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Instilling Eye Drops

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181. Delivery of Topically Applied Calpain Inhibitory Peptide to the Posterior Segment of the Rat Eye Full Text available with Trip Pro

of the eye. Immunoactivities gradually diminished at 3 and 6 h after the final eye drop. Quantitative estimations of the amount of peptide in the retina were 15.3, 5.8 and 1.0 pg/μg protein at 1, 3 and 6 h after the final instillation, respectively. Current results suggest that while the topically applied Tat-μCL peptide reaches the posterior segment of the retina and the optic nerve, the sufficient concentration (> IC50) is maintained for at least 6 h in the rat retina. Our findings suggest (...) topical application in adult rats. Distribution of the peptide was determined by immunohistochemical analysis, and enzyme-linked immune-absorbent assay was used to quantify the accumulation in the retina. Peptides were prominently detected in both the anterior and posterior segments of the eye at 1 h after the final eye drop application. Immunohistochemically positive reactions were observed in the retina, optic nerve, choroid, sclera and the retrobulbar tissues, even in the posterior portion

2015 PloS one

182. Effects of Topical Fucosyl-Lactose, a Milk Oligosaccharide, on Dry Eye Model: An Example of Nutraceutical Candidate Full Text available with Trip Pro

test), tear film breakup time (TBUT), corneal staining and tear osmolarity were assessed. Fucosyl-lactose eye drops was instilled at different concentrations (0.01, 0.1, and, 1%).After 24 h from first atropine administration, tear volume and TBUT values were significantly improved in groups treated with 2-fucosyl-lactose in a dose-dependent manner. Tear volume increased from 5.25 to 10.75 mm and TBUT values from 8.75 to 34.5 s with 0.01% or 1% 2-fucosyl-lactose treatment, respectively. No changes (...) Effects of Topical Fucosyl-Lactose, a Milk Oligosaccharide, on Dry Eye Model: An Example of Nutraceutical Candidate Colostrum has been proposed to treat severe dryness and problematic eye lesions showing a beneficial effect. The aim of the study was to investigate the effect of 2-fucosyl-lactose, a natural sugar present in the human colostrum, in an experimental dry eye.Dry eye was induced in adult male New Zealand albino rabbits by topical administration of 1% atropine. Tear volume (Schirmer's

2015 Frontiers in pharmacology

183. Tear film thickness after treatment with artificial tears in patients with moderate dry eye disease. (Abstract)

Tear film thickness after treatment with artificial tears in patients with moderate dry eye disease. This study was designed to investigate the effect of a single-drop instillation of different lacrimal substitutes on tear film thickness (TFT) assessed with optical coherence tomography in patients with mild to moderate dry eye disease.The study was performed in a randomized, double-masked, controlled parallel group design. Patients received a single dose of either unpreserved trehalose 30 mg/mL (...) and sodium hyaluronate 1.5 mg/mL (TH-SH, Thealoz Duo), unpreserved sodium hyaluronate, 0.15% (HA, Hyabak) or sodium chloride, 0.9% (NaCl, Hydrabak) eye drops. Sixty patients finished the study according to the protocol. TFT was measured with a custom-built ultrahigh-resolution Fourier domain optical coherence tomography system providing a resolution of 1.2 μm.The mean TFT before treatment was 2.5 ± 0.4 μm. Ten minutes after instillation, TFT significantly increased in the TH-SH group from 2.4 ± 0.4

2015 Cornea Controlled trial quality: uncertain

184. A Pilot Study: The Efficacy of Virgin Coconut Oil as Ocular Rewetting Agent on Rabbit Eyes Full Text available with Trip Pro

A Pilot Study: The Efficacy of Virgin Coconut Oil as Ocular Rewetting Agent on Rabbit Eyes Purpose. An open-label pilot study of virgin coconut oil (VCO) was conducted to determine the safety of the agent as ocular rewetting eye drops on rabbits. Methods. Efficacy of the VCO was assessed by measuring NIBUT, anterior eye assessment, corneal staining, pH, and Schirmer value before instillation and at 30 min, 60 min, and two weeks after instillation. Friedman test was used to analyse any changes (...) (P > 0.05). Conclusion. VCO acts as safe rewetting eye drops as it has shown no significant difference in the measurable parameter compared to commercial brand eye drops and saline. These study data suggest that VCO is safe to be used as ocular rewetting agent on human being.

2015 Evidence-based Complementary and Alternative Medicine : eCAM

185. Immediate Effects of 3% Diquafosol and 0.1% Hyaluronic Acid Ophthalmic Solution on Tear Break-Up Time in Normal Human Eyes. (Abstract)

Immediate Effects of 3% Diquafosol and 0.1% Hyaluronic Acid Ophthalmic Solution on Tear Break-Up Time in Normal Human Eyes. The purpose of this study was to evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear break-up time (TBUT) in normal human eyes, and to compare it with that of saline and 0.1% hyaluronate ophthalmic solution.Cross sectional comparative study in the first study, 10 healthy volunteers underwent topical application of 2 different ophthalmic solutions (...) in each eye. Saline was randomly applied to one eye and 3% diquafosol ophthalmic solution was added to the fellow eye. TBUT was measured and video recorded before application and at 5, 10, 15, and 20 min after. The TBUT in each eye was compared at each time point with regard to the 2 different ophthalmic solutions. In the second study, another 10 healthy volunteers were included. The same methods were used to compare the immediate effects of 0.1% hyaluronate and 3% diquafosol ophthalmic solution

2015 Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Controlled trial quality: uncertain

186. Comparison of three lubricant eye drop solutions in dry eye patients. Full Text available with Trip Pro

Comparison of three lubricant eye drop solutions in dry eye patients. Lubricant eye drops that restore physiological osmolarity represent a promising strategy for dry eye syndrome as hyperosmolarity plays a central role in this disease. This preliminary study compared three lubricant eye drop solutions with different osmolarities and compositions in subjects with this condition.Subjects with dry eye syndrome undergoing treatment with benzalkonium chloride-containing lubricant eye drops were (...) Optive and Blu Sal in subjects with dry eye syndrome over a 1 h period, possibly because of its hypo-osmolarity and high osmolyte (in particular L-carnitine) content. The instillation of compounds that improve the quality and stability of the tear film, which are impaired in dry eye syndrome, could be effective in the treatment of this condition.

2011 Optometry and vision science : official publication of the American Academy of Optometry Controlled trial quality: uncertain

187. Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye

2012 Resource links provided by the National Library of Medicine related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Thymosin Beta 4 eye drops It is a preservative-free, sterile eye drop solution containing Tβ4 for direct instillation into each eye, six times daily for 28 days Drug: Thymosin Beta 4 eye drops Patients will be randomized and will receive the same eye drops the Thymosin Beta 4. Other Name: Tβ4 Placebo Comparator: Vehicle Control (...) It is composed of the same excipients as RGN-259 but does not contain Tβ4 for direct instillation into each eye, six times daily for 28 days. Drug: Vehicle Control Patients will be randomized and will receive the same eye drops without the Thymosin Beta 4. Other Name: Vehicle Outcome Measures Go to Primary Outcome Measures : Safety [ Time Frame: Day 1, Day 14, Day 28 and Day 56 ] Sum of adverse events observed at Day 1, Day 14, Day 28 and Day 56. Measurable by Intra-ocular pressure (IOP) by applanation

2011 Clinical Trials

188. Effect of prophylactic antibiotic drops on ocular microbiota and physiology during silicone hydrogel lens wear. Full Text available with Trip Pro

% (test) or saline (control) drop group. Two drops were instilled into each eye on waking and before sleep. At monthly visits, lenses were collected aseptically, and ocular and throat swabs were performed, followed by standard microbial recovery and identifications. Any corneal infiltrative event at scheduled or unscheduled visits was recorded.Numbers of microbes recovered from eye swabs from the tobramycin (test) group were significantly lower than the control (p = 0.01). Gram-positive cocci were (...) Effect of prophylactic antibiotic drops on ocular microbiota and physiology during silicone hydrogel lens wear. Bacterial contamination of the contact lens surface has been demonstrated to cause corneal infiltrative events. A reduction in the rate of bacterially driven corneal infiltrative events associated with lens wear is one of the major goals of the contact lens industry. There is a concern over the potential of any antimicrobial strategy that there will be unwanted changes to the ocular

2012 Optometry and vision science : official publication of the American Academy of Optometry Controlled trial quality: uncertain

189. Noninvasive, objective, multimodal tear dynamics evaluation of 5 over-the-counter tear drops in a randomized controlled trial. (Abstract)

)-400, 1 carboxymethyl cellulose (CMC), 1 polyvinyl alcohol/PEG-400 (PVA), and 1 glycerine/polysorbate-80] were administered to 23 patients with aqueous-deficient dry eye in a randomized, controlled, double-masked trial. Measurements at each of the 5 visits were taken from both eyes at baseline and 5, 20, and 40 minutes after drop instillation.At 5 minutes after drop instillation, the 2 PEG drops showed significant worsening of visual quality (-128.87%, P = 0.001) compared with CMC, PVA (...) Noninvasive, objective, multimodal tear dynamics evaluation of 5 over-the-counter tear drops in a randomized controlled trial. To assess the ability of a noninvasive, objective, multimodal system to compare the efficacy and optical quality of 4 different groups of 5 over-the-counter tear drops.Wavefront sensing and optical coherence tomography (OCT) were used to objectively assess visual quality and tear volume, respectively, after the over-the-counter tear drops [2 polyethylene glycol (PEG

2012 Cornea Controlled trial quality: uncertain

190. Determining the Effect of Antibiotic Drop Prophylaxis on the Conjunctival Flora

but devastating infection of the eye that occurs in approximately 0.2% of patients after IVT injection. Many ophthalmologists ask patients to use antibiotic eye drops after IVT injection in the hope that this may reduce the risk of endophthalmitis. There is no proof that this happens and there is a possible risk that repeated exposure to the same antibiotic may cause antibiotic resistance organisms (bacteria) to develop over time. The investigators hypothesize that repeated exposure to antibiotic during (...) Drop Prophylaxis on the Conjunctival Flora Study Start Date : November 2010 Actual Primary Completion Date : December 2011 Actual Study Completion Date : December 2011 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Moxifloxacin 0.5% 1 drop four times daily for 3 days in affected eye post intravitreal injection Drug: Moxifloxacin 0.5% 1 drop 4 times daily times 3

2012 Clinical Trials

191. Effects of Benzalkonium Chloride on the Blood-Aqueous and Blood-Retinal Barriers of Pseudophakic Eyes. (Abstract)

Effects of Benzalkonium Chloride on the Blood-Aqueous and Blood-Retinal Barriers of Pseudophakic Eyes. To evaluate the effects of benzalkonium chloride (BAK) on the blood-aqueous (BAB) and blood-retinal barriers (BRB) of pseudophakic eyes.Prospective, randomized, investigator-masked, comparative study. Patients were randomly assigned to preservative-free artificial tears or BAK-preserved artificial tears. One drop of artificial tears was instilled 4 times a day in the study eye, starting (...) the day after randomization for 30 days. Anterior chamber flare was assessed by a laser flare meter (LFM) and macular thickness measurements were obtained with optical coherence tomography, before, 15, and 30 days after randomization.A total of 44 healthy eyes of 44 pseudophakic volunteers were recruited. There were no significant differences regarding demographics (age, gender, and race distributions) and clinical characteristics (eye, mean intraocular pressure, and mean best-corrected visual acuity

2014 Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Controlled trial quality: uncertain

192. Prospective, randomized, contralateral eye comparison of tetracaine and proparacaine for pain control in laser in situ keratomileusis and photorefractive keratectomy. Full Text available with Trip Pro

-masked, randomized study comprised 256 eyes from 128 consecutive patients being treated with LASIK or PRK who were randomized to receive tetracaine in one eye and proparacaine in the other. The patients were blinded as to which anesthetic agent was used in each eye. Pain levels were graded on a 0-10 scale, and were assessed upon instillation, during surgery, immediately postoperatively, 30 minutes postoperatively, overnight, and on postoperative day 1. Patients were asked 30 minutes after surgery (...) which anesthetic agent they would choose.Both anesthetic agents resulted in diminished amounts of subjective pain in patients undergoing LASIK and PRK. Tetracaine caused significantly more pain upon instillation than proparacaine for both LASIK and PRK patients. LASIK patients noted significantly less pain 30 minutes after surgery when treated with tetracaine. Significantly more LASIK patients preferred the eye treated with tetracaine. These differences were not present in the PRK group.Both

2014 Clinical ophthalmology (Auckland, N.Z.) Controlled trial quality: uncertain

193. A Novel OCT technique to Measure in vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and its validity in the Diagnosis of Dry Eye. Full Text available with Trip Pro

significant intraclass correlation (ICC) value of 0.99 was found for measurements of corneal adhesiveness on two subsequent days at the same time (P < 0.001).This minimally invasive, novel technique of OCT imaging of the corneal surface following NaCMC drop instillation provides a measure of corneal adhesiveness. This technique may improve the clinician's ability in the understanding and diagnosis of the dry eye syndrome.Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc. (...) A Novel OCT technique to Measure in vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and its validity in the Diagnosis of Dry Eye. The purpose of this work was to gather preliminary data on tear film stability, and the adhesive properties of the corneal surface in dry eye patients and control group subjects, using a new, minimally invasive optical coherence tomography (OCT) imaging method.We screened 85 human subjects for dry eye and classified them in two groups

2014 Investigative Ophthalmology & Visual Science

194. Ocular tolerability and efficacy of a cationic emulsion in patients with mild to moderate dry eye disease - A randomised comparative study. (Abstract)

] and for the Van Bijsterveld score [CE: -1.4 ± 1.2; PVA-P: -0.9 ± 1.2; P=0.046] in the CE group. The same applied for the palpebral erythema score (P=0.023), overall efficacy assessed by the investigators (P<0.001), and symptoms not related to eye drop instillation (P=0.021). Improvement was observed from D7. No difference was observed between the two treatments with regard to ocular safety.These results suggest that in patients with mild to moderate dry eye, Cationorm, in addition to its moisturizing (...) objective criteria were assessed to compare the two eye drops: tear Break-up Time (TBUT), Schirmer's test, lissamine green staining (Van Bijsterveld score), corneal fluorescein staining (Oxford scale) and oculopalpebral examination, on D7 and D28 (end of study). At these visits, ocular symptoms and safety were also assessed.Seventy-nine patients were randomised: CE: 44 patients; PVA-P: 35 patients. At D28, improvement was significantly better for TBUT [CE: 1.7 ± 2.4 s; PVA-P: 0.6 ± 1.8 s; P=0.015

2014 Journal français d'ophtalmologie Controlled trial quality: uncertain

195. Effects of sodium hyaluronate on wavefront aberrations in dry eye patients. Full Text available with Trip Pro

Effects of sodium hyaluronate on wavefront aberrations in dry eye patients. To investigate the effects of a single instillation of hypotonic 0.18% sodium hyaluronate artificial tears on wavefront aberrations in dry eye patients.Fifty patients with dry eye were recruited into this single-center, prospective, double-masked, randomized controlled trial. Patients were randomly assigned to receive one drop of preservative-free, hypotonic 0.18% sodium hyaluronate (treatment) in one eye and one drop (...) of sterile 0.9% sodium chloride solution (control) in the other eye. Ocular aberrations evaluated by a Hartmann-Shack aberrometer and severity of dry eye symptoms graded by a questionnaire (at baseline, 1, 10, 30, 60, and 120 minutes after instillation) were the main outcome measures.After a single instillation of one drop of the allocated eye drops, there were no statistically significant differences between the treatment and control groups in total higher-order aberrations, coma, and spherical

2014 Optometry and vision science : official publication of the American Academy of Optometry Controlled trial quality: predicted high

196. A Phase IV, Randomized, Parallel Group, Investigator-Masked Evaluation of the Effect of Loteprednol Etabonate Ophthalmic Gel 0.5% on the Initiation of Dry Eye Treatment With Restasis®

provided per the protocol. Have a condition for which steroid use would be contraindicated (e.g. viral infection). Use other topical ocular agents other than tear replacements within 1 week prior to the Screening and Baseline Visit and throughout the study. Have been exposed to an investigational drug within the preceding 30 days. In the opinion of the investigator or study coordinator, be unwilling or unable to comply with the study protocol or unable to successfully instill eye drops. Contacts (...) is not abstinent must have been using an acceptable method of birth control for at least 4 weeks prior to Visit 1 and throughout the study. Are women who have undergone one of the following sterilization procedures at least 1 month prior to Visit 1: Bilateral tubal ligation Hysterectomy Hysterectomy with unilateral or bilateral oophorectomy. Bilateral oophorectomy Are likely to comply with the eye drop regime, study guidelines, and study visits. Exclusion Criteria: Have a history of Stevens-Johnson Syndrome

2014 Clinical Trials

197. Topical Infliximab in Autoimmune Eyes With Keratoprosthesis

pemphigoid, have a higher risk of failure for the KPro. Because of chronic inflammation, the cornea supporting the KPro may melt, leading to a higher risk of infection, loss of the KPro and loss of the eye. Infliximab is an antibody against tumor necrosis factor alpha and is used intravenously to control inflammation in several diseases. It has been used in some cases of corneal melting with significant success. This study's hypothesis is that infliximab can be successfully used as an eye drop (instead (...) had prior KPro surgery and have a diagnosis of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis syndrome (TENS) or mucous membrane pemphigoid (MMP). Only one eye per patient will be considered for inclusion. This is a phase I/II study to evaluate the safety and tolerance of topical infliximab 10 mg/mL eye drops. Research subjects will be required to administer infliximab eye drops four times per day for three months followed by twice daily administration for nine months. The subjects

2014 Clinical Trials

198. Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease

Details Study Description Go to Brief Summary: The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease. The product will be studied over 28 days, with 1-2 drops instilled in each eye four times daily (QID). Condition or disease Intervention/treatment Phase Dry Eye Syndromes Keratoconjunctivitis Sicca Drug: KPI-121 Drug: Placebo Phase 2 Detailed (...) , be unwilling or unable to comply with study protocol or unable to successfully instill eye drops. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02188160 Locations Layout table for location information United States, California Sall Research Medical

2014 Clinical Trials

199. Efficacy and Safety of Fluorometholone (FML) in Dry Eye Disease (Keratoconjunctivitis Sicca)

of fluorometholone 0.1% 4 times a day during 22 days Other Name: 0.1% fluorometholone Active Comparator: Liquifilm artificial tears eyedrops Topical application 4 times a day in both eyes for 22 days Drug: Liquifilm artificial tears eyedrops Liquifilm instillation 4 times a day for 22 days Other Name: Artificial tears Outcome Measures Go to Primary Outcome Measures : Fluorescein corneal staining [ Time Frame: 22 days ] Evidence of statistically significant changes in the number of subjects with an increase ≥ 1 (...) : January 2015 Keywords provided by Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA: keratoconjunctivitis sicca dry eye dry eye syndrome dry eye disease steroids Additional relevant MeSH terms: Layout table for MeSH terms Keratoconjunctivitis Sicca Dry Eye Syndromes Eye Diseases Keratoconjunctivitis Conjunctivitis Conjunctival Diseases Keratitis Corneal Diseases Lacrimal Apparatus Diseases Lubricant Eye Drops Ophthalmic Solutions Fluorometholone

2014 Clinical Trials

200. A preliminary investigation into the effects of ocular lubricants on higher order aberrations in normal and dry eye subjects. Full Text available with Trip Pro

intervention.Hypromellose drops caused an increase in total higher order aberrations (p=<0.01 in normal and dry eyes) and a reduction in Strehl ratio (normal eyes: p=<0.01, dry eyes p=0.01) immediately after instillation. There were no significant differences between normal and self-diagnosed dry eyes for response to intervention and no improvement in visual quality or reduction in higher order aberrations after 60 min. Differences in comfort levels failed to reach statistical significance.Combining treatments does (...) A preliminary investigation into the effects of ocular lubricants on higher order aberrations in normal and dry eye subjects. To study the effects of ocular lubricants on higher order aberrations in normal and self-diagnosed dry eyes.Unpreserved hypromellose drops, Tears Again™ liposome spray and a combination of both were administered to the right eye of 24 normal and 24 dry eye subjects following classification according to a 5 point questionnaire. Total ocular higher order aberrations, coma

2014 Contact lens & anterior eye : the journal of the British Contact Lens Association Controlled trial quality: uncertain

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