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Insomnia Causes

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101. Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current Insomnia

Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current Insomnia Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current Insomnia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2016 Clinical Trials

102. Auricular Acupressure for Hemodialysis Patients With Insomnia

: Presence of co-morbidities including cancer, congestive heart failure, connective tissue disease and hematologic diseases; Inadequately dialyzed, indicating by urea clearance index (KT/V) < 1.20; Presence of severe physical symptoms such as bone pain, itchy skin, sleep apnea and restless legs which are obviously causative for insomnia; and weary condition caused by severe anemia (hemoglobin<60g/L) or malnutrition (serum albumin<30g/L). Infections of external ears or malformed ears. Contacts (...) Auricular Acupressure for Hemodialysis Patients With Insomnia Auricular Acupressure for Hemodialysis Patients With Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Auricular Acupressure

2016 Clinical Trials

103. Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1)

Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1) Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1) (SUNRISE 1) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02783729 Recruitment Status : Completed First Posted : May

2016 Clinical Trials

104. Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure

difficulties, satisfaction with current sleep pattern, interference with daily functioning, noticeability of impairment attributed to the sleep problem, and degree of distress or concern caused by the sleep problem. Each item is rated on a 0-4 scale (4 indicates greater severity) with a total score ranging from 0 to 28. Scores are categorized as not clinically significant, subthreshold insomnia, moderate insomnia or severe insomnia. Secondary Outcome Measures : Depressive symptoms [ Time Frame: Baseline (...) Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cognitive Behavioral

2016 Clinical Trials

105. Insomnia From Drug Treatments: Evidence From Meta-analyses of Randomized Trials and Concordance With Prescribing Information. (PubMed)

Insomnia From Drug Treatments: Evidence From Meta-analyses of Randomized Trials and Concordance With Prescribing Information. To determine whether drugs used to treat diverse conditions cause insomnia symptoms and whether their prescription information is concordant with this evidence.We conducted a survey of meta-analyses (Cochrane Database of Systematic Reviews) and comparisons with package inserts compiled in the Physicians' Desk Reference (PDR). We identified randomized controlled trials (...) (RCTs) in which any drug had been evaluated vs placebo and sleep had been assessed. We collectively referred to insomnia-related outcomes as sleep disturbance. We also searched the PDR to identify any insomnia symptoms listed for drugs with RCT evidence available.Seventy-four Cochrane systematic reviews corresponding to 274 RCTs assessed 88 drugs in 27 different conditions, providing evidence on 109 drug-condition pairs. Of these 88 drugs, 5 decreased sleep problems and 19 increased sleep problems

2016 Mayo Clinic Proceedings

106. Altered nocturnal blood pressure profiles in women with insomnia disorder in the menopausal transition. (PubMed)

regulatory control of BP during sleep in the MT insomnia. The causes and long-term consequences of this altered nocturnal BP profile remain to be determined. (...) Altered nocturnal blood pressure profiles in women with insomnia disorder in the menopausal transition. Insomnia disorder is a risk factor for cardiovascular (CV) pathology. It is unknown whether insomnia that develops in the context of the menopausal transition (MT) impacts the CV system. We assessed nocturnal blood pressure (BP) and heart rate (HR) profiles in women with insomnia disorder in the MT.Twelve women meeting DSM-IV criteria for insomnia in the MT (age, mean ± SD: 50.5 ± 3.6 y

2016 Menopause

107. Insomnia and risk of dementia in older adults: Systematic review and meta-analysis. (PubMed)

Insomnia and risk of dementia in older adults: Systematic review and meta-analysis. There are cross-sectional evidences of an association between sleep disorders and cognitive impairment on older adults. However, there are no consensus by means of longitudinal studies data on the increased risk of developing dementia related to insomnia. We conduct a systematic review and meta-analysis to evaluate the risk of incident all-cause dementia in individuals with insomnia in population-based (...) prospective cohort studies. Five studies of 5.242 retrieved references were included in the meta-analysis. We used the generic inverse variance method with a random effects model to calculate the pooled risk of dementia in older adults with insomnia. We assessed heterogeneity in the meta-analysis by means of the Q-test and I2 index. Study quality was assessed with the Newcastle-Ottawa Scale The results showed that Insomnia was associated with a significant risk of all-cause dementia (RR = 1.53 CI95% (1.07

2016 Journal of psychiatric research

108. Effects of armodafinil and cognitive behavior therapy for insomnia on sleep continuity and daytime sleepiness in cancer survivors. (PubMed)

Effects of armodafinil and cognitive behavior therapy for insomnia on sleep continuity and daytime sleepiness in cancer survivors. This study involves the analysis of a secondary outcome of a trial examining whether cognitive behavior therapy for insomnia (CBT-I), a wake-promoting medication (armodafinil), or both results in greater improvement in prospectively assessed sleep continuity and daytime sleepiness than a placebo-alone group among a heterogeneous group of cancer survivors. Whether (...) or not armodafinil alone, and/or when combined with CBT-I, affected adherence with CBT-I was evaluated.This study is a randomized, placebo-controlled, clinical trial.This study was conducted at two northeastern academic medical centers.Eighty-eight cancer survivors with chronic insomnia were recruited between October 2008 and November 2012. Participants were assigned to one of four conditions: 1) CBT-I and placebo (CBT-I+P); 2) CBT-I and armodafinil (CBT-I + A); 2) armodafinil alone (ARM); or 4) placebo alone

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2016 Sleep medicine

109. Insomnia and Restless Leg Syndrome in Patients Undergoing Chronic Hemodialysis in Rafsanjan Ali Ibn Abitaleb Hospital (PubMed)

Insomnia and Restless Leg Syndrome in Patients Undergoing Chronic Hemodialysis in Rafsanjan Ali Ibn Abitaleb Hospital Sleep is one of the most fundamental human needs; without any doubt sleep is even more essential for sick patients, especially for patients with chronic illnesses. Sleep disturbance may lead to anxiety and reduced quality of life. Restless leg syndrome (RLS) is a sensory-motor disorder accompanied by a strong desire to move the legs or other parts of the body, which can cause (...) sleep disturbance. Its etiology is unknown, but increased urea and creatinine levels before dialysis, iron deficiency due to kidney failure and end-stage renal disease (ESRD) are mentioned as causes.This study is designed to examine the prevalence of insomnia and restless leg syndrome in patients undergoing chronic hemodialysis in Rafsanjan Ali Ibn Abitaleb Hospital.In this study we used two questionnaires to evaluate the presence of RLS and insomnia in ESRD patients who were undergoing hemodialysis

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2016 Nephro-urology monthly

110. Insomnia

or more) Impaired memory, concentration, attention about sleep Daytime , , or malaise Depressed mood, irritability or poor motivation Accidents or errors while working or driving Poor work or school performance s or gastrointestinal upset Frequency At least 3 times weekly Duration Transient Insomnia: <7 days Acute Insomnia: <30 days Chronic Insomnia: 30 days or more Subtypes based on cause Primary Insomnia (no cause): <20% of chronic cases Difficult sleep despite adequate conditions and opportunity (...) No other sleep disorder (e.g. ) Comorbid Insomnia ( ) Insomnia secondary to other cause (medication, medical condition) VIII. Management: Non-Pharmacologic Consider written sleep plan Lifestyle changes See Regular (6 hours before bedtime) Cognitive behavior therapy for Insomnia ( ) Preferred first-line management Combines techniques therapy Paradoxical intention (stay awake to reduce anxiety about not falling asleep) Replace dysfunctional beliefs about sleep (e.g. hours of sleep needed per night

2018 FP Notebook

111. A pilot trial of brief group cognitive-behavioral treatment for insomnia in an adult cancer survivorship program. (PubMed)

completed sleep logs throughout the study and measures of sleep at baseline and week 4.Participants reported experiencing insomnia symptoms an average of 2.4 years, with 89.7% indicating that the cancer experience had caused/exacerbated symptoms. Significant pre/post-intervention group improvements in sleep efficiency (77.3% to 88.5%), sleep quality, and insomnia symptoms were reported (all ps < .01). Less than 1 in 3 had discussed insomnia symptoms with their oncology providers in the prior year.Pilot (...) A pilot trial of brief group cognitive-behavioral treatment for insomnia in an adult cancer survivorship program. Cognitive-behavioral therapy for insomnia (CBT-Insomnia) is effective, yet rarely available for cancer survivors. This is unfortunate because survivors are at elevated risk for insomnia, which is associated with significant health consequences in this already at-risk population. Barriers to delivering CBT-Insomnia in oncology settings include a lack of trained providers, distance

2016 Psycho-oncology

112. BDNF in sleep, insomnia, and sleep deprivation. (PubMed)

BDNF in sleep, insomnia, and sleep deprivation. The protein brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors involved in plasticity of neurons in several brain regions. There are numerous evidence that BDNF expression is decreased by experiencing psychological stress and that, accordingly, a lack of neurotrophic support causes major depression. Furthermore, disruption in sleep homeostatic processes results in higher stress vulnerability (...) and is often associated with stress-related mental disorders. Recently, we reported, for the first time, a relationship between BDNF and insomnia and sleep deprivation (SD). Using a biphasic stress model as explanation approach, we discuss here the hypothesis that chronic stress might induce a deregulation of the hypothalamic-pituitary-adrenal system. In the long-term it leads to sleep disturbance and depression as well as decreased BDNF levels, whereas acute stress like SD can be used as therapeutic

2016 Annals of Medicine

113. Magnetic Resonance Spectroscopy in Patients with Insomnia: A Repeated Measurement Study (PubMed)

Magnetic Resonance Spectroscopy in Patients with Insomnia: A Repeated Measurement Study Chronic insomnia is one of the most prevalent central nervous system disorders. It is characterized by increased arousal levels, however, the neurobiological causes and correlates of hyperarousal in insomnia remain to be further determined. In the current study, magnetic resonance spectroscopy was used in the morning and evening in a well-characterized sample of 20 primary insomnia patients (12 females; 8 (...) males; 42.7 ± 13.4 years) and 20 healthy good sleepers (12 females; 8 males; 44.1 ± 10.6 years). The most important inhibitory and excitatory neurotransmitters of the central nervous system, γ-aminobutyric acid (GABA) and glutamate/glutamine (Glx), were assessed in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC). The primary hypothesis, a diurnal effect on GABA levels in patients with insomnia, could not be confirmed. Moreover, the current results did not support

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2016 PloS one

114. Insomnia and its associations in patients with recurrent glial neoplasms (PubMed)

Insomnia and its associations in patients with recurrent glial neoplasms Patient with neurological disorders and cancer can develop sleep disturbance, in particular insomnia. Etiology of insomnia is multi-factorial in primary brain tumour patients with possible causes including corticosteroids, psychoactive medications, co-morbid psychiatric/medical conditions, and damage to neuronal tissue.To understand better insomnia in recurrent glioma patients, a single-center retrospective analysis (...) was performed looking at recurrent glioma patients from January 2004 to May 2009. Data was extracted and included demographics, clinical factors, psychoactive medications, and co-morbid symptoms. Presence and absence of insomnia complaints was evaluated with other co-morbidities using Chi square and Wilcoxon analyses. Records from 340 recurrent glioma patients were evaluated and 46.8 % (n = 159) indicated presence of insomnia with 20 % (n = 66) actively using medications for sleep. Use of corticosteroids

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2016 SpringerPlus

115. CBT for insomnia in people with active psychotic symptoms

CBT for insomnia in people with active psychotic symptoms CBT for insomnia in people with active psychotic symptoms Search National Elf Service Search National Elf Service » » » » CBT for insomnia in people with active psychotic symptoms Nov 26 2015 Posted by The Better Sleep Trial (BEST) was designed to determine if the proven efficacy of CBT for insomnia would hold true for adults with a diagnosis of a schizophrenia spectrum disorder . This was a pilot study, comparing 24 people receiving CBT (...) that disturbed and disordered sleep have on mental health, and the common co-morbidity of psychosis with sleep disorders, it seems surprising that no RCTs have been conducted to look at insomnia therapies for people with psychotic disorders. Although the authors conducted what seems to be a limited literature search, only using PubMed and the ISRCTN trial registry, my brief Google Scholar and Medline searches did not spring up any hidden gems. Baglioni & Riemann (2012) provide a brief summary of the mental

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2015 The Mental Elf

116. Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia. (PubMed)

Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia. Objective. To study the effect of Heweianshen decoction (HAD) on orexin-A and cholecystokinin-8 (CCK-8) expression in rat models of insomnia caused by injecting parachlorophenylalanine (PCPA) intraperitoneally. Methods. Fifty male Wistar rats were randomly divided into five groups (10 rats in each group): blank group, model group, and low-, medium-, and high-dose HAD-treated groups. A rat (...) model of insomnia was established by injecting intraperitoneally with PCPA (300 mg/kg body weight). Rats were given normal saline (10 mL/kg) or 5.25, 10.5, and 21 g/kg HAD by intragastric administration once a day for 6 days. After that, the rats were sacrificed to collect the hypothalamus for tests, using radioimmunoassay to detect the expression of orexin-A and CCK-8. Results. Heweianshen decoction reduced the expression of orexin-A and increased the expression of CCK-8 in the hypothalamus of rat

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2016 Evidence-based Complementary and Alternative Medicine (eCAM)

117. Cost-effectiveness of i-Sleep, a guided online CBT intervention, for patients with insomnia in general practice: protocol of a pragmatic randomized controlled trial. (PubMed)

Cost-effectiveness of i-Sleep, a guided online CBT intervention, for patients with insomnia in general practice: protocol of a pragmatic randomized controlled trial. Insomnia is a highly prevalent disorder causing clinically significant distress and impairment. Furthermore, insomnia is associated with high societal and individual costs. Although cognitive behavioural treatment for insomnia (CBT-I) is the preferred treatment, it is not used often. Offering CBT-I in an online format may increase (...) access. Many studies have shown that online CBT for insomnia is effective. However, these studies have all been performed in general population samples recruited through media. This protocol article presents the design of a study aimed at establishing feasibility, effectiveness and cost-effectiveness of a guided online intervention (i-Sleep) for patients suffering from insomnia that seek help from their general practitioner as compared to care-as-usual.In a pragmatic randomized controlled trial

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2016 BMC psychiatry

118. ‘Folk theories’ about the causes of insomnia (PubMed)

‘Folk theories’ about the causes of insomnia The present study investigates 'folk theories' about the causes of insomnia. Participants with insomnia (n = 69) completed a qualitative and quantitative assessment of their folk theories. The qualitative assessment was to speak aloud for 1 minute in response to: 'What do you think causes your insomnia?'. The quantitative assessment involved completing the 'Causal Attributions of My Insomnia Questionnaire' (CAM-I), developed for this study (...) . The three most common folk theories for both the causes of one's own insomnia as well as insomnia in others were 'emotions', 'thinking patterns' and 'sleep-related emotions'. Interventions targeting these factors were also perceived as most likely to be viable treatments. Seventy-five percent of the folk theories of insomnia investigated with the CAM-I were rated as more likely to be alleviated by a psychological versus a biological treatment. The results are consistent with research highlighting

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2013 Cognitive Therapy and Research

119. Adult Primary Insomnia - Diagnosis to Management

that induces awakenings as a result of withdrawal during the sleep period • Smoking cessation aids (nicotine replacement products and bupropion) can cause insomnia sleep consolidation 4 Some insomnia patients spend excessive time in bed trying to attain more sleep. Sleep consol- idation is accomplished by compressing the total time in bed to match the total sleep need of the patient. This improves the sleep efficiency. • Devise a “sleep prescription” with the patient: a fixed bedtime and wake time (...) the causes of insomnia (e.g., “I have a chemical imbalance causing my insomnia”) • Amplifying the consequences (e.g., “I cannot do anything after a bad night’s sleep”) • Performance anxiety and loss of control over ability to sleep (e.g., “I am afraid of losing control over my ability to sleep”) Pharmacologic Pharmacotherapy should be considered an adjunctive therapy to cognitive and behavioural therapies in the comprehensive management of primary insomnia. Principles of Treatment Pharmacotherapy

2010 Toward Optimized Practice

120. Adult Insomnia - Assessment to Diagnosis

patients it is important to note that “late life insomnia” requires specific interventions not addressed in this guideline. 1 Insomnia Insomnia Assessment to Diagnosis 2 (see algorithm on page 15) 1. Acute Insomnia - Identify and address trigger(s) - Consider short-term pharmacotherapy with a sedative to prevent a chronic insomnia (nightly sedation for 4 weeks) Insomnia Screening Questionnaire Page 3 SECONDARY CAUSES OF INSOMNIA M: Mood disorders (MDD/GAD) M: Medical disorders M: Medications. Consider (...) Adult Insomnia - Assessment to Diagnosis 1 Guideline for Adult Introduction Acute Insomnia: 1. Duration of 4 weeks or less. 2,3,4,5 Chronic Insomnia: 2. Duration of 4 weeks or more. 2,3,4,5 Primary Sleep Disorder: 3. A primary or intrinsic sleep disorder is one that arises out of the physiological processes of sleep. Examples of primary sleep disorders are obstructive sleep apnea, restless legs syndrome, periodic limb movement disorder or parasomnias. 2 Secondary Insomnia 4. : Secondary

2010 Toward Optimized Practice

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