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Hypertension Causes

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81. Objective short sleep duration modifies the relationship between hypertension and all-cause mortality. (PubMed)

Objective short sleep duration modifies the relationship between hypertension and all-cause mortality. Short sleep duration has been associated with cardiovascular morbidity and mortality. However, previous studies were limited by using subjective sleep measures and treating sleep duration as a sole, independent predictor. Therefore, the role of sleep duration in predicting mortality is still not well understood. We posit that objective sleep duration is an effect modifier of the relationship (...) between hypertension and all-cause mortality.We addressed this question in the Penn State Adult Cohort, a random, general population sample of 1741 men and women (48.7 ± 13.5 years) who were studied in the sleep laboratory and followed up for 15.5 ± 4.1 years. Hypertension was defined on the basis of SBP and DBP (≥140/≥90 mmHg) or use of antihypertensive medication. Polysomnographic sleep duration was classified into three clinically meaningful categories.We tested the interaction between hypertension

2017 Journal of Hypertension

82. Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism. (PubMed)

Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism. Previous studies support an association between elevated total homocysteine (tHcy) levels and increased all-cause mortality. However, few prospective studies have examined this association in hypertensive patients, and/or tested any effect modification by the methylene tetrahydrofolate reductase (MTHFR) C677T genotype.This was a post hoc (...) , adjusting for age, sex, baseline folate, vitamin B12, blood pressure, body mass index, smoking and alcohol drinking status, study center, total cholesterol, triglycerides, high-density lipoprotein cholesterol, fasting glucose, creatinine, and treatment group. Potential effect modification by the MTHFR genotype on the relationship between tHcy and all-cause mortality was tested.The analyses included 20,424 hypertensive patients (41% males) without a history of myocardial infarction or stroke. Baseline

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2017 Medicine

83. Transcranial Doppler Ultrasound Examination in Dogs with Suspected Intracranial Hypertension Caused by Neurologic Diseases (PubMed)

Transcranial Doppler Ultrasound Examination in Dogs with Suspected Intracranial Hypertension Caused by Neurologic Diseases Transcranial Doppler ultrasound examination (TCD) is a rapid, noninvasive technique used to evaluate cerebral blood flow and is useful for the detection of intracranial hypertension in humans. However, the clinical usefulness of TCD in diagnosing intracranial hypertension has not been demonstrated for intracranial diseases in dogs.To determine the association between (...) the TCD variables and intracranial hypertension in dogs with intracranial diseases.Fifty client-owned dogs with neurologic signs.Cross-sectional study. All dogs underwent TCD of the basilar artery under isoflurane anesthesia after magnetic resonance imaging (MRI). Dogs were classified into 3 groups based on MRI findings: no structural diseases (group I), structural disease without MRI evidence of intracranial hypertension (group II), and structural disease with MRI evidence of intracranial

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2017 Journal of Veterinary Internal Medicine

84. Misdiagnosis of a hidden cause of hypertension: a case report (PubMed)

Misdiagnosis of a hidden cause of hypertension: a case report 29192119 2019 02 28 2019 02 28 1478-5242 67 665 2017 12 The British journal of general practice : the journal of the Royal College of General Practitioners Br J Gen Pract Misdiagnosis of a hidden cause of hypertension: a case report. 578-579 10.3399/bjgp17X693869 de Lima Andrés A Universidad de los Andes, School of Medicine, Bogotá, Colombia. El-Sharkawy Farah F Department of Surgical Oncology, The Institute for Cancer Care at Mercy (...) complications diagnosis Adrenalectomy Adult Aldosterone metabolism Diagnostic Errors Female Humans Hypertension etiology Hypokalemia Middle Aged Thyroid Diseases complications diagnosis Treatment Outcome 2017 03 27 2017 05 29 2017 12 2 6 0 2017 12 2 6 0 2019 3 1 6 0 ppublish 29192119 67/665/578 10.3399/bjgp17X693869 PMC5697549 J Clin Endocrinol Metab. 2004 Mar;89(3):1045-50 15001583 World J Biol Psychiatry. 2014 Jan;15(1):26-35 22568586 Hypertens Res. 2011 Jan;34(1):98-102 20927116 Surgery. 2014 Dec;156(6

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2017 The British Journal of General Practice

85. Impact Of Hypertension versus Diabetes on Cardiovascular and All-cause Mortality in Iranian Older Adults: Results of 14 Years of Follow-up (PubMed)

Impact Of Hypertension versus Diabetes on Cardiovascular and All-cause Mortality in Iranian Older Adults: Results of 14 Years of Follow-up To evaluate the joint effect of hypertension (HTN) and diabetes (DM) on coronary heart disease (CHD), and stroke event, all-cause, and cardiovascular disease (CVD) mortality in Middle Eastern older adults, 2747 people (1436 women) aged ≥ 50 years, free of CVD at baseline, were categorized into four groups (HTN-/DM-, HTN+/DM-, HTN-/DM+, HTN+/DM (...) +). Multivariate Cox proportional hazard models were run for different outcomes. To compare the impact of HTN versus DM, HTN+/DM- was considered as reference. In a median of 13.9 years, incidence rate of CHD, and stroke event, all-cause and CVD mortality in total population were 19.0, 4.7, 13.5, and 6.4 per 1000 person-years, respectively. The multivariate sex-adjusted hazard ratios (HRs) of HTN-/DM+ for CHD, stroke, all-cause mortality and CVD mortality were 1.19 (confidence interval (CI): 0.9-1.57), 1.07 (CI

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2017 Scientific reports

86. Mid-aortic Syndrome: A Rare Cause of Juvenile Hypertension (PubMed)

Mid-aortic Syndrome: A Rare Cause of Juvenile Hypertension 29093417 2018 11 13 1349-7235 57 3 2018 02 01 Internal medicine (Tokyo, Japan) Intern. Med. Mid-aortic Syndrome: A Rare Cause of Juvenile Hypertension. 447 10.2169/internalmedicine.9337-17 Kadoya Yoshito Y Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan. Zen Kan K Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural (...) University of Medicine, Japan. Saburi Makoto M Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan. Matoba Satoaki S Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan. eng Journal Article 2017 11 01 Japan Intern Med 9204241 0918-2918 hypertension mid-aortic syndrome 2017 11 3 6 0 2017 11 3 6 1 2017 11 3 6 0 ppublish 29093417 10.2169/internalmedicine.9337-17

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2017 Internal Medicine

87. Aortic Thrombus Causing a Hypertensive Emergency (PubMed)

Aortic Thrombus Causing a Hypertensive Emergency Thoracic aorta thrombi are a rare condition typically presenting as a source for distal embolization in elderly patients with atherosclerotic risk factors. However, young patients with a variety of presentations resulting from such thrombi have rarely been reported. We describe a case of a young patient with refractory hypertensive emergency caused by a large thoracic aorta thrombus. Investigation was guided by abnormal physical exam findings.

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2017 Clinical Practice and Cases in Emergency Medicine

88. Time in Therapeutic Range, as a Determinant of All‐Cause Mortality in Patients With Hypertension (PubMed)

Time in Therapeutic Range, as a Determinant of All‐Cause Mortality in Patients With Hypertension Accumulating evidence indicates that reducing systolic blood pressure (BP) to <140 mm Hg improves health outcomes; however, an optimal level has not yet been determined. Many population studies or post hoc analyses suggest a target systolic BP between 120 and 140 mm Hg with increased risk above and below that range. We tested the hypothesis that consistent control of systolic BP between 120 (...) and 140 mm Hg-time in therapeutic range-is a strong determinant of all-cause mortality among US veterans.A total of 689 051 individuals from 15 Veterans Administration Medical Centers were followed over a 10-year period. Participants were classified as hypertensive, intermediate hypertensive, and normotensive according to the number of elevated BP recordings (>3, 1 or 2, and none, respectively). Time within, above, or below therapeutic range (120-140 mm Hg) was considered in quartiles and related

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2017 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

89. Pulmonary Hypertension Due to Left Ventricular Cardiomyopathy: Is it the Result or Cause of Disease Progression? (PubMed)

Pulmonary Hypertension Due to Left Ventricular Cardiomyopathy: Is it the Result or Cause of Disease Progression? The purpose of this review is to define pulmonary hypertension in the setting of left heart disease (PH-LHD), discuss its epidemiology and pathophysiology, and highlight the cause and effect relationship it has with disease progression in the setting of cardiomyopathy.Both pulmonary hypertension (PH) and heart failure are becoming increasingly common. As such, PH-LHD is now the most (...) common form of PH. The pathophysiology of the condition relates to backward transmission of elevated left ventricular filling pressures into the pulmonary circulation and, ultimately, right ventricular (RV) strain/dysfunction. It is evident that these pathophysiologic processes are both the effect and cause of left heart disease progression. In this review, we describe the complex relationship between disease progression in left ventricular cardiomyopathy and PH-LHD. Clinicians and researchers should

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2017 Current heart failure reports

90. The Safety and Efficiency of Sildenafil in the Treatment of Severe Post-capillary Pulmonary Hypertension Caused by COPD

The Safety and Efficiency of Sildenafil in the Treatment of Severe Post-capillary Pulmonary Hypertension Caused by COPD The Safety and Efficiency of Sildenafil in the Treatment of Severe Post-capillary Pulmonary Hypertension Caused by COPD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. The Safety and Efficiency of Sildenafil in the Treatment of Severe Post-capillary Pulmonary Hypertension Caused by COPD The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2017 Clinical Trials

91. Intra-Abdominal Hypertension Causes Bacterial Growth in Lungs: An Animal Study (PubMed)

Intra-Abdominal Hypertension Causes Bacterial Growth in Lungs: An Animal Study To study the effect of intra-abdominal hypertension (IAH) on the frequency of pneumonia with an experimental study, thirteen Sprague-Dawley rats were included. Eight out of thirteen animals were randomly assigned to receive 10 ml of benzalkonium chloride 0.2% (megacolon group) and five animals received 10 ml NaCl 0.9% (controls). Animals were anaesthetized by intramuscular delivery of ketamine. The incidence

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2017 BioMed research international

92. A Rare Cause of Portal Hypertension: Behcet’s Disease and Nodular Regenerative Hyperplasia of the Liver (PubMed)

A Rare Cause of Portal Hypertension: Behcet’s Disease and Nodular Regenerative Hyperplasia of the Liver Nodular regenerative hyperplasia (NRH) is a rare liver condition in which widespread benign transformation of the hepatic parenchyma into small regenerative nodules occur, leading to development of non-cirrhotic portal hypertension. Conditions associated with NRH include rheumatologic, hematological, autoimmune, infectious, neoplastic, or drug-related etiology. Accurate diagnosis is made

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2017 Cureus

93. A Rare Cause of Hemoperitoneum in a Patient with Cirrhosis and Portal Hypertension (PubMed)

A Rare Cause of Hemoperitoneum in a Patient with Cirrhosis and Portal Hypertension 28638590 2019 02 26 2008-5230 9 2 2017 Apr Middle East journal of digestive diseases Middle East J Dig Dis A Rare Cause of Hemoperitoneum in a Patient with Cirrhosis and Portal Hypertension. 118-119 10.15171/mejdd.2017.62 Philips Cyriac Abby CA Department of Hepatology and Transplant Medicine, PVS Institute of Digestive Diseases, PVS Memorial Hospital, Kochi, India. Kumar Lijesh L Department of Diagnostic

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2017 Middle East journal of digestive diseases

94. Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition (PubMed)

Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition Our understanding of the pathophysiological basis of chronic thromboembolic pulmonary hypertension (CTEPH) will be accelerated by an animal model that replicates the phenotype of human CTEPH. Sprague-Dawley rats were administered a combination of a single dose each of plastic microspheres and vascular endothelial growth factor receptor antagonist in polystyrene microspheres (PE (...) ) + tyrosine kinase inhibitor SU5416 (SU) group. Shams received volume-matched saline; PE and SU groups received only microspheres or SU5416, respectively. PE + SU rats exhibited sustained pulmonary hypertension (62 ± 13 and 53 ± 14 mmHg at 3 and 6 weeks, respectively) with reduction of the ventriculoarterial coupling in vivo coincident with a large decrement in peak rate of oxygen consumption during aerobic exercise, respectively. PE + SU produced right ventricular hypokinesis, dilation, and hypertrophy

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2017 The American journal of pathology

95. Oxidative stress causes hypertension and activation of nuclear factor-κB after high-fructose and salt treatments (PubMed)

Oxidative stress causes hypertension and activation of nuclear factor-κB after high-fructose and salt treatments There is evidence that diets rich in salt or simple sugars as fructose are associated with abnormalities in blood pressure regulation. However, the mechanisms underlying pathogenesis of salt- and fructose-induced kidney damage and/or consequent hypertension yet remain largely unexplored. Here, we tested the role of oxidative state as an essential factor along with high salt (...) and fructose treatment in causing hypertension. Fischer male rats were supplemented with a high-fructose diet (20% in water) for 20 weeks and maintained on high-salt diet (8%) associate in the last 10 weeks. Fructose-fed rats exhibited a salt-dependent hypertension accompanied by decrease in renal superoxide dismutase activity, which is the first footprint of antioxidant inactivation by reactive oxygen species (ROS). Metabolic changes and the hypertensive effect of the combined fructose-salt diet (20 weeks

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2017 Scientific reports

96. Post-transplantation nephroptosis causing recurrent episodes of acute renal failure and hypertension secondary to intermittent vascular torsion of intraperitoneal renal allograft (PubMed)

Post-transplantation nephroptosis causing recurrent episodes of acute renal failure and hypertension secondary to intermittent vascular torsion of intraperitoneal renal allograft Nephroptosis is a rare complication in renal transplantation, but one with significant associated risk. Due to non-specific clinical features, there may be a substantial delay in diagnosis and loss of the transplanted kidney due to renal pedicle thrombosis. We present a case of post-transplantation nephroptosis after (...) simultaneous pancreas and kidney transplant, which resulted in accelerated hypertension and reversible acute kidney injury >1 year after transplantation. Prompt detection of this rare entity leading to expeditious surgical intervention is necessary to preserve viability of the renal allograft.

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2017 Journal of surgical case reports

97. The Effects of Urinary Albumin and Hypertension on All-Cause and Cardiovascular Disease Mortality in Korea (PubMed)

The Effects of Urinary Albumin and Hypertension on All-Cause and Cardiovascular Disease Mortality in Korea Urinary albumin levels and hypertension (HTN) are independently associated with an increased risk of all-cause mortality. The effect of albuminuria on mortality in the absence or presence of HTN is uncertain. This study aimed to evaluate the effect of albuminuria and HTN on all-cause and cardiovascular disease (CVD) mortality.Mortality outcomes for 32,653 Koreans enrolled in a health (...) determinant of CVD and death. Urinary albumin might be more attributable to CVD and all-cause mortality than HTN.© The Author 2017. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd.

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2017 American journal of hypertension

98. Right ventricular ST-elevation myocardial infarction as a cause of death in idiopathic pulmonary arterial hypertension (PubMed)

Right ventricular ST-elevation myocardial infarction as a cause of death in idiopathic pulmonary arterial hypertension A 32-year-old woman with advanced idiopathic pulmonary arterial hypertension (PAH), treated with oral tadalafil and intravenous epoprostenol, presented with typical angina pectoris of one day's duration. Her electrocardiogram, previously typical of pulmonary hypertension, revealed an acute ST-elevation myocardial infarction in the anterior precordial leads. She had a prior

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2017 Pulmonary circulation

99. Large Isolated Major Aortopulmonary Collateral Artery Causing Severe Pulmonary Hypertension in an Infant: A Rare and Challenging Diagnosis (PubMed)

Large Isolated Major Aortopulmonary Collateral Artery Causing Severe Pulmonary Hypertension in an Infant: A Rare and Challenging Diagnosis Major Aortopulmonary Collateral Artery (MAPCA) as an isolated congenital anomaly, without evidence of any structural heart disease, is a very rare observation. Previously published reports indicate that symptomatic infants with large isolated MAPCA usually present with congestive heart failure or recurrent respiratory tract infections. To the best of our (...) knowledge, the present case of an infant with large isolated MAPCA is a unique case with a diagnostic dilemma due to presentation with severe pulmonary hypertension as a predominant sign. The infant was managed successfully by percutaneous obliteration with amplatzer vascular plugs, along with perioperative and postoperative sildenafil.

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2017 Journal of clinical and diagnostic research : JCDR

100. Primary aldosteronism: a common cause of resistant hypertension (PubMed)

Primary aldosteronism: a common cause of resistant hypertension 28584041 2017 10 30 2018 11 13 1488-2329 189 22 2017 06 05 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Primary aldosteronism: a common cause of resistant hypertension. E773-E778 10.1503/cmaj.161486 Kline Gregory A GA Department of Endocrinology (Kline, Leung), University of Calgary, Calgary, Alta.; Department of Internal Medicine, Endocrinology and Metabolism (Prebtani), McMaster (...) , Endocrinology and Metabolism (Prebtani), McMaster University, Hamilton, Ont.; Department of Medicine (Schiffrin), Jewish General Hospital and Lady Davis Research Institute, McGill University, Montréal, Que. eng Journal Article Review Canada CMAJ 9711805 0820-3946 4964P6T9RB Aldosterone EC 3.4.23.15 Renin AIM IM Aldosterone blood Humans Hyperaldosteronism complications diagnosis therapy Hypertension blood etiology Renin blood Competing interests: Ally Prebtani has received consultant and speaker fees from

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2017 CMAJ : Canadian Medical Association Journal

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