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Hypochloremia

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1. Prognostic Impact of Hypochloremia in Patients With Stage I to III Colorectal Cancer After Radical Resection. (PubMed)

Prognostic Impact of Hypochloremia in Patients With Stage I to III Colorectal Cancer After Radical Resection. Recent studies have suggested that electrolyte disorders might be a negative prognostic factor for some diseases.The purpose of this study was to systematically evaluate the prognostic role of electrolyte disorders in patients with stage I to III colorectal cancer who received radical surgical resection.This study was retrospectively performed.The study was conducted at a single (...) tertiary care center.Patients with colorectal cancer who underwent radical resection in between April 2007 and April 2014 were included.The Kaplan-Meier method was adopted to estimate the overall and disease-free survival with and without propensity score matching.In total, our study recruited 5089 eligible patients. In prematching analysis, patients with hypochloremia showed both shorter overall survival (HR = 0.943 (95% CI, 0.908-0.980); p = 0.003) and disease-free survival (HR = 0.957 (95% CI, 0.933

2018 Diseases of the Colon & Rectum

2. An increased chloride level in hypochloremia is associated with decreased mortality in patients with severe sepsis or septic shock (PubMed)

An increased chloride level in hypochloremia is associated with decreased mortality in patients with severe sepsis or septic shock Only a few observational studies investigated the association between hypochloremia and mortality in critically ill patients, and these studies included small number of septic patients. Also, no study has evaluated the effect of an increase in chloride (Cl-) concentration in hypochloremia on the mortality. A total of 843 Korean septic patients were divided (...) into three groups based on their baseline Cl- level, and Cox analyses were performed to evaluate the 28-day mortality. Moreover, the change in Cl- level (ΔCl) from baseline to 24, 48, or 72 hour was determined, and Cox analyses were also conducted to evaluate the relationship of ΔCl with mortality. 301 (35.7%) patients were hypochloremic (Cl- < 97 mEq/L), and 38 (4.5%) patients were hyperchloremic (Cl- > 110 mEq/L). During the follow-up period, 119 (14.1%) patients died. Hypochloremia was significantly

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2017 Scientific reports

3. Treatment of hypochloremia with acetazolamide in an advanced heart failure patient and importance of monitoring urinary electrolytes (PubMed)

Treatment of hypochloremia with acetazolamide in an advanced heart failure patient and importance of monitoring urinary electrolytes Chloride was recently recognized to play an important role in the pathophysiology of heart failure (HF). Chloride manipulation, including the use of acetazolamide, may be a requisite therapeutic target in HF treatment. An 87-year-old male patient with advanced HF and hypertrophic cardiomyopathy was admitted to the hospital due to hypochloremia (94 mEq/L (...) ) and hyponatremia (134 mEq/L) under diuretic treatment with azosemide, spironolactone, and tolvaptan. On admission, HF-related signs of overhydration were lacking, but B-type natriuretic peptide was moderately elevated. The etiology of the hypochloremia/natremia state was depletion of both electrolytes based on serum analysis and spot urinary concentrations. Immediately after admission, acetazolamide (500 mg/d) was prescribed to correct the hypochloremia in parallel with cessation of the preceding

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2017 Journal of cardiology cases

4. Hypochloremia

Hypochloremia Hypochloremia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hypochloremia Hypochloremia Aka: Hypochloremia , Low Serum (...) Chloride From Related Chapters II. Pathophysiology 1 meq/L drop: 1% all body Chloride fall III. Causes s Gastric suction (NG Suction) Respiratory losses Steroid medications ( ) tous states Salt-losing nephritis Excessive sweating Excessive IV D5W s Burns Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Hypochloremia." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip

2018 FP Notebook

5. Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure. (PubMed)

Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure. Chloride plays a role in renal salt sensing, neurohormonal activation, and regulation of diuretic targets, and hypochloremia predicts mortality in acute heart failure (AHF). AHF therapies, such as diuretics, alter chloride homeostasis. We studied the association between (changes in) chloride levels and diuretic responsiveness, decongestion, and mortality in patients with AHF.Patients hospitalized for AHF (...) in the PROTECT trial (n=2033) with serum chloride levels within 24 hours of admission and 14 days later were studied (n=1960). Hypochloremia was defined as serum chloride <96 mEq/L. Mean baseline chloride was 100.8±5.0 mEq/L. Low baseline chloride was associated with high bicarbonate, poor diuretic response, less hemoconcentration, and worsening heart failure (all P<0.01). Newly developed hypochloremia at day 14 was common and associated with a decline in renal function and an increase in blood urea nitrogen

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2016 Circulation. Heart failure

6. Hypochloremia and Diuretic Resistance in Heart Failure: Mechanistic Insights. (PubMed)

Hypochloremia and Diuretic Resistance in Heart Failure: Mechanistic Insights. Recent epidemiological studies have implicated chloride, rather than sodium, as the driver of poor survival previously attributed to hyponatremia in heart failure. Accumulating basic science evidence has identified chloride as a critical factor in renal salt sensing. Our goal was to probe the physiology bridging this basic and epidemiological literature.Two heart failure cohorts were included: (1) observational (...) : patients receiving loop diuretics at the Yale Transitional Care Center (N=162) and (2) interventional pilot: stable outpatients receiving ≥80 mg furosemide equivalents were studied before and after 3 days of 115 mmol/d supplemental lysine chloride (N=10). At the Yale Transitional Care Center, 31.5% of patients had hypochloremia (chloride ≤96 mmol/L). Plasma renin concentration correlated with serum chloride (r=-0.46; P<0.001) with no incremental contribution from serum sodium (P=0.49). Hypochloremic

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2016 Circulation. Heart failure

7. Efficacy of oral potassium chloride administration in treating lactating dairy cows with experimentally induced hypokalemia, hypochloremia, and alkalemia. (PubMed)

Efficacy of oral potassium chloride administration in treating lactating dairy cows with experimentally induced hypokalemia, hypochloremia, and alkalemia. Hypokalemia occurs commonly in lactating dairy cows. The objectives of this study were to determine (1) whether a 24-h oral KCl dose of 0.4 g/kg of body weight (BW) was effective and safe in hypokalemic cattle; (2) whether potassium was best administered as 2 large doses or multiple smaller doses over a 24-h period; and (3) the effect of oral

2014 Journal of dairy science

8. The Incidence and Prognostic Value of Hypochloremia in Critically Ill Patients (PubMed)

The Incidence and Prognostic Value of Hypochloremia in Critically Ill Patients Little is known on the clinical effects of chloride on critically ill patients. We conducted this retrospective, observational study in 488 critically ill patients to investigate the incidence of chloride abnormalities, effects of hypochloremia in acid-base disorders, and association between chloride and clinical outcome. The study involved retrieval of arterial blood gas analyses, biochemical and demographical data (...) from electrical records as well as quantitative acid-base analyses. For statistical analysis, the patients were stratified into three groups according to their chloride level (normal range: 98-106 mEq/L). The distribution of chloride levels was hyperchloremia 16.6%, normochloremia 74.6%, and hypochloremia 8.8%. The hypochloremic group was significantly alkalemic (P < 0.0001) and has significantly higher apparent strong ion difference (SIDa) (P < 0.0001) compared to the two other groups

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2012 The Scientific World Journal

9. Hypochloremia

Hypochloremia Hypochloremia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hypochloremia Hypochloremia Aka: Hypochloremia , Low Serum (...) Chloride From Related Chapters II. Pathophysiology 1 meq/L drop: 1% all body Chloride fall III. Causes s Gastric suction (NG Suction) Respiratory losses Steroid medications ( ) tous states Salt-losing nephritis Excessive sweating Excessive IV D5W s Burns Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Hypochloremia." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip

2015 FP Notebook

10. The Paradox of Aciduria in the Presence of Alkalosis Caused by Hypochloremia (PubMed)

The Paradox of Aciduria in the Presence of Alkalosis Caused by Hypochloremia 17859015 2007 09 17 2018 12 01 0003-4932 126 4 1947 Oct Annals of surgery Ann. Surg. The Paradox of Aciduria in the Presence of Alkalosis Caused by Hypochloremia. 545-67 Van Slyke K K KK Evans E I EI eng Journal Article United States Ann Surg 0372354 0003-4932 0 Adjuvants, Immunologic OM Actinomycosis Adjuvants, Immunologic Alkalosis Humans Water-Electrolyte Imbalance 4713:1298o ACIDURIA/paradox, in alkalosis (...) ACTINOMYCOSIS/surgical arrest, adjuvants ALKALOSIS/by hypochloremia HYPOCHLOREMIA/alkalosis and paradox aciduria 1947 10 1 0 0 1947 10 1 0 1 1947 10 1 0 0 ppublish 17859015 PMC1803443 J Clin Invest. 1944 Jan;23(1):93-101 16695087 J Physiol. 1934 May 21;81(2):162-6 16994531

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1947 Annals of Surgery

11. STUDIES ON EXPERIMENTAL AND CLINICAL HYPOCHLOREMIA IN MAN (PubMed)

STUDIES ON EXPERIMENTAL AND CLINICAL HYPOCHLOREMIA IN MAN 16694984 2006 05 31 2018 11 13 0021-9738 22 1 1943 Jan The Journal of clinical investigation J. Clin. Invest. STUDIES ON EXPERIMENTAL AND CLINICAL HYPOCHLOREMIA IN MAN. 95-102 Kirsner J B JB Frank Billings Clinic, Chicago. Palmer W L WL Knowlton K K eng Journal Article United States J Clin Invest 7802877 0021-9738 1943 1 1 0 0 1943 1 1 0 1 1943 1 1 0 0 ppublish 16694984 10.1172/JCI101373 PMC435212 J Clin Invest. 1925 Jun;1(5):403-23

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1943 Journal of Clinical Investigation

12. ACID-BASE BALANCE, RENAL FUNCTION, AND GASTRIC SECRETION DURING HYPOCHLOREMIA IN THE DOG (PubMed)

ACID-BASE BALANCE, RENAL FUNCTION, AND GASTRIC SECRETION DURING HYPOCHLOREMIA IN THE DOG 16694836 2006 05 31 2018 11 13 0021-9738 20 3 1941 May The Journal of clinical investigation J. Clin. Invest. ACID-BASE BALANCE, RENAL FUNCTION, AND GASTRIC SECRETION DURING HYPOCHLOREMIA IN THE DOG. 303-12 Kirsner J B JB Department of Medicine, University of Chicago, Chicago. Knowlton K K eng Journal Article United States J Clin Invest 7802877 0021-9738 1941 5 1 0 0 1941 5 1 0 1 1941 5 1 0 0 ppublish

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1941 Journal of Clinical Investigation

13. The Effects of Acute Hypochloremia on the Distribution of Body Fluid and Composition of Tissue Electrolytes in Man (PubMed)

The Effects of Acute Hypochloremia on the Distribution of Body Fluid and Composition of Tissue Electrolytes in Man 13181329 2003 05 01 2018 12 01 0003-4932 140 2 1954 Aug Annals of surgery Ann. Surg. The effects of acute hypochloremia on the distribution of body fluid and composition of tissue electrolytes in man. 150-63 ARIEL I M IM eng Journal Article United States Ann Surg 0372354 0003-4932 0 Chlorides 0 Electrolytes OM Body Fluids Chlorides blood Electrolytes analysis Humans Male Water

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1954 Annals of Surgery

14. The Pathogenesis Of Hypochloremia in Respiratory Acidosis (PubMed)

The Pathogenesis Of Hypochloremia in Respiratory Acidosis 13611033 2000 07 01 2018 12 01 0021-9738 37 12 1958 Dec The Journal of clinical investigation J. Clin. Invest. The pathogenesis of hypochloremia in respiratory acidosis. 1667-75 LEVITIN H H BRANSCOME W W EPSTEIN F H FH eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Chlorides OM Acidosis Acidosis, Respiratory Chlorides blood 5935:40682:7:134 ACIDOSIS CHLORIDES/in blood 1958 12 1 1958 12 1 0 1 1958 12 1 0 0 ppublish

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1958 Journal of Clinical Investigation

15. TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: XI. Hypochloremia and Total Salt Deficiency in Nephritis (PubMed)

TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: XI. Hypochloremia and Total Salt Deficiency in Nephritis 16693844 2006 05 31 2018 11 13 0021-9738 6 4 1929 Feb The Journal of clinical investigation J. Clin. Invest. TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: XI. Hypochloremia and Total Salt Deficiency in Nephritis. 551-75 Peters J P JP Department of Internal Medicine of Yale University and the Medical Service of the New Haven Hospital, New Haven, Connecticut

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1929 Journal of Clinical Investigation

16. HYPOCHLOREMIA (PubMed)

HYPOCHLOREMIA 18741498 2008 08 29 2014 03 10 0093-4038 33 3 1930 Sep California and western medicine Cal West Med HYPOCHLOREMIA. 625-8 Curtis G M GM eng Journal Article United States Cal West Med 0414326 0093-4038 1930 9 1 0 0 1930 9 1 0 1 1930 9 1 0 0 ppublish 18741498 PMC1657514

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1930 California and western medicine

18. CRACKCast E141 – Heat Illness

amounts of thermal sweat and subsequently drink copious amounts of hypotonic fluid. Clinical Features: athletes, roofers, steelworkers, coal miners, field workers, and boiler operators are among the most common victims of heat cramps. Heat cramps tend to occur after exercise, when the victim stops working and is relaxing Usually have total body hyponatremia and hypochloremia. Most cases respond well to PO salt intake (tablets dissolved in oral solution). IV NS may be needed in severe cases. Essentials

2018 CandiEM

19. A young man with back spasms

+ (therefore net gain of HCO3-), others argue that H+ and HCO3- are simply the dependent variables of acid-base processes, with the actual independent variables being strong ions, CO2, and weak acids. In this view, it would be the loss of Cl and free water that best explains the severe metabolic alkalosis. Hypochloremia causes metabolic alkalosis. Loss of Cl and free water (with SID=0) in this case results in a Strong Ion Difference (SID) = Na - Cl = 133 - 61 = 72. In this case, the SID is much much

2018 Dr Smith's ECG Blog

20. Genetic investigation confirmed the clinical phenotype of congenital chloride diarrhea in a Hungarian patient: a case report. (PubMed)

Genetic investigation confirmed the clinical phenotype of congenital chloride diarrhea in a Hungarian patient: a case report. Congenital chloride diarrhea (CCD, OMIM 214700) is a rare autosomal recessively inherited condition characterized by watery diarrhea, hypochloremia and metabolic alkalosis. Mutations of the solute carrier family 26, member 3 (SLC26A3, OMIM 126650) gene are responsible for the disease. The gene encodes a transmembrane protein, which is essential for intestinal chloride

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2019 BMC Pediatrics

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