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Hypertension Causes

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34861. Noninvasive Evaluation of Cardiac Allograft Vasculopathy

History of chronic kidney disease Active infection History of organ transplantation Diabetes Mellitus History of Hypertension Known coronary artery disease Connective tissue disorder History of hyperlipidemia History of Migraine or Chronic unevaluated headaches Patients with chronic kidney disease stage 4 defined as GFR<30 mL/min/1.73 m2 or acute renal failure Patients with acute rejection, Grade 3A or greater Active infection Re-transplant or Multi-organ transplant recipient Surgery within 3 months (...) , begins hours after brain death in a donor. VCAM-1, e-selectin, and p-selectin are expressed early after brain death in the donor and are elevated throughout transplantation in the recipient as a response to injury in the donor heart. P-selectin and VCAM remain elevated while e-selectin gradually decrease over three months. There is data suggesting that p-selectin and VCAM remain elevated up to 2 years after transplantation, suggesting persistent inflammation and immune activation after transplant

2011 Clinical Trials

34862. Safety and Pharmacokinetics of ASA404 When Given Together With Fluvoxamine, a Selective Serotonin Receptor Reuptake Inhibitor and CYP1A2 Inhibitor

clinical or electrocardiographic evidence of cadiac ischemia poorly controlled hypertension family history of unexplained sudden death long QT syndrome history of ventricular fibrillation or torsade de pointes congestive heart failure (NYHA class III or IV) myocardial infarction within 12 months of starting study treatment History of neuroendocrine tumors (e.g. carcinoid tumor, pancreatic islet cell tumor). Significant neurological or psychiatric disorder. Smokers (use of cigarettes within the last 3 (...) months). Concomitant use of drugs that are associated with QTc interval prolongation or have a risk of causing torsade de pointes. Concomitant use of serotonin reuptake inhibitors (SSRIs), 5-hydroxytryptamine (5-HT) receptor agonists or selective serotonin / nor-epinephrine reuptake inhibitors (SNRIs) within 30 days prior to starting study treatment. Concomitant use of somatostain analogues (i.e. octreotide, lanreotide within 30 days prior to starting study treatment. Other protocol-defined inclusion

2011 Clinical Trials

34863. A Study on the Effects of Soulera Herbal Blend Intake on Chronic Stress in Healthy Adults

: The subject has a history of hypersensitivity to any of the compounds used in the study The subject is pregnant or breast feeding. Note: If the potential subject is a post-menarche female, a urine pregnancy test must be performed within 24 hours prior to study drug administration and confirmed negative in order for the potential subject to eb enrolled. History of Psychiatric Illness or Chronic Stress or Anxiety Hypertension, cardiovascular disease, liver, hypokalemia, or kidney disease or other health (...) concerns that the study physician feels may confound study results Individuals who are cognitively impaired or who are not able to give informed consent Any routine prescription medication that the study physician feels may cause drug interaction with Soulera or alter the prescription medications' activity Previous participation in a clinical research trial within 30 days prior to randomization The subject has an ongoing abuse of illicit substances, alcohol, or actively smoking marijuana The subject

2011 Clinical Trials

34864. Bevacizumab and Lomustine for Recurrent GBM

crisis or hypertensive encephalopathy No inadequately controlled hypertension (defined as systolic blood pressure >150 mmHg and/or diastolic blood pressure >100 m Hg) Absence of any thrombotic or hemorrhagic event, including but not limited to: No evidence of recent hemorrhage on MRI of the brain. However, patients with clinically asymptomatic presence of hemosiderin depositions, resolving hemorrhagic changes related to surgery, and presence of punctate hemorrhage in the tumor are permitted entry (...) of the cervix Absence of any cardiovascular disorder, including but not limited to: No history of myocardial infarction, unstable angina within 6 months prior to randomization No "New York Heart Association" (NYHA) Grade II or greater congestive heart failure, or serious cardiac arrhythmia requiring medication. No significant vascular disease (e.g. aortic aneurysm requiring surgical repair or recent peripheral arterial thrombosis) within 6 months prior to randomization No prior history of hypertensive

2011 Clinical Trials

34865. Effect of Blueberries on Vascular Function in Healthy Men

by: University of Reading Study Details Study Description Go to Brief Summary: Scientific question to be addressed: To determine the effects of acute blueberry ingestion on vascular function and blood pressure in humans Hypothesis: Acute consumption of blueberry induces an improvement in blood pressure and vascular function through the impact of blueberry flavonoids on the vascular system. Study objectives: To determine the dose-dependency of a blueberry drink on blood pressure and vascular function (...) the endothelium and regulates vascular tone by promoting the expansion and contraction of the blood vessel. There are a variety of non-invasive techniques for measuring endothelial function. Research provides evidence that consumption of a diet high in plant foods and rich in polyphenols is associated with a reduction in incidence of coronary heart disease (CHD). Polyphenols, of which the flavonoids are the largest group, are thought to play a role in the reduction of incidence of chronic diseases

2011 Clinical Trials

34866. Vitamin D Supplementation in Chronic Stable Heart Failure

failure, as studied in a recent interventional trial. In animal models, vitamin D deficiency was proven to be associated with developing myocardial hypertrophy and fibrosis with aberrant cardiac contractility and relaxation. Moreover, vitamin D deficiency can raise parathyroid hormone secretion, which in turn may increase insulin resistance and be associated with the development of diabetes, hypertension and inflammation. In summary, vitamin D seems to exert a multitude of different effects all (...) of Graz Study Details Study Description Go to Brief Summary: In cross-sectional and prospective cohort studies, vitamin D deficiency is associated with increased mortality, cardiovascular events including sudden cardiac death and stroke, diabetes, hypertension and impaired function of the immune and musculoskeletal system. The action of vitamin D on the cardiovascular system regulates cardiac function, endothelial and vascular smooth muscle, and, the renin-angiotensin system. Treatment

2011 Clinical Trials

34867. Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion

, 2012 Sponsor: Yonsei University Information provided by (Responsible Party): Yonsei University Study Details Study Description Go to Brief Summary: Obstructive sleep apnea is a common disorder linked to serious long-term adverse health consequences; such as hypertension, metabolic dysfunction, cardiovascular disease. Retinal vascular occlusion is related to many systemic illnesses especially hypertension. Obstructive sleep apnea is also related to vascular endothelial dysfunction and vascular (...) endothelial growth factor elevation which causes vision threatening complications of retinal vascular occlusion. Therefore the relationship between obstructive sleep apnea and retinal vascular occlusion should be studied. Condition or disease Intervention/treatment Phase Retinal Vascular Occlusion Device: Watchpat 100 Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 30 participants Intervention Model: Single Group

2011 Clinical Trials

34868. Assessment of Central Pain in the Peripartum Period

of fibromyalgia etc/ Secondary Outcome Measures : Patient report of pain intensity during delivery [ Time Frame: up to 3 days after delivery ] Information will be collected regarding pain levels during delivery, regarding hemodynamic changes during delivery, regarding the mode of delivery as well as standard neonatal data (APGAR score etc) Blood pressure and pulse recordings [ Time Frame: During labor ] Standard clinical recording of hemodynamic measurments during labor Mode of delivery [ Time Frame: During (...) pain conditions not characterized as central (e.g. malignancy - associated pain). Thus, opioids and Non Steroidal Anti-Inflammatory Drugs (NSAIDS) are relatively ineffective for the treatment of central pain (the former may even cause paradoxical hyperalgesia) (5) while medications which increase levels of norepinephrine and serotonin (NSRIs) are often effective. FMS is also characterized by disturbances of the autonomic nervous system such as orthostatic intolerance, postural tachycardia etc.(6

2011 Clinical Trials

34869. Nebivolol Versus Sustained Release Metoprolol Succinate in Patients With Chronic Kidney Disease

in menopause at least 2 years, had tubal ligation at least 1 year prior to screening or who have had a total hysterectomy Exclusion Criteria: Use of a BB in the 3 months prior to study enrollment, other than atenolol or metoprolol Uncontrolled hypertension with a blood pressure > 160/100 mm Hg or those with changes to their antihypertensive regime during the last 2 months Concurrent disease or conditions that would interfere with study participation or safety, such as bleeding disorders, history of syncope (...) protection in this high risk population. The objective of this proposal is to conduct a randomized pilot clinical trial to determine the relative efficacy and tolerability of nebivolol versus sustained release metoprolol succinate in improving blood pressure in patients with CKD and albuminuria. The primary endpoint would be a decrease in asymmetric dimethyl arginine (ADMA). Secondary endpoints would include a reduction in blood pressure, urinary F2-isoprostanes and albuminuria. Condition or disease

2011 Clinical Trials

34870. Randomized Controlled Trial of Vaginal Progesterone in Women With Threatened Preterm Labor

: January 31, 2011 Last Update Posted : January 8, 2015 Sponsor: University of Calgary Information provided by (Responsible Party): Dr. Sue Ross, University of Calgary Study Details Study Description Go to Brief Summary: Prematurity remains the most important single factor in perinatal morbidity and mortality. Unfortunately, the rate of premature delivery is increasing in Canada and is especially high in Alberta with 7.5% of pregnancies ending before 37 weeks gestation. Despite years of research (...) into the causes of spontaneous preterm labor, few effective treatments have been identified. Progesterone is one candidate treatment. The purpose of this study is to investigate whether progesterone can prolong pregnancy in women who have symptoms of preterm labor. Pregnant women who have symptoms of premature labor will be invited to take part in the study if they are between 22 to 24 weeks pregnant. If they agree to join the study, they will be randomly allocated to either take progesterone 200mg each day

2011 Clinical Trials

34871. Intravenous Norepinephrine for Orthostatic Hypotension

by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Institute of Neurological Disorders and Stroke (NINDS) ) Study Details Study Description Go to Brief Summary: Background: - Orthostatic hypotension is a fall in blood pressure when standing up. Normally, a reflex action of the automatic nervous system makes blood vessels tighten when people stand up. The nervous system releases the chemical norepinephrine, which tightens blood vessels and keeps blood pressure in check (...) . In orthostatic hypotension, the nervous system does not release enough norepinephrine when a person stands up, which can cause fainting or falling. Researchers are interested in determining whether norepinephrine given as a drug by vein can help maintain blood pressure during changes in body position. Objectives: - To determine whether intravenous norepinephrine can maintain blood pressure in people with orthostatic hypotension. Eligibility: - Individuals at least 18 years of age who have been diagnosed

2011 Clinical Trials

34872. Safety And Tolerability Of Escalating Intravenous Doses Of PF-05231023 In Adult Subjects With Type 2 Diabetes

); sodium, potassium, chloride, calcium, bicarbonate (<0.9*LLN/>1.1*ULN); urine RBCs, urine white blood cells (WBCs) (> or equal[=]20 high-powered field), urine bacteria >20 high-powered field. Total number of participants with any laboratory abnormalities was reported. Number of Participants With Vital Signs Abnormalities [ Time Frame: Day 1 up to Day 15 ] Criteria for vital signs abnormalities: supine systolic blood pressure (SBP) <90 millimeter of mercury (mmHg), supine diastolic BP (DBP) <50 mmHg (...) Drug: PF-05231023 200 mg QD IV x 1 day Placebo Comparator: Placebo 0.9% w/v sodium chloride injection, USP Other: Placebo 0.9% w/v sodium chloride injection, USP QD IVx 1 day Outcome Measures Go to Primary Outcome Measures : Number of Participants With Abnormal Physical Examination Findings [ Time Frame: Day -1 up to Day 22 ] Physical examination included assessment of height, weight, blood pressure and pulse rate. Criteria for abnormal physical findings was based on investigator's discretion

2011 Clinical Trials

34873. Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans

is a lung disorder that occurs as a complication of either lung transplantation or bone marrow/blood stem cell transplantation. In bronchiolitis obliterans, the body s white blood cells or white blood cells from the transplant attack the lungs, which leads to the destruction of lung tissue, and ultimately, scarring or fibrosis of the lung tissues. When a patient develops fibrosis of the lungs or bronchioles, the lungs no longer work properly, which causes difficulties with breathing that lead (...) to a diminished quality of life and an increased risk of death. Treatment typically involves immunosuppressive therapy such as oral cyclosporine or steroid therapy, but these treatments are only marginally effective and can cause significant toxicities and increase the risk of infections. Inhaled cyclosporine (CIS) achieves higher concentrations of cyclosporine in the lungs and lower concentrations of cyclosporine in the blood than oral cyclosporine. Therefore, it could have advantages over conventional oral

2011 Clinical Trials

34874. Type 2 Diabetes Self-management Intervention for Low-income Women

combination Behavioral: Control group Not Applicable Detailed Description: In recent years, the prevalence of diabetes has significantly increased among women and because of the expected fast growth rate of minority populations, the number of women in these groups who will be diagnosed with diabetes is also expected to increase significantly over the coming years. Among women from minority groups diabetes is the fourth leading cause of death while it is the seventh among non-Hispanic White females. Non (...) -compliance to diabetes self-care is a major concern for type 2 diabetic women of racial/ethnic groups because of the existing socio-economic and environmental barriers. Often, these women live in poverty; have less than a high school education as well as language barriers and inadequate health literacy, which further place them at risk for complications, and the daily activities of diabetes self-care are implemented within the context of family responsibilities and patient's priorities. This study

2011 Clinical Trials

34875. A Study of Irinotecan, Levofolinate, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab (IMC-1121B)

; Grade 4 thrombocytopenia or ≥Grade 3 with bleeding requiring platelet transfusion; ≥Grade 3 altered coagulation tests and no anticoagulation; ≥Grade 4 or uncontrolled hypertension; ≥Grade 3 non-hematologic toxicity (except non-clinically significant Grade 3 events like electrolyte abnormality, hypersensitivity, and arthralgia/myalgia); urine protein >3 grams/24 hours; study drug-related toxicity causing Cycle 3, Day 1 treatment delay until Day 44 or later. Grade 3 or Grade 4 infusion-related (...) The participant experienced any of the following during first-line therapy with a bevacizumab-containing regimen: an arterial thrombotic/thromboembolic event; Grade 4 hypertension; Grade 4 proteinuria; a Grade 3-4 bleeding event; or bowel perforation Has received wide-field (full-dose pelvic) radiotherapy within 28 days prior to study registration Has undergone major surgery within 28 days or subcutaneous venous access device placement within 7 days prior to study registration Has elective or planned surgery

2011 Clinical Trials

34876. Study of Rifampicin in Multiple System Atrophy

conditions causing significant Central Nervous System (CNS) or autonomic dysfunction, including congestive heart failure, recent (<6 months) myocardial infarct, thrombocytopenia (<50 x10(9)/L), immunosuppressed state, severe uncontrolled hypertension, severe cardiopulmonary disease, severe anemia (<8g/dl), severe liver or kidney disease (creatinine >2.3 mg/dl) uncontrolled diabetes mellitus (HbA1c >10g%), alcoholism, malignant neoplasms, amyloidosis, uncontrolled hypothyroidism, unstable peripheral (...) , 2014 Sponsor: Phillip Low Collaborators: National Institute of Neurological Disorders and Stroke (NINDS) Vanderbilt University Rare Disease Research Network Autonomic Consortium Information provided by (Responsible Party): Phillip Low, Mayo Clinic Study Details Study Description Go to Brief Summary: The purpose of this study was to determine whether Rifampicin was effective in slowing or reversing the progression of multiple system atrophy (MSA). Research studies indicate

2011 Clinical Trials

34877. Yttrium Y 90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome

Yttrium Y 90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome Yttrium-90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk AML, ALL, or MDS - Full Text View - Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search (...) for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Yttrium-90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk AML, ALL, or MDS The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal

2011 Clinical Trials

34878. An Observational Study of Mircera (Methoxy Polyethylene Glycol-Epoetin Beta) in Patients With Chronic Kidney Disease in Pre-Dialysis or Dialysis

kidney disease patients initiated on Mircera treatment Criteria Inclusion Criteria: Adult patients, >/= 18 years of age Chronic kidney disease, in pre-dialysis or dialysis Appropriate for treatment with Mircera according to current guidelines and Summary of Product Characteristics Exclusion Criteria: Anemia due to non-renal causes Pregnant or lactating women Uncontrolled hypertension Known hypersensitivity to methoxy polyethylene glycol-epoetin beta Contacts and Locations Go to Information from

2011 Clinical Trials

34879. Microarray Analysis of Scalp Biopsies After Minoxidil Treatment

ketaconazole shampoo or cream Has a significant medical condition including, but not limited to: Hypertension (acceptable if controlled by other than a beta blocker); angina, myocardial infarction; history of fainting or dizziness; history of kidney or urinary disorders; diabetes; hemophilia or any condition determined by the Investigator as significant and therefore considered a cause for exclusion Has recently been on, or is currently on a medically managed weight reduction program. Has had a significant (...) shampoos or anti-dandruff shampoo treatment products over the past year or at all during the two months prior to the Baseline visit. Has a history of alopecia areata, totalis, universalis or any other hair loss disorder except male pattern baldness. Evidence of significant scalp scarring. Has skin cancer or actinic keratoses currently within the balding area. Has a history of skin cancer on the scalp. Has undergone a hair transplant or scalp reduction surgery. Has exhibited hypersensitivity, rash

2011 Clinical Trials

34880. Magnetic Resonance-Guided High Intensity Focused Ultrasound for Palliation of Painful Skeletal Metastases

Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Patients with painful bone metastasis Patients with bone metastasis causing pain Device: Philips MR-guided HIFU system HIFU is the use of focused ultrasound energy to penetrate through soft tissue and causes localized high temperatures (55°C to 70°C) for a few seconds within the target producing well defined regions of protein and nerve denaturation (...) Magnetic Resonance-Guided High Intensity Focused Ultrasound for Palliation of Painful Skeletal Metastases Magnetic Resonance-Guided High Intensity Focused Ultrasound for Palliation of Painful Skeletal Metastases - Full Text View - Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2011 Clinical Trials

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