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Insomnia Causes

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61. Insomnia Caused by Serotonin Depletion is Due to Hypothermia (PubMed)

Insomnia Caused by Serotonin Depletion is Due to Hypothermia Serotonin (5-hydroxytryptamine, 5-HT) neurons are now thought to promote wakefulness. Early experiments using the tryptophan hydroxylase inhibitor para-chlorophenylalanine (PCPA) had led to the opposite conclusion, that 5-HT causes sleep, but those studies were subsequently contradicted by electrophysiological and behavioral data. Here we tested the hypothesis that the difference in conclusions was due to failure of early PCPA (...) -chlorophenylalanine that led to the conclusion that 5-hydroxytryptamine (5-HT) causes sleep were likely confounded by hypothermia. Temperature controls should be considered in experiments using 5-HT depletion.© 2015 Associated Professional Sleep Societies, LLC.

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2015 Sleep

62. Internet-Based Cognitive Behavioral Therapy for Insomnia: A Health Economic Evaluation. (PubMed)

Internet-Based Cognitive Behavioral Therapy for Insomnia: A Health Economic Evaluation. Lost productivity caused by insomnia is a common and costly problem for employers. Although evidence for the efficacy of Internet-based cognitive behavioral therapy for insomnia (iCBT-I) already exists, little is known about its economic effects. This study aims to evaluate the cost-effectiveness and cost-benefit of providing iCBT-I to symptomatic employees from the employer's perspective.School teachers (N (...) = 128) with clinically significant insomnia symptoms and work-related rumination were randomized to guided iCBT-I or a waitlist-control-group, both with access to treatment as usual. Economic data were collected at baseline and 6-mo follow-up. We conducted (1) a cost-effectiveness analysis with treatment response (Reliable Change [decline of 5.01 points] and Insomnia Severity Index < 8 at 6-month follow-up) as the outcome and (2) a cost-benefit analysis. Because both analyses were performed from

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2017 Sleep

63. Sleeping for Two: RCT of CBT-Insomnia in Pregnancy

, sleep dissatisfaction, and perceived distress caused by sleep problems. It was found to be a clinically useful tool in assessing changes in insomnia symptoms in insomnia treatment research. Change in the Pittsburgh Sleep Quality Index [ Time Frame: Change between 3 time-points: baseline, 8-week follow-up, 3-months postpartum follow-up ] The PSQI instrument is used in assessing one's sleep quality during the previous month. It consists of 19 self-rated items and 5 questions rated by the roommate (...) Sleeping for Two: RCT of CBT-Insomnia in Pregnancy Sleeping for Two: RCT of CBT-Insomnia in Pregnancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Sleeping for Two: RCT of CBT-Insomnia in Pregnancy

2017 Clinical Trials

64. Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder. (PubMed)

Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder. To assess the efficacy and safety of novel pediatric-appropriate, prolonged-release melatonin minitablets (PedPRM) versus placebo for insomnia in children and adolescents with autism spectrum disorder (ASD), with or without attention-deficit/hyperactivity disorder (ADHD) comorbidity, and neurogenetic disorders (NGD).A total of 125 children and adolescents (2-17.5 years of age (...) -blind treatment, participants slept on average 57.5 minutes longer at night with PedPRM compared to 9.14 minutes with placebo (adjusted mean treatment difference PedPRM-placebo -32.43 minutes; p = .034). Sleep latency (SL) decreased by 39.6 minutes on average with PedPRM and 12.5 minutes with placebo (adjusted mean treatment difference -25.30 minutes; p = .011) without causing earlier wakeup time. The rate of participants attaining clinically meaningful responses in TST and/or SL was significantly

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2017 Journal of the American Academy of Child and Adolescent Psychiatry

65. Fatal familial insomnia with abnormal signals on routine MRI: a case report and literature review. (PubMed)

Fatal familial insomnia with abnormal signals on routine MRI: a case report and literature review. Fatal familial insomnia (FFI) is a rare autosomal dominant disease caused by the PRNP D178N/129 M mutation. Routine brain CT and MRI usually reveal non-specific features. We report a patient with FFI presenting with diffuse abnormal signals on MRI, later confirmed as combined with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).The patient (...) was a 58-year-old female, whose main clinical manifestations were insomnia, movement disorders, autonomic hyperactivity and mental deterioration. The patient also suffered a typical episode of transient global amnesia. MRI indicated a diffuse white matter abnormality and microbleeding on the susceptibility-weighted imaging. On biopsy, the brain tissue sections showed spongiform changes with gliosis, neuronal degeneration, and prion protein deposition in a portion of the neurons. In addition

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2017 BMC Neurology

66. Low doses of mirtazapine or quetiapine for transient insomnia: A randomised, double-blind, cross-over, placebo-controlled trial. (PubMed)

reported that both mirtazapine and quetiapine eased getting to sleep and improved sleep quality. Both drugs caused daytime sleepiness and lessened sustained attention. These findings support the use of low doses of mirtazapine and quetiapine for the treatment of insomnia. Further prospective studies on the long-term effects regarding effectiveness and adverse effects are needed. (...) Low doses of mirtazapine or quetiapine for transient insomnia: A randomised, double-blind, cross-over, placebo-controlled trial. Low doses of the antidepressant mirtazapine or the neuroleptic quetiapine are often prescribed off-label for insomnia. However, studies on the effects on sleep and hangover effects the following day are scarce. In this randomised, double-blind, cross-over, placebo-controlled trial, the influence of 7.5 mg mirtazapine and 50 mg quetiapine on both normal sleep and sleep

2017 Journal of psychopharmacology (Oxford, England)

67. Exercise Using Chinese Yoga Improving Insomnia

Exercise Using Chinese Yoga Improving Insomnia Exercise Using Chinese Yoga Improving Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Exercise Using Chinese Yoga Improving Insomnia (Yoga) The safety (...) of the general public(20.8%). As a result, people with diabetes mellitus are at high risk of sleep disorder. Not having enough sleep or sleep badly tend to cause abnormal metabolism, which influence the control of glycemia and worsen the disease. Currently investigations emphasize prevalence rate, risk factors and diabetes mellitus, increasing glycemia, complications which result from lack of sleep. Primary improving methods include the improvement of sleeping environment, recommendation of healthy diet

2017 Clinical Trials

68. Sleep Healthy Using The Internet for Older Adult Sufferers of Insomnia and Sleeplessness

) and/or wake after sleep onset (WASO) (>30 minutes for at least 3 nights/week) insomnia symptoms for ≥ 6 months no more than 6.5 hours of sleep per night the sleep disturbance (or associated daytime fatigue) must cause significant distress or - impairment in social, occupational, or other areas of functioning regular access (at least 2/week) and willingness to use a computer and the Internet and check email ability to read and speak English resident of the US Exclusion Criteria: irregular sleep schedules (...) Sleep Healthy Using The Internet for Older Adult Sufferers of Insomnia and Sleeplessness Sleep Healthy Using The Internet for Older Adult Sufferers of Insomnia and Sleeplessness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2017 Clinical Trials

69. Non-inferiority Study of Telemedicine Versus Conventional CBT-I in Recently Hospitalized Patients With Insomnia

% of U.S. adults, and persistent (or chronic) insomnia affects nearly 10-15% of U.S. adults. In a community-based prospective observational study, preliminary data suggests that insomnia is associated with hospitalizations due to cardiovascular, cancer, or any cause over a 4-year period. Cognitive Behavioral Therapy for Insomnia (CBT-I) is considered the gold-standard in the treatment of insomnia. There are 5 components of CBT-I, sleep restriction therapy, stimulus control instructions, relaxation (...) Non-inferiority Study of Telemedicine Versus Conventional CBT-I in Recently Hospitalized Patients With Insomnia Non-inferiority Study of Telemedicine Versus Conventional CBT-I in Recently Hospitalized Patients With Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

70. Cognitive Behavioral Therapy for Insomnia in Substance Use Disorders

intervention can be implemented as part of an evidence-based SUD treatment program within a residential facility. Condition or disease Intervention/treatment Phase Substance Use Disorders Insomnia Behavioral: Cognitive Behavioral Therapy for Insomnia (CBT-I) Not Applicable Detailed Description: Substance use disorders (SUDs) are a leading cause of global disease burden with significant epidemiological and economic consequences. Sleep disturbances (i.e., difficulty initiating or maintaining sleep (...) Cognitive Behavioral Therapy for Insomnia in Substance Use Disorders Cognitive Behavioral Therapy for Insomnia in Substance Use Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cognitive Behavioral

2017 Clinical Trials

71. Predictors of Response to Insomnia Treatments for Gulf War Veterans

Predictors of Response to Insomnia Treatments for Gulf War Veterans Predictors of Response to Insomnia Treatments for Gulf War Veterans - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Predictors of Response (...) to Insomnia Treatments for Gulf War Veterans The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03208049 Recruitment Status : Recruiting First Posted : July 5, 2017 Last Update Posted : November 30, 2018 See Sponsor: VA Office

2017 Clinical Trials

72. Acupuncture Regulates Default Mode Network of Chronic Insomnia Disorder Patients : A fMRI Study

connectivity in the default mode network and the salience network by functional magnetic resonance imaging, and combine with clinical efficacy assessment to analyze the association between the results of imaging and behavioristic. Condition or disease Intervention/treatment Phase Chronic Insomnia Device: Ture acupuncture Device: Sham acupuncture Not Applicable Detailed Description: Chronic insomnia which can cause daytime function impairments like abnormal emotion and hypomnesis is important risk factors (...) Acupuncture Regulates Default Mode Network of Chronic Insomnia Disorder Patients : A fMRI Study Acupuncture Regulates Default Mode Network of Chronic Insomnia Disorder Patients : A fMRI Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

73. A Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42847922 in Participants With Insomnia Disorder

by others; and distress caused by the sleep difficulties. A 5-point Likert scale (0-4) is used to rate each item, yielding a total score ranging from 0 to 28. The total score is interpreted as follows: absence of insomnia (0-7); sub-threshold insomnia (8-14); moderate insomnia (15-21); and severe insomnia (22-28). Percentage of Participants with Remission of Insomnia Symptoms, Defined as a Total Score <=10 on the ISI on Day 14 [ Time Frame: Day 14 ] Participants with a total score of less than or equal (...) to (<=) 10 on the ISI scale will be reported. ISI is a 7-item questionnaire assessing the nature, severity, and impact of insomnia. The dimensions evaluated are: severity of sleep onset, sleep maintenance, early morning awakening problems; sleep dissatisfaction; interference of sleep problem with daytime functioning; noticeability of sleep problems by others; and distress caused by the sleep difficulties. A 5-point Likert scale (0-4) is used to rate each item, yielding a total score ranging from 0 to 28

2017 Clinical Trials

74. Group Cognitive Behavioral Therapy and Acupressure for Insomnia

Group Cognitive Behavioral Therapy and Acupressure for Insomnia Group Cognitive Behavioral Therapy and Acupressure for Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Group Cognitive Behavioral (...) Therapy and Acupressure for Insomnia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03291301 Recruitment Status : Completed First Posted : September 25, 2017 Last Update Posted : October 24, 2018 Sponsor: Chinese University of Hong Kong Information provided by (Responsible Party): Fiona YY Ho, Chinese

2017 Clinical Trials

75. Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury

Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03261674 Recruitment Status : Recruiting First Posted : August 25, 2017 Last Update Posted

2017 Clinical Trials

76. Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depression

Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depression Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depression - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depression The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03207438 Recruitment Status : Active, not recruiting First Posted : July 2, 2017

2017 Clinical Trials

77. The Study of the Relationship of Insomnia in the Traditional Chinese Medicine and Western Medicine at Local Clinic

Actual Study Start Date : May 19, 2017 Estimated Primary Completion Date : May 4, 2018 Estimated Study Completion Date : May 4, 2018 Groups and Cohorts Go to Group/Cohort Insomnia those with unsatisfactory sleep quantity and/or quality (difficulty with sleep induction, awakenings during the night, early morning awakening, total sleep time, and overall quality of sleep), complaint of a minimum frequency (at least three times a week) and duration (1 month), marked distress caused by the sleep problem (...) The Study of the Relationship of Insomnia in the Traditional Chinese Medicine and Western Medicine at Local Clinic The Study of the Relationship of Insomnia in the Traditional Chinese Medicine and Western Medicine at Local Clinic - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

78. Efficacy of EA on Depression Related Insomnia: Study Protocol for a Multicenter RCT

Edition (DSM-IV); Participants whose HAMD score is 20-35; Participants who have complaint about insomnia at the first visit to the doctor; Participants whose PSQI score is more than 7; Participants who voluntarily agree with the investigation and sign a written informed consent form for the clinical trial. Exclusion Criteria: Participants with secondary depressive disorders caused by organic diseases, medicine, or psychotic disorders including schizophrenia, etc; Participants who are in the depressive (...) Efficacy of EA on Depression Related Insomnia: Study Protocol for a Multicenter RCT Efficacy of EA on Depression Related Insomnia: Study Protocol for a Multicenter RCT - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2017 Clinical Trials

79. Relationship of Nocturnal Concentrations of Melatonin, γ-aminobutyric Acid and Total Antioxidants With Insomnia

-risk sleep apnea, i.e., STOP-Bang Questionnaire ≥ 3 Unexplained limb pain, many times of getting up in the night to urinate or restless legs syndrome Frequency of application of sleeping drugs > once/week or the use of psychotropic drugs, such as anti-anxiety and depression drugs, and antipsychotic drugs Frequency of drinking coffee and other stimulating drinks > three times/week Drug or alcohol abuse Insomnia caused by poor sleeping conditions, such as noise, light, and bedmate interference (...) Relationship of Nocturnal Concentrations of Melatonin, γ-aminobutyric Acid and Total Antioxidants With Insomnia Relationship of Nocturnal Concentrations of Melatonin, γ-aminobutyric Acid and Total Antioxidants With Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

80. A Trial of Mindfulness Meditation for Chronic Insomnia

A Trial of Mindfulness Meditation for Chronic Insomnia A Trial of Mindfulness Meditation for Chronic Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Trial of Mindfulness Meditation for Chronic (...) Insomnia (MMI) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03337061 Recruitment Status : Not yet recruiting First Posted : November 8, 2017 Last Update Posted : April 11, 2018 See Sponsor: Guy's and St Thomas' NHS

2017 Clinical Trials

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