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Hypertrichosis

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122. Coffin-Siris syndrome with café-au-lait spots, obesity and hyperinsulinism caused by a mutation in the ARID1B gene (Full text)

Coffin-Siris syndrome with café-au-lait spots, obesity and hyperinsulinism caused by a mutation in the ARID1B gene Coffin-Siris syndrome (CSS) (MIM 135900) is characterized by developmental delay, severe speech impairment, distinctive facial features, hypertrichosis, aplasia or hypoplasia of the distal phalanx or nail of the fifth digit and agenesis of the corpus callosum. Recently, it was shown that mutations in the ARID1B gene are the main cause of CSS, accounting for 76% of identified

2016 Intractable & rare diseases research PubMed

123. Fluoxetine-Induced Hypoglycaemia in a Patient with Congenital Hyperinsulinism on Lanreotide Therapy (Full text)

Fluoxetine-Induced Hypoglycaemia in a Patient with Congenital Hyperinsulinism on Lanreotide Therapy Antidepressant drugs are reported to cause alterations in blood glucose homeostasis in adults with diabetes mellitus. We report a patient with persistent congenital hyperinsulinism (CHI) who developed recurrent hypoglycaemia following fluoxetine therapy. This 15-year-old girl was initially managed with diazoxide therapy. She developed troublesome hypertrichosis, which affected her quality of life

2016 Journal of clinical research in pediatric endocrinology PubMed

124. Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia (Full text)

children with severe diffuse HH, thus obviating the need for pancreatectomy. We report a girl with HH, with a novel heterozygous ABCC8 gene missense mutation (c.4154A>T/ p.Lys1385Thr), who was initially responsive to diazoxide therapy. After 11 months of diazoxide treatment, she developed intermittent, unpredictable breakthrough episodes of hypoglycaemia, in addition to generalized hypertrichosis and weight gain from enforced feeding to avoid hypoglycaemia. Sirolimus, which was commenced at 15 months (...) of age, gradually replaced diazoxide, with significant reduction and abolition of hypoglycaemia. The hypertrichosis resolved and there was less weight gain given the reduced need for enforced feeding. Sirolimus, which was administered over the next 15 months, was well tolerated with no significant side effects and was gradually weaned off. After stopping sirolimus, apart from hypoglycaemia developing during an episode of severe viral gastroenteritis, the capillary glucose concentrations were

2016 Endocrinology, diabetes & metabolism case reports PubMed

125. A Study to Assess the Safety and Efficacy of a Tacrolimus Based Immunosuppressive Regimen in Stable Kidney Transplant Recipients Converted From Cyclosporine Based Immunosuppressive Regimen

and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients received a kidney transplant at least 12 months before enrollment. Patients whose dosage of previous immunosuppressants has not been changed and remained for at least 4 weeks before enrollment, and blood trough level of cyclosporine is 100 to 200 ng/mL. Patients who have the side effects (hypertension, hyperlipidemia, gingival hyperplasia and hypertrichosis/hirsutism) during

2016 Clinical Trials

126. Investigation of FOL-005 on Clinical Safety and Effect on Hair Growth

Study Description Go to Brief Summary: A study to investigate clinical safety and effect on hair growth of FOL-005 in healthy volunteers. The study is divided in two parts, a single ascending dose (SAD) part and a multiple dose (MD) part. Condition or disease Intervention/treatment Phase Hypertrichosis Alopecia Hirsutism Drug: FOL-005 Other: Placebo Phase 1 Phase 2 Detailed Description: SAD part: A total of 3 weeks dosing, the two lowest concentrations in week 1, dose 3 at week 2 and finally dose 4 (...) to Layout table for additonal information Responsible Party: Follicum AB ClinicalTrials.gov Identifier: Other Study ID Numbers: FCS-001 First Posted: June 8, 2016 Last Update Posted: August 1, 2017 Last Verified: July 2017 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Additional relevant MeSH terms: Layout table for MeSH terms Alopecia Hirsutism Hypertrichosis Hypotrichosis Hair Diseases Skin Diseases Pathological Conditions, Anatomical Virilism Signs and Symptoms

2016 Clinical Trials

127. Long-Term Outcome of Interdisciplinary Management of Patients with Duchenne Muscular Dystrophy Receiving Daily Glucocorticoid Treatment. (PubMed)

patients with DMD aged 10 to <16 years treated with daily glucocorticoid (89% on deflazacort) for a mean of 8.5 years. Outcome measures were motor, pulmonary, and cardiac function, and scoliosis. Side effects were growth failure and weight gain, facial fullness, blood pressure, bone health, cataracts, gastrointestinal symptoms, behavior, hypertrichosis, and need for medication interventions.For 13- to 16-year-old patients, 40% could rise from the floor and 50% could perform the 30-foot run test. Forced

2016 Journal of Pediatrics

128. A randomized clinical trial on the comparison between hair shaving and snipping prior to laser hair removal sessions in women suffering from hirsutism. (PubMed)

A randomized clinical trial on the comparison between hair shaving and snipping prior to laser hair removal sessions in women suffering from hirsutism. Hirsutism or excess hair growth is a common dermatological problem in females, affecting up to 10% of females worldwide. We aimed this study to compare the two hair-shortening methods shaving vs. snipping among hirsute women regarding the outcome of the therapy and also the paradoxical hypertrichosis phenomenon (terminal hair regrowth) 6 months (...) session, the counts were 11.27 ± 9.30 in group A and 8.15 ± 3.12 in group B (P = 0.012). Paradoxical hypertrichosis was observed in three patients of group A vs. no patients in group B.We found that alexandrite laser therapy is really effective for treating hirsutism. Both shaving and using a scissor for hair shortening showed similar short-term results, but in one-year follow-up, paradoxical hypertrichosis was only observed in shaving group and also a lower hair count was observed in the snipping

2016 Journal of cosmetic dermatology

129. Choice, Transparency, Coordination, and Quality Among Direct-to-Consumer Telemedicine Websites and Apps Treating Skin Disease. (Full text)

was proffered in 48 encounters (77%). Prescription medications were ordered in 31 of 48 diagnosed cases (65%), and relevant adverse effects or pregnancy risks were disclosed in a minority (10 of 31 [32%] and 6 of 14 [43%], respectively). Websites made several correct diagnoses in clinical scenarios where photographs alone were adequate, but when basic additional history elements (eg, fever, hypertrichosis, oligomenorrhea) were important, they regularly failed to ask simple relevant questions and diagnostic

2016 JAMA dermatology (Chicago, Ill.) PubMed

130. Blepharoptosis and hypertrophic osteoarthropathy: A case report (Full text)

Blepharoptosis and hypertrophic osteoarthropathy: A case report A 52-year-old male patient presented to our hospital with a history of secondary hypertrophic osteoarthropathy (HOA) associated with an abdominal neoplasia and blepharoptosis. He had finger clubbing, hyperhidrosis, and hypertrichosis. He also had a recent history of extensive abdominal surgery with a pathology report of myelolipoma. Routine blood work was unremarkable. Upper eyelid reconstruction with blepharoplasty, upper eyelid

2016 Indian journal of ophthalmology PubMed

131. Cushing's Disease

Institute of Diabetes and Digestive and Kidney Diseases Definition (NCI) A syndrome caused by high levels of cortisol in the blood either due to excessive production and secretion of corticosteroids secondary to pituitary or adrenocortical neoplasms, or intake of glucocorticoid drugs. Signs and symptoms include a round face, upper body obesity, fragile and thin skin, purple stretch marks in the skin, fatigue, muscle weakness, hypertension, diabetes mellitus, hypertrichosis and amenorrhea in women (...) , amenorrhea, hypertrichosis in females, impotence in males, dusky complexion with purple markings, polycythemia, pain in the abdomen and back, and muscular wasting and weakness. Concepts Disease or Syndrome ( T047 ) MSH ICD9 255.0 ICD10 , SnomedCT 154705004 , 190505004 , 47270006 English Cushing Syndrome , Cushing's Syndrome , Syndrome, Cushing's , CUSHING'S SYNDROME , Cushing's syndrome, unspecified , Cushing syndrome , Cushing's basophilism , pituitary basophilism , Syndrome, Cushing , Cushing's

2018 FP Notebook

132. Medication Causes of Hyperandrogenism

Causes of Hyperandrogenism Medication Causes of Hyperandrogenism Aka: Medication Causes of Hyperandrogenism , Medication Causes of Hirsutism , Medication Causes of Hypertrichosis , Hirsutism due to Medication , Hypertrichosis due to Medication , Hyperandrogenism due to Medication II. Causes: Hypertrichosis (non-androgen related) - common Acitretin (Soriatane) (Finacea) ( ) ( ) s Etonogestrel Implant ( ) (Dylantin) III. Causes: Hirsutism (related to excessive androgen exposure) Endocrine agents s Sex (...) hair growth on a female.(NICHD) Definition (MSH) A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth. Definition (CSP) excess hair in females and children with an adult male pattern of distribution

2018 FP Notebook

133. Hair Removal Technique

Technique Aka: Hair Removal Technique , Hirsutism Management , Hypertrichosis Management , Epilation , Electrolysis From Related Chapters II. Indications III. Technique: Epilation (Hair plucking) Removes and for 6-8 weeks Only effective for hairs in phase Adverse effects Risk of damage to hair matrix Limited to localized areas of Risk of inflammation or Risk of or scarring Methods Hot waxing with resin (risk of ) plucking with tweezers Depilation (chemical dissolving of ) Effects last only 2 weeks (does (...) HYPERTRICHOSIS, which is an androgen-independent excessive hair growth. Definition (CSP) excess hair in females and children with an adult male pattern of distribution. Concepts Finding ( T033 ) MSH ICD9 704.1 ICD10 SnomedCT 40090008 , 399939002 English Hirsutism , HIRSUTISM , Excessive growth of hair , Excessive hair growth , Hairiness , hirsutism , excessive facial or body hair (symptom) , hirsutism (diagnosis) , excessive facial or body hair (hirsutism) , excessive facial or body hair , Hirsutism [Disease

2018 FP Notebook

134. Hirsutism

and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth. Definition (CSP) excess hair in females and children with an adult male pattern of distribution. Concepts Finding ( T033 ) MSH ICD9 704.1 ICD10 SnomedCT 40090008 , 399939002 English (...) Hirsutism , HIRSUTISM , Excessive growth of hair , Excessive hair growth , Hairiness , hirsutism , excessive facial or body hair (symptom) , hirsutism (diagnosis) , excessive facial or body hair (hirsutism) , excessive facial or body hair , Hirsutism [Disease/Finding] , hypertrichosis , polytrichia , excessive hairiness , excessive growth hair , hairiness , excessive growth of hair , excessive hair growth , pilosis , hirsuitism , hirsute , Hirsuitism , Hirsutism (disorder) , Hirsuties , Pilosis

2018 FP Notebook

135. A Study to Assess the Efficacy and Safety of Dupilumab in Patients With Severe Atopic Dermatitis (AD) That Are Not Controlled With Oral Cyclosporine A (CSA) or for Those Who Cannot Take Oral CSA Because it is Not Medically Advisable

or excipients OR Previously exposed to CSA, and CSA treatment should not be continued or restarted due to: intolerance and/or unacceptable toxicity (eg, elevated creatinine, elevated liver function tests, uncontrolled hypertension, paraesthesia, headache, nausea, hypertrichosis, etc), or inadequate response to CSA (defined as flare of AD on CSA tapering after a maximum of 6 weeks of high dose [5 mg/kg/day] to maintenance dose [2 to 3 mg/kg/day] or a flare after a minimum of 3 months on maintenance dose

2016 Clinical Trials

136. Classic Case Report of Donohue Syndrome (Leprechaunism; OMIM *246200): The Impact of Consanguineous Mating. (Full text)

due to infection, and jaundice. Dysmorphic features, abnormalities of the craniofacial region, low birth weight, skin abnormalities, abdominal distension and hypertrichosis were observed. Laboratory examinations showed, hyperinsulinism, increased C-peptide, thrombocytopenia, leucopenia, and anemia.The diagnosis of DS was done based on the combinations of typical dysmorphic characteristics, clinical evaluation, supported by genetic analysis and exaggerated biochemical results. Genetic diagnosis

2016 Medicine PubMed

137. Scar Management in the Pediatric and Adolescent Populations. (Full text)

Scar Management in the Pediatric and Adolescent Populations. For most children and adolescents who have developed symptomatic scars, cosmetic concerns are only a portion of the motivation that drives them and their caregivers to obtain treatment. In addition to the potential for cosmetic disfigurement, scars may be associated with a number of physical comorbidities including hypertrichosis, dyshidrosis, tenderness/pain, pruritus, dysesthesias, and functional impairments such as contractures

2016 Pediatrics PubMed

138. A Phase III, Multicenter, Parallel-Design Clinical Trial to Compare the Efficacy and Safety of 5% Minoxidil Foam Versus Vehicle in Women With Female Pattern Hair Loss. (PubMed)

(0.36-point improvement over the vehicle foam; P<.0001). TUAD increased by 658 μm/cm2 and 644 μm/cm2 more with 5% MTF than with vehicle foam at weeks 12 and 24, respectively (both P<.0001). MTF was well tolerated. A low incidence of scalp irritation and facial hypertrichosis was observed, with no clinically significant differences between groups.
Five percent MTF once daily for 24 weeks was well tolerated and promoted hair regrowth in women

2016 Journal of drugs in dermatology : JDD

139. Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation (Full text)

Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation Many cutaneous complications have been described in patients treated with cyclosporin. Alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent. However, the occurrence of sebaceous hyperplasia is exceptional. These lesions seem to be specific to cyclosporin rather than secondary to immunosuppression. Here, we report an exceptional case of eruptive

2016 Dermatopathology PubMed

140. Rabson Mendenhall Syndrome caused by a novel missense mutation (Full text)

and polydipsia. He was noted to have coarse facies, severe acanthosis nigricans, hypertrichosis, retarded growth and developmental delay. Investigations revealed severe hyperglycemia which was poorly responsive to high doses of insulin. A diagnosis of Rabson Mendenhall syndrome was suspected based on his physical characteristics in the presence of insulin resistance. Genetic studies revealed a homozygous missense mutation in the Insulin receptor gene confirming the diagnosis of Rabson Mendenhall syndrome

2016 International journal of pediatric endocrinology PubMed

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