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Indinavir

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1. The mechanism for differential effect of nelfinavir and indinavir on collagen metabolism in human skin fibroblasts. (PubMed)

The mechanism for differential effect of nelfinavir and indinavir on collagen metabolism in human skin fibroblasts. The mechanism for differential effects of human immune deficiency virus protease inhibitors (HIVPIs), nelfinavir (NEL) and indinavir (IND) on collagen metabolism disturbances was studied in human skin fibroblasts. It has been considered that HIVPIs-dependent deregulation of collagen biosynthesis involves prolidase (an enzyme providing proline for collagen biosynthesis), glutamine

2019 Experimental Dermatology

2. Indinavir and atazanavir; comparison of predicted property by chemoinformatics technique and implication on renal problem in HIV infected patients (PubMed)

Indinavir and atazanavir; comparison of predicted property by chemoinformatics technique and implication on renal problem in HIV infected patients 28197526 2018 11 13 2345-4202 6 1 2017 Journal of nephropharmacology J Nephropharmacol Indinavir and atazanavir; comparison of predicted property by chemoinformatics technique and implication on renal problem in HIV infected patients. 21-22 Joob Beuy B Sanitation 1 Medical Academic Center, Bangkok, Thailand. Wiwanitkit Viroj V Visiting Professor (...) , Hainan Medical University, Haikou, China ; Visiting Professor, Faculty of Medicine, University of Nis, Serbia; adjunct professor, Joseph Ayobabalola University, Nigeria; Honorary Professor, Dr DY Patil Medical University, India. eng Journal Article 2016 01 21 Iran J Nephropharmacol 101679372 2345-4202 Atazanavir Human immunodeficiency virus Indinavir Renal 2016 01 01 2016 01 18 2017 2 16 6 0 2017 2 16 6 0 2017 2 16 6 1 epublish 28197526 PMC5295654 Chem Biol Drug Des. 2013 Apr;81(4):527-36 23279875 J

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2016 Journal of nephropharmacology

3. α-7-nicotinic acetylcholine receptor inhibition by indinavir: implications for cognitive dysfunction in treated HIV disease. (PubMed)

α-7-nicotinic acetylcholine receptor inhibition by indinavir: implications for cognitive dysfunction in treated HIV disease. The study set out to determine if the HIV protease inhibitor, indinavir, alters responsiveness of α7-nicotinic acetylcholine receptors to acetylcholine.Treatment with HAART has dramatically reduced development of HIV-associated dementia and more severe forms of cognitive impairment. However, many individuals continue to experience cognitive decline of uncertain cause (...) was tested using a ScreenPatch IonWorks Barracuda-based assay in a mammalian cell model.At low concentrations (0.0003-10 μmol/l) indinavir acts as a positive allosteric modulator (EC50 = 0.021 μmol/l), whereas at concentrations greater than 10 μmol/l (30-100 μmol/l) indinavir acts as an inhibitor of the α7-nicotinic acetylcholine receptor.At concentrations greater than 10 μmol/l indinavir reduces synaptic transmission in the acetylcholine neurotransmitter system, which could possibly contribute

2017 AIDS

4. Indinavir

Indinavir Indinavir Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Indinavir Indinavir Aka: Indinavir , Crixivan From Related (...) Chapters II. Mechanism III. Efficacy Very effective in combination with (AZT) IV. Dosing Indinavir 600 mg PO tid ($360/month) Take on empty One hour before or 2 hours after a meal Concurrent food reduces concentration up to 80% Drink at least 1.5 Liters (50 oz) liquid per day Drink 150 ml water per hour for 3 hours after dose Avoids and V. Adverse Effects See for adverse effects attributed to the class Well tolerated elevation in 10% of patients in 2-3% of patients s VI. Drug Interactions May reduce

2018 FP Notebook

5. A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. (PubMed)

A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. HIV-associated sensory neuropathy (HIV-SN) is the most frequent manifestation of HIV disease. It often presents with significant neuropathic pain and is associated with previous exposure to neurotoxic nucleoside reverse transcriptase inhibitors. However, HIV-SN prevalence remains high even in resource-rich settings where these drugs are no longer used. Previous evidence suggests that exposure to indinavir (...) , a protease inhibitor commonly used in antiretroviral therapy, may link to elevated HIV-SN risk. Here, we investigated whether indinavir treatment was associated with the development of a "dying back" axonal neuropathy and changes in pain-relevant limb withdrawal and thigmotactic behaviours. After 2 intravenous injections of indinavir (50 mg/kg, 4 days apart), adult rats developed hind paw mechanical hypersensitivity, which peaked around 2 weeks post first injection (44% reduction from baseline

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2016 Pain

6. Lack of a pharmacokinetic drug-drug interaction with venlafaxine extended-release/indinavir and desvenlafaxine extended-release/indinavir. (PubMed)

Lack of a pharmacokinetic drug-drug interaction with venlafaxine extended-release/indinavir and desvenlafaxine extended-release/indinavir. To assess the effects of venlafaxine extended-release (XR) capsules and desvenlafaxine extended-release (XR) tablets upon indinavir pharmacokinetic properties when co-administrated to healthy volunteers.This was an open-label, two-period, fixed-dose study conducted at the clinical research unit located on a university campus. Twenty-four healthy volunteers (...) enrolled in the study (mean age 28.3 ± 8.0 years). Each subject received a single dose of indinavir 800 mg on day 1. Subsequently, subjects were then randomly assigned to either the venlafaxine XR group (N = 12) or the desvenlafaxine XR group (N = 12). Starting on day 2, venlafaxine XR was dosed at 37.5 mg/day for 4 days and increased to 75 mg/day for 6 days. Desvenlafaxine XR was dosed at 50 mg/day for 10 days. On day 12, indivanvir 800 mg was co-administered to both the venlafaxine XR

2012 European journal of clinical pharmacology Controlled trial quality: uncertain

7. Enhanced anti-HIV efficacy of Indinavir after inclusion in CD4 targeted lipid nanoparticles (PubMed)

Enhanced anti-HIV efficacy of Indinavir after inclusion in CD4 targeted lipid nanoparticles Combination drug therapy has reduced plasma HIV to undetectable levels; however, drug-sensitive virus persists in patients' lymphoid tissue. We have reported significant lymphoid tissue drug localization with indinavir-associated lipid nanoparticles (LNPs). Our current objective is to evaluate whether additional enhancement is achievable by targeting these particles to CD4-HIV host cells.We characterized (...) 2 peptide-coated (CD4-BP2 and CD4-BP4) drug-associated LNPs and demonstrated CD4-cell specificity. Drug-associated LNPs expressing polyethyleneglycol were exposed on HIV-2-infected cells under dynamic conditions that emulated lymph node physiology for 15, 30, and 60 minutes at concentrations from 0 to 25 μM and evaluated for antiviral activity and cell-associated drug concentrations. The specificity of CD4-mediated enhancement of indinavir LNPs antiviral activity was evaluated by blocking

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2012 Journal of acquired immune deficiency syndromes (1999)

8. Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A). (PubMed)

Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A). Methadone disposition and pharmacodynamics are highly susceptible to interactions with antiretroviral drugs. Methadone clearance and drug interactions have been attributed to cytochrome P4503A4 (CYP3A4), but actual mechanisms are unknown. Drug interactions can be clinically and mechanistically informative. This investigation assessed effects of the protease inhibitor (...) indinavir on methadone pharmacokinetics and pharmacodynamics, hepatic and intestinal CYP3A4/5 activity (using alfentanil), and intestinal transporter activity (using fexofenadine).Twelve healthy volunteers underwent a sequential crossover. On three consecutive days they received oral alfentanil plus fexofenadine, intravenous alfentanil, and intravenous plus oral (deuterium-labeled) methadone. This was repeated after 2 weeks of indinavir. Plasma and urine analytes were measured by mass spectrometry

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2012 Anesthesiology

9. Indinavir

Indinavir Indinavir Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Indinavir Indinavir Aka: Indinavir , Crixivan From Related (...) Chapters II. Mechanism III. Efficacy Very effective in combination with (AZT) IV. Dosing Indinavir 600 mg PO tid ($360/month) Take on empty One hour before or 2 hours after a meal Concurrent food reduces concentration up to 80% Drink at least 1.5 Liters (50 oz) liquid per day Drink 150 ml water per hour for 3 hours after dose Avoids and V. Adverse Effects See for adverse effects attributed to the class Well tolerated elevation in 10% of patients in 2-3% of patients s VI. Drug Interactions May reduce

2015 FP Notebook

10. Development of Indinavir Submicron Lipid Emulsions Loaded with Lipoamino Acids—In Vivo Pharmacokinetics and Brain-Specific Delivery (PubMed)

Development of Indinavir Submicron Lipid Emulsions Loaded with Lipoamino Acids—In Vivo Pharmacokinetics and Brain-Specific Delivery The aim of our present work was to develop indinavir O/W submicron lipid emulsions (SLEs) loaded with lipoamino acids for specific delivery to brain. Tetradecyl aspartic acid (A) and decyl glutamic acid (G) loaded stable SLEs of indinavir having a mean size range of 210-220 nm and average zeta potential of -23.54±1.2 mV were developed using homogenization (...) and ultrasonication. The cumulative % drug release from different SLEs varied in between 26% and 85%. The formulations, SLE, SLE-A3, and SLE-G3 were stable to the centrifugal stress, dilution stress, and storage at RT. The total drug content and entrapment efficiency were determined by HPLC method. During pharmacokinetic studies in male Wistar rats there was no significant difference in the serum levels of indinavir for SLE, SLE-A3 and SLE-G3 formulations at all time points. In tissue distribution studies

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2011 AAPS PharmSciTech

11. Lead expansion and virtual screening of Indinavir derivate HIV-1 protease inhibitors using pharmacophoric - shape similarity scoring function (PubMed)

Lead expansion and virtual screening of Indinavir derivate HIV-1 protease inhibitors using pharmacophoric - shape similarity scoring function Indinavir (Crivaxan®) is a potent inhibitor of the HIV (human immunodeficiency virus) protease. This enzyme has an important role in viral replication and is considered to be very attractive target for new antiretroviral drugs. However, it becomes less effective due to highly resistant new viral strains of HIV, which have multiple mutations

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2010 Bioinformation

12. Treatment With Indinavir and Chemotherapy for Advanced Classical Kaposi's Sarcoma

Treatment With Indinavir and Chemotherapy for Advanced Classical Kaposi's Sarcoma Treatment With Indinavir and Chemotherapy for Advanced Classical Kaposi's Sarcoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Treatment With Indinavir and Chemotherapy for Advanced Classical Kaposi's Sarcoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01067690 Recruitment Status : Completed First Posted : February 11, 2010 Last Update Posted : August 30, 2016 Sponsor: Barbara Ensoli, MD, PhD Information provided

2010 Clinical Trials

13. The efficacy of post-exposure prophylaxis (PEP) for HIV

) Tenofovir disoproxil fumarate (TDF) Zidovudine (ZDV*; AZT) Non-nucleoside reverse tran­scriptase inhibitors (NNRTIs) Efavirenz (EFV) Nevirapine (NVP) Rilpivirine (RPV) Protease inhibitors (PIs) Atazanavir (ATV) Darunavir (DRV) Indinavir (IDV) Lopinavir (LPV) Nelfinavir (NFV) Entry inhibitors (EIs) Maraviroc (MVC) Integrase strand transfer inhibi­tors (INSTIs) Dolutegravir (DTG) Elvitegravir (EVG) Raltegravir (RAL) Booster drugs Cobicistat (c) Ritonavir (r) *this review uses ZDV as the acronym

2019 Ontario HIV Treatment Network

14. Acute Kidney Injury (AKI)

sulphonamides, acyclovir, triamterene, indinavir and phosphate-rich laxatives. The role of urinary electrolyte measurement in determining the aetiology of an episode of AKI remains unclear. In pre-renal disease (i.e. acute kidney impairment rather than injury) there is increased urinary sodium reabsorption. This should be reflected by a low urine sodium concentration and a low fractional excretion of sodium (FENa, where FENa = (urine Na + x plasma Cr)/(plasma Na + x urine Cr)). However, results should

2019 Renal Association

16. Urolithiasis

era? Clin Radiol, 2008. 63: 1131. 40. Worster, A., et al. The accuracy of noncontrast helical computed tomography versus intravenous pyelography in the diagnosis of suspected acute urolithiasis: a meta-analysis. Ann Emerg Med, 2002. 40: 280. 41. Wu, D.S., et al. Indinavir urolithiasis. Curr Opin Urol, 2000. 10: 557. 42. El-Nahas, A.R., et al. A prospective multivariate analysis of factors predicting stone disintegration by extracorporeal shock wave lithotripsy: the value of high-resolution

2019 European Association of Urology

17. Depression: Adult and Adolescent

, amitriptyline), and medications to treat HIV infection (e.g., indinavir). Consult a pharmacist to determine any possible drug interactions before recommending this treatment option. Additionally, do not use St. John’s wort as a treatment for severe depression. Not recommended There is insufficient evidence to recommend the following supplements for treatment of depression: 5HTP, folate, Ginkgo biloba, ginseng, glutamine, or inositol. Bright light therapy Moderate evidence supports the use of bright light

2017 Kaiser Permanente Clinical Guidelines

18. Erectile Dysfunction

, doxycycline, grapefruit, isoniazid, protease inhibitors, quinidine, verapamil If must use interacting drug, use lowest dose of PDE-5 inhibitors and increase interval of dosing to 24h; maximum vardenafil dose not to exceed 5 mg Concurrent use of vardenafil with indinavir, ritonavir, ketoconazole, or itraconazole is contraindicated CYP 3A4 inducers can significantly reduce therapeutic effect: carbamazepine, phenytoin, phenobarbital, rifampin High fat meals can delay onset time for sildenafil, and may reduce

2018 medSask

19. BHIVA guidelines on the management of HIV in pregnancy and postpartum

population has been excluded [24]. • Darunavir, efavirenz, indinavir, raltegravir and rilpivirine have been shown to have congenital malformation rates within the expected range, and a congenital malformation rate greater than 1.5-fold higher than in the general population has been excluded. • For newer agents (cobicistat, dolutegravir, elvitegravir and tenofovir alafenamide) and a number of less commonly prescribed older compounds (saquinavir, fosamprenavir, enfuvirtide, tipranavir, maraviroc

2019 British HIV Association

20. Urolithiasis

era? Clin Radiol, 2008. 63: 1131. 40. Worster, A., et al. The accuracy of noncontrast helical computed tomography versus intravenous pyelography in the diagnosis of suspected acute urolithiasis: a meta-analysis. Ann Emerg Med, 2002. 40: 280. 41. Wu, D.S., et al. Indinavir urolithiasis. Curr Opin Urol, 2000. 10: 557. 42. El-Nahas, A.R., et al. A prospective multivariate analysis of factors predicting stone disintegration by extracorporeal shock wave lithotripsy: the value of high-resolution

2018 European Association of Urology

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