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Hypertension Evaluation History

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101. Novel Evaluation With QGC001 in Hypertensive Overweight Patients of Multiple Ethnic Origins

Genomics SA Information provided by (Responsible Party): Quantum Genomics SA Study Details Study Description Go to Brief Summary: Essential hypertension (HTN) is a disease that affects approximately 1 billion individuals worldwide. Despite the availability of effective and safe anti-hypertensive drugs, 65% of subjects diagnosed with HTN do not have their blood pressure (BP) controlled (<140/90 mmHg). The overall incidence of resistant HTN, (defined as requiring 3 or more anti-hypertensive drugs (...) of oral (PO) QGC001 (250 mg BID, 500 mg BID, and 500 mg BID + hydrochlorothiazide (HCTZ) 25 mg once daily [QD]) on blood pressure (BP) over 8 weeks in hypertensive overweight/obese subjects of multiple races/ethnicities. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 256 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Phase 2, Open-Label, Dose

2017 Clinical Trials

102. Evaluation of a community-based hypertension improvement program (ComHIP) in Ghana: data from a baseline survey. Full Text available with Trip Pro

Evaluation of a community-based hypertension improvement program (ComHIP) in Ghana: data from a baseline survey. Ghana faces an increasing burden of non-communicable disease with rates of hypertension estimated as high as 36% in adults. Despite these high rates, hypertension control remains very poor in Ghana (4%). The current project aims to implement and evaluate a community-based programme to raise awareness, and to improve treatment and control of hypertension in the Eastern Region of Ghana (...) ), waist, and hip circumferences. After adjusting for age, the risk factors with the greatest association with hypertension were being overweight (aOR = 2.30; 95% CI 1.53-3.46) or obese (aOR = 3.61; 95% CI 2.37-5.51). Older individuals were more likely to be aware of their hypertension status than younger people. After adjusting for age people with a family history of hypertension or CVD, or having an unhealthy waist hip ratio, were more likely to be aware of their hypertension status.The high burden

2017 BMC Public Health

103. Hypertension - Diagnosis and Management

are based on the 2011 Oxford Centre for Evidence-Based Medicine version. 2 BCGuidelines.ca: Hypertension – Diagnosis and Management (2015, Revised 2016) Diagnosis 7 - 9 Assessment of Elevated Blood Pressure If average BP is elevated again, proceed to investigations and work-up to assess target organ damage and cardiovascular disease (CVD) risk. Select which arm to use by measuring BP in both arms with the patient in a seated position. Measure BP three more times using the arm with the higher reading (...) : AOBP = automatic office blood pressure; ABPM = ambulatory blood pressure monitoring; BP = blood pressure; CVD = cardiovascular disease; DBP = diastolic blood pressure; Dx = diagnosis; HBPM = home blood pressure monitoring; HTN = hypertension; MOBP = manual office blood pressure. Footnote: a Out-of-office method may include automated BP machines at pharmacies or grocery stores. b Sign/symptoms may include papilloedema and retinal hemorrhage. Investigations and work-up includes: • Medical history

2015 Clinical Practice Guidelines and Protocols in British Columbia

104. Hypertension in pregnancy

antihypertensive therapy for severe hypertension in pregnancy (systolic blood pressure (BP) of at least 160 mmHg and/or diastolic BP of at least 110 mmHg). The authors concluded that oral nifedipine was the most effective drug, while labetolol and methyldopa were less effective but were also suitable options. Conclusions were however limited by the quality of the studies [ ]. Target blood pressure The recommended target blood pressures are based on the NICE guideline The management of hypertensive disorders (...) the first and second trimesters and a woman with a high blood pressure before week 20 of pregnancy can therefore be assumed to have pre-existing hypertension. Gestational hypertension New hypertension presenting after 20 weeks' gestation without significant proteinuria. Pre-eclampsia New hypertension presenting after 20 weeks' gestation with significant proteinuria. Pre-eclampsia is a multi-system disorder which can affect the placenta, kidney, liver, brain, and other organs of the mother. HELLP

2019 NICE Clinical Knowledge Summaries

105. Hypertension - Diagnosis and Management

management is recommended for those with mild hypertension (average blood pressure = 140 – 159/90 – 99), low-risk for cardiovascular disease and no co-morbidities. [Level 1, 2008] Definition An elevated blood pressure (BP) is defined as a systolic blood pressure (SBP) > 140 mm Hg or diastolic blood pressure (DBP) > 90 mm Hg or both. Detection In patients aged ≥ 45 years, BP should be recorded at least once every 5 years. This recording should be the average of several measurements. Ensure standardized (...) ; 57(4):689–94. Roush GC, Holford TR, Guddati AK. Chlorthalidone compared with hydrochlorothiazide in reducing cardiovascular events: Systematic review and network meta-analyses. Hypertension. 2012;59(6):1110–17. Messerli FH, Makani H, Benjo A, et al. Antihypertensive efficacy of hydrochlorothiazide as evaluated by ambulatory blood pressure monitoring: A meta-analysis of randomized trials. JACC. 2011;57(5):590-300. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group

2015 Clinical Practice Guidelines and Protocols in British Columbia

106. Multidrug intolerance in the treatment of hypertension: result from an audit of a specialized hypertension service Full Text available with Trip Pro

intolerance (MDI) is hardly considered. A situation when a patient is willing to adhere but is compelled otherwise could frustrate both patient and physician. Encountering a few such cases prompted the author to audit his specialized hypertension service in order to evaluate the burden of MDI and its associations.Between 7 May and 30 July 2016 (to cover a 12-week cycle which ensured all attendees were captured), all patients attending follow up for blood pressure control had their records evaluated (...) -morbidity. A total of four patients (three men, one woman) had history suggesting allergy and two (one man, one woman) were on treatment for anxio-depressive illness.MDI does occur in sub-Sahara African patients with hypertension and should be considered before describing hypertension as resistant or considering alternative treatments including device therapy. Staggering doses or trying different formulations could be of benefit.

2017 Therapeutic advances in drug safety

107. Association between hypertensive disorders of pregnancy and the risk of postpartum hypertension: a cohort study in women with gestational diabetes Full Text available with Trip Pro

hypertension among GDM women. To evaluate the association between HDP and the risk of postpartum hypertension among GDM women, a retrospective cohort study was conducted in 1261 women with prior GDM at their postpartum 1-5 years using the baseline data from Tianjin Gestational Diabetes Mellitus Prevention Program. Cox regression models were applied to assess the single and joint associations of having a history of HDP, maternal pre-pregnancy Body mass index (BMI) (normal weight, overweight and obesity (...) ), and weight change from preconception to post-delivery with the risk of subsequent hypertension among the GDM women. We found that GDM women with a history of HDP, high pre-pregnancy BMI and weight gain >7 kg from preconception to post-delivery had an increased risk of postpartum hypertension. Joint effects analysis revealed that the positive association between a history of HDP in the index pregnancy and the risk of postpartum hypertension was consistent in GDM women with different levels of pre

2017 Journal of human hypertension

108. Cardiovascular risk model performance in women with and without hypertensive disorders of pregnancy (Abstract)

Cardiovascular risk model performance in women with and without hypertensive disorders of pregnancy Compare the predictive performance of Framingham Risk Score (FRS), Pooled Cohort Equations (PCEs) and Systematic COronary Risk Evaluation (SCORE) model between women with and without a history of hypertensive disorders of pregnancy (hHDP) and determine the effects of recalibration and refitting on predictive performance.We included 29 751 women, 6302 with hHDP and 17 369 without. We assessed

2018 EvidenceUpdates

109. Impact of the ACOG guideline regarding low-dose aspirin for prevention of superimposed preeclampsia in women with chronic hypertension. (Abstract)

with chronic hypertension requiring antihypertensive medication, history of preeclampsia, and pregestational diabetes.We identified 457 pregnant women with chronic hypertension, 203 in the post-American College of Obstetricians and Gynecologists group and 254 in the pre-American College of Obstetricians and Gynecologists group. Aspirin 81 mg was offered to 142 (70%) in the post-American College of Obstetricians and Gynecologists group and 18 (7.0%) in the pre-American College of Obstetricians (...) =.03. There were no significant differences in small for gestational age neonates or preterm birth <37 weeks incidences between groups. There were no significant differences in the subgroup analysis based on the severity of chronic hypertension requiring antihypertensive medication, history of preeclampsia, or pregestational diabetes.After the adoption of the American College of Obstetricians and Gynecologists guidelines in 70% of the cohort, superimposed preeclampsia, small for gestational age

2020 American Journal of Obstetrics and Gynecology

110. Pulmonary arterial hypertension with below threshold pulmonary vascular resistance. (Abstract)

Pulmonary arterial hypertension with below threshold pulmonary vascular resistance. Pulmonary vascular resistance (PVR)>3 WU is a criterion of the haemodynamic definition of pulmonary arterial hypertension (PAH). However, this cut-off is conservative and arbitrarily defined. Data is lacking on the natural history, response to therapy and survival of patients diagnosed with precapillary pulmonary hypertension with mild or borderline elevation of PVR.In Australia, PAH therapy could be prescribed (...) solely on mean pulmonary artery pressure (mPAP) and pulmonary artery wedge pressure (PAWP) criteria. Using the Australian and New Zealand Pulmonary Hypertension Registry, we aimed to study a population diagnosed with PAH between Jan 2004 and Dec 2017 with the pre-defined haemodynamic characteristics of mPAP≥25 mmHg, PAWP≤15 mmHg and PVR<3 WU.Eighty-two patients met the pre-defined haemodynamic inclusion criteria (mean age 63±11 years; 67 females). Underlying aetiologies included idiopathic disease(n

2020 European Respiratory Journal

111. Clinical outcome and hemodynamic changes following HCV eradication with oral antiviral therapy in patients with clinically significant portal hypertension. (Abstract)

and 53% had CSPH (65% if we assume persistence of CSPH in all 59 non-evaluated patients). The proportion of high-risk patients (HVPG ≥ 16mmHg) diminished from 41% to 15%. Liver stiffness decreased markedly after SVR (median decrease 10.5 ± 13kPa) but did not correlate with HVPG changes (30% of patients with LSM <13.6kPa still had CSPH). Seventeen (7%) patients presented de novo/additional clinical decompensation, which was independently associated with baseline HVPG ≥ 16mmHg and history (...) of ascites.Patients achieving SVR present a progressive reduction in portal pressure during follow-up. However, CSPH may persist in up to 53-65% of patients at SVR96, indicating persistent risk of decompensation. History of ascites and high-risk HVPG values identified patients at higher risk of de novo or further clinical decompensation.Copyright © 2020. Published by Elsevier B.V.

2020 Journal of Hepatology

112. Multicenter, prospective, comparative cohort study evaluating the efficacy and safety of alfuzosin 10 mg with regard to blood pressure in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia with or without antihypertensive med Full Text available with Trip Pro

Multicenter, prospective, comparative cohort study evaluating the efficacy and safety of alfuzosin 10 mg with regard to blood pressure in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia with or without antihypertensive med The objective of this study was to assess the efficacy and safety of alfuzosin 10 mg monotherapy or combined antihypertensive medication on blood pressure (BP) in patients with lower urinary tract symptoms suggestive of benign prostatic (...) combination therapy (group 2). Based on baseline BP and hypertensive history with or without antihypertensive medications at first medical examination, group 1 was divided into two subgroups of normotensive and untreated hypertensive patients, and group 2 into two subgroups of controlled hypertensive and uncontrolled hypertensive patients. The primary study outcomes were change in IPSS, BP, and heart rate from baseline. Secondary outcomes were change in IPSS-quality of life score, maximum flow rate

2015 Clinical interventions in aging Controlled trial quality: uncertain

113. Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy

regimens: nifedipine, labetalol or methyldopa. This trial will compare the efficacy, safety and side effects of these three oral regimens for management of hypertension in pregnant women. The investigators hypothesize that nifedipine treatment of severe hypertensive parturient women is more effective than treatment with labetalol or methyldopa in controlling high blood pressure within six hours. Condition or disease Intervention/treatment Phase Hypertension in Pregnancy Preeclampsia Drug: Nifedipine (...) of hypertension in pregnant women. The investigators hypothesize that nifedipine treatment of severe hypertensive parturient women is more effective than treatment with labetalol or methyldopa in controlling high blood pressure within six hours. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 894 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title

2013 Clinical Trials

114. The Prevalence of Coronary Spasm in Hypertensive Patients Treated With Antihypertensive Medication

Sponsor: Korea University Collaborator: Korea Institute of Science and Technology Information provided by (Responsible Party): Hong Seog Seo, Korea University Study Details Study Description Go to Brief Summary: Autonomic nerve function is involved in both blood pressure (BP) regulation and the pathogenesis of coronary artery spasm(CAS), but few studies have been published about the relationship between CAS and effect of BP lowering drugs in patients with hypertension. The purpose of this study (...) is to investigate the incidence of CAS, atrioventricular (AV) block and effect of BP lowering drugs on CAS in hypertensive patients treated with BP lowering agents. The investigators will register consecutive patients who underwent coronary angiography with an acetylcholine (Ach)-induced provocation test. The investigators will include hypertensive patients who were taking antihypertensive drugs, and exclude patients who had a documented history of cardiovascular disease or who were not treated

2013 Clinical Trials

115. Impact of antihypertensive medication adherence on blood pressure control in hypertension: the COMFORT study. Full Text available with Trip Pro

Impact of antihypertensive medication adherence on blood pressure control in hypertension: the COMFORT study. It has not been fully elucidated whether antihypertensive medication adherence affects blood pressure (BP) control in hypertension cases.To investigate the association of adherence to antihypertensive drug regimens and BP control using data from the Combination Pill of Losartan Potassium and Hydrochlorothiazide for Improvement of Medication Compliance Trial (COMFORT) study.An (...) observational analysis from a randomized controlled trial.A total of 203 hypertensive subjects were randomly assigned to a daily regimen of a combination pill (losartan 50 mg/hydrochlorothiazide 12.5 mg) or two pills, an angiotensin II receptor blocker and a thiazide diuretic. Medication adherence calculated based on pill counts and BPs was evaluated at 1, 3 and 6 months after randomization.The subjects were divided into three groups according to their adherence, i.e. relatively low-adherence (<90%; n = 19

2013 QJM : monthly journal of the Association of Physicians

116. Hypertension - not diabetic

Hypertension - not diabetic Hypertension - not diabetic - NICE CKS Share Hypertension - not diabetic: Summary Hypertension is persistently raised arterial blood pressure (BP). It is one of several risk factors for diseases such as heart failure, myocardial infarction, stroke, and chronic kidney disease. Hypertension should be suspected if clinic systolic BP is sustained above or equal to 140 mmHg, or diastolic BP is sustained above or equal to 90 mmHg, or both. Clinical criteria for diagnosing (...) or clinic diastolic blood pressure at least 110 mmHg. Primary hypertension has no identifiable cause (about 90% of people). Secondary hypertension has a known underlying cause (about 10% of people). 'White coat' hypertension is BP that is unusually raised when measured during consultations with clinicians. Same-day admission should be arranged if a person has: Blood pressure higher than 180/110 mmHg with signs of papilloedema and/or retinal haemorrhage (accelerated hypertension). Suspected

2018 NICE Clinical Knowledge Summaries

117. Hypertension Evaluation Labs

degeneration , Hypertensive vascular disease , BP - High blood pressure , High blood pressure disorder , Systemic arterial hypertension , HBP - High blood pressure , BP+ - Hypertension , HT - Hypertension , Hypertensive disorder, systemic arterial (disorder) , Hypertensive disorder , HTN - Hypertension , blood pressure; high , high; arterial tension , high; blood pressure , Hypertension, NOS , Hypertensive disease, NOS , Raised blood pressure (disorder) , Blood Pressure, High , Blood Pressures, High , High (...) Hg systolic or 80 mm Hg diastolic in patients with diabetes or chronic kidney disease; Currently on pharmacological therapy for the treatment of hypertension. Definition (NCI) Blood pressure that is abnormally high. Definition (NCI_CTCAE) A disorder characterized by a pathological increase in blood pressure; a repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg. Definition (NCI_NCI-GLOSS) A blood pressure of 140/90 or higher. High blood pressure usually has no symptoms. It can

2018 FP Notebook

118. Hypertension Evaluation Exam

pressure , Hyperpiesia , Hyperpiesis , Hypertensive vascular degeneration , Hypertensive vascular disease , BP - High blood pressure , High blood pressure disorder , Systemic arterial hypertension , HBP - High blood pressure , BP+ - Hypertension , HT - Hypertension , Hypertensive disorder, systemic arterial (disorder) , Hypertensive disorder , HTN - Hypertension , blood pressure; high , high; arterial tension , high; blood pressure , Hypertension, NOS , Hypertensive disease, NOS , Raised blood pressure (...) without diabetes or chronic kidney disease, or blood pressure greater than 130 mm Hg systolic or 80 mm Hg diastolic in patients with diabetes or chronic kidney disease; Currently on pharmacological therapy for the treatment of hypertension. Definition (NCI) Blood pressure that is abnormally high. Definition (NCI_CTCAE) A disorder characterized by a pathological increase in blood pressure; a repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg. Definition (NCI_NCI-GLOSS) A blood

2018 FP Notebook

119. Hypertension Evaluation

) , (Hypertensive disease) or (hypertension) (disorder) , [X]Hypertensive diseases (disorder) , hypertension , BLOOD PRESSURE, INCREASED , BLOOD PRESSURE, HIGH , Hypertensive Disorder , HIGH BLOOD PRESSURE , INCREASED BLOOD PRESSURE , HYPERTENSION , PRESSURE, HIGH BLOOD , High blood pressure , Hyperpiesia , Hyperpiesis , Hypertensive vascular degeneration , Hypertensive vascular disease , BP - High blood pressure , High blood pressure disorder , Systemic arterial hypertension , HBP - High blood pressure , BP (...) + - Hypertension , HT - Hypertension , Hypertensive disorder, systemic arterial (disorder) , Hypertensive disorder , HTN - Hypertension , blood pressure; high , high; arterial tension , high; blood pressure , Hypertension, NOS , Hypertensive disease, NOS , Raised blood pressure (disorder) , Blood Pressure, High , Blood Pressures, High , High Blood Pressures , Vascular Hypertensive Disorder , Hypertensive disease , HYPERTENSIVE DISEASE French HYPERTENSION ARTERIELLE , Pression artérielle élevée , PAH

2018 FP Notebook

120. Hypertensive disorders of pregnancy

to, *:First line drugs, ^: Not on QH List of approved medicines (LAM), ": Second line drugsQueensland Clinical Guideline: Hypertensive disorders of pregnancy Refer to online version, destroy printed copies after use Page 5 of 32 Abbreviations ACE Angiotensin Converting Enzyme AFI Amniotic fluid index APLS Antiphospholipid syndrome BMI Body Mass Index BP Blood pressure CI Confidence Interval CMACE Centre for Maternal and Child Enquiries CTG Cardiotocograph dBP Diastolic blood pressure DIC Disseminated (...) intravascular coagulation DVP Deepest vertical pocket FBC Full blood count FHR Fetal heart rate GA General anaesthesia HDP Hypertensive disorders of pregnancy GP General Practitioner HELLP Haemolysis, Elevated Liver enzymes and Low Platelet count IUGR/FGR Intrauterine growth restriction/Fetal growth restriction LAM List of approved medicines LDH Lactate dehydrogenase LFT Liver function test sBP Systolic blood pressure SLE Systemic lupus erythematosus RR Relative risk SpO 2 Saturation of peripheral oxygen

2016 Queensland Health

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