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65. Alopecia, androgenetic - male

with: Known cardiovascular disease or cardiac arrhythmias. Advise men not to apply topical minoxidil to areas of the body other than the scalp, and to wash hands thoroughly after applying the solution or foam. [ ; ; ] Adverse effects What are the adverse effects of topical minoxidil 2% and 5%? Adverse effects of topical minoxidil 2% and 5% include: Hypertrichosis (unwanted non-scalp hair). Local redness, itching, and flaking. Skin reactions are largely due to the presence of the propylene glycol vehicle

2018 NICE Clinical Knowledge Summaries

66. Polycystic ovary syndrome

-acanthosis nigricans (HAIRAN) syndrome. High-dose exogenous androgens. Drug-related causes. Androgenic drugs that may cause hirsutism include testosterone, danazol, gestrinone, adrenocorticotropic hormone, high-dose corticosteroids, androgenic progestogens in oral contraceptives, and anabolic steroids. Non-androgenic drugs that may cause hirsutism include ciclosporin, diazoxide, minoxidil, phenytoin, and rarely, carbamazepine, sodium valproate, and acetazolamide. Drugs that may cause hypertrichosis

2018 NICE Clinical Knowledge Summaries

67. Corticosteroids - topical (skin), nose, and eyes

reversible. Excessive hair growth at the site of application (hypertrichosis). Systemic adverse effects are rare, but any of the adverse effects of corticosteroids, may also occur with topical corticosteroids, especially in infants and children. This includes adrenal suppression, that can result in symptoms of Cushing's syndrome and (in children) growth retardation. They are more likely to occur when potent or very potent topical corticosteroids are used over a large surface area for a prolonged period

2018 NICE Clinical Knowledge Summaries

68. Cholesterol homeostasis: links to hair follicle biology and hair disorders. (Full text)

Cholesterol homeostasis: links to hair follicle biology and hair disorders. Lipids and lipid metabolism are critical factors in hair follicle (HF) biology and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms

2019 Experimental Dermatology PubMed

69. Intense pulsed light treatment for Becker's nevus. (PubMed)

Intense pulsed light treatment for Becker's nevus. Background: Becker's Nevus (BN) is a benign hamartoma with an esthetically troublesome condition secondary to hyperpigmentation and hypertrichosis. Many treatment modalities have been utilized with variable outcomes. Objectives: To evaluate the efficacy and safety of intense pulsed light (IPL) in the treatment of BN. Patients and methods: IPL was used at filter of 590 nm, fluence of 18-22 J/cm2, double-pulse mode (pulse width of 3-10 ms, pulse

2019 Journal of Dermatological Treatment

70. An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing FGF7 production in outer root sheath keratinocytes. (PubMed)

An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing FGF7 production in outer root sheath keratinocytes. Given that unwanted hair growth (hirsutism, hypertrichosis) can cause major psychological distress, new pharmacological treatment strategies by safe and effective hair growth inhibitors that do not destroy the hair follicle (HF) and its stem cells need to be developed.Since human HFs express the multifunctional, immunomodulatory glycoprotein, osteopontin (...) signs of drug toxicity. qRT-PCR and immunohistochemistry revealed decreased transcription of the hair growth promoter, FGF7 by FOL-005, while co-treating HFs with recombinant FGF7 partially abrogated FOL-005-induced catagen promotion.With caveats in mind, our study identifies this osteopontin-derived peptide as an effective, novel inhibitory principle for human hair growth ex vivo and in vivo, which deserves systematic clinical testing in hirsutism and hypertrichosis. This article is protected

2019 British Journal of Dermatology

71. A novel homozygous frame-shift mutation in the SLC29A3 gene: a new case report and review of literature. (PubMed)

A novel homozygous frame-shift mutation in the SLC29A3 gene: a new case report and review of literature. The SLC29A3 gene, encoding a nucleoside transporter protein, is found in intracellular membranes. Based on the literatures, mutations in this gene cause a wide range of clinical manifestations including H syndrome, pigmented hypertrichosis with insulin dependent diabetes, Faisalabad histiocytosis, and dysosteosclerosis. However, all these disorders with their different names

2019 BMC Medical Genetics

72. Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel SK3 Cause Zimmermann-Laband Syndrome. (PubMed)

Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca2+-Activated K+ Channel SK3 Cause Zimmermann-Laband Syndrome. Zimmermann-Laband syndrome (ZLS) is characterized by coarse facial features with gingival enlargement, intellectual disability (ID), hypertrichosis, and hypoplasia or aplasia of nails and terminal phalanges. De novo missense mutations in KCNH1 and KCNK4, encoding K+ channels, have been identified in subjects with ZLS and ZLS-like phenotype (...) identified in a family with portal hypertension indicated basal constitutive channel activity and thus a different gain-of-function mechanism compared to the ZLS-associated mutant channels. With the report on de novo KCNK4 mutations in subjects with facial dysmorphism, hypertrichosis, epilepsy, ID, and gingival overgrowth, we propose to combine the phenotypes caused by mutations in KCNH1, KCNK4, and KCNN3 in a group of neurological potassium channelopathies caused by an increase in K

2019 American Journal of Human Genetics

73. Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®): Health Professional Version

microcephaly, hypertrichosis, nevus flammeus, severe myopia, unusual posture, severe intellectual disability, and feeding issues. The syndrome is associated with ASXL1 mutations and an estimated 7% incidence of Wilms tumor.[ ] Nonsyndromic causes of Wilms tumor Nonsyndromic causes of Wilms tumor include the following: Familial Wilms tumor. Despite the number of genes that appear to be involved in the development of Wilms tumor, familial Wilms tumor is uncommon, with approximately 2% of patients having

2017 PDQ - NCI's Comprehensive Cancer Database

75. Altim (Cortivazol) - arthritis, osteoarthritis, tendinitis, bursitis, talalgia, carpal tunnel syndrome, Dupuytren's contracture, radiculalgia

With corticosteroid treatment administered via the general route the following may be observed: - Clinical signs: excess weight, obesity, muscle atrophy, digestive disorders, osteoporosis, AHT, hypertrichosis, purpura, acne, - Neuropsychiatric signs: excitement, agitation, - Endocrinal and metabolic signs: true iatrogenic Cushing's syndrome, stunted growth in children, - Biological signs: glycosuria, hyperglycaemia, hypokalaemia.

2014 Haute Autorite de sante

76. Atopic dermatitis – Treatment with phototherapy and systemic agents

), x 21 Stern, R.S., Nichols, K.T., and Vakeva, L.H. Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA follow-up study. N Engl J Med . 1997 ; 336 : 1041–1045 | | | lentigines, photosensitive eruptions (especially polymorphous light eruption), folliculitis, photo-onycholysis, herpes simplex virus (HSV) reactivation, and facial hypertrichosis. Cataract formation is a recognized side effect specific to UVA therapy, whereas

2014 American Academy of Dermatology

78. Effect of dietary carbohydrates and time of year on ACTH and cortisol concentrations in adult and aged horses. (PubMed)

dexamethasone suppression tests in March, May, August, and October on 16 healthy Thoroughbred and Standardbred mares and geldings. Horses were grouped by age: adult (mean ± SD; 8.8 ± 2.9 yr; n = 8) and aged (20.6 ± 2.1 yr; n = 8). None of the horses showed clinical signs (hypertrichosis, regional adiposity, skeletal muscle atrophy, lethargy) of pituitary pars intermedia dysfunction. Horses were randomly assigned to groups of 4, blocked for age, and fed grass hay plus 4 isocaloric concentrate diets (control

2018 Domestic animal endocrinology

79. Safety and effectiveness, including intelligence prognosis, of diazoxide in pediatric patients with hyperinsulinemic hypoglycemia: special survey in Japan (long-term, all-case survey) (Full text)

one adverse drug reaction (ADR). The most commonly observed ADR was hypertrichosis (8.6%). The incidence of water retention-related ADRs and cardiac failure-related ADRs was 8.3% and 3.4%, respectively, and many of these occurred within the first 2 mo of treatment. The mean fasting blood glucose level was 44.9 mg/dL at baseline and was maintained at > 70 mg/dL, the control target, for 4 yr. A total of 113 infants < 1 yr of age were evaluated for the prognosis for intelligence, and a majority (77.9

2018 Clinical Pediatric Endocrinology PubMed

80. CME Part 1: Hair disorders in cancer patients. (PubMed)

CME Part 1: Hair disorders in cancer patients. Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders (including alopecia, hirsutism, hypertrichosis, pigmentary and textural hair changes). The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy -induced

2018 Journal of American Academy of Dermatology

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