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Hyperthyroidism

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2. Tachycardia, hyperthyroid, and ST elevation. What is it?

Tachycardia, hyperthyroid, and ST elevation. What is it? Dr. Smith's ECG Blog: Tachycardia, hyperthyroid, and ST elevation. What is it? Monday, April 9, 2018 This ECG was texted to me on my phone, with the words "Asymptomatic with hyperthyroidism:" What do you think? I replied that precordial leads are misplaced and to record it again. How did I know this? There are well formed R-waves in V1, but none in V2 and V3, then they return in V4. It is possible that there is focal infarction over V3 (...) in right precordial leads, and ST elevation concordant to a tall R-wave in V4, with a well formed J-wave. I was then told the clinical history: 46 y.o. male without PMH who presents for weight loss for 1 week and back pain. Patient reports that he had noticed weight lost for a long time, but particularly in the last week. An ECG was recorded because of a heart rate in the 120s. He denied chest pain or dyspnea. His labs had just returned consistent with hyperthyroidism. The clinicians had been very

2018 Dr Smith's ECG Blog

3. Hyperthyroidism Following Radiation Therapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study. (PubMed)

Hyperthyroidism Following Radiation Therapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study. The association of hyperthyroidism with exposure to ionizing radiation is poorly understood. This study addresses the risk of hyperthyroidism in relation to incidental therapeutic radiation dose to the thyroid and pituitary glands in a large cohort of survivors of childhood cancer.Utilizing the Childhood Cancer Survivor Study, a cohort of five-year survivors of childhood cancer (...) diagnosed at hospitals in the United States and Canada between 1970 and 1986, the occurrence of hyperthyroidism through 2009 was ascertained among 12,183 survivors based on serial questionnaires. Radiation doses to the thyroid and pituitary glands were estimated from radiotherapy records, and chemotherapy exposures were abstracted from medical records. Binary outcome regression was used to estimate prevalence odds ratios (ORs) for hyperthyroidism at five years from diagnosis of childhood cancer

2019 Biology and Physics

4. Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles. (PubMed)

Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles. The secretion of pituitary hormones oscillates throughout the 24-hour period, indicating that circadian clock-mediated mechanisms regulate this process in the gland. Additionally, pituitary hormone synthesis has been shown to be altered in hypo- and hyperthyroidism. Although thyroid hormones can modulate the other peripheral clocks (...) , the interaction between thyroid hormone levels and circadian clock gene expression in the anterior pituitary has yet to be elucidated.Male Wistar rats were divided into three groups: control, hypothyroid, and hyperthyroid. Following the experimental procedures, animals were euthanized every three hours over the course of a 24-hour period. The anterior pituitary glands were excised and processed for mRNA expression analysis by quantitative reverse transcriptase polymerase chain reaction. One- and two-way

2019 Thyroid

5. Serum zinc-α2-glycoprotein levels are elevated and correlated with thyroid hormone in newly diagnosed hyperthyroidism. (PubMed)

Serum zinc-α2-glycoprotein levels are elevated and correlated with thyroid hormone in newly diagnosed hyperthyroidism. Zinc-α2-glycoprotein (ZAG) is a recently novel lipolytic adipokine implicated in regulation of glucose and lipid metabolism in many metabolic disorders. In vitro and animal studies suggest that thyroid hormones (TH) up-regulates ZAG production in hepatocytes. However, there is no data evaluating the possible relationship between ZAG and TH in a human model of hyperthyroidism (...) . The objective of the present study is to assess the association of serum ZAG levels with TH and lipid profile in patients with hyperthyroidism before and after methimazole treatment.A total of 120 newly diagnosed overt hyperthyroidism and 122 healthy control subjects were recruited. Of them, 39 hyperthyroidism patients were assigned to receive methimazole treatment as follow-up study for 2 months.The clinical consequence showed that serum ZAG levels were elevated in patients with hyperthyroidism (P < 0.01

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2019 BMC Endocrine Disorders

6. Duration of hyperthyroidism and lack of sufficient treatment are associated with increased cardiovascular risk. (PubMed)

Duration of hyperthyroidism and lack of sufficient treatment are associated with increased cardiovascular risk. Cardiovascular disease remains the most prevalent cause of death in hyperthyroidism. However, the impact on cardiovascular events of varying thyroid status and of treatment remains unclarified. The aims of this study were to investigate the association between hyperthyroidism and cardiovascular events in treated and untreated hyperthyroid individuals, as well as exploring the impact (...) of cumulative periods of hyperthyroidism as a proxy for undertreatment on cardiovascular events.This was a case-control study nested within a population-based cohort of individuals attending health services in Funen County, Denmark, in the period from 1995 to 2011. Data on comorbidities and mortality were collected from The Danish National Patient Register and The Danish Register of Causes of Death. Participants were 275,467 individuals with at least one serum thyrotropin (TSH) measurement in the study

2019 Thyroid

7. Adjuvant rituximab, a potential treatment for the young patient with Graves' hyperthyroidism (RiGD): study protocol for a single-arm, single-stage, phase II trial. (PubMed)

Adjuvant rituximab, a potential treatment for the young patient with Graves' hyperthyroidism (RiGD): study protocol for a single-arm, single-stage, phase II trial. Graves' disease (Graves' hyperthyroidism) is a challenging condition for the young person and their family. The excess thyroid hormone generated by autoimmune stimulation of the thyroid stimulating hormone receptor on the thyroid gland can have a profound impact on well-being. Managing the young person with Graves' hyperthyroidism (...) of rituximab (500 mg) and a 12-month course of antithyroid drug (usually carbimazole) can result in a meaningful increase in the proportion of patients in remission at 2 years, the primary endpoint. A single-stage, phase II A'Hern design is used. 27 patients aged 12-20 years with newly presenting Graves' hyperthyroidism will be recruited. Markers of immune function, including lymphocyte numbers and antibody levels (total and specific), will be collected regularly throughout the trial.The trial

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2019 BMJ open

8. Impaired quality of life after radioiodine therapy compared with antithyroid drugs or surgical treatment for Graves' hyperthyroidism. A long-term follow-up with ThyPRO and SF-36. (PubMed)

Impaired quality of life after radioiodine therapy compared with antithyroid drugs or surgical treatment for Graves' hyperthyroidism. A long-term follow-up with ThyPRO and SF-36. Hyperthyroidism is known to have a significant impact on quality of life (QoL), at least in the short term. The purpose of the present study was to assess QoL in patients 6-10 years after treatment for Graves' disease (GD) with radioiodine (RAI) compared to those treated with thyroidectomy or antithyroid drugs (ATD

2019 Thyroid

9. Interventions for hyperthyroidism pre-pregnancy and during pregnancy. (PubMed)

Interventions for hyperthyroidism pre-pregnancy and during pregnancy. Women with hyperthyroidism in pregnancy have increased risks of miscarriage, stillbirth, preterm birth, and intrauterine growth restriction; and they can develop severe pre-eclampsia or placental abruption.To identify interventions used in the management of hyperthyroidism pre-pregnancy or during pregnancy and to ascertain the impact of these interventions on important maternal, fetal, neonatal and childhood outcomes.We (...) searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2013).We planned to include randomised controlled trials, quasi-randomised controlled trials, and cluster-randomised trials comparing antithyroid interventions for hyperthyroidism pre-pregnancy or during pregnancy with another intervention or no intervention (placebo or no treatment).Two review authors assessed trial eligibility and planned to assess trial quality and extract the data independently.No trials were

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2013 Cochrane

10. Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice. (PubMed)

Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice. Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To address the pathological features and establish a therapeutic approach of this disease, an animal model carrying the phenotype of Graves' disease (GD) in concert with Graves' Ophthalmopathy (GO) will be very important. However (...) , combined with hypertrophy and hyperplasia of thyroid follicles. A significantly increased synthesis of hyaluronic acid was detected in in the immunized mice compared with the control groups.We have successfully established an animal model manifesting Graves' hyperthyroidism and ophthalmopathy, which provides a useful tool for future study of the pathological features and the development of novel therapies of the diseases.

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2017 PLoS ONE

11. Hypothyroidism conversion to hyperthyroidism: it’s never too late (PubMed)

Hypothyroidism conversion to hyperthyroidism: it’s never too late Primary hypothyroidism is a common endocrine condition, most commonly caused by autoimmune thyroiditis (Hashimoto's disease) while Graves' disease is the most common cause of hyperthyroidism. Hypothyroidism is usually a permanent condition in most patients requiring lifelong levothyroxine treatment. Transformation from Hashimoto's disease to Graves' disease is considered rare but recently been increasingly recognised. We (...) describe a case of a 61-year-old lady who was diagnosed with hypothyroidism approximately three decades ago and treated with levothyroxine replacement therapy. Approximately 27 years after the initial diagnosis of hypothyroidism, she started to become biochemically and clinically hyperthyroid. This was initially managed with gradual reduction in the dose of levothyroxine, followed by complete cessation of the medication, but she remained hyperthyroid, ultimately requiring anti-thyroid treatment

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2018 Endocrinology, diabetes & metabolism case reports

12. Size dependent effects of Gold Nanoparticles in ISO-induced Hyperthyroid Rats (PubMed)

Size dependent effects of Gold Nanoparticles in ISO-induced Hyperthyroid Rats In this study, we applied different sizes of gold nanoparticles (Au-NPs) to isoproterenol (ISO)-induced hyperthyroid heart disease rats (HHD rats). Single dose of 5, 40, 100 nm Au-NPs were injected intravenously. Cardiac safety tests were evaluated by cardiac marker enzymes in serum and cardiac accumulation of Au-NPs were measured by ICP-MS. Our results showed that size-dependent cardiac effects of Au-NPs in ISO (...) -induced hyperthyroid rats. 5 nm Au-NPs had some cardiac protective effect  but little accumulation in heart, probably due to smaller size Au-NPs can adapt to whole body easily in vivo. Histological analysis and TUNEL staining showed that Au-NPs can induce pathological alterations including cardiac fibrosis, apoptosis in control groups, however they can protect HHD groups from these harmful effects. Furthermore, transmission electron microscopy and western blotting employed on H9C2 cells showed

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2018 Scientific reports

13. Echocardiographic evolution of pulmonary hypertension in female patients with hyperthyroidism (PubMed)

Echocardiographic evolution of pulmonary hypertension in female patients with hyperthyroidism The objective of this study was to highlight the impact of increased cardiac output (CO) and/or pulmonary vascular resistance (PVR) on the occurrence and evolution of pulmonary hypertension (PH) in hyperthyroidism and to follow their evolution in patients under therapy.Our study group consisted of 142 women with hyperthyroidism of different severities and etiologies. We divided our patients into three (...) groups: groups A (overt hyperthyroidism), B (recurrent disease), and C (subclinical forms). We performed echocardiography to determine echocardiographically estimated systolic pulmonary arterial pressure (eePAP), CO, and PVR before and at 3, 6, and 12 months after treatment with thyroid suppression therapy and beta-blockers.In our study group we documented PH of various severities in 73 patients (51.4%). Increased CO, induced mostly by hyperthyroidismspecific tachycardia, was frequently detected

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2018 Anatolian journal of cardiology

14. A Prospective Comparative Study on Improvement of Hyperthyroid Cardiovascular Dysfunction in Patients Undergoing Total Thyroidectomy Versus Medical Management. (PubMed)

A Prospective Comparative Study on Improvement of Hyperthyroid Cardiovascular Dysfunction in Patients Undergoing Total Thyroidectomy Versus Medical Management. Cardiovascular dysfunction (CVD) is a well-recognized complication in patients with hyperthyroidism and is the major cause of mortality. Very few studies have compared the outcome of CVD following different treatment modalities. In this study we intended to compare treatment modalities (antithyroid drugs vs surgery) for reversal (...) of CVD.Patients with newly detected hyperthyroidism were grouped into, Group I [n = 123, age <60 years, undergoing total thyroidectomy], Group II [n = 42, age <60 years, treated with antithyroid medications] were evaluated with 2D echocardiography, serum N terminal pro brain natriuretic peptide (NT-pro-BNP) at the time of diagnosis (Point A), after achieving euthyroidism (Point B) with antithyroid drugs and 6 months after surgery/continuation of antithyroid medications (Point C). Forty patients (Group III

2018 World Journal of Surgery

15. Impending thyroid storm in a pregnant woman with undiagnosed hyperthyroidism: A case report and literature review. (PubMed)

Impending thyroid storm in a pregnant woman with undiagnosed hyperthyroidism: A case report and literature review. Thyroid storm is a rare complication during caesarean section of patients with hyperthyroidism. It occurs abruptly, with a high mortality rate if not recognized immediately and aggressively treated. Herein, we reported a case of impending thyroid storm during a caesarean section.A healthy 23-year-old woman with undiagnosed hyperthyroidism underwent an emergency caesarean section (...) , more serious manifestations of thyroid storm were avoided.Good antenatal care is very important for pregnant women, and they should be generally screened for thyroid disorders, especially if the resting heart rate is >100 beats/min and weight increases are inconsistent with gestational age. When hyperthyroidism is suspected, drugs that excite the sympathetic nerves or promote the release of histamine should not be used during caesarean section.Copyright © 2017 The Authors. Published by Wolters

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2018 Medicine

16. Rapid remission of Graves' hyperthyroidism without thionamides under immunosuppressive treatment for concomitant autoimmune hepatitis. (PubMed)

Rapid remission of Graves' hyperthyroidism without thionamides under immunosuppressive treatment for concomitant autoimmune hepatitis. 29336235 2018 12 11 2018 12 11 1557-9077 28 2 2018 02 Thyroid : official journal of the American Thyroid Association Thyroid Rapid Remission of Graves' Hyperthyroidism Without Thionamides Under Immunosuppressive Treatment for Concomitant Autoimmune Hepatitis. 276-278 10.1089/thy.2017.0613 Papadakis Georgios E GE 1 Service of Endocrinology, Diabetes

2018 Thyroid

17. A Trial for the Evaluation of the Treatment and Outcome of Hyperthyroidism With Iodized Salt and Non Iodized Salt

A Trial for the Evaluation of the Treatment and Outcome of Hyperthyroidism With Iodized Salt and Non Iodized Salt A Trial for the Evaluation of the Treatment and Outcome of Hyperthyroidism With Iodized Salt and Non Iodized Salt - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. A Trial for the Evaluation of the Treatment and Outcome of Hyperthyroidism With Iodized Salt and Non Iodized Salt The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2018 Clinical Trials

18. PREDICTIVE SCORE FOR THE DEVELOPMENT OR PROGRESSION OF GRAVES' ORBITOPATHY IN PATIENTS WITH NEWLY DIAGNOSED GRAVES' HYPERTHYROIDISM. (PubMed)

PREDICTIVE SCORE FOR THE DEVELOPMENT OR PROGRESSION OF GRAVES' ORBITOPATHY IN PATIENTS WITH NEWLY DIAGNOSED GRAVES' HYPERTHYROIDISM. To construct a predictive score for the development or progression of Graves' orbitopathy (GO) in Graves' hyperthyroidism (GH).Prospective observational study in patients with newly diagnosed GH, treated with antithyroid drugs (ATD) for 18 months at ten participating centers from EUGOGO in 8 European countries.348 patients were included with untreated GH (...) but without obvious GO. Mixed effects logistic regression was used to determine the best predictors. A predictive score (called PREDIGO) was constructed.GO occurred in 15% (mild in 13% and moderate to severe in 2%), predominantly at 6-12 months after start of ATD. Independent baseline determinants for the development of GO were clinical activity score (assigned 5 points if score > 0), TSH-binding inhibitory immunoglobulins (2 points if TBII 2-10 U/L, 5 points if TBII > 10 U/L), duration of hyperthyroid

2018 European Journal of Endocrinology

19. Prediction of Neonatal Hyperthyroidism. (PubMed)

Prediction of Neonatal Hyperthyroidism. To assess whether it is possible to identify the neonatal predictors of neonatal hyperthyroidism at the presymptomatic stage of the disease.This retrospective multicenter study in 10 maternity units was based on the medical records of all patients monitored for a pregnancy between January 1, 2007, and January 1, 2014. Among 280 000 births, 2288 medical records of women with thyroid dysfunction were selected and screened. Of these, 415 women had Graves (...) disease and were positive for thyrotropin receptor antibody during pregnancy, and were included.A thyroid-stimulating hormone (TSH) level of less than 0.90 mIU/L between days 3 and 7 of life predicted neonatal hyperthyroidism with a sensitivity 78% (95% CI, 74%-82%) and a and specificity of 99% (95% CI, 98%-100%), a positive predictive value of 90% (95% CI, 87%-93%), a negative predictive value of 98% (95% CI, 97%-99%), and an area under the receiver operating characteristic curve of 0.99 (95% CI

2018 Journal of Pediatrics

20. Epidemiology of childhood hyperthyroidism in France: a nationwide population-based study. (PubMed)

Epidemiology of childhood hyperthyroidism in France: a nationwide population-based study. Hyperthyroidism affects all age groups, but epidemiological data for children are scarce.To perform a nationwide epidemiological survey of hyperthyroidism in children and adolescents.A cross-sectional descriptive study.Identification of entries corresponding to reimbursements for antithyroid drugs in the French national insurance database.All cases of childhood hyperthyroidism (6 months to 17 years of age (...) ) in 2015.National incidence rate estimated with a nonlinear Poisson model and spatial distribution of cases.A total of 670 cases of childhood hyperthyroidism were identified. Twenty patients (3%) had associated autoimmune or genetic disease, with type 1 diabetes and Down syndrome the most frequent. The annual incidence for 2015 was 4.58/100,000 person-years (95% CI 3.00 to 6.99/100,000). Incidence increased with age, in both sexes. This increase accelerated after the age of 8 in girls and 10 in boys

2018 Journal of Clinical Endocrinology and Metabolism

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