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Insomnia Causes

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181. Comfrey herbal remedy causing second-degree heart block: do not be outfoxed by digitalis (PubMed)

Comfrey herbal remedy causing second-degree heart block: do not be outfoxed by digitalis A previously well woman aged 63 years presents to the emergency department with vomiting, palpitations and 3 presyncopal episodes. She had no previous medical or cardiac history, with the patient stating that she tried a herbal remedy of boiled comfrey leaves for insomnia 18 hours before arrival to the department. Her ECG showed multiple abnormalities, including bradycardia, second-degree atrioventricular

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2016 BMJ case reports

182. Postmortem diagnosis of infectious heart diseases: A mystifying cause of Sudden Infant Death (PubMed)

Postmortem diagnosis of infectious heart diseases: A mystifying cause of Sudden Infant Death Sudden infant death (SID) is an unresolved problem of high relevance and previous studies have indicated a role of viral heart infections. The diagnosis remains difficult in clinical practice using routine diagnostic tests and must be substantially improved. A prospective study based on post-mortem samples from SID victims whose heart disease was not clinically recognized was conducted for 4 years (...) in a Tunisian University Hospital. Pediatric cases of unnatural death served as controls. Both SID victims and controls were investigated for possible coxsackievirus-B (CV-B) infection in heart tissue. During the study period, 39 cases with a male predominance (77%) were reported. There was no positive family history of coronary artery disease among the victims. In 35 cases (90%), low birth weight and/or critical development period were reported. All SID victims had complained of mild fever and insomnia

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2016 Forensic science international

183. Atypical parkinsonism caused by Pro105Leu mutation of prion protein: A broad clinical spectrum (PubMed)

Atypical parkinsonism caused by Pro105Leu mutation of prion protein: A broad clinical spectrum To delineate molecular and clinical characteristics of 3 families with PRNP P105L mutation, a variant of Gerstmann-Sträussler-Scheinker syndrome whose main motor symptoms were parkinsonism and/or involuntary movements.The causative mutation was first determined in the affected patients of family 1 using whole-exome sequencing, and then mutational analysis was extended to families 2 and 3. The clinical (...) . The clinical features of our patients with PRNP P105L mutation included various motor symptoms such as parkinsonism and involuntary movements in addition to progressive dementia. The clinical features in part overlapped with those of other forms of inherited prion diseases, such as fatal familial insomnia and Huntington disease-like type 1. The patients with PRNP P105L mutation shared a haplotype spanning 7.1 Mb around PRNP, raising the possibility that the mutations in the patients originated from

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2016 Neurology: Genetics

184. A case of gait disturbance caused by low-dose gabapentin (PubMed)

A case of gait disturbance caused by low-dose gabapentin Gabapentin, an anticonvulsant agent, is now often used for the treatment of neuropathic pain all over the world. It is unclear whether the combined use of gabapentin, sodium valproate, and flunitrazepam results in enhancement of the side effect, a gait disturbance. A 60-year-old man was taking oral sodium valproate for symptomatic epilepsy after a brain contusion and flunitrazepam to relieve insomnia. Oral gabapentin therapy was started

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2016 Therapeutics and clinical risk management

185. A 91 year old with history of anxiety has long term insomnia. Is there any guidance on sedative use?

weeks. This states: “Manage any underlying cause of insomnia or associated comorbidities. Cognitive and behavioural interventions are recommended first line. Advise good sleep hygiene and regular exercise in addition to cognitive and behavioural interventions. Hypnotics are not generally recommended for the management of long-term insomnia. A short course of a hypnotic drug may be considered for immediate relief or to manage an acute exacerbation of persistent insomnia. If a hypnotic is prescribed (...) seeing the person again. • Use caution when prescribing hypnotics for older people. In older people (more than 55 years of age) with persistent insomnia, consider modified-release melatonin. The recommended initial duration of treatment is 3 weeks. If there is a response to treatment, it can be continued for a further 10 weeks. If insomnia persists or recurs on stopping melatonin: • Reconsider whether there may be an underlying cause of insomnia or associated comorbidity. • Consider cognitive

2011 TRIP Answers

186. Benzodiazepines linked to dementia risk: cause for concern or lacking causality?

benzodiazepines to older people anyway? Dr Liz Coulthard, Consultant Senior Lecturer in Dementia Neurology at the University of Bristol said: This work provides yet another reason to avoid prescription of benzodiazepines for anything other than very short term relief of insomnia or anxiety. In addition to short term cognitive impairment, falls and car accidents already known to be associated with benzodiazepine use. The study raises questions about the safety of benzodiazepines, but is there really cause (...) Benzodiazepines linked to dementia risk: cause for concern or lacking causality? Benzodiazepines linked to dementia risk Search National Elf Service Search National Elf Service » » » » Benzodiazepines linked to dementia risk: cause for concern or lacking causality? Oct 8 2014 Posted by This is one of those studies that the media thoroughly enjoy: taking benzodiazepines can “raise chance of developing Alzheimer’s by 50%” . The leapt upon it as did . These stories are a bit scary as association

2014 The Mental Elf

187. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders

rather than via measurements; in this sense, it is a syndrome similar to pain. The cause of insomnia may be known or not, and knowledge of causation is not necessary for a diagnosis. However, in some cases it may be possible to identify and remedy a physical cause for insomnia (see treatment section). Insomnia often starts with a speci?c problem, for example a stressful life event such as the loss of a job or change to a more demanding one, or through something that changes sleep patterns (...) prevalence of chronic health conditions, including sleep apnoea, in older adults did not explain changes ofsleep parameters with aging and age/sex di?erences in these relationships. There is some disagreement about how long insomnia should have been present for before it requires intervention (see treatment section), but there is general agreement that when insomnia causes signi?cant personal distress or marked impairment then some form of treatment is appropriate. 1578 Journal of Psychopharmacology 24

2010 British Association for Psychopharmacology

188. Dyspepsia - unidentified cause

Dyspepsia - unidentified cause Dyspepsia - unidentified cause - NICE CKS Clinical Knowledge Summaries Share Dyspepsia - unidentified cause: Summary The term 'dyspepsia' is used to describe a complex of upper gastrointestinal tract symptoms which are typically present for four or more weeks, including upper abdominal pain or discomfort, heartburn, acid reflux, nausea and/or vomiting. Reported symptoms are a poor predictor of significant disease or underlying pathology. 'Uninvestigated' dyspepsia (...) describes symptoms in people who have not had an endoscopy. The most common causes of dyspepsia include: Gastro-oesophageal reflux disease (GORD). Peptic ulcer disease (gastric or duodenal ulcers). Functional dyspepsia (non-ulcer dyspepsia) Dyspepsia symptoms are estimated to occur in about 40% of the population each year. Assessment of a person with unexplained dyspepsia should include: Asking about any alarm symptoms that may suggest a complication or other serious underlying pathology. Asking about

2015 NICE Clinical Knowledge Summaries

189. Tinnitus and insomnia: is hyperarousal the common denominator? (PubMed)

Tinnitus and insomnia: is hyperarousal the common denominator? Tinnitus is an auditory sensation that is generated by aberrant activation within the auditory system. Sleep disturbances are a frequent problem in the tinnitus population. They are known to worsen the distress caused by the tinnitus which in turn worsens sleep quality. Beyond that, disturbed sleep is a risk factor for mental health problems and distressing tinnitus is often associated with enhanced depressivity, anxiety (...) , and somatic symptom severity. Moreover there is evidence that therapies which alleviate tinnitus-related distress have a positive influence on sleep quality and help interrupt this vicious cycle. This suggests that distressing tinnitus and insomnia may both be promoted by similar physiological mechanisms. One candidate mechanism is hyperarousal caused by enhanced activation of the sympathetic nervous system. There is increasing evidence for hyperarousal in insomnia patients, and animal models of tinnitus

2013 Sleep medicine reviews

190. Sleep Duration, Insomnia, and Coronary Heart Disease Among Postmenopausal Women in the Women's Health Initiative (PubMed)

) in fully adjusted models.Sleep duration and insomnia are associated with CHD and CVD risk, and may interact to cause almost double the risk of CHD and CVD. Additional research is needed to understand how sleep quality modifies the association between prolonged sleep and cardiovascular outcomes. (...) Sleep Duration, Insomnia, and Coronary Heart Disease Among Postmenopausal Women in the Women's Health Initiative Long and short sleep duration are associated with increased risk for coronary heart disease (CHD) and cardiovascular disease (CVD); however, evidence is inconsistent. We sought to identify whether self-reported sleep duration and insomnia, based on a validated questionnaire, are associated with increased incident CHD and CVD among postmenopausal women.Women's Health Initiative

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2013 Journal of Women's Health

191. High-resolution, Relational, Resonance-based, Electroencephalic Mirroring (HIRREM) to Relieve Insomnia

High-resolution, Relational, Resonance-based, Electroencephalic Mirroring (HIRREM) to Relieve Insomnia High-resolution, Relational, Resonance-based, Electroencephalic Mirroring (HIRREM) to Relieve Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. High-resolution, Relational, Resonance-based, Electroencephalic Mirroring (HIRREM) to Relieve Insomnia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01971567 Recruitment Status : Completed First Posted : October 29, 2013 Results First Posted : May 21

2013 Clinical Trials

192. Understanding the Sleep Apnea/Insomnia Interaction

of Pennsylvania Study Details Study Description Go to Brief Summary: Nearly half of all patients with obstructive sleep apnea have insomnia symptoms, and in some, but not all cases, these insomnia symptoms are caused by the obstructive sleep apnea. The purpose of this study is to find out what type of insomnia symptoms are caused by obstructive sleep apnea and therefore most likely to respond to obstructive sleep apnea treatment with continuous positive airway pressure (also known as CPAP) and if additional (...) : Sedative/psychoactive drug use recently Other clinically significant sleep disorders Previous treatment for OSA Requires oxygen or bilevel PAP therapy Clinically unstable medical condition Recent shift work Significant alcohol use Other clinically significant causes of insomnia Illicit drug use Prescription stimulants Safety restrictions Unable to treat sleep apnea with positive airway pressure therapy Communication barriers Cognitive impairment Contacts and Locations Go to Information from

2013 Clinical Trials

193. Piloting an Internet-based Therapy for Insomnia in a Population of Veterans With Substance Use Disorders

to Primary Outcome Measures : Insomnia Severity Index (Total), Change From Baseline to Follow-up [ Time Frame: pre-intervention, intervention completion (expected average of 7 weeks) ] Insomnia Severity Index (Total) following completion of the intervention (expected average of 7 weeks) The Insomnia Severity Index is a self-report seven-item measure that targets the subjective symptoms and functional consequences of insomnia as well as the degree of concerns or distress caused by those difficulties (...) Piloting an Internet-based Therapy for Insomnia in a Population of Veterans With Substance Use Disorders Piloting an Internet-based Therapy for Insomnia in a Population of Veterans With Substance Use Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2013 Clinical Trials

194. A High Density EEG Comparison of Sleep Patterns in Insomnia

): University of Wisconsin, Madison Study Details Study Description Go to Brief Summary: Insomnia, defined as a subjective report of difficulty initiating sleep, maintaining sleep, and/or non-restorative sleep, leads to significant daytime dysfunction and increased health risks. A commonly held hypothesis is that insomnia is caused by a state of hyperarousal, but the neurobiological mechanisms of hyperarousal in insomnia are poorly understood, in part because of limitations in our ability to image the brain (...) A High Density EEG Comparison of Sleep Patterns in Insomnia A High Density EEG Comparison of Sleep Patterns in Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A High Density EEG Comparison of Sleep

2013 Clinical Trials

195. Auricular Acupuncture and Cognitive Behavioral Therapy Treatment for Insomnia

- and/or maintaining sleep, involuntary awakenings during the night of early morning, day time sleepiness and decreased will for day time activity due to sleepiness. Insomnia is ranked to be the fifth most common cause of prescription of medicine at the outpatient clinics in general health care in Sweden. In 2008 a prevalence study was initiated in Sweden by the Swedish Council on Health Technology Assessment (SBU). The study showed that 24% of the Swedish population suffered from sleep disorders. Sleeping (...) Auricular Acupuncture and Cognitive Behavioral Therapy Treatment for Insomnia Auricular Acupuncture and Cognitive Behavioral Therapy Treatment for Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2013 Clinical Trials

196. The caudate: a key node in the neuronal network imbalance of insomnia? (PubMed)

density contributes to altered caudate recruitment in patients with insomnia. Attenuated caudate recruitment persisted after successful treatment of insomnia, warranting evaluation as a potential vulnerability trait. A similar selective reduction in caudate recruitment could be elicited in participants without sleep complaints by slow-wave sleep fragmentation, providing a model to facilitate investigation of the causes and consequences of insomnia. (...) The caudate: a key node in the neuronal network imbalance of insomnia? Insomnia is prevalent, severe and partially heritable. Unfortunately, its neuronal correlates remain enigmatic, hampering the development of mechanistic models and rational treatments. Consistently reported impairments concern fragmented sleep, hyper-arousal and executive dysfunction. Because fronto-striatal networks could well play a role in sleep, arousal regulation and executive functioning, the present series of studies

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2013 Brain

197. The joint contribution of pain and insomnia to sickness absence and disability retirement: A register-linkage study among Norwegian and Finnish employees. (PubMed)

covariates.Norwegian Hordaland Health Study (n = 6892, 59% women) and Finnish Helsinki Health Study (n = 6060, 78% women) data were used. Those with only pain, only insomnia or both conditions at baseline were compared with those with no pain and no insomnia. Work disability outcomes were derived from national and employers' register data. Medically certified sickness absence spells lasting 2 weeks or more and all-cause disability retirement were examined. Register-based follow-up was 4 years for sickness absence (...) The joint contribution of pain and insomnia to sickness absence and disability retirement: A register-linkage study among Norwegian and Finnish employees. Pain and insomnia are both independently associated with work disability. Although pain and insomnia often co-occur, their joint associations with subsequent sickness absence and disability retirement have not been studied. We aimed to examine these associations in two prospective occupational cohorts while considering key

2013 European Journal of Pain

198. Insomnia and the risk of incident heart failure: a population study. (PubMed)

failure. A total of 1412 cases of heart failure occurred during a mean follow-up of 11.3 years (SD = 2.9 years), either identified at hospitals or by the National Cause of Death Registry. There was a dose-dependent association between the number of insomnia symptoms and risk of heart failure. The multi-adjusted hazard ratios were 0.96 (0.57-1.61), 1.35 (0.72-2.50), and 4.53 (1.99-10.31) for people with one, two, and three insomnia symptoms, compared with people with none of the symptoms (P for trend (...) Insomnia and the risk of incident heart failure: a population study. Insomnia is highly prevalent among heart failure patients, but only a few small studies have investigated insomnia symptoms and risk of heart failure. We aimed to assess the prospective association between self-reported insomnia symptoms and the risk of incident heart failure in a large Norwegian cohort.Baseline data on insomnia symptoms, including difficulty initiating sleep, difficulty maintaining sleep and having non

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2013 European Heart Journal

199. Levofloxacin-induced acute anxiety and insomnia (PubMed)

Levofloxacin-induced acute anxiety and insomnia Fluoroquinolones can cause adverse neuropsychiatric side effects, which are more common in older age. We present three cases of levofloxacin-induced acute anxiety and insomnia in young adults. In all the cases, discontinuation of levofloxacin immediately lead to remission.

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2012 Journal of neurosciences in rural practice

200. Resource Utilization and Costs Associated With Insomnia Treatment in Patients With Major Depressive Disorder (PubMed)

for an antidepressant between January 1, 2006, and December 31, 2007 (index date), were included in the analysis if they had ≥ 1 MDD diagnosis (ICD-9-CM criteria) in the 12 months prior to the claim and 24 months of continuous insurance coverage. Patients were categorized into 2 groups on the basis of the presence or absence of insomnia medication during the 12 months following the index date. Multivariate analyses were conducted to compare all-cause and MDD-related hospitalization and emergency room (ER) visits (...) (OR = 1.84, 95% CI = 1.73-1.96 for all cause; OR = 1.50, 95% CI = 1.43-1.57 for MDD related; P < .0001) and to have ER visits (OR = 4.25, 95% CI = 3.65-4.95 for all cause; OR = 2.51, 95% CI = 2.24-2.81 for MDD related; P < .0001) than the patients not taking insomnia medication. Adjusted all-cause health care costs were $3,918 (95% CI = $3,599-$4,290) higher and MDD-related health care costs were $537 (95% CI = $492-$586) higher in the insomnia medication cohort compared with controls in the 12-months

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2012 The Primary Care Companion for CNS Disorders

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