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Hypertrophic Scar

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2. Development of a Porcine Full-Thickness Burn Hypertrophic Scar Model and Investigation of the Effects of Shikonin on Hypertrophic Scar Remediation (PubMed)

Development of a Porcine Full-Thickness Burn Hypertrophic Scar Model and Investigation of the Effects of Shikonin on Hypertrophic Scar Remediation Hypertrophic scars formed after burns remain a challenge in clinical practice. Development of effective scar therapies relies on validated animal models that mimic human hypertrophic scars. A consistent porcine full-thickness burn hypertrophic scar model has yet to be developed. We have previously reported that Shikonin induces apoptosis and reduces (...) collagen production in hypertrophic scar fibroblasts in vitro and may therefore hold potential as a novel scar remediation therapy. In this study, we aimed to validate the potential of Shikonin on scar remediation in vivo. A novel porcine hypertrophic scar model was created after full-thickness burn wounds, and the effect of Shikonin on scar remediation was investigated. Clinical scar assessments, histology, and immunohistochemistry were used to evaluate scar appearance, morphology, and protein

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2018 Frontiers in pharmacology

3. Hypertrophic and keloid scars fail to progress from the CD34-/α-SMA+ immature scar phenotype and show gradient differences in α-SMA and P16 expression. (PubMed)

Hypertrophic and keloid scars fail to progress from the CD34-/α-SMA+ immature scar phenotype and show gradient differences in α-SMA and P16 expression. Our understanding of the pathogenesis underlying keloid scar formation is still very limited, and the morphological distinction between hypertrophic and keloid scars remains difficult.Using whole biopsy imaging and an objectively quantifiable way to analyze immunoreactivity, we have compared young immature scars (Yscar) with mature normal (Nscar (...) ) scars, hypertrophic (Hscar) scars, and keloid (Kscar) scars with their surrounding skin (sNskin).Abnormal scars (Hscar and Kscar) maintain the Yscar phenotype, characterized by a CD34- (tumour biomarker) / α-SMA+ (myofibroblast) dermal region in contrast to Nskin (normal skin), sNskin and mature Nscar which were CD34+/α-SMA-. Yscar, Kscar and Hscar showed abnormal epidermal differentiation (involucrin), but only Hscar and Kscar showed increased epidermal thickness. Yscar did show increased epidermal

2019 British Journal of Dermatology

4. “Scarless world or scar-less world”: expedition on new perspectives on management of post-burn hypertrophic scar (PubMed)

“Scarless world or scar-less world”: expedition on new perspectives on management of post-burn hypertrophic scar 27574691 2016 08 30 2019 01 12 2321-3868 4 2016 Burns & trauma Burns Trauma "Scarless world or scar-less world": expedition on new perspectives on management of post-burn hypertrophic scar. 22 10.1186/s41038-016-0049-5 Li-Tsang Cecilia W P CW Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom Hong Kong, China. eng Journal Article 2016 05 24

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2016 Burns & trauma

5. Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction. (PubMed)

Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction. Hypertrophic scarring poses a clinically relevant problem as it can be cosmetically disfiguring and functionally debilitating. A lack of animal models has hindered an understanding of the pathogenesis and development of new treatment strategies therefore has largely been empiric. Our group has developed a unique hypertrophic scar (...) role in the development of HS. Additionally, we will present new data supporting the importance of the epidermis and further clarify the mechanism of action of silicone sheeting. When a semi-occlusive polyurethane film was left in place for an additional time period, scar formation was reduced. HSs of this model covered with silicone sheets and five layers of Tegaderm showed a significant scar reduction by 80% compared with wounds with only one layer of Tegaderm. The HS model in the rabbit ear

2017 Wound Repair and Regeneration

6. The Development and Application of "Scar-care" Padding on Management of Hypertrophic Scar

The Development and Application of "Scar-care" Padding on Management of Hypertrophic Scar The Development and Application of "Scar-care" Padding on Management of Hypertrophic Scar - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. The Development and Application of "Scar-care" Padding on Management of Hypertrophic Scar The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03469830 Recruitment Status : Completed First Posted : March 19, 2018 Last Update Posted : March 29, 2018 Sponsor: The Hong Kong

2018 Clinical Trials

7. Linear scar sarcoidosis on thin blepharoplasty line mimicking a hypertrophic scar: A case report (PubMed)

Linear scar sarcoidosis on thin blepharoplasty line mimicking a hypertrophic scar: A case report Sarcoidosis is a multisystem inflammatory disease of unknown aetiology. Skin involvement has been reported in 12%-27% of patients with systemic disease, and scar sarcoidosis is a form of sarcoidosis developing in previous cutaneous scar areas. Scars due to all kinds of trauma, including surgery, vaccines, cosmetic tattoos, and herpes zoster infection, have been reported to be associated (...) with sarcoidosis. Upper eyelid blepharoplasty is a mainstay of aesthetic procedure and of surgical rejuvenation of the orbital region. There have been relatively few reported scar sarcoidosis on blepharoplasty scar, considering many blepharoplasty procedures done for the last century. We report a case of 47-year-old woman presented with abruptly forming bilateral scar sarcoidosis on upper eyelid linear scars of 20 years of duration.

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2018 SAGE Open Medical Case Reports

8. Autologous chyle fat grafting for the treatment of hypertrophic scars and scar-related conditions (PubMed)

Autologous chyle fat grafting for the treatment of hypertrophic scars and scar-related conditions Scarring is the product of natural restoration, yet its treatment remains challenging. Both collagen and fibroblasts are abnormally abundant in scars, leading to scar hyperplasia or contracture. Several clinical studies have reported that wrinkles at the recipient site are reduced, pores are narrowed, pigmentation is decreased, and skin is softened after autologous fat transplantation (...) . In this study, we investigated the ability of autologous chyle fat injection to normalize the fibroblasts and collagen of scar tissue in 80 adult patients with hypertrophic scars resulting from severe burns received more than 1 year previously.The patients underwent autologous chyle fat injection, and scar samples were collected at different time points. Differences in the number of adipocytes before and after chylosis were assessed by cell culture, and changes in the structural organization of the scars

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2018 Stem cell research & therapy

9. Intralesional injection treatment of hypertrophic scars and keloids: a systematic review regarding outcomes.

Intralesional injection treatment of hypertrophic scars and keloids: a systematic review regarding outcomes. The aim of this review was to explore the existing body of literature focusing on the intralesional treatments of keloids and hypertrophic scars.A comprehensive systematic review of related articles was conducted across multiple databases. Article selection was limited to those published in the English language between 1950 and 2014. Search terms for the on-line research were "scar(s (...) )," "keloid(s)," "hypertrophic," "injection," "intralesional," and "treatment".The initial search returned 2548 published articles. After full text review, the final search yielded 11 articles that met inclusion criteria. A total of 14 patient samples in 11 articles were collected. The most frequent intralesional injection treatment studied was triamcinolone (n = 5), followed by bleomycin (n = 3), 5-fluorouracil (n = 2), verapamil (n = 2), cryosurgery, and collagenase. The scar height reduction for all

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2017 Burns & trauma

10. A prospective study of time to healing and hypertrophic scarring in paediatric burns: every day counts (PubMed)

A prospective study of time to healing and hypertrophic scarring in paediatric burns: every day counts It is commonly accepted that burns taking longer than 3 weeks to heal have a much higher rate of hypertrophic scarring than those which heal more quickly. However, some of our patients develop hypertrophic scars despite healing within this 3-week period.We performed a prospective study of 383 paediatric burns treated non-operatively at a regional burns centre over a 2-year period from May 2011 (...) to April 2013. Scar assessment was performed by a senior burns therapist using the Vancouver Scar Scale.Overall rates of hypertrophic scarring were 17.2%. Time to healing was the strongest predictor of developing hypertrophic scarring, and the earliest hypertrophic scar developed in a patient who was healed after 8 days. The risk of hypertrophic scarring was multiplied by 1.138 for every additional day taken for the burn wound to heal. There was a trend towards higher rates of hypertrophic scarring

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2017 Burns & trauma

11. Roles of peptides for prevention or treatment of hypertrophic scars and keloids: a systematic review

Roles of peptides for prevention or treatment of hypertrophic scars and keloids: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

12. Silicone gel sheeting for treating hypertrophic scars [Cochrane protocol]

Silicone gel sheeting for treating hypertrophic scars [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

13. Clinical efficacy of intralesional botulinum toxin type a monotherapy or combination therapy with corticosteroid to inhibit hypertrophic scar and keloid: a meta-analysis

Clinical efficacy of intralesional botulinum toxin type a monotherapy or combination therapy with corticosteroid to inhibit hypertrophic scar and keloid: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

14. Effect of pressure therapy (PST) for treatment of hypertrophic scar (HS): a systematic review protocol

Effect of pressure therapy (PST) for treatment of hypertrophic scar (HS): a systematic review protocol Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

15. Intralesional bleomycin injection for the treatment of hypertrophic scars and keloids: a systematic review and meta-analysis of randomised controlled trials

Intralesional bleomycin injection for the treatment of hypertrophic scars and keloids: a systematic review and meta-analysis of randomised controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

16. Topical Oxandrolone Reduces Ear Hypertrophic Scar Formation in Rabbits. (PubMed)

Topical Oxandrolone Reduces Ear Hypertrophic Scar Formation in Rabbits. Wound healing is a complex process. Despite extensive studies, hypertrophic and keloid scars still occur, and can be functionally and cosmetically problematic. In an attempt to prevent hypertrophic scar formation, the effects of topical oxandrolone, using hyaluronic acid as a biomaterial, were studied on ear wounds in rabbits.Deep second-degree burns were inflicted on each ear in 10 New Zealand rabbits. On the left ears (...) , considered the control side, hyaluronic acid gel was applied, whereas on the right ears, the study side, a combination of oxandrolone and hyaluronic acid was applied. Dressings were changed every 2 days for 2 weeks. At week 10, biopsy specimens from the postburn scars were harvested for histologic and immunohistochemical examinations.Fourteen wounds were studied, half on the control side and half on the study side. Six hypertrophic scars were encountered on the control side and only one scar

2019 Plastic and reconstructive surgery

17. The Efficacy of Combining Fractional Carbon Dioxide Laser With Verapamil Hydrochloride or 5-Fluorouracil in the Treatment of Hypertrophic Scars and Keloids: A Clinical and Immunohistochemical Study. (PubMed)

The Efficacy of Combining Fractional Carbon Dioxide Laser With Verapamil Hydrochloride or 5-Fluorouracil in the Treatment of Hypertrophic Scars and Keloids: A Clinical and Immunohistochemical Study. Ablative fractional laser-assisted therapy is increasingly used to facilitate drug delivery and intensify clinical efficacy of topically applied drugs.To evaluate the effectiveness of combined ablative fractional CO2 laser and topically applied 5-fluorouracil (5-FU) or verapamil hydrochloride (...) in the treatment of hypertrophic scars (HTSs) and keloids and to examine their possible effects on TGF-β1 expression.Thirty patients with HTSs and keloids were randomly treated with combined CO2 laser followed by topical verapamil or 5-FU application or CO2 laser monotherapy. All patients received 4 treatments with 1-month interval. Subjective and objective assessment was obtained using the Vancouver Scar Scale (VSS). Histological changes and immunohistochemical staining for TGF-β1 were performed.Compared

2019 Dermatologic Surgery

18. Effect of pressure therapy for treatment of hypertrophic scar. (PubMed)

Effect of pressure therapy for treatment of hypertrophic scar. Pressure therapy (PST) has been reported for the treatment of hypertrophic scar (HS) effectively. However, no study has assessed its effect and safety systematically. Therefore, this study will investigate its effect and safety for patients with HS.A comprehensive literature search will be performed from the electronic databases and grey literatures. The electronic databases include MEDILINE, EMBASE, Cochrane Library, Web of Science (...) will provide the most recent evidence of PST on HS by evaluating primary outcomes of scar pruritus and improvement of scar; and secondary outcomes of scar blood flow, elasticity, volume, pain and burning. In addition, we will also evaluate adverse events.This study will provide up-to-date evidence of PST in patients with HS.Systematic review registration: PROSPERO CRD42019136627.

2019 Medicine

19. Experimental Models for Cutaneous Hypertrophic Scar Research. (PubMed)

Experimental Models for Cutaneous Hypertrophic Scar Research. Human skin wound repair may result in various outcomes with most of them leading to scar formation. Commonly seen in many cutaneous wound healing cases, hypertrophic scars are considered as phenotypes of abnormal wound repair. To prevent the formation of hypertrophic scars, efforts have been made to understand the mechanism of scarring following wound closure. Numerous in vivo and in vitro models have been created to facilitate (...) investigations into cutaneous scarring and the development of anti-scarring treatments. To select the best model for a specific study, background knowledge of the current models of hypertrophic scars is necessary. In this review, we describe in vivo and in vitro models for studying hypertrophic scars, as well as the distinct characteristics of these models. The choice of models for a specific study should be based on the characteristics of the model and the goal of the study. In general, in vivo animal

2019 Wound Repair and Regeneration

20. Fractional Ablative Laser Therapy is an Effective Treatment for Hypertrophic Burn Scars: A Prospective Study of Objective and Subjective Outcomes. (PubMed)

Fractional Ablative Laser Therapy is an Effective Treatment for Hypertrophic Burn Scars: A Prospective Study of Objective and Subjective Outcomes. The aim of this study is to determine objective and subjective changes in mature hypertrophic burn scars treated with a fractional ablative carbon dioxide (CO2) laser.Fractional CO2 laser treatment has been reported to improve burn scars, with increasing clinical use despite a paucity of controlled, prospective clinical studies using objective (...) quality of life, patient and investigator scar assessment scales, and blinded scoring of before and after photographs. Subjects aged 11 years or older with hypertrophic burn scars were recruited. Each subject received 3 monthly treatment sessions with an ablative fractionated CO2 laser.Twenty-nine subjects were enrolled, of whom 26 received at least 1 fractional CO2 laser treatment and 22 received 3 treatments. Mean age of those completing all 3 treatments was 28 years. Statistically significant

2019 Annals of Surgery

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