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Instilling Eye Drops

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61. Don't Open Eyes Technique for Eye Drop Instillation

Don't Open Eyes Technique for Eye Drop Instillation Dont Open Eyes Technique for Eye Drop Instillation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Don't Open Eyes Technique for Eye Drop Instillation Don't Open Eyes Technique for Eye Drop Instillation Aka: Don't Open Eyes Technique for Eye Drop Instillation , DOT for Topical Ophthalmic II. Indications Reduces systemic absorption of ophthalmic preparations Ophthalmic s have been associated with III. Technique Keep eyes closed for 1-5 minutes following installation of eye drops Consider also applying pressure at lacrimal ducts to prevent drainage IV. Mechanism Keeping eyes closed limits

2015 FP Notebook

62. Corneal sensitivity after topical bromfenac sodium eye-drop instillation. (Full text)

Corneal sensitivity after topical bromfenac sodium eye-drop instillation. To evaluate the safety of bromfenac sodium eye drops from the standpoint of corneal sensitivity and tear secretion in healthy controls following instillation for 1 month.A prospective single-blind parallel clinical study was conducted in 20 eyes of ten healthy volunteers with no history of ocular or systemic allergic disease, dry eye, contact lens wear, or ocular surgery. Participants were instructed to instill either (...) bromfenac sodium or artificial tears in each eye twice daily for 28 days. Corneal sensitivity tested using a Cochet-Bonnet esthesiometer was evaluated before and immediately after instillation at 7, 14, and 28 days after the initiation of treatment. Tear secretion was also evaluated by Schirmer's eye test before and at 28 days.No significant difference in mean corneal sensitivity and tear-secretion rate was observed between the bromfenac and artificial-tear treatment groups at any time.These results

2013 Clinical ophthalmology (Auckland, N.Z.) PubMed

63. Effect of Instillation of Dry Eye Drops on Optical Quality. (Full text)

Effect of Instillation of Dry Eye Drops on Optical Quality. To investigate the effects of viscosity and suspensibility of eyedrops for dry eye by evaluating an eyedrop with one of the solutions or no solution (0.3% sodium hyaluronate ophthalmic solution, 3% diquafosol ophthalmic solution, and 2% rebamipide ophthalmic suspension) on ocular higher-order aberrations (HOAs) and forward light scatter.We evaluated ocular HOAs and forward light scatter before and 1, 5, and 10 minutes after (...) instillation of three eyedrops for dry eye in 15 healthy subjects. Saline served as the control. The HOAs were measured for a 4-mm pupil using a wavefront sensor. The obtained aberration data were analyzed in the central 4-mm diameter for total HOAs up to the sixth-order Zernike polynomials. Forward light scatter was quantified with a straylight meter.A significant increase was seen in the HOAs 1 minute after instillation of the three eyedrops for dry eye; the HOAs recovered to the baseline level

2013 Investigative Ophthalmology & Visual Science PubMed

64. Comparison of the effectiveness of mydriasis by two instillation methods of combined 0.75% tropicamide and 2.5% phenylephrine eye drop in preterm infants. (PubMed)

Comparison of the effectiveness of mydriasis by two instillation methods of combined 0.75% tropicamide and 2.5% phenylephrine eye drop in preterm infants. To compare the effectiveness and safety of two instillation methods of combined 0.75% tropicamide and 2.5% phenylephrine at 0, 5 minutes (min) with the same combined regimen at 0,30 minutes in preterm infants.A prospective, cross-over, randomized controlled trial was performed to compare 0, 5-min instillation (Method A) of combined 0.75 (...) % tropicamide and 2.5% phenylephrine with 0, 30-min instillation (Method B) of the same regimen. Forty-two preterm infants scheduled for screening retinopathy of prematurity (ROP) were randomly assigned to two groups. Group 1 was defined as preterms applied by Method A at first examination then by Method B 1-4 weeks apart whereas vice versa in Group 2. Pupil size, heart rate (HR), systolic and diastolic blood pressure (SBP, DBP) were recorded before and after eye-drop instillation.Mean time to 7-mm pupil

2012 Journal of the Medical Association of Thailand = Chotmaihet thangphaet

65. Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage. (Full text)

Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage. To evaluate if coenzyme Q10 (CoQ10) can protect retinal ganglion cells (RGCs) from apoptosis and, when instilled as eye drops on the cornea, if it can reach the retina and exert its antiapoptotic activity in this area in a mouse model of kainate (KA)-induced retinal damage.Rat primary or cultured RGCs were subjected to glutamate (50 (...) μM) or chemical hypoxia (Antimycin A, 200 μM) or serum withdrawal (FBS, 0.5%) in the presence or absence of CoQ10 (10 μM). Cell viability was evaluated by light microscopy and fluorescence-activated cell sorting analyses. Apoptosis was evaluated by caspase 3/7 activity and mitochondrion depolarization tetramethylrhodamine ethyl ester analysis. CoQ10 transfer to the retina following its instillation as eye drops on the cornea was quantified by HPLC. Retinal protection by CoQ10 (10 μM) eye drops

2012 Investigative Ophthalmology & Visual Science PubMed

66. Comparative Efficacy of Different Regimens of PVPI 5% Eye Drops Instillation in Reducing Conjunctival Bacterial Flora

Comparative Efficacy of Different Regimens of PVPI 5% Eye Drops Instillation in Reducing Conjunctival Bacterial Flora Comparative Efficacy of Different Regimens of PVPI 5% Eye Drops Instillation in Reducing Conjunctival Bacterial Flora - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Comparative Efficacy of Different Regimens of PVPI 5% Eye Drops Instillation in Reducing Conjunctival Bacterial Flora The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01739920 Recruitment Status : Completed First Posted

2012 Clinical Trials

67. Effect of Benzalkonium Chloride Containing Eye Drops on the Conjunctival Bacterial Flora of Dry Eye Patients

Effect of Benzalkonium Chloride Containing Eye Drops on the Conjunctival Bacterial Flora of Dry Eye Patients Effect of Benzalkonium Chloride Containing Eye Drops on the Conjunctival Bacterial Flora of Dry Eye Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Effect of Benzalkonium Chloride Containing Eye Drops on the Conjunctival Bacterial Flora of Dry Eye Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2015 Clinical Trials

68. Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome. (Full text)

biomicroscopy, tonometry, blood pressure, and heart rate. Tolerability was also evaluated.This clinical study showed the effectiveness of Visomitin eye drops in the treatment of signs and symptoms of DES compared with placebo. The study showed that a 6-week course of TID topical instillation of Visomitin significantly improved the functional state of the cornea; Visomitin increased tear film stability and reduced corneal damage. Significant reduction of dry eye symptoms (such as dryness, burning, grittiness (...) Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome. This article presents the results of an international, multicenter, randomized, double-masked, placebo-controlled clinical study of Visomitin (Mitotech LLC, Moscow, Russian Federation) eye drops in patients with dry eye syndrome (DES). Visomitin is the first registered (in Russia) drug with a mitochondria-targeted antioxidant

2015 Advances in therapy PubMed

69. Glaucoma Eye Drop Instillation: Impact of Education

Glaucoma Eye Drop Instillation: Impact of Education Glaucoma Eye Drop Instillation: Impact of Education - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Glaucoma Eye Drop Instillation: Impact of Education (...) on proper eye drop instillation technique Other: Placebo video education on healthy eating tips Not Applicable Detailed Description: Glaucoma is a leading cause of irreversible vision loss worldwide, and as such has a large public health impact. The only treatment proven to slow or arrest the progression of the disease process is intraocular pressure (IOP) reduction, which relies heavily on patient cooperation. Previously, nonadherence to glaucoma medications has ranged from 24% to 59%. Barriers

2011 Clinical Trials

70. The effect of cold tetracaine on the severity of burning sensation upon instillation. (Full text)

The effect of cold tetracaine on the severity of burning sensation upon instillation. Tetracaine is one of the most common eye drops that are used for analgesia in clinical practice. However, it causes ocular burning sensation when instilled. This study aimed to compare the effects of the cold and room temperature tetracaine on burning sensation.We conducted a prospective, double-blinded, randomized controlled trial at the ophthalmology outpatient clinic, Phramongkutklao Hospital during January (...) 2016-February 2017. In this study, 424 consecutive patients (those with a history of keratopathy or neuropathy were excluded) who received dilated fundus examination were randomized to receive cold tetracaine (4°C) in one eye and room temperature tetracaine (22.5°C) in the other eye. Each patient was asked to answer the questionnaire on the severity of burning sensation using 100 mm visual analog scale.Patients reported less burning sensation on the eye that received cold tetracaine (visual analog

2018 Clinical ophthalmology (Auckland, N.Z.) PubMed

71. Increase in the OCT angiographic peripapillary vessel density by ROCK inhibitor ripasudil instillation: a comparison with brimonidine (Full text)

the response of optical coherence tomography angiography (OCTA) parameters to drugs in 24 eyes treated with ripasudil and 23 eyes treated with brimonidine at the Sensho-kai Eye Institute. After division by the signal strength (SS), we compared the responses of peripapillary VD/SS and PLFI/unit area (UA)/SS to topical eye drops in eyes with primary open-angle glaucoma (POAG) and ocular hypertension (OH).In the superficial peripapillary retina, VD/SS increased significantly in the ripasudil-treated eyes (...) Increase in the OCT angiographic peripapillary vessel density by ROCK inhibitor ripasudil instillation: a comparison with brimonidine To assess the responses of the superficial peripapillary retinal vessel density (VD) and prelaminar flow index (PLFI) to topical Rho-assisted coiled-coil forming protein kinase (ROCK) inhibitor ripasudil and alpha-2 agonist brimonidine using optical coherence tomography angiography.This is a prospective, non-randomized, comparative cohort study. We studied

2018 Graefe's Archive for Clinical and Experimental Ophthalmology PubMed

72. Corneal epithelial permeability to fluorescein in humans by a multi-drop method. (Full text)

for this study. First, a probe-drop of fluorescein (0.35%, 2 μL) was instilled on the conjunctiva. The clearance of the dye from the tears was immediately measured using the fluorometer. Following this, two loading drops (2%; 6 μL each) were administered 10 min apart. Fifteen minutes later, the ocular surface was washed and fluorescence from the stroma Fs was measured. Permeability was calculated using Pdc = (Q x Fs)/ (2 x AUC), where Q is the stromal thickness and AUC is the area under the fluorescence vs (...) . time curve for the loading drops.After the probe drop, the tear fluorescence followed an exponential decay (elimination rate constant; kd = 0.41 ± 0.28 per min; 49 eyes of 29 subjects), but the increase in Fs was negligible. However, after the loading drops, the measured Fs was ~ 20-fold higher than the autofluorescence and could be recorded at a high signal to noise ratio (SNR > 40). The intra-subject variability of kd was insignificant. Since fluorescein undergoes concentration quenching at > 0.5

2018 PLoS ONE PubMed

73. DRY EYE (Tear deficiency (KCS)

or function is abnormal, refer. If the condition is not idiopathic, for example if Sjögren’s syndrome or an unidentified underlying disease are suspected, refer. A3: if SJS or OCP are suspected, refer urgently (within one week) to ophthalmologist Possible management by ophthalmologist drug treatment for underlying disease (eg SJS, OCP) ciclosporin eye drops (Ikervis) autologous serum eye drops electrolysis, cryotherapy protection with therapeutic contact lenses of all types permanent (surgical) occlusion (...) by the American Academy of Ophthalmology. Ophthalmology. 2015;122(8):1681-7 Pucker AD, Ng SM, Nichols JJ. Over the counter (OTC) artificial tear drops for dry eye syndrome. Cochrane Database Syst Rev. 2016;2:CD009729 Wolffsohn JS, Arita R, Chalmers R, Djalilian A, Dogru M, Dumbleton K, Gupta PK, Karpecki P, Lazreg S, Pult H, Sullivan BD, Tomlinson A, Tong L, Villani E, Yoon KC, Jones L, Craig JP. TFOS DEWS II Diagnostic Methodology Report. Ocul Surf.2017;15:539-74 Lay summary Dry Eye Disease is also known

2018 College of Optometrists

74. Respiratuvar depression after accidental nasal ingestion of brimonidine eye drops in infant (Full text)

Respiratuvar depression after accidental nasal ingestion of brimonidine eye drops in infant Brimonidine tartrate is an alpha-2 agonist used for glaucoma treatment. It can lead to serious poisoning symptoms when misused by children.In this case report, 3 months-old male patient with severe central nervous system depression and respiratory arrest as a result of accidentally nasal instillation of 1 cc brimonidine tartrate that benefited from mechanic ventilation and naloxone treatment (...) was presented.This case report suggested, that misuse of nasal brimonidine eye drop could result in serious respiratory distress and central nervous system depression. Mechanical ventilation and naloxone administration can be useful for these patients.

2016 Turkish journal of emergency medicine PubMed

75. Objective and subjective assessing efficacy of a lubricating drop in eyes wearing silicone hydrogel contact lenses (Full text)

coefficients, and subjective symptoms were assessed in 43 volunteers (mean age 19.58 ± 1.63, 86 eyes) at 6 h after inserting the contact lens and then at 60 min after instilling a lubricating drop (Comfort drops, Avizor, Madrid-Spain).PL-TDT, LOA-RMS, and HOA-RMS values measured before drop instillation were not significantly different with those measured after drop. None of the Zernike coefficients were significantly different after instilling lubricating drop. Statistically significant decrement in both (...) Objective and subjective assessing efficacy of a lubricating drop in eyes wearing silicone hydrogel contact lenses To investigate the effect of a lubricating drop on optical quality, tear film stability, and subjective symptoms in individuals wearing silicone hydrogel contact lens.In this one-day, prospective single-center clinical study, Pre-lens Tear Deformation Time (PL-TDT), Root-Mean-Square (RMS) of Low Order Aberrations (LOA) and High Order Aberrations (HOA), individual twelve Zernike

2016 Journal of current ophthalmology PubMed

76. Eye Care in the Intensive Care Unit

not give them at the same time as one drop may wash out another, thereby reducing its effectiveness. Allow ideally 5 minutes and at least 1 minute between each medication ? Always put drops in before ointment. The ointment is water repellent and prevents the drops from getting into the eye tissues. ? When putting in ointment in poor lid closure, after instilling ointment manually shut eyelids to ensure ointment is spread over whole eye surface. Hypopyon – pus in the eye 2017/PROF/350 12 Table 1 Patient (...) lead to some degree of facial skin or eyelid injury or irritation. It should therefore only be undertaken when necessary. ? Liberal use of lubricants into the eye: ointment (such as simple eye ointment, Lacrilube TM and VitA-POS TM ) is recommended as drops do not last long enough. This needs to be applied correctly into the eye and not, as is sometimes found, over closed eyelids. Such action is superior to manual eye closure alone and to the (once prevalent) application of Geliperm TM (3

2017 Intensive Care Society

77. Safety and Efficacy of Autologous PRP and PPP Eye Drops in the Treatment of Ocular GVHD

Safety and Efficacy of Autologous PRP and PPP Eye Drops in the Treatment of Ocular GVHD Safety and Efficacy of Autologous PRP and PPP Eye Drops in the Treatment of Ocular GVHD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Safety and Efficacy of Autologous PRP and PPP Eye Drops in the Treatment of Ocular GVHD The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02561520 Recruitment Status : Withdrawn (Study did not enroll participants is being withdrawn from the system.) First Posted : September 28, 2015

2015 Clinical Trials

78. Adverse reactions following routine anticholinergic eye drops in a paediatric population: an observational cohort study. (Full text)

Adverse reactions following routine anticholinergic eye drops in a paediatric population: an observational cohort study. To investigate the presence, nature and relationship to age, sex, ethnicity and body mass index (BMI) of adverse reactions following routine cycloplegic eye drops in children.Prospective observational cohort study.Ophthalmology outpatient clinic Dutch metropolitan hospital; February, March and April 2009.Children aged 3-14-year-old children receiving two drops (...) of cyclopentolate 1% (C+C) or one drop of cyclopentolate 1% and one drop of tropicamide 1% (C+T). Patients were categorised by age (3-6, 7-10 and 11-14 years), sex, ethnicity and body mass index (BMI) (low, normal or high).Rate and nature of adverse reactions reported at 45 min following treatment. Crude and adjusted ORs for reporting an adverse reaction using stepwise regression analysis with BMI, age, ethnicity and sex.912 of 915 eligible patients participated (99.7%). Adverse reactions were reported for C+C

2015 BMJ open PubMed

79. Dropless vs. Standard Drops Contralateral Eye Study

and able to provide written informed consent for participation in the study. Willing and able to comply with scheduled visits and other study procedures. Willing and able to administer eye drops and record the times the drops were instilled. Scheduled to undergo standard cataract surgery with topical anesthesia in both eyes within 6-15 days between surgeries. Potential postoperative best-corrected visual acuity of 20/30 or better Exclusion Criteria: Severe preoperative ocular pathology: amblyopia (...) Dropless vs. Standard Drops Contralateral Eye Study Dropless vs. Standard Drops Contralateral Eye Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Dropless vs. Standard Drops Contralateral Eye Study

2015 Clinical Trials

80. Tolerability and Acceptability of an Investigational Eye Drop Formulation (IE)

. The participant answered each questions using the scale: a=first product better, b=second product better or c=equal. The percentage of participants in each response category is reported. Distance Visual Acuity in Period 1 [ Time Frame: After 14 days of treatment in Period 1 (Follow-up 1 Day 14), 5 and 30 minutes post drop instillation ] Distance visual acuity is measured in each eye at 5 and 30 minutes post drop instillation using an eye chart at 4 meters and is reported as the number of letters read (...) correctly (ranging from 0 to 100 letters). Distance Visual Acuity in Period 2 [ Time Frame: After 14 days of treatment in Period 2 (Follow-up 2 Day 35), 5 and 30 minutes post drop instillation ] Distance visual acuity is measured in each eye at 5 and 30 minutes post drop instillation using an eye chart at 4 meters and is reported as the number of letters read correctly (ranging from 0 to 100 letters). Tear Break-Up Time With Fluorescein in Period 1 [ Time Frame: After 14 days of treatment in Period 1

2015 Clinical Trials

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