, 0.3%). The majority of treatment-emergent adverse events were mild to moderate in severity. Discontinuation due to treatment-emergent adverse events occurred in 7.0% (lifitegrast) versus 2.6% (placebo) of participants (ocular: 5.5% vs 1.5%; nonocular: 1.9% vs 1.1%). Drop comfort scores with lifitegrast improved within 3 min of instillation

2018 European journal of ophthalmology Controlled trial quality: uncertain

98. [Comparison of objective optical quality measured by double-pass aberrometry in patients with moderate dry eye: Normal saline vs. artificial tears: A pilot study]. (Abstract)

quality of vision measured by OQAS between treatment with normal saline eye drops and treatment with carmellose 0.5% and hyaluronic acid 0.1% (Optive Fusion [OF], Allergan) in patients with moderate dry eye syndrome. Optical quality was measured by evaluating the variations in the Optical Scattering Index (OSI) over 20seconds using the OQAS. Inclusion criteria were dry eye syndrome with an Ocular Surface Disease Index (OSDI) score>23 treated only with artificial tears. The patients were their own (...) controls: OF in one eye and normal saline in the fellow eye. The choice of the subject eye and control eye was determined in a randomized fashion. OSI variations were measured in each eye before instillation, 5minutes and 2hours after instillation. The primary endpoint was OSI fluctuation over 20seconds of measurement. Secondary endpoints were the number of blinks and patient's preference (preferred eye). Preliminary results were obtained on 19 patients. Average OSDI score was 36.8. Visual acuity

2018 Journal francais d'ophtalmologie Controlled trial quality: uncertain

99. Comparison of objective optical quality measured by double-pass aberrometry in patients with moderate dry eye: Normal saline vs. artificial tears: A pilot study. Full Text available with Trip Pro

of vision measured by OQAS between treatment with normal saline eye drops and treatment with carmellose 0.5% and hyaluronic acid 0.1% (Optive Fusion [OF], Allergan) in patients with moderate dry eye syndrome. Optical quality was measured by evaluating the variations in the Optical Scattering Index (OSI) over 20seconds using the OQAS. Inclusion criteria were dry eye syndrome with an ocular surface disease index (OSDI) score >23 treated only with artificial tears. The patients were their own controls (...) : OF in one eye and normal saline in the fellow eye. The choice of the subject eye and control eye was determined in a randomized fashion. OSI variations were measured in each eye before instillation, 5minutes and 2hours after instillation. The primary endpoint was OSI fluctuation over 20seconds of measurement. Secondary endpoints were the number of blinks and patient preference (preferred eye). Preliminary results were obtained on 19 patients. Average OSDI score was 36.8. Visual acuity was 10/10

2018 Journal francais d'ophtalmologie Controlled trial quality: uncertain

100. [Walnut-shell moxibustion for dry eye symptoms: a randomized controlled trial]. (Abstract)

times a day, one drop instilled in each eye each time, for 4 weeks totally. At the baseline (before treatment) and in 4 weeks of treatment, the score of the ocular surface disease index (OSDI), the score of visual analogous scale (VAS) for eye symptoms, the tear film break-up time (BUT), the cornea fluorescent pigmentation (FL) and SchirmerⅠ(SchⅠ) were evaluated. In 1-month follow-up after treatment termination, the changes of OSDI and VAS scores were evaluated in the two groups.In 4 weeks (...) [Walnut-shell moxibustion for dry eye symptoms: a randomized controlled trial]. To evaluate the effects of walnut-shell moxibusiton on dry eye symptoms.A total of 67 patients with dry eye symptoms were randomized into a walnut moxibustion group and a sodium hyaluronate eye drops group.In the walnut moxibustion group, the walnut moxibustion was used, once every two days, 3 times a week, for 4 weeks totally. In the sodium hyaluronate eye drops group, sodium hyaluronate eye drops were selected, 4

2018 Zhongguo zhen jiu = Chinese acupuncture & moxibustion Controlled trial quality: uncertain

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