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121. [Effectiveness of reslip (doxylamine) in short-term insomnia: multicenter comparative randomized study]. (PubMed)

and regimen.The complete clinical remission of insomnia was achieved in majority of patients in both groups. Indicators of insomnia severity, sleep quality and daytime sleepiness in both groups improved with a high significance. Side effects were mild and in most cases did not result in treatment cessation. No significant differences between the groups in terms of clinical efficacy were found.Short-term doxylamine intake causes significant positive clinical effect in short-term insomnia with satisfactory (...) [Effectiveness of reslip (doxylamine) in short-term insomnia: multicenter comparative randomized study]. Evaluate the efficiency of reslip (doxylamine) in short-term insomnia in comparison with donormyl in multicenter comparative randomized study.The study was conducted in 6 medical centers and included 60 patients aged from 30 to 59 years with short-term insomnia. Patients were divided into two groups: in first one patients took reslip and in the second one donormyl in same dosage

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2017 Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

122. The Association between Insomnia and Prescription Opioid Use: Results from a Community Sample in Northeast Florida (PubMed)

The Association between Insomnia and Prescription Opioid Use: Results from a Community Sample in Northeast Florida The current analysis examines whether opioid use is associated with insomnia in a community sample, as the consequences of the growing epidemic of prescription opioid use continue to cause public health concern.A cross-sectional study including 8433 members in a community outreach program, HealthStreet, in Northeast Florida.Community Health Workers (CHWs) assessed health (...) information, including use of opioids (i.e., Vicodin®, Oxycodone, Codeine, Demerol®, Morphine, Percocet®, Darvon®, Hydrocodone) from community members during field outreach. Insomnia was determined based on self-report: "Have you ever been told you had, or have you ever had a problem with insomnia?" Summary descriptive statistics were calculated and logistic regression modeling was used to calculate adjusted odds ratios (ORs) with 95% confidence intervals for insomnia, by opioid use status, after

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2017 Sleep health

123. Letermovir (Prevymis) - to prevent illness caused by cytomegalovirus (CMV) in adults having an allogeneic haematopoietic stem cell transplant

Letermovir (Prevymis) - to prevent illness caused by cytomegalovirus (CMV) in adults having an allogeneic haematopoietic stem cell transplant 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 9 November 2017 EMA/CHMP/490007/2017 (...) population being CMV-seropositive in most countries. Similar to other herpesviruses, acute infection is generally followed by latent (dormant) infection. Among individuals with intact immune systems, reactivation of CMV infection is uncommon and is generally asymptomatic. However, CMV reactivation in immunocompromised patients, such as transplant recipients, can cause significant morbidity and mortality. Annually, approximately 27,000 allogeneic HSCTs are performed worldwide (Gratwohl 2015): in 2014

2018 European Medicines Agency - EPARs

124. Insomnia

or gastroesophageal reflux disease. Drugs and substance abuse such as excessive alcohol intake. Medications such as methylphenidate. Insomnia may be associated with stress, psychiatric comorbidities, medical comorbidities, drug and substance misuse, or current medication (secondary insomnia). However, in up to 20% of people with persistent insomnia, there is no associated cause or comorbidity (primary insomnia). A sleep diary can help identify how much someone is actually sleeping each night, and any factors (...) be required if a primary sleep disorder is suspected, there is doubt regarding the diagnosis, or long-term insomnia has not responded to management in primary care. Have I got the right topic? Have I got the right topic? From age 16 years onwards. This CKS topic covers the management of insomnia in primary care. This CKS topic does not cover the management of underlying causes of insomnia or the management of sleep-related breathing disorders (such as sleep apnoea), circadian rhythm disorders

2014 NICE Clinical Knowledge Summaries

125. Cathy A Alessi and Michael V Vitiello: Cognitive behavioral therapy for insomnia

Cathy A Alessi and Michael V Vitiello: Cognitive behavioral therapy for insomnia Cathy A Alessi and Michael V Vitiello: Cognitive behavioral therapy for insomnia - The BMJ ---> This blog is part of a series of blogs linked with , a database of systematic overviews of the best available evidence on the effectiveness of commonly used interventions. has been consistently demonstrated to be efficacious in a wide variety of settings and patient populations including older adults and settings (...) . This efficacy has been demonstrated in both patients with uncomplicated insomnia and in those whose insomnia is comorbid with a variety of medical and psychiatric conditions including: chronic pain, breast cancer, chronic obstructive pulmonary disease, coronary artery disease, osteoarthritis, fibromyalgia, Alzheimer’s disease, depression, alcohol abuse, and post traumatic stress disorder. Additional randomized clinical trials of CBT-I are being conducted in numerous other patient populations, including

2015 The BMJ Blog

126. Cognitive Behavioral Therapy for Insomnia

Cognitive Behavioral Therapy for Insomnia BMJ Blogs: BMJ Clinical Evidence Blog​ » Blog Archive » Cognitive Behavioral Therapy for Insomnia '); document.write(''); function OAS_AD(pos) { if (OAS_version >= 11) OAS_RICH(pos); else OAS_NORMAL(pos); } OAS_AD('Top'); //--> Search BMJ Clinical Evidence Blog​ blog: You don't need to be signed in to read BMJ Blogs, but you can to receive updates about other BMJ products and services via our site. Subscribe to the BMJ Clinical Evidence Blog​ blog feed (...) here. Either copy this feed address and paste it into your news reader software or click the relevant one-click subscription button: Feed URL: One click: Close 28 May, 15 | by BMJ Clinical Evidence by Cathy A. Alessi and Michael V. Vitiello Cognitive-behavioral therapy for insomnia in a wide variety of settings and patient populations including older adults. This efficacy has been demonstrated in both patients with uncomplicated insomnia and in those whose insomnia is comorbid with a variety

2015 BMJ Clinical Evidence Blog

127. Prevalence of causes of insomnia in primary care: a cross-sectional study. (PubMed)

Prevalence of causes of insomnia in primary care: a cross-sectional study. As a result of a research interest in primary insomnia, the prevalence of other causes of insomnia in primary care must be ascertained. No source was found in the literature. It is also essential to know the epidemiology of the common causes of a condition to make an accurate diagnosis in primary care.To determine the prevalence of causes of insomnia in primary care, as part of a method of identifying patients (...) with primary insomnia.Cross-sectional study in three general practices in Auckland, New Zealand.Consecutive patients from the waiting room were asked to complete a nine-page questionnaire on possible causes of insomnia.In total, 1517 patients were approached and 955 completed the nine-page questionnaire (63%). Of the 41% (388) who reported difficulty with sleeping, primary insomnia occurred in 12% (45) of the population (95% confidence interval = 9% to 15%); 50% (195) had depression, 48% (185) had

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2012 British Journal of General Practice

128. Medication Causes of Insomnia

Medication Causes of Insomnia Medication Causes of Insomnia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Medication Causes (...) of Insomnia Medication Causes of Insomnia Aka: Medication Causes of Insomnia , Insomnia due to Medications From Related Chapters II. Causes: Recreational Drugs Nicotine s or s III. Causes: Cardiovascular agents s s ( ) IV. Causes: Antineoplastics Interferon alpha V. Causes: Neurologic and psychiatric agents ( ) ( ) s ( ) Activating agents such as ( ) Stimulants ( ) ( ) VI. Causes: Endocrine agents s hormone VII. Causes: Miscellaneous agents s Protriptyline (Vivactil) ( ) Pseudophedrine ( ) s VIII

2015 FP Notebook

129. Insomnia Causes

Insomnia Causes Insomnia Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Insomnia Causes Insomnia Causes Aka: Insomnia Causes (...) , Insomnia Associated Conditions , Organic Insomnia From Related Chapters II. Causes: Medications See III. Causes: Chronic medical conditions Endocrine conditions (and ) (and ) Musculoskeletal conditions Joint or muscle pain (e.g. , ) Genitourinary (and ) Cardiopulmonary (and ) Miscellaneous conditions due to dermatologic or systemic conditions IV. Causes: Psychiatric disorders (including ) V. Causes: Sleep disorders disorder Extrinsic (e.g. , , ) Intrinsic (e.g. ) VI. References Images: Related links

2015 FP Notebook

130. Lorazepam as a Cause of Drug-Induced Liver Injury (PubMed)

Lorazepam as a Cause of Drug-Induced Liver Injury Lorazepam is a benzodiazepine derivative that is globally used for the therapy of anxiety and insomnia. A 51-year-old Japanese man with yellowish discoloration of the eyes and skin and pruritus was admitted due to liver dysfunction. He had taken lorazepam approximately 5 months prior to this admission. The clinical presentation and pathologic findings in the liver were consistent with drug-induced liver injury. After cessation of lorazepam (...) , treatment with Stronger neo-minophagen C and ursodeoxycholic acid was started, and his liver injury resolved after 59 days. This case must serve as a warning to physicians to be aware of the possibility of unexpected liver injury caused by lorazepam.

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2018 Case reports in gastroenterology

131. Clinical analysis of 86 botulism cases caused by cosmetic injection of botulinum toxin (BoNT). (PubMed)

Clinical analysis of 86 botulism cases caused by cosmetic injection of botulinum toxin (BoNT). This study was conducted to analyze the clinical characteristics of and treatment strategies for botulism among patients receiving cosmetic injection of botulinum toxin (BoNT).A total of 86 botulism patients caused by cosmetic injection of BoNT were enrolled in our study. All of the patients were diagnosed according to their history of cosmetic BoNT injection, clinical symptoms and signs, and other (...) auxiliary examinations (including those on renal and liver functions, blood index detection, and chest X-ray). All of the patients received comprehensive treatments and botulinum antitoxin serum injection.The main symptoms of botulism patients included headache, dizziness, insomnia, fatigue, blurred vision, eye opening difficulty, slurred speech, dysphagia, bucking, constipation, and anxiety. These clinical symptoms occurred 0∼36 days after BoNT injection, especially from 2nd to 6th day after

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2018 Medicine

132. Low-value clinical practices and harm caused by non-adherence to 'do not do' recommendations in primary care in Spain: a Delphi study. (PubMed)

and none for PNs were cataloged as frequent. A total of 37% (10/27) of these practices for GPs, 25% (2/8) for PEDs, 33% (3/9) for RNs and 25% (1/4) for PNs were considered as potential causes of harm. Only 26% (7/27) of the DNDs for GPs showed scores equal to or higher than 36 points. The impact measure was higher for ordering benzodiazepines to treat insomnia, agitation or delirium in elderly patients (mean = 57.8, SD = 25.3).Low-value and potentially dangerous practices were identified; avoiding (...) Low-value clinical practices and harm caused by non-adherence to 'do not do' recommendations in primary care in Spain: a Delphi study. To determine the non-adherence to the primary care 'do not do' recommendations (DNDs) and their likelihood to cause harm.Delphi study.Spanish National Health System.A total of 128 professionals were recruited (50 general practitioners [GPs], 28 pediatricians [PEDs], 31 nurses who care for adult patients [RNs] and 19 pediatric nurses [PNs]).A selection of 27 DNDs

2018 International Journal for Quality in Health Care

133. The assessment and management of insomnia in primary care

of the key points: Insomnia affects a third of people and is a common cause of consultation in primary care History is the main diagnostic tool There are many causes of secondary insomnia, which should be ruled out and treated first Excessive daytime sleepiness should raise questions about obstructive sleep apnoea Primary insomnia is diagnosed after excluding other causes of insomnia. It can be treated effectively by sleep hygiene techniques, by restricting time in bed, or with behavioural interventions (...) The assessment and management of insomnia in primary care The assessment and management of insomnia in primary care - National Elf Service Search National Elf Service Search National Elf Service » » » » The assessment and management of insomnia in primary care May 28 2011 Posted by There’s a nice review in this week’s BMJ for primary care professionals who haven’t had much time this week to think about the mental health awareness week topic – sleep. The authors provide a short summary

2011 The Mental Elf

134. “Opioid painkillers cause chronic pain” stories leave physician reader in agony

the cardiovascular, immune, neurologic, and endocrine systems. Not to mention the psychological disorders..depression, anxiety, and insomnia. I live in constant fear that my medication will be reduced or that I’ll be taken off my medication completely. I already live a life on house arrest. 95% of the time leaving the house only for doctor appointments, tests, or procedures. My crime? Having diseases that cause severe chronic pain. The media only tells one side of the story…and most of what is reported is untrue (...) “Opioid painkillers cause chronic pain” stories leave physician reader in agony "Opioid painkillers cause chronic pain" stories leave physician reader in agony - HealthNewsReview.org Note to our followers: Our nearly 13-year run of daily publication of new content on HealthNewsReview.org came to a close at the end of 2018. Publisher Gary Schwitzer and other contributors may post new articles periodically. But all of the 6,000+ articles we have published contain lessons to help you improve your

2016 HealthNewsReview

135. Diphenhydramine as a Cause of Drug-Induced Liver Injury (PubMed)

Diphenhydramine as a Cause of Drug-Induced Liver Injury Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the Unites States and accounts for 10% of acute hepatitis cases. We report the only known case of diphenhydramine-induced acute liver injury in the absence of concomitant medications. A 28-year-old man with history of 13/14-chromosomal translocation presented with fevers, vomiting, and jaundice. Aspartate-aminotransferase and alanine-aminotransferase levels (...) peaked above 20,000 IU/L and 5,000 IU/L, respectively. He developed coagulopathy but without altered mental status. Patient reported taking up to 400 mg diphenhydramine nightly, without concomitant acetaminophen, for insomnia. He denied taking other medications, supplements, antibiotics, and herbals. A thorough workup of liver injury ruled out viral hepatitis (including A, B, C, and E), autoimmune, toxic, ischemic, and metabolic etiologies including Wilson's disease. A liver biopsy was consistent

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2017 Case Reports in Hepatology

136. Overcoming Insomnia: Impact on Sleep, Health and Work of Online CBT-I

Name: SHUTi Active Comparator: Psychoeducation about Sleep (PE) The PE intervention gives participants access to a website with information about insomnia symptoms; the impact, prevalence, and causes of insomnia; when to seek input from a doctor; and basic lifestyle, environmental, and behavioral strategies that may help to improve sleep. Behavioral: Psycho-Education about Sleep (PE) PE provides online information about insomnia symptoms; the impact, prevalence, and causes of insomnia; when to seek (...) Overcoming Insomnia: Impact on Sleep, Health and Work of Online CBT-I Overcoming Insomnia: Impact on Sleep, Health and Work of Online CBT-I - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Overcoming

2015 Clinical Trials

137. Yoga, Survivorship Health Education, and Cognitive Behavioral Therapy in Reducing Insomnia in Cancer Survivors

(insomnia) in cancer survivors. Insomnia can be described as excessive daytime napping, difficulty falling asleep, difficulty staying asleep, or waking up earlier than desired. Insomnia can increase fatigue, impair physical function, impair immune function, cause circadian rhythms (known as the biological clock) to be disrupted and decrease quality of life. Yoga may improve circadian rhythms, physical and immune function, and improve insomnia and sleep quality in cancer survivors. It is not yet known (...) Yoga, Survivorship Health Education, and Cognitive Behavioral Therapy in Reducing Insomnia in Cancer Survivors Yoga, Survivorship Health Education, and Cognitive Behavioral Therapy in Reducing Insomnia in Cancer Survivors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2015 Clinical Trials

138. Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. (PubMed)

Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. We performed a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials evaluating suvorexant for primary insomnia.Relevant studies were identified through searches of PubMed, databases of the Cochrane Library, and PsycINFO citations through June 27, 2015. We performed a systematic review and meta-analysis of suvorexant trial efficacy and safety (...) were excluded following a review of titles and abstracts and another eight review articles after full-text review. Thus, we identified 4 trials that included a total of 3,076 patients. Suvorexant was superior to placebo with regard to the two primary efficacy outcomes (sTST: WMD = -20.16, 95% CI = -25.01 to -15.30, 1889 patients, 3 trials, sTSO: WMD = -7.62, 95% CI = -11.03 to -4.21, 1889 patients, 3 trials) and was not different from placebo in trial discontinuations. Suvorexant caused a higher

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2015 PloS one

139. Pediatric Insomnia. (PubMed)

Pediatric Insomnia. Insomnia in children is complex and frequently multifactorial. This review discusses the major categories of insomnia as well as common causes. The consequences of insomnia, including issues with mood, behavior, and cognition, are discussed. Sleep disorders are much more prevalent in certain pediatric populations, such as children with autism spectrum disorders. The evaluation of insomnia in children includes a focused history and examination and occasionally actigraphy

2015 Chest

140. Aromatherapy and Essential Oils in Improving Insomnia and Other Symptoms in Patients With Newly Diagnosed Acute Leukemia Undergoing Chemotherapy

leukemia. Aromatherapy and essential oils may help improve insomnia and other complications caused by chemotherapy. Condition or disease Intervention/treatment Phase Acute Leukemia Anorexia Anxiety Depression Dyspnea Insomnia Nausea Pain Procedure: Aromatherapy and Essential Oils Other: Placebo Other: Questionnaire Administration Not Applicable Detailed Description: PRIMARY OBJECTIVES: I. Does the addition of aromatherapy by diffusion of essential oils improve insomnia in newly diagnosed, hospitalized (...) Aromatherapy and Essential Oils in Improving Insomnia and Other Symptoms in Patients With Newly Diagnosed Acute Leukemia Undergoing Chemotherapy Aromatherapy and Essential Oils in Improving Insomnia and Other Symptoms in Patients With Newly Diagnosed Acute Leukemia Undergoing Chemotherapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save

2015 Clinical Trials

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