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Instilling Eye Drops

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1. Comparison of success rates in eye drop instillation between sitting position and supine position. Full Text available with Trip Pro

Comparison of success rates in eye drop instillation between sitting position and supine position. To compare the success rates of eye drop instillation in the sitting position and supine position among Japanese patients with ocular diseases (cataract, glaucoma, or retinal and vitreous diseases).Patients who were hospitalized in Okayama University Hospital for eye surgery were studied. Instillation procedures of each patient in both the sitting and supine positions were recorded using a video (...) camera at the time of instillation. We defined "success" when one drop fell accurately onto the ocular surface at the first attempt. Instillation of two or more drops, drops delivered to a site other than the eye surface, and touching the eyelashes, eyelids, or conjunctiva with the tip of the eye drop bottle were regarded as "failure". We excluded patients with vision below counting finger.One-hundred and two patients (54 males and 58 females, aged 70.2 ± 12.3 years) with ocular disease who were

2018 PLoS ONE

2. Shortening of Interpupillary Distance after Instillation of Topical Prostaglandin Analogue Eye Drops. (Abstract)

Shortening of Interpupillary Distance after Instillation of Topical Prostaglandin Analogue Eye Drops. To investigate changes in the interpupillary distance (IPD) after continual instillation of topical prostaglandin analogues (PGAs) in glaucoma patients as an objective indicator of prostaglandin-associated periorbitopathy (PAP).Retrospective, comparative case series.SETTING: Institutional.Patients (n=152) with glaucoma. Inclusion criteria were visual acuities exceeding 10/20 bilaterally (...) and no intraocular surgery during observation.First-time bilateral instillation of bimatoprost, travoprost, latanoprost, or tafluprost and IPDs measured by automatic refractometry. IPDs, intraocular pressures (IOPs), and refractive errors were measured before and after continual drug administration (treatment, 2-24 months).Post-treatment changes in IPDs. Sixty-one untreated patients served as controls.The IPDs shortened significantly (P<0.001) post-treatment (-0.80±2.1 mm); the controls remained unchanged (0.05

2019 American Journal of Ophthalmology

3. Factors affecting eye drop instillation in glaucoma patients with visual field defect. Full Text available with Trip Pro

Factors affecting eye drop instillation in glaucoma patients with visual field defect. To investigate the success rate of eye drop instillation in glaucoma patients with visual field defect as well as non-glaucoma volunteers. Factors that may affect the success rate of eye drop instillation were also evaluated.A prospective, observational study.Seventy-eight glaucoma patients and 85 non-glaucoma volunteers were recruited in this study.Open angle glaucoma patients with visual field defect (...) as well as non-glaucoma volunteers were asked to video record their procedures of eye drop instillation using a 5-mL plastic bottle of artificial tear solution. Success of eye drop instillation was judged on video based on the first one drop of solution successfully applied on the cornea, by two investigators.Success rate of eye drop instillation in glaucoma patients and non-glaucoma volunteers. Factors related to success rate of eye drop instillation, such as visual field defect and clinical

2017 PLoS ONE

4. Evaluating Eye Drop Instillation Technique and Its Determinants in Glaucoma Patients Full Text available with Trip Pro

associated with eye drop instillation techniques was used to quantify the instillation technique and explore its determinants such as demographic and clinical characteristics.Half of the patients (48.67%) finished the administration of eye drop on first attempt.1.7 eye drops were squeezed out on average. 43 patients (37.17%) got contact with ocular surface or adnexa. Only 19.7% patients had eye drop instillation techniques being defined as well. 11 patients (9.7%) had prior instruction regarding using (...) Evaluating Eye Drop Instillation Technique and Its Determinants in Glaucoma Patients To evaluate eye drop instillation technique and to explore its determinants in glaucoma patients.One hundred and thirteen patients diagnosed with glaucoma and self-administering topical antiglaucoma eye drops for at least 1 month were evaluated. All patients instilled artificial tear solution in one eye as they would do at home. The whole process was evaluated by two study staff. A comprehensive score system

2018 Journal of ophthalmology

5. A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of Instillation of Eye Drops in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of Instillation of Eye Drops in Patients With Primary Open Angle Glaucoma or Ocular Hypertension A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of Instillation of Eye Drops in Patients With Primary Open Angle Glaucoma or Ocular Hypertension - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of Instillation of Eye Drops in Patients With Primary Open Angle Glaucoma or Ocular Hypertension The safety and scientific validity of this study

2017 Clinical Trials

6. Glaucoma: brinzolamide/brimonidine combination eye drops

with the combination eye drops compared with the individual constituent drugs. There are no published studies comparing brinzolamide/brimonidine combination eye drops with other drug treatments for managing glaucoma and ocular hypertension. Brinzolamide/brimonidine may be an alternative treatment option for some people, for whom prostaglandin analogues and beta-blockers are unsuitable. Regulatory status: Regulatory status: Brinzolamide/brimonidine eye drops (Simbrinza) received a European marketing authorisation (...) with brinzolamide and brimonidine monotherapy (both p<0.0001). In a non-inferiority study in people with glaucoma (n=890), at 3 months brinzolamide/brimonidine was non-inferior to brinzolamide plus brimonidine administered concomitantly for mean change from baseline in diurnal intraocular pressure. There are no published data comparing brinzolamide/brimonidine combination eye drops with other drug treatments used for managing glaucoma and ocular hypertension. Safety Safety Across both studies, there were few

2015 National Institute for Health and Clinical Excellence - Advice

7. Efficacy and Necessity of Time Interval Between Instillation of Two Glaucoma Eye Drops

Efficacy and Necessity of Time Interval Between Instillation of Two Glaucoma Eye Drops Efficacy and Necessity of Time Interval Between Instillation of Two Glaucoma Eye Drops - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Efficacy and Necessity of Time Interval Between Instillation of Two Glaucoma Eye Drops The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03220490 Recruitment Status : Not yet recruiting First Posted

2017 Clinical Trials

8. Evaluation of Short Term Use of Experimental Eye Drops BHVI2, 0.02% Atropine and BHVI2 Plus 0.02% Atropine Eye Drops

Posted : October 1, 2018 Last Update Posted : February 22, 2019 Sponsor: Hai Yen Eye Care Collaborator: Brien Holden Vision Information provided by (Responsible Party): Hai Yen Eye Care Study Details Study Description Go to Brief Summary: To assess the one-month ocular effects of nightly application of experimental BHVI2 and 0.02% atropine eye drops either alone or in combination, in children aged between 6 to 13 years old with myopia and randomized to use of experimental BHVI2 eye drops, 0.02 (...) Ocular Effects of Experimental BHVI2 and 0.02% Atropine Eye Drops Either Alone or in Combination Actual Study Start Date : October 1, 2018 Actual Primary Completion Date : February 2, 2019 Estimated Study Completion Date : April 2019 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Experimental BHVI2 eye drops 20 participants will receive one drop per eye every night for four weeks

2018 Clinical Trials

9. Instilling Eye Drops

Instilling Eye Drops Instilling Eye Drops Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Instilling Eye Drops Instilling Eye Drops (...) Aka: Instilling Eye Drops , Don't Open Eyes Technique for Eye Drop Instillation , DOT for Topical Ophthalmic , Eye Drop Technique II. Precautions Proper use of eye drops prevents systemic absorption, inaccurate dosing and medication waste Avoid touching dropper tip to eye (avoids bottle contamination) Wait at least 5 minutes before instilling another drop of the same or a different agent Allows for maximal concentration delivery of each medication drop without dilution Alternatively, may stagger

2018 FP Notebook

10. Instilling Eye Drops

Instilling Eye Drops Instilling Eye Drops Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Instilling Eye Drops Instilling Eye Drops (...) Aka: Instilling Eye Drops , Don't Open Eyes Technique for Eye Drop Instillation , DOT for Topical Ophthalmic , Eye Drop Technique II. Precautions Proper use of eye drops prevents systemic absorption, inaccurate dosing and medication waste Avoid touching dropper tip to eye (avoids bottle contamination) Wait at least 5 minutes before instilling another drop of the same or a different agent Allows for maximal concentration delivery of each medication drop without dilution Alternatively, may stagger

2018 FP Notebook

11. Noninferiority of Preservative-free Versus BAK-preserved Latanoprost-timolol Fixed Combination Eye Drops in Patients With Open-angle Glaucoma or Ocular Hypertension. Full Text available with Trip Pro

Noninferiority of Preservative-free Versus BAK-preserved Latanoprost-timolol Fixed Combination Eye Drops in Patients With Open-angle Glaucoma or Ocular Hypertension. PRéCIS:: Noninferiority of efficacy was demonstrated for a preservative-free latanoprost-timolol fixed combination compared with a BAK-containing formulation at 84 days after treatment in patients with open-angle glaucoma or ocular hypertension.The purpose of this study was to compare the effect on intraocular pressure and safety (...) of preservative-free latanoprost-timolol fixed combination (T2347) to benzalkonium chloride-preserved latanoprost-timolol fixed combination in patients with open-angle glaucoma or ocular hypertension.Phase III, randomized, parallel-group, investigator-masked study in 10 countries. A total of 242 patients aged 18 years or older with open-angle glaucoma or ocular hypertension in both eyes controlled with a preserved latanoprost-timolol fixed combination (15.7±2.4 mm Hg overall before inclusion) were randomized

2019 Journal of Glaucoma Controlled trial quality: uncertain

12. Tear film lipid layer increase after diquafosol instillation in dry eye patients with meibomian gland dysfunction: a randomized clinical study. Full Text available with Trip Pro

Tear film lipid layer increase after diquafosol instillation in dry eye patients with meibomian gland dysfunction: a randomized clinical study. Diquafosol promotes secretion of tear fluid and mucin at the ocular surface and is administered for treatment of dry eye (DE). Tear film lipid layer is secreted from meibomian glands and stabilizes the tear film. We recently showed that diquafosol administration increased lipid layer thickness (LLT) for up to 60 min in normal human eyes. We here (...) evaluated tear film lipid layer in DE patients (n = 47) with meibomian gland dysfunction (MGD) before as well as 30, 60, and 90 min after diquafosol administration. One drop of artificial tears or one drop of diquafosol was applied randomly to the eyes of each patient. Diquafosol significantly increased LLT at 30 (P < 0.001) and 60 (P = 0.042) min and noninvasive tear film breakup time for at least 90 min (P < 0.001 at each assessment point). Artificial tears had no such effect. Diquafosol significantly

2019 Scientific reports Controlled trial quality: uncertain

13. Comparison of Eye Drop Instillation Before and After Use of Drop Application Strips in Glaucoma Patients on Chronic Topical Therapy. (Abstract)

Comparison of Eye Drop Instillation Before and After Use of Drop Application Strips in Glaucoma Patients on Chronic Topical Therapy. To evaluate the impact of using drop application strips on eye drop instillation in glaucoma patients on chronic topical ocular hypotensive therapy.A total of 72 patients with primary open-angle glaucoma with an uncorrected visual acuity of 3/60 or more, self-administering topical antiglaucoma medication for >1 year were evaluated. One eye of each patient (...) without any contact (P=0.025). The number of patients putting the first drop of drug into the eye without spilling over the adenexae increased from 30 (41.67%) to 45 (62.5%) after application of the strip (P<0.001). The mean number of drops instilled to get 1 drop into the eye decreased from 2 ± 0.95 to 1.56 ± 0.78 when the drop application strip was used (P<0.001).Use of a drop application strip causes a significant decrease in contact of the eye drop bottle nozzle with the eyeball and eyelid

2015 Journal of Glaucoma

14. Use of Ozone-Based Eye Drops: A Series of Cases in Veterinary and Human Spontaneous Ocular Pathologies Full Text available with Trip Pro

Use of Ozone-Based Eye Drops: A Series of Cases in Veterinary and Human Spontaneous Ocular Pathologies Conjunctivitis, keratoconjunctivitis, and corneal ulcers are common eye disorders frequently diagnosed in both humans and animals, and are currently treated by topical administration of eye drops containing anti-inflammatory and antibacterial agents. The current molecules often lack efficacy because infections in hypoxic tissue contain methicillin-resistant Staphylococcus aureus (...) in liposomes plus hypromellose (Ozodrop®, FB Vision, Ascoli Piceno, Italy) instilled 3-4 times a day in external ocular spontaneous pathologies both in animals and humans are reported.

2018 Case reports in ophthalmology

15. Glaucoma Patient Preferences for Video Education on Eye Drop Technique. (Abstract)

Glaucoma Patient Preferences for Video Education on Eye Drop Technique. Glaucoma patients express a strong need for practical instruction on instilling eye drops correctly. To maximize the benefit of a video intervention to improve eye drop technique, patients recommend that video education be provided both in the clinic setting and online.The purposes of this study were to (1) describe glaucoma patients' perspectives on how to improve an online eye drop technique video and how to disseminate (...) it to other glaucoma patients and (2) examine how these perspectives differ across demographics.Glaucoma patients (N = 43) who viewed an online eye drop technique educational video as part of a randomized controlled trial were interviewed to assess their overall rating of the video on a 4-point scale, with whom they had watched the video, whether they would recommend the video to others, how the video helped them, how they would recommend improving the video, and how they would like the video

2019 Optometry and vision science : official publication of the American Academy of Optometry Controlled trial quality: uncertain

16. Effect of Single Instillation of Two Hyaluronic Acid-Based Topical Lubricants on Tear Film Thickness in Patients with Dry Eye Syndrome. (Abstract)

Effect of Single Instillation of Two Hyaluronic Acid-Based Topical Lubricants on Tear Film Thickness in Patients with Dry Eye Syndrome. This study investigated the effect of single administration of 2 different hyaluronic acid-based topical lubricants on tear film thickness (TFT) in patients with moderate-to-severe dry eye disease (DED).Sixty patients were randomized to receive eye drops containing unpreserved sodium hyaluronate, triglycerides, and phospholipids (HTP), unpreserved sodium (...) hyaluronate (HA), or unpreserved sodium chloride (NaCl). TFT and lipid layer thickness (LLT) were assessed before and at defined time points after single instillation with a custom-built ultrahigh-resolution optical coherence tomography system and a white light interferometer. Standard tests for DED such as a visual analogue scale (VAS), corneal fluorescein staining (CFS), Schirmer I test, and tear break-up time (BUT) were performed.The time course in TFT was significantly different between the 3

2018 Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Controlled trial quality: uncertain

17. Increase in tear film lipid layer thickness after instillation of 3% diquafosol ophthalmic solution in healthy human eyes. Full Text available with Trip Pro

Increase in tear film lipid layer thickness after instillation of 3% diquafosol ophthalmic solution in healthy human eyes. To evaluate the effect of 3% diquafosol ophthalmic solution on tear film lipid layer thickness (LLT) in normal human eyes by tear interferometry.Forty-seven healthy men (mean age of 42.4 years) randomly received one drop of artificial tears in one eye and one drop of 3% diquafosol ophthalmic solution in the other. LLT of each eye was quantified by tear interferometry before (...) and 15, 30, and 60 min after instillation. Ocular symptoms were assessed before and 30 min after instillation. Baseline LLT, tear film breakup time (TBUT), meibomian gland area (meiboscore) of the upper and lower eyelids, and Schirmer test value were evaluated on a different day before treatment.LLT before and 15, 30, and 60 min after diquafosol instillation was 62.3 ± 31.1, 77.0 ± 39.5, 79.3 ± 40.5, and 77.7 ± 43.6 nm, respectively, with the diquafosol-induced increase in LLT being significant

2018 The ocular surface Controlled trial quality: uncertain

18. Pharmacological Treatment of Presbyopia by Novel Binocularly Instilled Eye Drops: A Pilot Study. Full Text available with Trip Pro

Pharmacological Treatment of Presbyopia by Novel Binocularly Instilled Eye Drops: A Pilot Study. The feasibility, in terms of safety and potential efficacy, of a new drug combination for binocular use as a noninvasive pharmacological solution for treating presbyopia was examined.Fourteen emmetropic presbyopic subjects (28 eyes) were given one drop of the preparation under study in each eye. For each patient, the uncorrected distance visual acuity, uncorrected near visual acuity, near and far (...) refraction, best corrected visual acuity, best corrected far-near visual acuity, photopic and scotopic pupil size, Schirmer's test, endothelial cell count, intraocular pressure, keratometry, pachymetry, and anterior chamber depth were all performed or assessed prior to the administration of the eye drops and then 0.5, 1, 2, 3, 4, and 5 h, 1 week, and 1 month post-administration prospectively in each eye and binocularly.The results showed that near uncorrected visual acuity improved by about 2-3 lines

2016 Ophthalmology and therapy Controlled trial quality: uncertain

19. Inter-Rater Agreement in the Assessment of Video Recordings of Eye Drop Instillation by Glaucoma Patients Full Text available with Trip Pro

Inter-Rater Agreement in the Assessment of Video Recordings of Eye Drop Instillation by Glaucoma Patients To create a standardized method for evaluating the video recordings of patients self-instilling eye drops and to determine the level of agreement of eye drop instillation efficacy, safety and efficiency ratings by three masked graders.Prospective cross-sectional study.78 patients with open-angle glaucoma or ocular hypertension who had at least 6 months of experience with the use of eye drop (...) medications.Participants were video recorded while self-instilling artificial tears sequentially to both eyes. Three masked observers graded these video recordings on three criteria: efficacy (the determination of whether an eye drop was instilled on the ocular surface), safety (assessment of whether the tip of the medication bottle made contact with the ocular surface or eyelids), and efficiency (the number of eye drops expressed from the bottle).After grading the video recordings based on efficacy, safety

2016 PloS one

20. Effect of cooling proparacaine 0.5% eye drops on patient's comfort during instillation. Full Text available with Trip Pro

Effect of cooling proparacaine 0.5% eye drops on patient's comfort during instillation. 25907208 2016 04 08 2018 11 13 1476-5454 29 8 2015 Aug Eye (London, England) Eye (Lond) Effect of cooling proparacaine 0.5% eye drops on patient's comfort during instillation. 1112-3 10.1038/eye.2015.59 Hu Youwei J J Department of Ophthalmology, Khoo Teck Puat Hospital, Singapore, Singapore. Chang B B Department of Ophthalmology, Khoo Teck Puat Hospital, Singapore, Singapore. eng Letter Randomized Controlled (...) Trial 2015 04 24 England Eye (Lond) 8703986 0950-222X 0 Anesthetics, Local 0 Ophthalmic Solutions B4OB0JHI1X proxymetacaine EPD1EH7F53 Propoxycaine IM Adult Anesthetics, Local administration & dosage adverse effects Double-Blind Method Eye Pain prevention & control Female Humans Male Middle Aged Ophthalmic Solutions Pain Measurement Propoxycaine administration & dosage adverse effects Prospective Studies Refrigeration Young Adult 2015 4 25 6 0 2015 4 25 6 0 2016 4 9 6 0 ppublish 25907208 eye201559

2016 Eye (London, England) Controlled trial quality: uncertain

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