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Hypertrichosis

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141. Desogestrel+ethinylestradiol versus levonorgestrel+ethinylestradiol. Which one has better affect on acne, hirsutism, and weight change. (Abstract)

Desogestrel+ethinylestradiol versus levonorgestrel+ethinylestradiol. Which one has better affect on acne, hirsutism, and weight change. To compare complications of third and second generation oral contraceptive pills (OCPs).In a randomized clinical trial from October 2007 to October 2008, 100 healthy women of reproductive age referred to Amir Hospital Family Planning Clinic and some heath centers in Semnan, Iran were randomized in 2 equal groups. They received either a third generation OCP (150 (...) microgram desogestrel [DSG] + 30 microgram ethinylestradiol [EE]) or a second generation type (150 microgram levonorgestrel [LNG] + 30 microgram EE). Six months later, changes of weight, acne, and hirsutism severity, as well as serum titers of sex hormone-binding globulin (SHBG) and free testosterone were compared between the 2 groups.Forty-five women were evaluated in the DSG+EE OCP group, and 46 women in the LNG+EE OCP group. The BMI was significantly higher in the second group (p=0.000) after 6

2011 Saudi medical journal Controlled trial quality: uncertain

142. Reanalyzing the modified Ferriman-Gallwey score: is there a simpler method for assessing the extent of hirsutism? Full Text available with Trip Pro

Reanalyzing the modified Ferriman-Gallwey score: is there a simpler method for assessing the extent of hirsutism? To determine whether assessing the extent of terminal hair growth in a subset of the traditional nine areas included in the modified Ferriman-Gallwey (mFG) score can serve as a simpler predictor of total body hirsutism when compared with the full scoring system, and to determine if this new model can accurately distinguish hirsute from nonhirsute women.Cross-sectional analysis.Two (...) tertiary care academic referral centers.1,951 patients presenting for symptoms of androgen excess.History and physical examination, including mFG score.Total body hirsutism.A regression model using all nine body areas indicated that the combination of upper abdomen, lower abdomen, and chin was the best predictor of the total full mFG score. Using this subset of three body areas is accurate in distinguishing true hirsute from nonhirsute women when defining true hirsutism as mFG >7.Scoring terminal hair

2011 Fertility and Sterility

143. Defining hirsutism in Chinese women: a cross-sectional study. (Abstract)

Defining hirsutism in Chinese women: a cross-sectional study. To determine the normative cut-off score that defines hirsutism among Chinese women, and the effect of age, menstrual irregularities, and polycystic ovaries on the same.Cross-sectional, population-based study.A multistage systematic cluster random sampling among 16 communities from two rural and two city regions.A representative sample of 2,988 women aged 20-45 years from the general population of Southern China.Subjects underwent (...) physical and ultrasound evaluations.Terminal hair growth was assessed using the modified Ferriman-Gallwey (mFG) scoring system.An mFG score ≥5 was observed in 10% and a score of ≥2 in 25% of the subjects. Cluster analysis identified an mFG score of 5 as the cut-off value that defines abnormal terminal facial and body hair growth in a male pattern (i.e., hirsutism) in the total population; scores of 6, 5, and 4 for women aged 20-25, 26-30, and >30 years, respectively. Defined by these cut-off values

2011 Fertility and Sterility

144. Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence. Full Text available with Trip Pro

Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence. Girls with a combined history of low(-normal) birth weight (LBW) and precocious pubarche (PP) are at high risk to develop polycystic ovary syndrome (PCOS).The objective of the study was to compare the capacity of early vs. late metformin treatment to prevent adolescent PCOS.This was a randomized, open-label study over 7 yr.The study was conducted (...) at a university hospital.Thirty-eight LBW-PP girls were followed up from the mean age 8 until age 15 yr.Early metformin (study yr 1-4; age 8-12 yr) vs. late metformin (yr 6; age 13-14 yr).Measures included height; weight; hirsutism score; menstrual cycle; endocrine-metabolic screening (fasting; follicular phase); C-reactive protein; body composition (absorptiometry); abdominal fat partitioning (magnetic resonance imaging); ovarian morphology (ultrasound); PCOS (National Institutes of Health and Androgen

2011 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

145. Idiopathic hirsutism: local and peripheral expression of aromatase (CYP19A) and 5α-reductase genes (SRD5A1 and SRD5A2). (Abstract)

Idiopathic hirsutism: local and peripheral expression of aromatase (CYP19A) and 5α-reductase genes (SRD5A1 and SRD5A2). To evaluate idiopathic hirsutism etiology via molecular studies testing peripheral and local aromatase and 5α-reductase expression.Assessment of the expression of messenger RNA (mRNA) for type 1 and 2,5α-reductase isoenzyme gene (SDR5A1, SDR5A2) and aromatase (CYP19A) in dermal papillae cells and peripheral blood mononuclear cells.University hospital.28 untreated idiopathic (...) hirsute patients and 20 healthy women (controls).Human skin biopsies and peripheral venous blood.SDR5A1, SDR5A2, CYP19A gene expression in skin biopsies and peripheral blood.A statistically significant reduction of SRD5A1, SRD5A2, and CYP19A gene expression was found in the dermal papillae cells and peripheral blood mononuclear cell between the study and control group.Further study, including protein expression and enzyme activity assays, are warranted to characterize the paradoxically low gene

2011 Fertility and Sterility

146. Hirsutism Full Text available with Trip Pro

% of all women across all ethnic backgrounds. Depending on the definition and the underlying data, estimates indicate that approximately 40% of women have some degree of unwanted facial hair. Contents Signs and symptoms [ ] Photo of , a , taken by around 1900. The cause of Jones' hypertrichosis is still unknown. Hirsutism affects members of either sex, since rising androgen levels can cause excessive body hair, particularly in locations where women normally do not develop terminal hair during (...) associated with hirsutism". Eur J Clin Invest . 42 (1): 86–94. : . . Chellini PR, Pirmez R, Raso P, Sodré CT (2015). . Int J Trichology . 7 (4): 182–3. : . . . Dawber RP, Rundegren J (2003). "Hypertrichosis in females applying minoxidil topical solution and in normal controls". J Eur Acad Dermatol Venereol . 17 (3): 271–5. : . . ^ Sachdeva, Silonie (2010). . Indian Journal of Dermatology . 55 (1): 3–7. : . . . Ferriman D, Gallwey JD (November 1961). . J. Clin. Endocrinol. Metab . 21 (11): 1440–7

2012 Wikipedia

147. Nevoid Hypertrichosis: Case Report with Review of the Literature Full Text available with Trip Pro

Nevoid Hypertrichosis: Case Report with Review of the Literature Nevoid hypertrichosis is a rare entity characterized by circumscribed patches of terminal hair. It is associated with many cutaneous and extra-cutaneous abnormalities. In our case, a single circumscribed patch of terminal hair growth was present without any underlying or associated cutaneous or systemic abnormalities.

2011 International journal of trichology

148. X-Linked Congenital Hypertrichosis Syndrome Is Associated with Interchromosomal Insertions Mediated by a Human-Specific Palindrome near SOX3. Full Text available with Trip Pro

X-Linked Congenital Hypertrichosis Syndrome Is Associated with Interchromosomal Insertions Mediated by a Human-Specific Palindrome near SOX3. X-linked congenital generalized hypertrichosis (CGH), an extremely rare condition characterized by universal overgrowth of terminal hair, was first mapped to chromosome Xq24-q27.1 in a Mexican family. However, the underlying genetic defect remains unknown. We ascertained a large Chinese family with an X-linked congenital hypertrichosis syndrome combining (...) and were not found in 1274 control individuals. Analysis of control individuals revealed deletions ranging from 173 bp to 9104 bp at the site of the insertions with no phenotypic consequence. Taken together, our results strongly support the pathogenicity of the identified insertions and establish X-linked congenital hypertrichosis syndrome as a genomic disorder.Copyright © 2011 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

2011 American Journal of Human Genetics

149. Hypertrichosis

is an increase in hair growth in a pattern formation. It is similar to acquired generalized hypertrichosis and is a sign of internal . Localized hypertrichosis Acquired localized hypertrichosis is an increase in hair density and length often secondary to irritation or trauma. This form is restricted to certain areas of the body. Hirsutism [ ] Main article: Hypertrichosis is often mistakenly classified as hirsutism. Hirsutism is a type of hypertrichosis exclusive to women and children, resulting from (...) to one family in Mexico. Acquired hypertrichosis and hirsutism are more common. For example, hirsutism occurs in about 10% of women between ages 18 and 45. Society and culture [ ] , the first recorded case of hypertrichosis 1874 London advertisement People with hair often found jobs as circus performers, barbers, making the best of their unusual appearance. ("Jo-Jo the Dog-faced Man"), ("Lionel the Lion-faced Man"), ("Wolfman"), ("the bearded woman") and ("The Minnesota Woolly Girl") all had

2012 Wikipedia

150. Is there evidence to support the use of topical preparations for the treatment of hirsutism in PMP women, in particular vaniqa

Is there evidence to support the use of topical preparations for the treatment of hirsutism in PMP women, in particular vaniqa Is there evidence to support the use of topical preparations for the treatment of hirsutism in PMP women, in particular vaniqa - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document (...) . As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Is there evidence to support the use of topical preparations for the treatment of hirsutism in PMP women, in particular vaniqa We found

2009 TRIP Answers

151. Is there any evidence that Eflornithine (Vaniqa) is effective for localised areas of non-facial hirsutism in women e.g. on the lower abdomen?

Is there any evidence that Eflornithine (Vaniqa) is effective for localised areas of non-facial hirsutism in women e.g. on the lower abdomen? Is there any evidence that Eflornithine (Vaniqa) is effective for localised areas of non-facial hirsutism in women e.g. on the lower abdomen? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only (...) for every single search. As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Is there any evidence that Eflornithine (Vaniqa) is effective for localised areas of non-facial hirsutism in women

2009 TRIP Answers

152. Acupuncture for polycystic ovarian syndrome. Full Text available with Trip Pro

Acupuncture for polycystic ovarian syndrome. Polycystic ovarian syndrome (PCOS) is characterised by the clinical signs of oligo-amenorrhoea, infertility and hirsutism. Conventional treatment of PCOS includes a range of oral pharmacological agents, lifestyle changes and surgical modalities. Beta-endorphin is present in the follicular fluid of both normal and polycystic ovaries. It was demonstrated that the beta-endorphin levels in ovarian follicular fluid of otherwise healthy women who were

2019 Cochrane

153. Polycystic ovary syndrome

://jcem.endojournals.org/cgi/content/full/91/11/4237 http://www.ncbi.nlm.nih.gov/pubmed/16940456?tool=bestpractice.com Azziz R, Carmina E, Dewailly D, et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril. 2009 Feb;91(2):456-88. http://www.ncbi.nlm.nih.gov/pubmed/18950759?tool=bestpractice.com History and exam presence of risk factors female of reproductive age irregular menstruation infertility hirsutism acne overweight or obesity

2019 BMJ Best Practice

154. Infertility Workup for the Women’s Health Specialist

, delivery route, and associated complications) c previous methods of contraception c coital frequency and timing c sexual dysfunction c past surgery (procedures, indications, and out- comes) focused on abdominal and pelvic procedures c previous hospitalizations, serious illnesses, or injuries c gynecologic history (eg, pelvicinflammatory disease, sexually transmitted infections, endometriosis, leiomyomas) c sexual history c reviewoforgansystems,includinghistoryofthyroid disease, galactorrhea, hirsutism

2020 Society for Assisted Reproductive Technology

155. European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

Symptoms and signs of hypogonadism LH FSH testosterone Androgen excess (women) Common Central obesity Irregular menses Hirsutism Acanthosis nigricans LH FSH oestradiol testosterone Cushing’s disease or Cushing’s syndrome Rare Central obesity Hypertension Type 2 diabetes 1 mg ODST Drug-induced endocrine dysfunction (e.g. lithium, anti-depressants, antipsychotics, glucocorticoids…) Common Psychiatric disorders Glucocorticoid therapy 1 mg ODST to exclude Cushing syndrome (except in glucocorticoid use

2020 European Society of Endocrinology

156. Management of Pilonidal Disease

-and-effect relationship, risk fac- tors associated with pilonidal disease include obesity, a sed- entary lifestyle, repetitive trauma or irritation to the gluteal cleft skin, familial history of pilonidal disease, and a hirsute body habitus. 2,3,8,9 Identification of these traits may direct counseling or aid in promoting lifestyle modifications. A positive family history of pilonidal disease is a risk factor for disease and may be associated with a higher recurrence rate after surgery. 10 Adjunctive

2020 American Society of Colon and Rectal Surgeons

157. Testosterone Testing - Protocol

of oral contraceptive medications. In polycystic ovarian syndrome, total testosterone concentrations are within the normal reference interval or slightly higher. Consequently, testosterone concentrations greater than twice the upper limit of normal (i.e., greater than 5 nmol/L) suggest an alternate etiology, such as an androgen-secreting tumour. Signs and Symptoms of Hyperandrogenism in Women A range of symptoms and signs from hirsutism to virilisation may occur. The Endocrine Society recommends (...) testing for hyperandrogenism in women with hirsutism that is moderate or severe, of rapid onset, or accompanied by menstrual dysfunction, obesity or clitoromegaly. Other indications for referral are outlined at the end of this document. Testing for Hyperandrogenism in Women Serum total testosterone is frequently normal in women with mild clinical hyperandrogenism (due to androgen suppression of SHBG production). cBAT testing (which includes SHBG) has a better diagnostic yield for testosterone excess

2019 Clinical Practice Guidelines and Protocols in British Columbia

158. Obesity Prevention and Management

to weight gain, psychosocial factors, family history of obesity and related conditions [I D]. Physical exam focusing on: BP and heart rate, and signs of related comorbidities (acanthosis nigricans, hirsutism in women for example) [II B]. Psychosocial assessment: identify motivated patients and also barriers to weight management [II C]. Limited lab panel: lipid panel, glucose (or HgB A1C in adults), AST & ALT [II B]. Treatment Goal. For children, decrease rate of weight gain or 1-2 lb/week weight loss

2020 University of Michigan Health System

160. Pilonidal disease

maceration acutely increased natal cleft pain and swelling fever or toxaemia male sex age 16 to 40 years FHx of pilonidal disease stiff hair and hirsutism Diagnostic investigations clinical diagnosis Treatment algorithm ACUTE ONGOING Contributors Authors Consultant Surgeon Department of General Surgery Northumbria Healthcare NHS Foundation Trust UK Disclosures IJDM is an author of a reference cited in this topic. Mr Iain J.D. McCallum would like to gratefully acknowledge Dr Seamus Kelly, a previous

2018 BMJ Best Practice

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