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Hypertrophic Scar

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2. Hypertrophic scars and keloids: overview of the evidence and practical guide for differentiating between these abnormal scars. Full Text available with Trip Pro

Hypertrophic scars and keloids: overview of the evidence and practical guide for differentiating between these abnormal scars. Although hypertrophic scars and keloidsboth generate excessive scar tissue, keloids are characterized by their extensive growth beyond the borders of the original wound, which is not observed in hypertrophic scars. Whether or not hypertrophic scars and keloids are two sides of the same coin or in fact distinct entities, remains a topic of much debate. However, proper (...) comparison between the two ideally occurs within the same study, but this is the exception rather than the rule. For this reason, the goal of this review was to summarize and evaluate all publications in which both hypertrophic scars and keloids were studied and compared to one anotherwithin the same study. The presence of horizontal growth is the mainstay of the keloid diagnosis and remains the strongest argument in support of keloids and hypertrophic scars being distinct entities, the histopathological

2020 Experimental Dermatology

3. Development of a Porcine Full-Thickness Burn Hypertrophic Scar Model and Investigation of the Effects of Shikonin on Hypertrophic Scar Remediation Full Text available with Trip Pro

Development of a Porcine Full-Thickness Burn Hypertrophic Scar Model and Investigation of the Effects of Shikonin on Hypertrophic Scar Remediation Hypertrophic scars formed after burns remain a challenge in clinical practice. Development of effective scar therapies relies on validated animal models that mimic human hypertrophic scars. A consistent porcine full-thickness burn hypertrophic scar model has yet to be developed. We have previously reported that Shikonin induces apoptosis and reduces (...) collagen production in hypertrophic scar fibroblasts in vitro and may therefore hold potential as a novel scar remediation therapy. In this study, we aimed to validate the potential of Shikonin on scar remediation in vivo. A novel porcine hypertrophic scar model was created after full-thickness burn wounds, and the effect of Shikonin on scar remediation was investigated. Clinical scar assessments, histology, and immunohistochemistry were used to evaluate scar appearance, morphology, and protein

2018 Frontiers in pharmacology

4. Hypertrophic and keloid scars fail to progress from the CD34-/α-SMA+ immature scar phenotype and show gradient differences in α-SMA and P16 expression. Full Text available with Trip Pro

Hypertrophic and keloid scars fail to progress from the CD34-/α-SMA+ immature scar phenotype and show gradient differences in α-SMA and P16 expression. Our understanding of the pathogenesis underlying keloid scar formation is still very limited, and the morphological distinction between hypertrophic and keloid scars remains difficult.Using whole biopsy imaging and an objectively quantifiable way to analyze immunoreactivity, we have compared young immature scars (Yscar) with mature normal (Nscar (...) ) scars, hypertrophic (Hscar) scars, and keloid (Kscar) scars with their surrounding skin (sNskin).Abnormal scars (Hscar and Kscar) maintain the Yscar phenotype, characterized by a CD34- (tumour biomarker) / α-SMA+ (myofibroblast) dermal region in contrast to Nskin (normal skin), sNskin and mature Nscar which were CD34+/α-SMA-. Yscar, Kscar and Hscar showed abnormal epidermal differentiation (involucrin), but only Hscar and Kscar showed increased epidermal thickness. Yscar did show increased epidermal

2019 British Journal of Dermatology

5. The Development and Application of "Scar-care" Padding on Management of Hypertrophic Scar

The Development and Application of "Scar-care" Padding on Management of Hypertrophic Scar The Development and Application of "Scar-care" Padding on Management of Hypertrophic Scar - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. The Development and Application of "Scar-care" Padding on Management of Hypertrophic Scar The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03469830 Recruitment Status : Completed First Posted : March 19, 2018 Last Update Posted : March 29, 2018 Sponsor: The Hong Kong

2018 Clinical Trials

6. Linear scar sarcoidosis on thin blepharoplasty line mimicking a hypertrophic scar: A case report Full Text available with Trip Pro

Linear scar sarcoidosis on thin blepharoplasty line mimicking a hypertrophic scar: A case report Sarcoidosis is a multisystem inflammatory disease of unknown aetiology. Skin involvement has been reported in 12%-27% of patients with systemic disease, and scar sarcoidosis is a form of sarcoidosis developing in previous cutaneous scar areas. Scars due to all kinds of trauma, including surgery, vaccines, cosmetic tattoos, and herpes zoster infection, have been reported to be associated (...) with sarcoidosis. Upper eyelid blepharoplasty is a mainstay of aesthetic procedure and of surgical rejuvenation of the orbital region. There have been relatively few reported scar sarcoidosis on blepharoplasty scar, considering many blepharoplasty procedures done for the last century. We report a case of 47-year-old woman presented with abruptly forming bilateral scar sarcoidosis on upper eyelid linear scars of 20 years of duration.

2018 SAGE Open Medical Case Reports

7. Autologous chyle fat grafting for the treatment of hypertrophic scars and scar-related conditions Full Text available with Trip Pro

Autologous chyle fat grafting for the treatment of hypertrophic scars and scar-related conditions Scarring is the product of natural restoration, yet its treatment remains challenging. Both collagen and fibroblasts are abnormally abundant in scars, leading to scar hyperplasia or contracture. Several clinical studies have reported that wrinkles at the recipient site are reduced, pores are narrowed, pigmentation is decreased, and skin is softened after autologous fat transplantation (...) . In this study, we investigated the ability of autologous chyle fat injection to normalize the fibroblasts and collagen of scar tissue in 80 adult patients with hypertrophic scars resulting from severe burns received more than 1 year previously.The patients underwent autologous chyle fat injection, and scar samples were collected at different time points. Differences in the number of adipocytes before and after chylosis were assessed by cell culture, and changes in the structural organization of the scars

2018 Stem cell research & therapy

8. A prospective study of time to healing and hypertrophic scarring in paediatric burns: every day counts Full Text available with Trip Pro

A prospective study of time to healing and hypertrophic scarring in paediatric burns: every day counts It is commonly accepted that burns taking longer than 3 weeks to heal have a much higher rate of hypertrophic scarring than those which heal more quickly. However, some of our patients develop hypertrophic scars despite healing within this 3-week period.We performed a prospective study of 383 paediatric burns treated non-operatively at a regional burns centre over a 2-year period from May 2011 (...) to April 2013. Scar assessment was performed by a senior burns therapist using the Vancouver Scar Scale.Overall rates of hypertrophic scarring were 17.2%. Time to healing was the strongest predictor of developing hypertrophic scarring, and the earliest hypertrophic scar developed in a patient who was healed after 8 days. The risk of hypertrophic scarring was multiplied by 1.138 for every additional day taken for the burn wound to heal. There was a trend towards higher rates of hypertrophic scarring

2017 Burns & trauma

9. Experimental Models for Cutaneous Hypertrophic Scar Research. (Abstract)

Experimental Models for Cutaneous Hypertrophic Scar Research. Human skin wound repair may result in various outcomes with most of them leading to scar formation. Commonly seen in many cutaneous wound healing cases, hypertrophic scars are considered as phenotypes of abnormal wound repair. To prevent the formation of hypertrophic scars, efforts have been made to understand the mechanism of scarring following wound closure. Numerous in vivo and in vitro models have been created to facilitate (...) investigations into cutaneous scarring and the development of anti-scarring treatments. To select the best model for a specific study, background knowledge of the current models of hypertrophic scars is necessary. In this review, we describe in vivo and in vitro models for studying hypertrophic scars, as well as the distinct characteristics of these models. The choice of models for a specific study should be based on the characteristics of the model and the goal of the study. In general, in vivo animal

2019 Wound Repair and Regeneration

10. Effect of pressure therapy for treatment of hypertrophic scar. Full Text available with Trip Pro

Effect of pressure therapy for treatment of hypertrophic scar. Pressure therapy (PST) has been reported for the treatment of hypertrophic scar (HS) effectively. However, no study has assessed its effect and safety systematically. Therefore, this study will investigate its effect and safety for patients with HS.A comprehensive literature search will be performed from the electronic databases and grey literatures. The electronic databases include MEDILINE, EMBASE, Cochrane Library, Web of Science (...) will provide the most recent evidence of PST on HS by evaluating primary outcomes of scar pruritus and improvement of scar; and secondary outcomes of scar blood flow, elasticity, volume, pain and burning. In addition, we will also evaluate adverse events.This study will provide up-to-date evidence of PST in patients with HS.Systematic review registration: PROSPERO CRD42019136627.

2019 Medicine

11. Early Postoperative Application of Botulinum Toxin Type A Prevents Hypertrophic Scarring after Epicanthoplasty: A Split-Face, Double-Blind, Randomized Trial. (Abstract)

Early Postoperative Application of Botulinum Toxin Type A Prevents Hypertrophic Scarring after Epicanthoplasty: A Split-Face, Double-Blind, Randomized Trial. Postoperative hypertrophic scarring of the medial canthal area is a common phenomenon and deterrent for patients considering epicanthoplasty. Botulinum toxin type A has been reported for hypertrophic scar and keloid treatment. However, there is a lack of high-level evidence regarding the effects of botulinum toxin type A in the medial (...) outcomes. No severe complications were reported.Early postoperative botulinum toxin type A injection in the medial canthal region efficiently reduces hypertrophic scarring and improves the outcome of epicanthoplasty. Therefore, botulinum toxin type A injection can be used as a routine method to prevent hypertrophic scarring and improve the outcome of epicanthoplasty.Therapeutic, II.

2019 Plastic and reconstructive surgery

12. Using Amniotic Membrane as a Novel Method to Reduce Post-burn Hypertrophic Scar Formation: A Prospective Follow-up Study. Full Text available with Trip Pro

Using Amniotic Membrane as a Novel Method to Reduce Post-burn Hypertrophic Scar Formation: A Prospective Follow-up Study. Several studies have shown that the application of amniotic membrane as a biological dressing in the management of burns is accompanied by rapid re-epithelialisation. In this follow-up study, we aimed to evaluate the possible role of amniotic membrane as an adjunct to split thickness skin grafting on reducing itching and severity of hypertrophic scar formation.From October (...) group) and in the other limb, the skin graft was covered with an amniotic membrane (amnion group). Therefore, in every patient, the graft was covered with an amniotic membrane in one extremity and fixed with skin staples in the other extremity. Finally, after 6 months, the degree of itching and hypertrophic scar formation was compared between the two groups.The study group was composed of 108 limbs in 54 patients (27 males and 27 females) with a mean age of 23.54 ± 4.9 years and burn 9.03 ± 2.69

2019 Journal of cutaneous and aesthetic surgery Controlled trial quality: uncertain

13. Fractional Ablative Laser Therapy is an Effective Treatment for Hypertrophic Burn Scars: A Prospective Study of Objective and Subjective Outcomes. (Abstract)

Fractional Ablative Laser Therapy is an Effective Treatment for Hypertrophic Burn Scars: A Prospective Study of Objective and Subjective Outcomes. The aim of this study is to determine objective and subjective changes in mature hypertrophic burn scars treated with a fractional ablative carbon dioxide (CO2) laser.Fractional CO2 laser treatment has been reported to improve burn scars, with increasing clinical use despite a paucity of controlled, prospective clinical studies using objective (...) quality of life, patient and investigator scar assessment scales, and blinded scoring of before and after photographs. Subjects aged 11 years or older with hypertrophic burn scars were recruited. Each subject received 3 monthly treatment sessions with an ablative fractionated CO2 laser.Twenty-nine subjects were enrolled, of whom 26 received at least 1 fractional CO2 laser treatment and 22 received 3 treatments. Mean age of those completing all 3 treatments was 28 years. Statistically significant

2019 Annals of Surgery

14. [Clinical effects of a combination treatment with narrow-spectrum intense pulsed light and fractional carbon dioxide laser on hypertrophic scar pruritus]. (Abstract)

[Clinical effects of a combination treatment with narrow-spectrum intense pulsed light and fractional carbon dioxide laser on hypertrophic scar pruritus]. Objective: To observe the effects of a combination treatment with narrow-spectrum intense pulsed light and fractional carbon dioxide laser on hypertrophic scar pruritus in clinic. Methods: A prospective randomized controlled study was conducted. A total of 90 patients with hypertrophic scars conforming to the inclusion criteria who were (...) % (1/45) of combination treatment group (P>0.05). Conclusions: The combination of narrow-spectrum intense pulsed light and fractional carbon dioxide laser can greatly reduce pruritus, improve effect of scar treatment, and bring higher patient satisfaction compared with narrow-spectrum intense pulsed light alone in treating hypertrophic scar pruritus. Clinical trial registration: Chinese Clinical Trial Registry, ChiCTR-ONH-17012350.

2019 Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns Controlled trial quality: uncertain

15. Reply to comments on "comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial". (Abstract)

Reply to comments on "comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial". 30655058 2019 01 18 1879-1409 2019 Jan 14 Burns : journal of the International Society for Burn Injuries Burns Reply to comments on "comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids (...) and hypertrophic scars: Randomised control trial". S0305-4179(18)31110-0 10.1016/j.burns.2018.12.014 Khalid Farrukh Aslam FA Jinnah Burn and Reconstructive Surgery Center, Allama Iqbal Medical College, Lahore, Pakistan. Electronic address: drfarrukhaslam@gmail.com. Mehrose Muhammad Younas MY Jinnah Burn and Reconstructive Surgery Center, Allama Iqbal Medical College, Lahore, Pakistan. Saleem Muhammad M Jinnah Burn and Reconstructive Surgery Center, Allama Iqbal Medical College, Lahore, Pakistan. Amin Muhammad

2019 Burns : journal of the International Society for Burn Injuries Controlled trial quality: uncertain

16. Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. Full Text available with Trip Pro

Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. The treatment of keloid and hypertrophic scar is challenging with no universally accepted mode for permanent ablation. Conventional therapies yield unpredictable results, significant complications and require elaborate hardware.The objective was to establish the safety and efficacy of intralesional 5 (...) -fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars.Randomized controlled trial (RCT).It was conducted at the Jinnah Burn and Reconstructive Surgery Center/Allama Iqbal Medical College, Lahore, Pakistan from May 2012 to March 2013.We included 120 patients divided in two groups. The group A patients received intralesional triamcinolone acetonide (TAC) and the group B patients received both 5-FU and TAC. 8 injections at a week interval were given and patients were evaluated at the start

2019 Burns : journal of the International Society for Burn Injuries Controlled trial quality: uncertain

17. The Efficacy of Combining Fractional Carbon Dioxide Laser With Verapamil Hydrochloride or 5-Fluorouracil in the Treatment of Hypertrophic Scars and Keloids: A Clinical and Immunohistochemical Study. (Abstract)

The Efficacy of Combining Fractional Carbon Dioxide Laser With Verapamil Hydrochloride or 5-Fluorouracil in the Treatment of Hypertrophic Scars and Keloids: A Clinical and Immunohistochemical Study. Ablative fractional laser-assisted therapy is increasingly used to facilitate drug delivery and intensify clinical efficacy of topically applied drugs.To evaluate the effectiveness of combined ablative fractional CO2 laser and topically applied 5-fluorouracil (5-FU) or verapamil hydrochloride (...) in the treatment of hypertrophic scars (HTSs) and keloids and to examine their possible effects on TGF-β1 expression.Thirty patients with HTSs and keloids were randomly treated with combined CO2 laser followed by topical verapamil or 5-FU application or CO2 laser monotherapy. All patients received 4 treatments with 1-month interval. Subjective and objective assessment was obtained using the Vancouver Scar Scale (VSS). Histological changes and immunohistochemical staining for TGF-β1 were performed.Compared

2019 Dermatologic Surgery

18. Topical Oxandrolone Reduces Ear Hypertrophic Scar Formation in Rabbits. (Abstract)

Topical Oxandrolone Reduces Ear Hypertrophic Scar Formation in Rabbits. Wound healing is a complex process. Despite extensive studies, hypertrophic and keloid scars still occur, and can be functionally and cosmetically problematic. In an attempt to prevent hypertrophic scar formation, the effects of topical oxandrolone, using hyaluronic acid as a biomaterial, were studied on ear wounds in rabbits.Deep second-degree burns were inflicted on each ear in 10 New Zealand rabbits. On the left ears (...) , considered the control side, hyaluronic acid gel was applied, whereas on the right ears, the study side, a combination of oxandrolone and hyaluronic acid was applied. Dressings were changed every 2 days for 2 weeks. At week 10, biopsy specimens from the postburn scars were harvested for histologic and immunohistochemical examinations.Fourteen wounds were studied, half on the control side and half on the study side. Six hypertrophic scars were encountered on the control side and only one scar

2019 Plastic and reconstructive surgery

19. “Scarless world or scar-less world”: expedition on new perspectives on management of post-burn hypertrophic scar Full Text available with Trip Pro

“Scarless world or scar-less world”: expedition on new perspectives on management of post-burn hypertrophic scar 27574691 2016 08 30 2019 01 12 2321-3868 4 2016 Burns & trauma Burns Trauma "Scarless world or scar-less world": expedition on new perspectives on management of post-burn hypertrophic scar. 22 10.1186/s41038-016-0049-5 Li-Tsang Cecilia W P CW Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom Hong Kong, China. eng Journal Article 2016 05 24

2016 Burns & trauma

20. Lasers and ancillary treatments for scar management Part 2: Keloid, hypertrophic, pigmented and acne scars Full Text available with Trip Pro

Lasers and ancillary treatments for scar management Part 2: Keloid, hypertrophic, pigmented and acne scars The formation of a wide range of excessive scars following various skin injuries is a natural consequence of healing. Scars resulting from surgery or trauma affect approximately 100 million people per annum in the developed world and can have profound physical, aesthetic, psychological and social consequences. Thus, scar treatment is a priority for patient and physician alike. Laser (...) treatment plays an important role in scar management with additional support from ancillary modalities. Subsequent to part 1: Burns scars, part 2 focuses on our strategies and literature review of treatment of keloid, hypertrophic, pigmented and acne scars where lasers are used in conjunction with other measures, and illustrated with case studies.

2017 Scars, Burns & Healing

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