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Hypertension Causes

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81. Time in Therapeutic Range, as a Determinant of All‐Cause Mortality in Patients With Hypertension (PubMed)

Time in Therapeutic Range, as a Determinant of All‐Cause Mortality in Patients With Hypertension Accumulating evidence indicates that reducing systolic blood pressure (BP) to <140 mm Hg improves health outcomes; however, an optimal level has not yet been determined. Many population studies or post hoc analyses suggest a target systolic BP between 120 and 140 mm Hg with increased risk above and below that range. We tested the hypothesis that consistent control of systolic BP between 120 (...) and 140 mm Hg-time in therapeutic range-is a strong determinant of all-cause mortality among US veterans.A total of 689 051 individuals from 15 Veterans Administration Medical Centers were followed over a 10-year period. Participants were classified as hypertensive, intermediate hypertensive, and normotensive according to the number of elevated BP recordings (>3, 1 or 2, and none, respectively). Time within, above, or below therapeutic range (120-140 mm Hg) was considered in quartiles and related

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2017 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

82. Pulmonary Hypertension Due to Left Ventricular Cardiomyopathy: Is it the Result or Cause of Disease Progression? (PubMed)

Pulmonary Hypertension Due to Left Ventricular Cardiomyopathy: Is it the Result or Cause of Disease Progression? The purpose of this review is to define pulmonary hypertension in the setting of left heart disease (PH-LHD), discuss its epidemiology and pathophysiology, and highlight the cause and effect relationship it has with disease progression in the setting of cardiomyopathy.Both pulmonary hypertension (PH) and heart failure are becoming increasingly common. As such, PH-LHD is now the most (...) common form of PH. The pathophysiology of the condition relates to backward transmission of elevated left ventricular filling pressures into the pulmonary circulation and, ultimately, right ventricular (RV) strain/dysfunction. It is evident that these pathophysiologic processes are both the effect and cause of left heart disease progression. In this review, we describe the complex relationship between disease progression in left ventricular cardiomyopathy and PH-LHD. Clinicians and researchers should

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2017 Current heart failure reports

83. The Safety and Efficiency of Sildenafil in the Treatment of Severe Post-capillary Pulmonary Hypertension Caused by COPD

The Safety and Efficiency of Sildenafil in the Treatment of Severe Post-capillary Pulmonary Hypertension Caused by COPD The Safety and Efficiency of Sildenafil in the Treatment of Severe Post-capillary Pulmonary Hypertension Caused by COPD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. The Safety and Efficiency of Sildenafil in the Treatment of Severe Post-capillary Pulmonary Hypertension Caused by COPD The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2017 Clinical Trials

84. Intra-Abdominal Hypertension Causes Bacterial Growth in Lungs: An Animal Study (PubMed)

Intra-Abdominal Hypertension Causes Bacterial Growth in Lungs: An Animal Study To study the effect of intra-abdominal hypertension (IAH) on the frequency of pneumonia with an experimental study, thirteen Sprague-Dawley rats were included. Eight out of thirteen animals were randomly assigned to receive 10 ml of benzalkonium chloride 0.2% (megacolon group) and five animals received 10 ml NaCl 0.9% (controls). Animals were anaesthetized by intramuscular delivery of ketamine. The incidence

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2017 BioMed research international

85. A Rare Cause of Portal Hypertension: Behcet’s Disease and Nodular Regenerative Hyperplasia of the Liver (PubMed)

A Rare Cause of Portal Hypertension: Behcet’s Disease and Nodular Regenerative Hyperplasia of the Liver Nodular regenerative hyperplasia (NRH) is a rare liver condition in which widespread benign transformation of the hepatic parenchyma into small regenerative nodules occur, leading to development of non-cirrhotic portal hypertension. Conditions associated with NRH include rheumatologic, hematological, autoimmune, infectious, neoplastic, or drug-related etiology. Accurate diagnosis is made

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2017 Cureus

86. A Rare Cause of Hemoperitoneum in a Patient with Cirrhosis and Portal Hypertension (PubMed)

A Rare Cause of Hemoperitoneum in a Patient with Cirrhosis and Portal Hypertension 28638590 2019 02 26 2008-5230 9 2 2017 Apr Middle East journal of digestive diseases Middle East J Dig Dis A Rare Cause of Hemoperitoneum in a Patient with Cirrhosis and Portal Hypertension. 118-119 10.15171/mejdd.2017.62 Philips Cyriac Abby CA Department of Hepatology and Transplant Medicine, PVS Institute of Digestive Diseases, PVS Memorial Hospital, Kochi, India. Kumar Lijesh L Department of Diagnostic

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2017 Middle East journal of digestive diseases

87. Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition (PubMed)

Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition Our understanding of the pathophysiological basis of chronic thromboembolic pulmonary hypertension (CTEPH) will be accelerated by an animal model that replicates the phenotype of human CTEPH. Sprague-Dawley rats were administered a combination of a single dose each of plastic microspheres and vascular endothelial growth factor receptor antagonist in polystyrene microspheres (PE (...) ) + tyrosine kinase inhibitor SU5416 (SU) group. Shams received volume-matched saline; PE and SU groups received only microspheres or SU5416, respectively. PE + SU rats exhibited sustained pulmonary hypertension (62 ± 13 and 53 ± 14 mmHg at 3 and 6 weeks, respectively) with reduction of the ventriculoarterial coupling in vivo coincident with a large decrement in peak rate of oxygen consumption during aerobic exercise, respectively. PE + SU produced right ventricular hypokinesis, dilation, and hypertrophy

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2017 The American journal of pathology

88. Oxidative stress causes hypertension and activation of nuclear factor-κB after high-fructose and salt treatments (PubMed)

Oxidative stress causes hypertension and activation of nuclear factor-κB after high-fructose and salt treatments There is evidence that diets rich in salt or simple sugars as fructose are associated with abnormalities in blood pressure regulation. However, the mechanisms underlying pathogenesis of salt- and fructose-induced kidney damage and/or consequent hypertension yet remain largely unexplored. Here, we tested the role of oxidative state as an essential factor along with high salt (...) and fructose treatment in causing hypertension. Fischer male rats were supplemented with a high-fructose diet (20% in water) for 20 weeks and maintained on high-salt diet (8%) associate in the last 10 weeks. Fructose-fed rats exhibited a salt-dependent hypertension accompanied by decrease in renal superoxide dismutase activity, which is the first footprint of antioxidant inactivation by reactive oxygen species (ROS). Metabolic changes and the hypertensive effect of the combined fructose-salt diet (20 weeks

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2017 Scientific reports

89. Post-transplantation nephroptosis causing recurrent episodes of acute renal failure and hypertension secondary to intermittent vascular torsion of intraperitoneal renal allograft (PubMed)

Post-transplantation nephroptosis causing recurrent episodes of acute renal failure and hypertension secondary to intermittent vascular torsion of intraperitoneal renal allograft Nephroptosis is a rare complication in renal transplantation, but one with significant associated risk. Due to non-specific clinical features, there may be a substantial delay in diagnosis and loss of the transplanted kidney due to renal pedicle thrombosis. We present a case of post-transplantation nephroptosis after (...) simultaneous pancreas and kidney transplant, which resulted in accelerated hypertension and reversible acute kidney injury >1 year after transplantation. Prompt detection of this rare entity leading to expeditious surgical intervention is necessary to preserve viability of the renal allograft.

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2017 Journal of surgical case reports

90. The Effects of Urinary Albumin and Hypertension on All-Cause and Cardiovascular Disease Mortality in Korea (PubMed)

The Effects of Urinary Albumin and Hypertension on All-Cause and Cardiovascular Disease Mortality in Korea Urinary albumin levels and hypertension (HTN) are independently associated with an increased risk of all-cause mortality. The effect of albuminuria on mortality in the absence or presence of HTN is uncertain. This study aimed to evaluate the effect of albuminuria and HTN on all-cause and cardiovascular disease (CVD) mortality.Mortality outcomes for 32,653 Koreans enrolled in a health (...) determinant of CVD and death. Urinary albumin might be more attributable to CVD and all-cause mortality than HTN.© The Author 2017. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd.

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2017 American journal of hypertension

91. Right ventricular ST-elevation myocardial infarction as a cause of death in idiopathic pulmonary arterial hypertension (PubMed)

Right ventricular ST-elevation myocardial infarction as a cause of death in idiopathic pulmonary arterial hypertension A 32-year-old woman with advanced idiopathic pulmonary arterial hypertension (PAH), treated with oral tadalafil and intravenous epoprostenol, presented with typical angina pectoris of one day's duration. Her electrocardiogram, previously typical of pulmonary hypertension, revealed an acute ST-elevation myocardial infarction in the anterior precordial leads. She had a prior

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2017 Pulmonary circulation

92. Large Isolated Major Aortopulmonary Collateral Artery Causing Severe Pulmonary Hypertension in an Infant: A Rare and Challenging Diagnosis (PubMed)

Large Isolated Major Aortopulmonary Collateral Artery Causing Severe Pulmonary Hypertension in an Infant: A Rare and Challenging Diagnosis Major Aortopulmonary Collateral Artery (MAPCA) as an isolated congenital anomaly, without evidence of any structural heart disease, is a very rare observation. Previously published reports indicate that symptomatic infants with large isolated MAPCA usually present with congestive heart failure or recurrent respiratory tract infections. To the best of our (...) knowledge, the present case of an infant with large isolated MAPCA is a unique case with a diagnostic dilemma due to presentation with severe pulmonary hypertension as a predominant sign. The infant was managed successfully by percutaneous obliteration with amplatzer vascular plugs, along with perioperative and postoperative sildenafil.

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2017 Journal of clinical and diagnostic research : JCDR

93. Primary aldosteronism: a common cause of resistant hypertension (PubMed)

Primary aldosteronism: a common cause of resistant hypertension 28584041 2017 10 30 2018 11 13 1488-2329 189 22 2017 06 05 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Primary aldosteronism: a common cause of resistant hypertension. E773-E778 10.1503/cmaj.161486 Kline Gregory A GA Department of Endocrinology (Kline, Leung), University of Calgary, Calgary, Alta.; Department of Internal Medicine, Endocrinology and Metabolism (Prebtani), McMaster (...) , Endocrinology and Metabolism (Prebtani), McMaster University, Hamilton, Ont.; Department of Medicine (Schiffrin), Jewish General Hospital and Lady Davis Research Institute, McGill University, Montréal, Que. eng Journal Article Review Canada CMAJ 9711805 0820-3946 4964P6T9RB Aldosterone EC 3.4.23.15 Renin AIM IM Aldosterone blood Humans Hyperaldosteronism complications diagnosis therapy Hypertension blood etiology Renin blood Competing interests: Ally Prebtani has received consultant and speaker fees from

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2017 CMAJ : Canadian Medical Association Journal

94. TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension (PubMed)

TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover, TGF-β blockade can prevent experimental pulmonary hypertension (PH) in pre-clinical models. TGF-β is regulated at the level

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2017 Nature communications

95. Induced vomiting for attention seeking and secondary gain: An unusual cause of pseudo-resistant hypertension (PubMed)

Induced vomiting for attention seeking and secondary gain: An unusual cause of pseudo-resistant hypertension In patients with complex psychosocial history presenting with resistant hypertension, observed therapy should be implemented early on to avoid unnecessary investigations and delayed diagnosis.

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2017 JRSM open

96. Hypertension Caused by Lenvatinib and Everolimus in the Treatment of Metastatic Renal Cell Carcinoma (PubMed)

Hypertension Caused by Lenvatinib and Everolimus in the Treatment of Metastatic Renal Cell Carcinoma Multikinase inhibitors (MKI) and mammalian target of rapamycin (mTOR) inhibitors prolong progression-free (PFS) and overall survival (OS) in the treatment of metastatic renal cell carcinoma (mRCC) by reducing angiogenesis and tumor growth. In this regard, the MKI lenvatinib and the mTOR inhibitor everolimus proved effective when applied alone, but more effective when they were administered (...) combined. Recently, both drugs were included in clinical trials, resulting in international clinical guidelines for the treatment of mRCC. In May 2016, lenvatinib was approved by the American Food and Drug Administration (FDA) for the use in combination with everolimus, as treatment of advanced renal cell carcinoma following one prior antiangiogenic therapy. A major problem of treating mRCC with lenvatinib and everolimus is the serious adverse event (AE) of arterial hypertension. During the treatment

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2017 International journal of molecular sciences

97. Liquorice: a root cause of secondary hypertension (PubMed)

Liquorice: a root cause of secondary hypertension We describe a patient presenting with hypertension and hypokalaemia who was ultimately diagnosed with liquorice- induced pseudohyperaldosteronism. This rare cause of secondary hypertension illustrates the importance of a methodical approach to the assessment of hypertension.

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2017 JRSM open

98. Causes of peripheral cytopenia in hepatitic cirrhosis and portal hypertensive splenomegaly (PubMed)

Causes of peripheral cytopenia in hepatitic cirrhosis and portal hypertensive splenomegaly The clinical data of 183 patients with hepatitic cirrhosis and portal hypertensive splenomegaly complicated by peripheral cytopenia were retrospectively analyzed to investigate the causes of peripheral cytopenia, as well as the proportion of the causes in these patients. All patients underwent splenectomy. Before operation, these patients had one or more types of peripheral cytopenia (cumulative cytopenia (...) to a combination of factors, and in 3.6% [14/390] it had nothing to do with the hypersplenism. Thus, hypersplenism is a major cause, but not the only cause, of peripheral cytopenia in patients with hepatic cirrhosis and portal hypertensive splenomegaly, and splenectormy is an effective treatment for these patients. Impact statement For a long time, the development of peripheral cytopenias as a complication to cirrhotic portal hypertension has been attributed to hypersplenism; however, this has never been fully

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2017 Experimental Biology and Medicine

99. Revascularization in a 17-Year-Old Girl with Neurofibromatosis and Severe Hypertension Caused by Renal Artery Stenosis (PubMed)

Revascularization in a 17-Year-Old Girl with Neurofibromatosis and Severe Hypertension Caused by Renal Artery Stenosis Renal artery stenosis caused by neurofibromatosis is a rare cause of renovascular hypertension. This hypertension can develop during childhood and is one of the leading causes of poor outcome. We report the case of a 17-year-old girl who was incidentally diagnosed with severe hypertension. During her examination for secondary hypertension, we reached a diagnosis (...) evaluation. We think that percutaneous transluminal renal angioplasty can be effective in select patients who have neurofibromatosis type 1 and refractory hypertension caused by renal artery stenosis.

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2017 Texas Heart Institute Journal

100. Drug-induced causes of secondary hypertension (PubMed)

Drug-induced causes of secondary hypertension 28936443 2018 11 13 2305-5839 5 17 2017 Sep Annals of translational medicine Ann Transl Med Drug-induced causes of secondary hypertension. 349 10.21037/atm.2017.06.16 Aronow Wilbert S WS Department of Medicine, Division of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY, USA. eng Editorial China Ann Transl Med 101617978 2305-5839 Conflicts of Interest: The author has no conflicts of interest to declare. 2017 9 23 6 (...) 0 2017 9 25 6 0 2017 9 25 6 1 ppublish 28936443 10.21037/atm.2017.06.16 atm-05-17-349 PMC5599270 J Child Psychol Psychiatry. 2013 Mar;54(3):227-46 23294014 Hypertension. 2000 Sep;36(3):461-5 10988282 Hypertension. 2011 Nov;58(5):811-7 21968750 Hypertension. 2008 Jun;51(6):1403-19 18391085 Chin Med J (Engl). 2014;127(12):2376-81 24931259 JAMA. 1994 Sep 14;272(10):781-6 8078142 Int Urol Nephrol. 2013 Jun;45(3):885-92 23065431 Am J Clin Nutr. 2011 Oct;94(4):1113-26 21880846 J Am Coll Cardiol. 2011

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2017 Annals of Translational Medicine

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