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41. Effects of Self-help Versus Group Cognitive Behavioural Therapy for Insomnia in Youth

Effects of Self-help Versus Group Cognitive Behavioural Therapy for Insomnia in Youth Effects of Self-help Versus Group Cognitive Behavioural Therapy for Insomnia in Youth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Effects of Self-help Versus Group Cognitive Behavioural Therapy for Insomnia in Youth The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03522701 Recruitment Status : Recruiting First Posted : May 11, 2018 Last

2018 Clinical Trials

42. Reducing Health Disparities for Black Women in the Treatment of Insomnia

Reducing Health Disparities for Black Women in the Treatment of Insomnia Reducing Health Disparities for Black Women in the Treatment of Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Reducing (...) Health Disparities for Black Women in the Treatment of Insomnia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03613519 Recruitment Status : Not yet recruiting First Posted : August 3, 2018 Last Update Posted : August 16

2018 Clinical Trials

43. Non-deceptive Application of Placebos in Insomnia

for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: age between 18 years to 69 years fluent in German language provide written informed consent ability to understand the explanations and instructions given by the study physician and the investigator Exclusion Criteria: evidence for sleep disorders caused by medical factors (e.g. sleep apnea, restless legs syndrome, narcolepsy, substance-induced insomnia) allergies to ingredients of placebo patients scoring below 8 or above 21 (...) Non-deceptive Application of Placebos in Insomnia Non-deceptive Application of Placebos in Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Non-deceptive Application of Placebos in Insomnia (NAP

2018 Clinical Trials

44. Cancer, Obesity/Overweight and Insomnia Study

Cancer, Obesity/Overweight and Insomnia Study Cancer, Obesity/Overweight and Insomnia Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cancer, Obesity/Overweight and Insomnia Study (COIN) The safety (...) : Under Armour Information provided by (Responsible Party): Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Study Details Study Description Go to Brief Summary: This is a randomized pilot study to better understand the relationships among insomnia, weight loss, and breast cancer. This study will assess the effectiveness of a sleep intervention prior to a web- and phone-based weight loss program. Condition or disease Intervention/treatment Phase Breast Cancer Overweight and Obesity Insomnia

2018 Clinical Trials

45. National Adaptive Trial for PTSD Related Insomnia

is a form of intense anxiety which sometimes results from severe trauma. Symptoms may include nightmares, flashbacks, troublesome memories, difficulty sleeping, poor concentration, irritability, anger, and emotional withdrawal. Insomnia is a disorder that can make it hard to fall sleep, stay asleep or cause a person to wake up too early and not be able to fall back to sleep. Condition or disease Intervention/treatment Phase Insomnia Drug: Trazodone Drug: Eszopiclone Drug: Gabapentin Other: Placebo Phase (...) National Adaptive Trial for PTSD Related Insomnia National Adaptive Trial for PTSD Related Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. National Adaptive Trial for PTSD Related Insomnia (NAP

2018 Clinical Trials

46. The Effect of Cognitive Behavioral Therapy for Insomnia on Type 2 Diabetes Health Outcomes

components. Behavioral: Cognitive behavioral therapy for insomnia CBT-I is designed to change sleep habits as well as direct misconceptions about sleep and insomnia. Participants will receive several face-to-face interview techniques: sleep restriction therapy, stimulus control procedures, sleep hygiene, relaxation training and cognitive components. The intervention will be provided in 6-session (one session/week). Active Comparator: Diabetes Education Sleep hygiene, foot care, causes and diagnosis (...) The Effect of Cognitive Behavioral Therapy for Insomnia on Type 2 Diabetes Health Outcomes The Effect of Cognitive Behavioral Therapy for Insomnia on Type 2 Diabetes Health Outcomes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2018 Clinical Trials

47. Response Inhibition Deficits in Insomnia Disorder: An Event-Related Potential Study With the Stop-Signal Task (PubMed)

Response Inhibition Deficits in Insomnia Disorder: An Event-Related Potential Study With the Stop-Signal Task Background: Response inhibition is a hallmark of executive function, which was detected impaired in various psychiatric disorders. However, whether insomnia disorder (ID) impairs response inhibition has caused great controversy. Methods: Using the auditory stop-signal paradigm coupled with event-related potentials (ERPs), we carried out this study to examine whether individuals with ID (...) inhibition among insomniacs. Their reaction time in go trials, however, showed no significant between-group difference. Considering the electrophysiological correlate underlying the longer SSRT, we found reduced P3 amplitude in patients with insomnia in the successful stop trials, which might reflect their poor efficiency of response inhibition. Finally, when we performed exploratory analyses in the failed stop and go trials, patients with ID presented reduced Pe and N1 amplitude in the failed sop trials

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2018 Frontiers in neurology

48. Ball Blankets on Insomnia in Depression in Outpatient Clinics

Ball Blankets on Insomnia in Depression in Outpatient Clinics Ball Blankets on Insomnia in Depression in Outpatient Clinics - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Ball Blankets on Insomnia (...) of Aarhus Collaborators: Innovation Fund Denmark Protac A/S Aarhus University Hospital Odense University Hospital Information provided by (Responsible Party): University of Aarhus Study Details Study Description Go to Brief Summary: The objective of the study is to examine the efficacy of Protac Ball BlanketsTM (PBB) and specifically if the PBB will extend the total sleep time of patients with insomnia due to depression in two psychiatric outpatient clinics at Aarhus University Hospital and Odense

2018 Clinical Trials

49. Association of Chronic Insomnia With Mortality and Adverse Renal Outcomes. (PubMed)

Association of Chronic Insomnia With Mortality and Adverse Renal Outcomes. To examine whether chronic insomnia is associated with an increased risk of adverse renal outcomes and all-cause mortality.We examined associations of chronic insomnia (defined as the presence of both International Classification of Diseases, Ninth Revision codes 307.42, 307.49, and 780.52 and long-term use of insomnia medications) with adverse renal outcomes (end-stage renal disease, incidence of estimated glomerular (...) filtration rate [eGFR] ≤45 mL/min per 1.73 m2, and eGFR slopes <-3.0 mL/min per 1.73 m2 per year) and all-cause mortality in a national cohort of 1,639,090 US veterans by using Cox proportional hazards and logistic regression models with multivariable adjustments.A total of 36,741 patients (2.24%) had chronic insomnia; 32,985 (89.8%) were male and 28,090 (76.5%) were white, with a mean baseline eGFR of 84.1±16.4 mL/min per 1.73 m2. Chronic insomnia was associated with a significantly higher risk of eGFR

2018 Mayo Clinic Proceedings

50. Chronic insomnia: therapies to start, therapies to stop

Chronic insomnia: therapies to start, therapies to stop The AFP Community Blog: Chronic insomnia: therapies to start, therapies to stop | Monday, September 24, 2018 - Kenny Lin, MD, MPH Can't sleep? Then spend your extra awake time reading the latest installment of in the September 1 issue of AFP , on . This evidence review, which supported an , examined the effectiveness of and for adults with insomnia disorder, defined as "poor sleep quality or quantity that causes distress or dysfunction (...) and lasts for longer than three months." The most beneficial sleep intervention overall is cognitive behavior therapy for insomnia (CBT-I), which produced sustained improvements for at least 6 months. CBT-I consists of cognitive therapy, sleep restriction and stimulus control, and sleep hygiene education. Medications that have sufficient evidence demonstrating improvement in short-term (3 months or less) sleep outcomes include eszopiclone, zolpidem, and suvorexant; there was insufficient data

2018 The AFP Community Blog

51. Provider Supported Self-Help Cognitive Behavioral Therapy for Insomnia (Tele-Self CBTI)

in depression, anxiety, suicidality, disability due to a mental health disorder, hypertension, obesity, metabolic syndrome, diabetes, and all-cause mortality, thus serving as an additional risk factor for some of the most common medical conditions seen in patients utilizing the VA healthcare system. Cognitive-Behavioral Therapy for Insomnia (CBTI) produces both short-term and sustained resolution of insomnia with fewer adverse side effects than pharmacotherapy. But access to behavioral sleep medicine (...) Provider Supported Self-Help Cognitive Behavioral Therapy for Insomnia (Tele-Self CBTI) Provider Supported Self-Help Cognitive Behavioral Therapy for Insomnia (Tele-Self CBTI) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

52. Traditional Use of Chinese Herbal Medicine for Insomnia and Priorities Setting of Future Clinical Research. (PubMed)

treatments were mentioned in 940 citations, and insomnia diagnosis treated with Chinese herbal formulae was specifically described in 800 citations. The traditional use of CHM appeared to be individualized based on the cause, pathogenesis, phase, phenotype, demographics, and concurrent medical conditions of insomnia. The most common herbal formulae for insomnia included Wen dan tang, Suan zao ren tang, Ban xia shu mi tang, and Gui pi tang. The most frequently cited herb was suan zao ren (Ziziphi spinosae (...) Traditional Use of Chinese Herbal Medicine for Insomnia and Priorities Setting of Future Clinical Research. To evaluate the traditional use of Chinese herbal medicine (CHM) for insomnia in pre-contemporary times.The Encyclopedia of Traditional Chinese Medicine (fifth edition) was systematically searched using seven Chinese medicine disease nomenclatures to identify insomnia citations. Citations were coded, and frequently used herbal formulae specific for insomnia were analyzed.Insomnia

2018 Journal of Alternative and Complementary Medicine

53. Effectiveness and safety of warm needle acupuncture on insomnia: Protocol for a systematic review and meta-analysis. (PubMed)

)]. Sleep quality value of the patient will be considered as the primary outcome and the secondary outcome will include biochemical, indicators total scores on the insomnia severity index, quality of life, adverse events caused by WNA, and changes of symptom in Traditional Chinese Medicine. The selection of the studies will be performed by EndnoteX7 software. All analyses will be conducted by using RevMan software V5.3.This study will provide a rational synthesis of current evidences for warm needle (...) Effectiveness and safety of warm needle acupuncture on insomnia: Protocol for a systematic review and meta-analysis. Warm needle acupuncture (WNA) combines acupuncture and moxibustion, which is an integral part of the acupuncture therapy. Insomnia is a common sleep disorder, which affects sub-healthy people and patients with chronic disease. The clinical practice indicates that WNA has a therapeutic effect on insomnia. Here we will provide a protocol to explore the effectiveness and safety

2018 Medicine

54. Suvorexant (Belsomra) for the Treatment of Bipolar Depression With Insomnia

at Screen visit, Baseline visit (Week 0), Week 2, Week 4, Week 6, Week 8, Week 10, Week 12, and Week 14. ] The ISI measures the subjective symptoms and consequences of difficulties initiating and maintaining sleep and self-perception of insomnia symptoms as well as the degree of concerns or distress caused by those symptoms. This scale includes 7 items, each scored on a 0-4 scale. Items are summed to produce a total score with a maximum of 28 and minimum of 0. Change in total score (sum of scores from 7 (...) Suvorexant (Belsomra) for the Treatment of Bipolar Depression With Insomnia Suvorexant (Belsomra) for the Treatment of Bipolar Depression With Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

55. Insomnia symptoms and mortality from all causes, cardiovascular disease, and cancer: systematic review and meta-analysis of cohort studies

Insomnia symptoms and mortality from all causes, cardiovascular disease, and cancer: systematic review and meta-analysis of cohort studies Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2018 PROSPERO

56. Insomnia Caused by Serotonin Depletion is Due to Hypothermia (PubMed)

Insomnia Caused by Serotonin Depletion is Due to Hypothermia Serotonin (5-hydroxytryptamine, 5-HT) neurons are now thought to promote wakefulness. Early experiments using the tryptophan hydroxylase inhibitor para-chlorophenylalanine (PCPA) had led to the opposite conclusion, that 5-HT causes sleep, but those studies were subsequently contradicted by electrophysiological and behavioral data. Here we tested the hypothesis that the difference in conclusions was due to failure of early PCPA (...) -chlorophenylalanine that led to the conclusion that 5-hydroxytryptamine (5-HT) causes sleep were likely confounded by hypothermia. Temperature controls should be considered in experiments using 5-HT depletion.© 2015 Associated Professional Sleep Societies, LLC.

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2015 Sleep

57. Internet-Based Cognitive Behavioral Therapy for Insomnia: A Health Economic Evaluation. (PubMed)

Internet-Based Cognitive Behavioral Therapy for Insomnia: A Health Economic Evaluation. Lost productivity caused by insomnia is a common and costly problem for employers. Although evidence for the efficacy of Internet-based cognitive behavioral therapy for insomnia (iCBT-I) already exists, little is known about its economic effects. This study aims to evaluate the cost-effectiveness and cost-benefit of providing iCBT-I to symptomatic employees from the employer's perspective.School teachers (N (...) = 128) with clinically significant insomnia symptoms and work-related rumination were randomized to guided iCBT-I or a waitlist-control-group, both with access to treatment as usual. Economic data were collected at baseline and 6-mo follow-up. We conducted (1) a cost-effectiveness analysis with treatment response (Reliable Change [decline of 5.01 points] and Insomnia Severity Index < 8 at 6-month follow-up) as the outcome and (2) a cost-benefit analysis. Because both analyses were performed from

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2017 Sleep

58. Sleeping for Two: RCT of CBT-Insomnia in Pregnancy

, sleep dissatisfaction, and perceived distress caused by sleep problems. It was found to be a clinically useful tool in assessing changes in insomnia symptoms in insomnia treatment research. Change in the Pittsburgh Sleep Quality Index [ Time Frame: Change between 3 time-points: baseline, 8-week follow-up, 3-months postpartum follow-up ] The PSQI instrument is used in assessing one's sleep quality during the previous month. It consists of 19 self-rated items and 5 questions rated by the roommate (...) Sleeping for Two: RCT of CBT-Insomnia in Pregnancy Sleeping for Two: RCT of CBT-Insomnia in Pregnancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Sleeping for Two: RCT of CBT-Insomnia in Pregnancy

2017 Clinical Trials

59. Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder. (PubMed)

Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder. To assess the efficacy and safety of novel pediatric-appropriate, prolonged-release melatonin minitablets (PedPRM) versus placebo for insomnia in children and adolescents with autism spectrum disorder (ASD), with or without attention-deficit/hyperactivity disorder (ADHD) comorbidity, and neurogenetic disorders (NGD).A total of 125 children and adolescents (2-17.5 years of age (...) -blind treatment, participants slept on average 57.5 minutes longer at night with PedPRM compared to 9.14 minutes with placebo (adjusted mean treatment difference PedPRM-placebo -32.43 minutes; p = .034). Sleep latency (SL) decreased by 39.6 minutes on average with PedPRM and 12.5 minutes with placebo (adjusted mean treatment difference -25.30 minutes; p = .011) without causing earlier wakeup time. The rate of participants attaining clinically meaningful responses in TST and/or SL was significantly

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2017 Journal of the American Academy of Child and Adolescent Psychiatry

60. Fatal familial insomnia with abnormal signals on routine MRI: a case report and literature review. (PubMed)

Fatal familial insomnia with abnormal signals on routine MRI: a case report and literature review. Fatal familial insomnia (FFI) is a rare autosomal dominant disease caused by the PRNP D178N/129 M mutation. Routine brain CT and MRI usually reveal non-specific features. We report a patient with FFI presenting with diffuse abnormal signals on MRI, later confirmed as combined with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).The patient (...) was a 58-year-old female, whose main clinical manifestations were insomnia, movement disorders, autonomic hyperactivity and mental deterioration. The patient also suffered a typical episode of transient global amnesia. MRI indicated a diffuse white matter abnormality and microbleeding on the susceptibility-weighted imaging. On biopsy, the brain tissue sections showed spongiform changes with gliosis, neuronal degeneration, and prion protein deposition in a portion of the neurons. In addition

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2017 BMC Neurology

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