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Hypertension Causes

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21. Hypertension Canada's 2016 Canadian Hypertension Education Program guidelines for pharmacists: an update

, conducted in different settings, consistently reported that elevated nonfasting lipid panels were predictive of cardiovascular events, mor - tality and all-cause mortality. 38,39,42 Nonfasting lipid panel testing can also help alleviate the burden placed on laboratories with morning testing, reduce hypoglycemia in those with diabetes and improve patient adher - ence. 44-46 It can thus provide a practical option for individuals with hypertension. Health behaviour management Increasing dietary potassium (...) Hypertension Canada's 2016 Canadian Hypertension Education Program guidelines for pharmacists: an update CPJ/RPC • november / december 2016 • VOL 149, NO 6 337 © The Author(s) 2016 DOI: 10.1177/1715163516671747 Practice guidelines Peer-reviewed Practice guidelines * Peer-reviewed 671747 CPHXXX10.1177/1715163516671747C P J / R P CC P J / R P C research-article2016 Hypertension Canada’s 2016 Canadian Hypertension Education Program guidelines for pharmacists: An update Yazid N. Al Hamarneh, BSc

2016 CPG Infobase

22. Hypertension in pregnancy: diagnosis and management

oedema other signs of severe pre-eclampsia suspected fetal compromise Hypertension in pregnancy: diagnosis and management (NG133) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 17 of 54any other clinical signs that cause concern. [2019] [2019] 1.5.3 Consider using either the fullPIERS or PREP-S validated risk prediction models to help guide decisions about the most appropriate place of care (such as the need (...) Hypertension in pregnancy: diagnosis and management Hypertension in pregnancy: diagnosis Hypertension in pregnancy: diagnosis and management and management NICE guideline Published: 25 June 2019 www.nice.org.uk/guidance/ng133 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful consideration

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

23. Hypertension in adults: diagnosis and management

average or HBPM average of 135/85 mmHg or higher. [2019] [2019] 1.2.9 If hypertension is not diagnosed but there is evidence of target organ damage, consider carrying out investigations for alternative causes of the target organ damage (for information on investigations, see NICE's guidelines on chronic kidney disease in adults and chronic heart failure). [2011] [2011] 1.2.10 If hypertension is not diagnosed, measure the person's clinic blood pressure at least every 5 years subsequently, and consider (...) ] 1.2.12 Consider the need for specialist investigations in people with signs and symptoms suggesting a secondary cause of hypertension. [2004, amended [2004, amended 2011] 2011] T o find out why the committee made the 2019 recommendations on diagnosing hypertension and how they might affect practice, see rationale and impact. 1.3 Assessing cardiovascular risk and target organ damage For guidance on the early identification and management of chronic kidney disease, see NICE's guideline on chronic

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

24. Postoperative hemorrhage caused by portal hypertension associated with autoimmune pancreatitis: A case report. (PubMed)

Postoperative hemorrhage caused by portal hypertension associated with autoimmune pancreatitis: A case report. Autoimmune pancreatitis is a form of chronic pancreatitis, characterized by diffused enlargement of the pancreas and irregular narrowing of the main pancreatic duct. The theory that portal hypertension is associated with autoimmune pancreatitis has not been emphasized. In addition, only a few studies report that the gastrointestinal tract hemorrhage caused by portal hypertension (...) . After the surgery, the patient suffered twice from postoperative hemorrhage (9 and 16 mos).Postoperative hemorrhage, autoimmune pancreatitis.Electronic gastroscopy, exploratory laparotomy, and titanium clips were used simultaneously to stop the bleeding.The patient recovered well after the surgery.In this study, we present the case of repeated postoperative hemorrhage (9 and 16 mos). We discussed the correlation between postoperative hemorrhage and autoimmune pancreatitis, and the cause

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2018 Medicine

25. Dietary Approach to Stop Hypertension (DASH) diet and risk of renal function decline and all-cause mortality in renal transplant recipients. (PubMed)

Dietary Approach to Stop Hypertension (DASH) diet and risk of renal function decline and all-cause mortality in renal transplant recipients. Renal transplant recipients (RTR) are at risk of decline of graft function and premature mortality, with high blood pressure as an important risk factor for both. To study the association of the Dietary Approach to Stop Hypertension (DASH) diet with these adverse events, we conducted a prospective cohort study of adult RTR. Dietary data were collected (...) of the DASH score had lower risk of both renal function decline (hazard ratio [HR] = 0.57; 95% confidence interval [CI], 0.33-0.96, P = .03) and all-cause mortality (HR = 0.52; 95%CI, 0.32-0.83, P = .006) compared to the lowest tertile, independent of potential confounders. Adherence to a DASH-style diet is associated with lower risk of both renal function decline and all-cause mortality. These results suggest that a healthful diet might benefit long-term outcome in RTR.© 2018 The Authors. American

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2018 American Journal of Transplantation

26. Pulmonary Arterial Bypass Surgery for Fibrosing Mediastinitis Causing Severe Pulmonary Hypertension. (PubMed)

Pulmonary Arterial Bypass Surgery for Fibrosing Mediastinitis Causing Severe Pulmonary Hypertension. In this case report, we present a patient with mediastinal fibrosis. The mass lesion was expanding from the mediastinum to the cervical region and surrounding the major vascular structures. The patient has symptomatic dyspnea at rest and pulmonary hypertension due to stenosis of the bilateral main pulmonary arteries (PA). To decrease pulmonary artery pressure (PAP) and improve blood flow

2018 Annals of Thoracic Surgery

27. Neonatal hypertension: cases, causes, and clinical approach. (PubMed)

Neonatal hypertension: cases, causes, and clinical approach. Neonatal hypertension is increasingly recognized as dramatic improvements in neonatal intensive care, advancements in our understanding of neonatal physiology, and implementation of new therapies have led to improved survival of premature infants. A variety of factors appear to be important in determining blood pressure in neonates, including gestational age, birth weight, and postmenstrual age. Normative data on neonatal blood (...) pressure values remain limited. The cause of hypertension in an affected neonate is often identified with careful diagnostic evaluation, with the most common causes being umbilical catheter-associated thrombosis, renal parenchymal disease, and chronic lung disease. Clinical expertise may need to be relied upon to decide the best approach to treatment in such patients, as data on the use of antihypertensive medications in this age group are extremely limited. Available data suggest that long-term

2018 Pediatric Nephrology

28. Portal Hypertensive Vesiculopathy: A Rare Cause of Hematuria, and A Unique Management Strategy. (PubMed)

Portal Hypertensive Vesiculopathy: A Rare Cause of Hematuria, and A Unique Management Strategy. Portosystemic collaterals are common sequelae of portal hypertension. These often present as gastroesophageal varices. Ectopic varices can rarely be seen in duodenum, jejunum, rectum, and sites of surgical anastomoses. Bladder varices are extremely rare presenting with recurrent hematuria, with only a few reported cases. We report here a management of an unusual case of hematuria managed with blood

2018 Urology

29. Nonlinear dose-response association between body mass index and risk of all-cause and cardiovascular mortality in patients with hypertension: A meta-analysis.

Nonlinear dose-response association between body mass index and risk of all-cause and cardiovascular mortality in patients with hypertension: A meta-analysis. The present study examined the dose-response association of body mass index (BMI) and risk of all-cause and cardiovascular mortality in patients with existing hypertension.A systematic search was done using PubMed and Scopus, from their inception up to January 25, 2017. Prospective and retrospective cohort studies reporting risk estimates (...) of all-cause and cardiovascular mortality for three or more quantitative categories of BMI were included. Studies which reported results as continuous also were included. Pooled relative risks (RRs) were calculated using random effects models.Of initial 34,938 identified studies, 14 studies with a total of 489,222 hypertensive patients, involving 41,872 cases of all-cause mortality and 2,123 cases of cardiovascular mortality were included. A five-unit increment in BMI was associated with an 8

2018 Obesity research & clinical practice

30. Drug nonadherence is a common but often overlooked cause of hypertensive urgency and emergency at the emergency department. (PubMed)

Drug nonadherence is a common but often overlooked cause of hypertensive urgency and emergency at the emergency department. Over 70% of patients who visit the emergency department with a hypertensive emergency or a hypertensive urgency have previously been diagnosed with hypertension. Drug nonadherence is assumed to play an important role in development of hypertensive urgency and hypertensive emergency, but exact numbers are lacking. We aimed to retrospectively compare characteristics (...) of patients with hypertensive urgency and hypertensive emergency and to prospectively quantify the attribution of drug nonadherence.We retrospectively analysed clinical data including information on nonadherence obtained by treating physicians of patients with SBP at least 180 mmHg and DBP at least 110 mmHg visiting the emergency department between 2012 and 2015. We prospectively studied drug adherence among patients admitted to the emergency department with severely elevated BP by measuring plasma drug

2018 Journal of Hypertension

31. Long‐Term Exposure of Fine Particulate Matter Causes Hypertension by Impaired Renal D1 Receptor–Mediated Sodium Excretion via Upregulation of G‐Protein–Coupled Receptor Kinase Type 4 Expression in Sprague‐Dawley Rats (PubMed)

Long‐Term Exposure of Fine Particulate Matter Causes Hypertension by Impaired Renal D1 Receptor–Mediated Sodium Excretion via Upregulation of G‐Protein–Coupled Receptor Kinase Type 4 Expression in Sprague‐Dawley Rats Epidemiological evidence supports an important association between air pollution exposure and hypertension. However, the mechanisms are not clear.Our present study found that long-term exposure to fine particulate matter (PM2.5) causes hypertension and impairs renal (...) role in the pathogenesis of PM2.5-induced hypertension.© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

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2018 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

32. PULMONARY HYPERTENSION ARISING FROM LEFT HEART DISEASE CAUSES INTRAPULMONARY VENOUS ARTERIALIZATION IN RATS (PubMed)

PULMONARY HYPERTENSION ARISING FROM LEFT HEART DISEASE CAUSES INTRAPULMONARY VENOUS ARTERIALIZATION IN RATS 29245197 2018 11 13 1097-685X 155 1 2018 Jan The Journal of thoracic and cardiovascular surgery J. Thorac. Cardiovasc. Surg. Pulmonary hypertension arising from left heart disease causes intrapulmonary venous arterialization in rats. 281-282 S0022-5223(17)31789-0 10.1016/j.jtcvs.2017.08.028 Katz Michael G MG Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York

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2018 The Journal of thoracic and cardiovascular surgery

33. Takayasu arteritis a cause of hypertensive disorder of pregnancy: a case report (PubMed)

Takayasu arteritis a cause of hypertensive disorder of pregnancy: a case report Takayasu arteritis is a rare, chronic, granulomatous systemic vasculitis of unknown etiology and a few cases have been reported in pregnancy. In pregnancies concomitant with Takayasu arteritis or after diagnosis, Takayasu arteritis negatively affects pregnancy by increasing 13-fold the odds of complications such as hypertensive disorders. The best recommendations in this scenario are still to be made.We present (...) a case of 21-year-old, gravid 1, Mexican woman of Mestizo descent with chronic hypertension diagnosed since she was 15-years old who presented severe hypertension during pregnancy (early second trimester); the diagnosis of hypertensive disorder of pregnancy was ruled out requiring first-line and second-line antihypertensive therapy without serious associated maternal or fetal morbidity.Takayasu arteritis and pregnancy play an important role in maternal and fetal outcomes. Efforts should be made

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2018 Journal of medical case reports

34. Bilateral Obstructive Uropathy Caused by Congenital Bladder Diverticulum Presenting as Hypertensive Retinopathy (PubMed)

Bilateral Obstructive Uropathy Caused by Congenital Bladder Diverticulum Presenting as Hypertensive Retinopathy A congenital bladder diverticulum (CBD) is caused by inherent muscular weakness instead of obstruction of the bladder outlet. The major clinical conditions are recurrent urinary tract infection (UTI) and voiding dysfunction. This report describes a 15-year-old male adolescent who developed sudden visual disturbance resulting from hypertensive retinopathy. The cause of hypertension (...) was bilateral obstructive uropathy caused by enlarged paraureteral bladder diverticula. After the non-functioning right kidney and ureter and the bilateral diverticula were removed, the left ureter was reimplanted in the bladder. Pathologic findings showed chronic pyelonephritis and partial loss of the bladder musculature in the diverticular wall. This observation indicates that dilated CBD can cause latent UTI, ureteral obstruction, hydronephrosis, and secondary hypertension.© 2018 The Korean Academy

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2018 Journal of Korean medical science

35. Atrial Septal Defect as Unexpected Cause of Pulmonary Artery Hypertension (PubMed)

Atrial Septal Defect as Unexpected Cause of Pulmonary Artery Hypertension Methamphetamine abuse is an increasingly prevalent cause of pulmonary artery hypertension in the United States. Conversely, an atrial septal defect rarely presents late as pulmonary artery hypertension. We present the case of a 44-year-old methamphetamine abuser who had a 3-month history of worsening fatigue and near-syncope. She had elevated cardiac enzyme levels and right-sided heart strain. Angiographic findings (...) suggested methamphetamine-induced pulmonary artery hypertension; however, we later heard S2 irregularities that raised suspicion of an atrial septal defect. Ultimately, the diagnosis was pulmonary artery hypertension and a large secundum atrial septal defect with left-to-right flow. One year after defect closure, the patient was asymptomatic. In addition to discussing this unexpected case of a secundum atrial septal defect masquerading as methamphetamine-induced pulmonary artery hypertension, we briefly

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2018 Texas Heart Institute Journal

36. Does Masked Hypertension Cause Early Left Ventricular Impairment in Youth? (PubMed)

Does Masked Hypertension Cause Early Left Ventricular Impairment in Youth? Objectives: Masked hypertension (MH) is not uncommon in the youth and may increase risks of long-term cardiovascular impairment. However, little is known about the subclinical heart damage in this group of patients. Currently, 3-layer speckle tracking imaging based on two-dimensional echocardiography is feasible to detect the early signs of myocardial damage. We therefore aimed to investigate whether subtle changes

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2018 Frontiers in pediatrics

37. Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis (PubMed)

Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has (...) been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant. Therefore, we hypothesized that the hypertension seen in PCOS has early origins in gut dysbiosis caused by in utero exposure to excess androgen. We investigated this hypothesis with a model of prenatal androgen (PNA) exposure and maternal hyperandrogenemia by single-injection of testosterone cypionate or sesame oil vehicle (VEH) to pregnant dams in late gestation. We

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2018 Gut microbes

38. Torsion of a wandering spleen as a cause of portal hypertension and mesenteric varices: a rare aetiology (PubMed)

Torsion of a wandering spleen as a cause of portal hypertension and mesenteric varices: a rare aetiology A wandering spleen is a condition characterized by excessive splenic mobility due to the mal-development or the laxity of its ligaments that leads to migration from its normal anatomical location. This condition renders its long mobile vascular pedicle liable to torsion and occasional infarction. Herein, we report a case of a 27-year-old nulliparous woman who presented with acute abdominal (...) pain and a tender right-sided pelvi-abdominal mass. CT scan of the abdomen and pelvis revealed a torted, infarcted wandering spleen with portal hypertension and mesenteric varices that mandated an emergency splenectomy. Although there are a few reported cases describing the association of wandering spleen with portal hypertension and fundal varices, cases of mesenteric varices are extremely rare. To the best of our knowledge, this case is considered the third reported case of a wandering spleen

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2018 Journal of surgical case reports

39. Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III Linked Mortality Study (PubMed)

Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III Linked Mortality Study Clinical trials had provided evidence for the benefit effect of antihypertensive treatments in preventing future cardiovascular disease (CVD) events; however, the association between hypertension, whether treated/untreated or controlled/uncontrolled and risk of mortality in US population has been poorly understood. A total of 13,947 US adults aged ≥18 (...) years enrolled in the Third National Health and Nutrition Examination Survey (1988-1994) were used to conduct this study. Mortality outcome events included all-cause, CVD-specific, heart disease-specific and cerebrovascular disease-specific deaths, which were obtained from linked 2011 National Death Index (NDI) files. During a median follow-up of 19.1 years, there were 3,550 all-cause deaths, including 1,027 CVD deaths. Compared with normotensives, treated but uncontrolled hypertensive patients were

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2018 Scientific reports

40. Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats (PubMed)

Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats Plasma prorenin is commonly elevated in diabetic patients and appears to predict the development of diabetic nephropathy. However, the pathological role of prorenin is unclear. In the present study, a transgenic, inducible, hepatic prorenin-overexpressing rat model was generated and the effect of prorenin in organ injury was examined. Four groups of rats (cyp1a1 prorenin transgenic male (...) in mRNA contents of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), β-myosin heavy chain (β-MHC), TGFβ1, PAI-1, and collagen in the heart tissue. Furthermore, renal protein levels of p-NF-κB-p65 and monocyte chemoattractant protein-1 (MCP-1), NAPDH oxidases, malondialdehyde (MDA) and 8-isoprostane (8-IP), p-ERK, p-β-catenin, and p-Akt were dramatically increased in prorenin overexpressing rats. These results indicate that prorenin, without being converted into renin, causes

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2018 Clinical science (London, England : 1979)

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