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Instilling Eye Drops

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41. Ophthalmic Insert versus Eye Drops for Mydriasis in Neonates: A Randomized Clinical Trial. (Abstract)

Ophthalmic Insert versus Eye Drops for Mydriasis in Neonates: A Randomized Clinical Trial. Eye drop treatment routinely used to obtain mydriasis prior to fundoscopy in neonates requires repeated instillations of mydriatic agents that can lead to systemic side effects.The aim of this study was to compare the mydriatic efficacy and tolerance of administration of phenylephrine and tropicamide via the ophthalmic insert Mydriasert® versus standard eye drop treatment in neonates.In this prospective (...) , single-blinded, noninferiority study, 80 hospitalized neonates (age < 18 months) requiring bilateral fundus examination were randomized to receive eye drops (repeated instillations of 2.5% phenylephrine and 0.5% tropicamide) or the insert. The primary outcome was mydriasis suitable for fundoscopy 75 min after mydriatic agent introduction (T75).Mydriasis was successfully achieved in both eyes at T75 in 97.5% (n = 39/40) of the insert group patients versus 90% (n = 36/40) receiving eye drops (between

2018 Neonatology Controlled trial quality: uncertain

42. A Phase I Safety and Tolerability Study of PP-001 Eye Drops in Healthy Adult Volunteers

A Phase I Safety and Tolerability Study of PP-001 Eye Drops in Healthy Adult Volunteers A Phase I Study of PP-001 Eye Drops in Healthy Adult Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . A Phase I Study of PP-001 Eye Drops in Healthy Adult Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03769454 Recruitment Status : Recruiting First Posted : December 7, 2018 Last Update Posted : December 17, 2018

2018 Clinical Trials

43. Effect of Single Instillation of Three Different Topical Lubricants on Tear Film Thickness in Patients With Dry Eye Syndrome

using this device. Tear film thickness will be measured at baseline and at defined time points after single instillation. The course of tear film thickness during this study day will provide information about the corneal residency time of the three different eye drops. Patients with moderate to severe DES will be randomized to receive either Neovis total multi®, Vismed multi® or Hydrabak® eye drops. Assessment of lipid layer thickness of the tear film will be performed before and at pre-specified (...) time points after instillation as secondary outcome. Other clinical measures for DES such as determination of tear film break up time (TFBUT), corneal fluorescein staining, Schirmer I test and subjective assessments will also be performed. Condition or disease Intervention/treatment Phase Dry Eye Syndromes Device: Neovis Total Multi® Eye Drops Device: Vismed Multi® Eye Drops Device: Hydrabak® Eye Drops Not Applicable Study Design Go to Layout table for study information Study Type : Interventional

2017 Clinical Trials

44. Micro-instillation of fluorescein with an inoculation loop for ocular surface staining in dry eye syndrome. (Full text)

eye syndrome were enrolled in a prospective interventional nonrandomized study. Fluorescein was instilled with the loop, and slit-lamp images were taken within 30 seconds using cobalt blue light with and without a yellow barrier filter. For comparison, after a washout period, the same images were retaken after instillation of one drop of fluorescein from a single-dose unit. The main outcome measure was the staining quality assessed by three experts, blind to the instillation method. Patient (...) Micro-instillation of fluorescein with an inoculation loop for ocular surface staining in dry eye syndrome. To describe and validate the micro-instillation of fluorescein on the ocular surface by a disposable calibrated inoculation loop to improve corneal and conjunctival staining quality.Accuracy and precision of the volume of 0.5% sodium fluorescein collected by a single use 1 μl-calibrated inoculation loop were measured using a precision balance. Twenty patients (40 eyes) suffering from dry

2017 Acta ophthalmologica PubMed abstract

45. A Two-Week, Randomized, Double-masked Study to Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye Disease. (Abstract)

, 51.9 ± 11.8 years) or HA (N=20, 61.8 ± 13.3 years). After a saline washout period, subjects administered BID therapy for 7 days, followed by instillation as needed (2-6 drops per eye) for 7 days. Visual analog scale (VAS) including foreign body sensation, burning/stinging, itching, pain, sticky feeling, blurred vision and photophobia were primary outcomes, with secondary endpoints of corneal fluorescein staining, Schirmer test, tear film breakup time (TFBUT), eyelid and conjunctival erythema (...) A Two-Week, Randomized, Double-masked Study to Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye Disease. The objective of this clinical trial (NCT02507934) was to assess the efficacy and safety of recombinant human lubricin as compared to a 0.18% sodium hyaluronate (HA) eye drop in subjects with moderate dry eye disease (DED).DEWS Grade 2-3 subjects were randomized to use lubricin (N=19

2016 The ocular surface Controlled trial quality: uncertain

46. A Study to Compare a New Eye Drop Formulation With Systane® Gel Drops and Genteal® Lubricant Gel Drops for Moderate to Severe Dry Eye Relief

blurring and Q4-preference/willingness to purchase the product. The participant answered each questions using the scale: a=first product better, b=second product better or c=equal. The percentage of participants in each response category is reported. Distance Visual Acuity in Period 1 [ Time Frame: After 14 days of treatment in Period 1 (Follow-up 1 Day 14), 5 and 30 minutes post drop instillation ] Distance visual acuity is measured in each eye at 5 and 30 minutes post drop instillation using an eye (...) chart at 4 meters and is reported as the number of letters read correctly (ranging from 0 to 100 letters). Distance Visual Acuity in Period 2 [ Time Frame: After 14 days of treatment in Period 2 (Follow-up 2 Day 35), 5 and 30 minutes post drop instillation ] Distance visual acuity is measured in each eye at 5 and 30 minutes post drop instillation using an eye chart at 4 meters and is reported as the number of letters read correctly (ranging from 0 to 100 letters). Tear Break-Up Time With Fluorescein

2015 Clinical Trials

47. Comparison of novel lipid-based eye drops with aqueous eye drops for dry eye: a multicenter, randomized controlled trial. (Full text)

was conducted. Subjects with signs and symptoms of dry eye were randomized to use one of two lipid-containing artificial tears, or one of two aqueous artificial tears. Subjects instilled assigned drops in each eye at least twice daily for 30 days. The primary efficacy analysis tested non-inferiority of a preservative-free lipid tear formulation (LT UD) to a preservative-free aqueous tear formulation (AqT UD) for change in Ocular Surface Disease Index (OSDI) score from baseline at day 30. Secondary measures (...) included OSDI at day 7, tear break-up time (TBUT), corneal and conjunctival staining, Schirmer's test, acceptability and usage questionnaires, and safety assessments.A total of 315 subjects were randomized and included in the analyses. Subjects reported instilling a median of three doses of study eye drops per day in all groups. At days 7 and 30, all groups showed statistically significant improvements from baseline in OSDI (P<0.001) and TBUT (P≤0.005). LT UD was non-inferior to AqT UD for mean change

2015 Clinical ophthalmology (Auckland, N.Z.) Controlled trial quality: predicted high PubMed abstract

48. The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients

The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01704248 Recruitment Status : Unknown Verified October 2012 by Mahidol University. Recruitment status

2012 Clinical Trials

49. Tear Lipid Layer Thickness With Emollient Eye Drops

Optive MEGA 3) in subjects with dry eye symptoms and lipid layer thickness < 65 nm at baseline in a randomized, cross-over (masked subject) design. We seek to objectively evaluate the increase in lipid layer thickness from baseline at 15 minutes and 1, 2 and 4 hours after each eye drop has been instilled. The Stroboscopic Video Color Microscope of King-Smith is used for non-invasive lipid layer thickness measurement. Study Design Go to Layout table for study information Study Type : Interventional (...) (Clinical Trial) Actual Enrollment : 20 participants Allocation: Randomized Intervention Model: Crossover Assignment Intervention Model Description: Single masked, randomized Masking: Single (Participant) Masking Description: Investigator instills eye drop masked to participant Primary Purpose: Treatment Official Title: Tear Lipid Layer Thickness With Emollient Eye Drops Actual Study Start Date : March 1, 2017 Actual Primary Completion Date : June 30, 2018 Actual Study Completion Date : June 30, 2018

2017 Clinical Trials

50. A Study to Evaluate the Efficacy of Investigational OTC Eye Drops

. Tetrahydrozoline 0.05%; Glycerin 0.40% 1-2 drops will be instilled as instructed over one day Experimental: Formula # 13418-158 Drug: F#13418-158 Eye Drops ocular clear liquid Tetrahydrozoline 0.05%; Glycerin 0.20%, Hypromellose 0.2%, Polyethylene glycol 400 1.0% 1-2 drops will be instilled as instructed over one day Active Comparator: Control Formula # PF004390 Drug: F# PF-004390 Eye Drops Ocular clear liquid Tetrahydrozoline 0.05%; 1-2 drops will be instilled as instructed over one day Outcome Measures Go (...) A Study to Evaluate the Efficacy of Investigational OTC Eye Drops A Study to Evaluate the Efficacy of Investigational OTC Eye Drops - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Evaluate

2017 Clinical Trials

51. Increase in esodeviation under cycloplegia with 0.5% tropicamide and 0.5% phenylephrine mixed eye drops in patients with hyperopia and esotropia. (Full text)

Increase in esodeviation under cycloplegia with 0.5% tropicamide and 0.5% phenylephrine mixed eye drops in patients with hyperopia and esotropia. To evaluate the manifestations of increased esodeviation under cycloplegia with 0.5% tropicamide and 0.5% phenylephrine in children with hyperopia and esotropia.We reviewed the medical record of 34 children with hyperopia and esotropia who underwent a prism alternate cover test before and after instillation of mixed eye drops containing 0.5 (...) after instillation of 0.5% tropicamide and 0.5% phenylephrine. This phenomenon reminded the clinicians that cycloplegics can have a different effect on esodeviation and suggested that increased angle of esodeviation may help to reveal the latent deviation in some patients with hyperopia and esotropia.

2017 BMC Ophthalmology PubMed abstract

52. Effect of Plum-blossom Needle vs. Tropicamide Eye Drops on Juvenile Myopia

-infraorbital margin will be tapped repeatedly. Acupuncturists should tap the points gently to make patients feel only a little pain and stop when the skin gets flushed but is not bleeding. Other Name: Double head dermal needles (HWATO, China) Drug: Tropicamide Eye Drops Instill one drop in both eyes every night before bed. Other Name: 6ml:30mg(0.5%)(FREDA, China) Experimental: TED-PbN Treated with Tropicamide Eye Drops for 10 days first, followed with a one-month wash-out period and 10 times of plum (...) will be tapped repeatedly. Acupuncturists should tap the points gently to make patients feel only a little pain and stop when the skin gets flushed but is not bleeding. Other Name: Double head dermal needles (HWATO, China) Drug: Tropicamide Eye Drops Instill one drop in both eyes every night before bed. Other Name: 6ml:30mg(0.5%)(FREDA, China) Outcome Measures Go to Primary Outcome Measures : Changes of vision acuity [ Time Frame: Every 30 days for 150 days ] International Standard Visual Acuity Chart

2017 Clinical Trials

53. Short-term Analysis of the Residual Volume of an Eye Drop Following 23-Gauge Microincision Vitrectomy Surgery (Full text)

Short-term Analysis of the Residual Volume of an Eye Drop Following 23-Gauge Microincision Vitrectomy Surgery To evaluate the change of residual volume of eye drop after instillation in patients with 23-gauge microincision vitrectomy surgery (MIVS).Patient who were treated 23-gauge MIVS from November 2014 to July 2015 were included. The residual volume was defined as the amount of remnant eye drop in patient's eyes after instillation, calculated as the difference between instillation volume (...) the volume at baseline (p = 0.105). The change of residual volume was significantly correlated with postoperative chemosis (r = 0.672, p < 0.001) and effected by the number of quadrant with postoperative chemosis (p < 0.05).This study shows that postoperative residual volume of eye drop after instillation decreased until postoperative day 4, and postoperative chemosis affects the change of residual volume. Thus, checking proper use of eye drops and teaching about instillation technique by physician

2017 Korean journal of ophthalmology : KJO PubMed abstract

54. Interstitial cystitis: dimethyl sulfoxide bladder instillation

Interstitial cystitis: dimethyl sulfoxide bladder instillation Interstitial cystitis: dimeth Interstitial cystitis: dimethyl sulfo yl sulfoxide bladder xide bladder instillation instillation Evidence summary Published: 20 February 2014 nice.org.uk/guidance/esuom26 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in February 2014. See summaries of product characteristics (SPCs), British national formulary (BNF) or the MHRA (...) : dimethyl sulfoxide bladder instillation (ESUOM26) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 6 of 28was found to be pregnant shortly after the first saline instillation and was removed from the study. Two patients in the placebo-first group dropped out before phase II of the trial. Assessment followed the completion of each treatment phase and comprised a subjective assessment by participants (participants were

2014 National Institute for Health and Clinical Excellence - Advice

55. Cetirizine Eye Drops for Allergic Conjunctivitis - Zerviate 1 drop twice daily

reported adverse reactions were ocular hyperemia (redness), instillation site pain, and reduction in visual acuity, which occurred in roughly 1% to 7% of patients. Treatment options for allergic conjunctivitis (eye drops) ( ). References: FDA Clears Cetirizine Eye Drops for Allergic Conjunctivitis Posted by Allergy on Labels: , No comments: Post a Comment Subscribe to: Total Pageviews About Us - : All opinions expressed here are those of their authors and not of their employer. The information provided (...) Cetirizine Eye Drops for Allergic Conjunctivitis - Zerviate 1 drop twice daily Allergy Notes: Cetirizine Eye Drops for Allergic Conjunctivitis - Zerviate 1 drop twice daily Allergy, Asthma and Immunology News Updated Daily by Board-certified Allergist at Cleveland Clinic Florida Pages Cetirizine Eye Drops for Allergic Conjunctivitis - Zerviate 1 drop twice daily The US Food and Drug Administration (FDA) approved the first topical ocular formulation of the antihistamine cetirizine

2017 Allergy Notes blog

56. Don't Open Eyes Technique for Eye Drop Instillation

Don't Open Eyes Technique for Eye Drop Instillation Dont Open Eyes Technique for Eye Drop Instillation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Don't Open Eyes Technique for Eye Drop Instillation Don't Open Eyes Technique for Eye Drop Instillation Aka: Don't Open Eyes Technique for Eye Drop Instillation , DOT for Topical Ophthalmic II. Indications Reduces systemic absorption of ophthalmic preparations Ophthalmic s have been associated with III. Technique Keep eyes closed for 1-5 minutes following installation of eye drops Consider also applying pressure at lacrimal ducts to prevent drainage IV. Mechanism Keeping eyes closed limits

2015 FP Notebook

57. Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation

Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail (...) Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read

2012 Clinical Trials

58. Effect of Instillation of Dry Eye Drops on Optical Quality. (Full text)

Effect of Instillation of Dry Eye Drops on Optical Quality. To investigate the effects of viscosity and suspensibility of eyedrops for dry eye by evaluating an eyedrop with one of the solutions or no solution (0.3% sodium hyaluronate ophthalmic solution, 3% diquafosol ophthalmic solution, and 2% rebamipide ophthalmic suspension) on ocular higher-order aberrations (HOAs) and forward light scatter.We evaluated ocular HOAs and forward light scatter before and 1, 5, and 10 minutes after (...) instillation of three eyedrops for dry eye in 15 healthy subjects. Saline served as the control. The HOAs were measured for a 4-mm pupil using a wavefront sensor. The obtained aberration data were analyzed in the central 4-mm diameter for total HOAs up to the sixth-order Zernike polynomials. Forward light scatter was quantified with a straylight meter.A significant increase was seen in the HOAs 1 minute after instillation of the three eyedrops for dry eye; the HOAs recovered to the baseline level

2013 Investigative Ophthalmology & Visual Science PubMed abstract

59. Corneal sensitivity after topical bromfenac sodium eye-drop instillation. (Full text)

Corneal sensitivity after topical bromfenac sodium eye-drop instillation. To evaluate the safety of bromfenac sodium eye drops from the standpoint of corneal sensitivity and tear secretion in healthy controls following instillation for 1 month.A prospective single-blind parallel clinical study was conducted in 20 eyes of ten healthy volunteers with no history of ocular or systemic allergic disease, dry eye, contact lens wear, or ocular surgery. Participants were instructed to instill either (...) bromfenac sodium or artificial tears in each eye twice daily for 28 days. Corneal sensitivity tested using a Cochet-Bonnet esthesiometer was evaluated before and immediately after instillation at 7, 14, and 28 days after the initiation of treatment. Tear secretion was also evaluated by Schirmer's eye test before and at 28 days.No significant difference in mean corneal sensitivity and tear-secretion rate was observed between the bromfenac and artificial-tear treatment groups at any time.These results

2013 Clinical ophthalmology (Auckland, N.Z.) Controlled trial quality: uncertain PubMed abstract

60. Safety and efficacy of a hydroxypropyl guar/polyethylene glycol/propylene glycol-based lubricant eye-drop in patients with dry eye. (Abstract)

Safety and efficacy of a hydroxypropyl guar/polyethylene glycol/propylene glycol-based lubricant eye-drop in patients with dry eye. To demonstrate non-inferiority of a hydroxypropyl guar/polyethylene glycol/propylene glycol lubricating eye-drop (HPG/PEG/PG) compared with an osmoprotective carboxymethylcellulose/glycerine eye-drop (O/CMC) for ocular surface staining.This was a multicentre, randomised, observer-masked, parallel-group study. Adults with dry eye instilled HPG/PEG/PG/ or O/CMC 4 (...) times daily for 35 days and then as needed through day 90. Total ocular surface staining (TOSS) score changes from baseline and Impact of Dry Eye on Everyday Life (IDEEL) treatment satisfaction module scores were assessed. Non-inferiority, based on TOSS score change from baseline, was concluded if the upper limit of the 2-sided CI was <2 units.Mean±SD patient age was 64.4±13.7 years; 94 patients were randomised to treatment (HPG/PEG/PG, n=46; O/CMC, n=48). Mean±SE TOSS score change from baseline

2016 British Journal of Ophthalmology Controlled trial quality: uncertain

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