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Hypertension Causes

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34721. Cardiovascular Effects of Exposure to Ozone

University of California, San Francisco University of North Carolina, Chapel Hill University of Rochester Information provided by (Responsible Party): Health Effects Institute Study Details Study Description Go to Brief Summary: The Multicenter Ozone Study in Elderly Subjects will investigate whether short-term exposure of elderly volunteers to ambient levels of ozone in a controlled exposure setting causes acute cardiovascular responses as assessed by changes in blood pressure, cardiac function (...) cotinine level > 3ng/mL. BMI >35 or <18 (35 is the official cut off for class 1 obesity). Hypertension (defined as blood pressure >140 systolic or >90diastolic) or on anti-hypertension medications other than diuretics. Pregnancy or nursing (breastfeeding). On the following medications: prednisone, statins, beta-blockers, anticoagulants, current hormonal therapy, tamoxifen. Subjects will not be asked to discontinue needed prescription medications for the purpose of this study. If any

2011 Clinical Trials

34722. NOX-A12 in Combination With Bendamustine and Rituximab in Relapsed Chronic Lymphocytic Leukemia (CLL)

or breast-feeding. Known infection with HIV, active Hepatitis B or Hepatitis C. The patient has a history of prior toxicity from bendamustine or rituximab that resulted in permanent discontinuation of treatments. Treatment with other investigational drugs, or participation in another clinical trial within 30 days prior to study drug administration. Uncontrolled hypertension (defined as systolic blood pressure (BP) > 160 mm Hg or diastolic BP > 100 mm Hg). Myocardial infarction or unstable angina within (...) cells express high levels of CXCR4 chemokine receptors, which cause leukemia cell migration and adhesion to stromal cells secreting the CXCR4 ligand, CXCL12 (or stromal-derived-factor 1, SDF-1). NOX A12 is a specific CXCL12 antagonist and may improve BR therapy by disrupting CXCR4-CXCL12 interactions, thereby mobilizing CLL cells from protective tissue microenvironments to the blood. Furthermore, SDF-1 inhibition may alter the activation status of CLL cells, thereby triggering apoptosis

2011 Clinical Trials

34723. Thyroxin Treatment in Sub Clinical Hypothyroidism, on the Apnea Hypopnea Index Score, Lipids and Highly Sensitive CRP

are at high risk of developing sleep disorder breathing and OSA, and adequate thyroxine treatment may reduce the sleep disordered breathing.. However, the time-course and effect of treating subclinical hypothyroidism in OSA patients on the respiratory events during sleep is not known. Subclinical hypothyroidism is associated with an increased risk of coronary heart disease (CHD). Dyslipidemia is a known complications of subclinical hypothyroidism and the effect of thyroxine treatment on lipid profile (...) is controversial . Some reports suggested higher serum high-sensitivity C-reactive protein (hs-CRP), than healthy subjects; however, the effect of levothyroxine is controversial. This project will help us to know if the treatment of subclinical hypothyroidism will improve the symptoms and reduce the progression of OSA, which may improve patients' quality of life by reducing the complication of OSA (hypertension, , depression, Cardiovascular diseases, etc.) or may even reduce mortality.It will help us to know

2011 Clinical Trials

34724. Pharmacogenomic Biomarker Study for Recombinant Human Activated Protein C Treatment in Severe Sepsis

Heart rate > 90 beats/minute Respiratory rate > 20 breaths/minute or PaC02 < 32 mm Hg) or on mechanical ventilation White blood cell count < 4,000/mm3 or > 12,000/mm3 At least one organ dysfunction due to sepsis based on definitions of clinically significant organ dysfunction Cardiovascular dysfunction [must meet one of (1), (2), or (3) below]: Systolic blood pressure ≤ 90 mmHg and pH ≤ 7.3 Mean arterial pressure ≤ 70 mmHg and pH ≤ 7.3 Reported use of a vasopressor alone is sufficient evidence (...) was: Active, not recruiting First Posted : December 6, 2011 Last Update Posted : December 6, 2011 Sponsor: Sirius Genomics Inc. Information provided by (Responsible Party): Sirius Genomics Inc. Study Details Study Description Go to Brief Summary: The overall purpose of the study is to determine whether either of the Improved Response Polymorphisms (IRPs) individually predicts a differential DrotAA treatment effect in patients with severe sepsis and high risk of death. This will be an international

2011 Clinical Trials

34725. Cetuximab and Dasatinib in Recurrent Squamous Cell Carcinoma

Criteria in Solid Tumors (RECIST) version 1.1. Secondary Outcome Measures : Progression-free Survival (PFS) [ Time Frame: Up to 36 months ] Overall Survival (OS) [ Time Frame: Up to 60 months ] From date of entry into the study until the date of death from any cause, assessed up to 60 months. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding (...) within 4 weeks of starting this trial. Patients with untreated brain metastases should be excluded from this clinical trial. History of allergic reactions to monoclonal antibodies. Inability to swallow oral medications (unless patients use a feeding tube in which case they are eligible). Uncontrolled angina or uncontrolled hypertension or any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes). Prolonged QTc

2011 Clinical Trials

34726. What is the Impact of Early Life Exposures on the Cardiovascular System in Young Adulthood?

dramatically, coinciding with favourable changes in risk factors, cardiovascular disease remains the single largest cause of mortality and premature mortality in the United Kingdom. Identification of novel biological pathways that underlie disease susceptibility raises the potential for new early primary prevention strategies to complement classical management. There is particular interest in the role of early environment in 'programming' risk of cardiovascular disease in later life and growing evidence (...) that various early life exposures impact cardiovascular health in the longer term. We have thus designed the Early Vascular Study to investigate the long-term impact of early life exposures, with a particular focus on the impact of preterm birth, in the presence or absence of pregnancy-induced hypertension in the mother, on the cardiovascular system in young adulthood. This study also allows investigation of the long term impact of perinatal interventions used in this cohort. Comprehensive multi-modality

2011 Clinical Trials

34727. Trial of Erlotinib and BKM120 in Patients With Advanced Non Small Cell Lung Cancer Previously Sensitive to Erlotinib

Petersburg, Florida, United States, 33705 Florida Cancer Specialists East West Palm Beach, Florida, United States, 33401 United States, Ohio Oncology Hematology Care, Inc. Cincinnati, Ohio, United States, 45242 United States, Tennessee Tennessee Oncology, PLLC Nashville, Tennessee, United States, 37023 United States, Texas Center for Cancer and Blood Disorders Fort Worth, Texas, United States, 76104 Sponsors and Collaborators SCRI Development Innovations, LLC Novartis Investigators Layout table (...) at 3 months (APF3) from first treatment. Secondary Outcome Measures : Overall Survival [ Time Frame: every 3 months after study treatment, projected 24 months ] Defined as the time from first treatment until death from any cause. Duration of Response [ Time Frame: every 8 weeks for 12 months, then every 12 weeks thereafter, estimated 18 months ] Defined as the time from complete or partial response (CR or PR) until objective tumor progression. Tumor measurements will be obtained using CT scans

2011 Clinical Trials

34728. Pharmacokinetics-based Mycophenolate Mofetil Dosing for GVHD Prevention

to GVHD prevention. MTX use is associated with painful mucositis, delay in engraftment and potential pulmonary toxicity. For cord blood transplants, commonly, a calcineurin inhibitor is used with corticosteroids and antithymocyte globulin. Steroid therapy is frequently complicated by high rates of infection, hyperglycemia and hypertension. Mycophenolate mofetil (MMF), whose metabolite mycophenolic acid (MPA) inhibits proliferation of lymphocytes, is approved for prevention of organ transplant (...) provided by (Responsible Party): Randy Windreich, University of Pittsburgh Study Details Study Description Go to Brief Summary: Bone marrow transplantation (BMT) is used to successfully treat high-risk forms of leukemia, lymphoma, and other childhood cancers that were once considered incurable. A major barrier to the application of this life-saving treatment is acute graft-versus-host disease (GVHD) which develops in approximately 30-80% of patients and is a leading cause of death from transplant

2011 Clinical Trials

34729. Bosentan for Treatment of Hepatopulmonary Syndrome in Patients With Liver Cirrhosis

of HPS Age ≥ 18 years Exclusion Criteria: Intracardiac shunting Pregnancy Known hypersensitivity to bosentan Use of glyburide Use of cyclosporin A Elevation of aminotransferase level of > 3 times the upper limit of normal Use of rifampicin Females of childbearing potential without use of adequate contraception Systolic blood pressure < 85 mmHg Clinical relevant anemia HIV-infection Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you (...) billion [ Time Frame: 3 months ] hepatic venous pressure gradient (HVPG) in mmHg [ Time Frame: 3 months ] HVPG will be assessed after inclusion in the study and after 3 months pulmonary hemodynamics [ Time Frame: 3 months ] pulmonary hemodynamics will be assessed after inclusion and after 3 months mean arterial blood pressue in mmHg [ Time Frame: 3 months ] partial pressure of arterial oxygen in mmHg [ Time Frame: 3 months ] Eligibility Criteria Go to Information from the National Library of Medicine

2011 Clinical Trials

34730. Clinical Evaluation of Florbetapir F 18 (18F-AV-45)

disease. Clinically significant cardiovascular disease usually includes one or more of the following: cardiac surgery or myocardial infarction within the last 4 weeks; unstable angina; acute decompensated congestive heart failure or class IV heart failure; current significant cardiac arrhythmia or conduction disturbance, particularly those resulting in ventricular fibrillation, or causing syncope, or near syncope; uncontrolled high blood pressure; or QTc > 450 msec (by history or for patients (...) Neurodegenerative Diseases Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases Tauopathies Neurocognitive Disorders Mental Disorders Cognition Disorders

2011 Clinical Trials

34731. Prophylactic Phenylephrine Infusion for Preventing Hypotension During Spinal Anesthesia

to 75 years receiving 100 µg/min of phenylephrine infusion; (2) patients from 60 to 75 years receiving saline infusion; (3) patients over 75 years receiving 100 µg/min of phenylephrine infusion; (4) patients over 75 years receiving saline infusion. Standard monitoring is applied including noninvasive arterial blood pressure, electrocardiography and pulse oximetry. The vasopressor solution and the saline solution will be prepared in identical 50 mL syringes by an investigator not involved in patient (...) care. The investigator administering the solution and the patient are blinded to the content of the syringe. The velocity of infusion will be the same between groups (1ml/min) and the infusion will start once the spinal anesthesia realized. Arterial blood pressure measurements are realized each 1 minute for the first 20 minutes and then each 5 minutes until the end of surgery. After each measurement of MAP, the infusion is stopped if the MAP is more than baseline, and it is continued or restarted

2011 Clinical Trials

34732. Study of a New Medication for Childhood Chronic Immune Thrombocytopenia (ITP), a Blood Disorder of Low Platelet Counts That Can Lead to Bruising Easily, Bleeding Gums, and/or Bleeding Inside the Body.

and included systolic blood pressure(SBP), diastolic blood pressure(DBP), and heart rate(HR). The number of participants are reported with vital sign data falling outside the standard reference ranges RR as reference range high(RRH) and reference range low(RRL). The Baseline(BL) value is defined as the value taken at Day 1 or if missing, the latest non-missing SCR value. RR for Blood Pressure (mmHg) are read as: Lower Limit of Normal, Normal Range, Upper Limit of Normal. For Ages 1 to 5 years (yrs) ranges (...) ) at the Indicated Visit During Part 2 [ Time Frame: From Week 1 up to Week 24 of Part 2 and Follow-up Week 1 to Week 4 (up to Week 41) ] Vital sign measurements were taken before any blood draw and included systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate(HR). The number of participants are reported with vital sign data falling outside the standard RR as reference range high(RRH) and reference range low(RRL) from SCR up to Week 24 of Part 2 and from Follow-up Week 1 to Week 4. RR

2011 Clinical Trials

34733. First Line Pazopanib in Poor Risk Patients With Metastatic Renal Cell Carcinoma

response rate of 8.6% according to Response Evaluation Criteria In Solid Tumor (RECIST) criteria and a Progression free Survival (PFS) of 5.5 months and not all patients are suitable for temsirolimus treatment. Thus, in clinical routine high-risk patients are also treated with multi Tyrosinkinase Inhibitors (mTKI). To date, a prospective data acquisition and control of effectiveness of a mTKI-treatment in high-risk patients has not been conducted. Pazopanib was recently approved for the first-line (...) treatment of advanced renal cell carcinoma in Europe and the USA. In the pivotal Phase III trial only nine patients in the pazopanib group were poor risk according to MSKCC risk criteria and no analysis of this subgroup was performed. Therefore further data in this group of patients with high medical need is needed. Currently there are no well-established predictive or prognostic biomarkers in RCC-mTKI treatment. This is one of the most important scientific questions in this field. In addition

2011 Clinical Trials

34734. Efficacy of Changing to TRAVATAN® From Prior Therapy

terms Glaucoma Glaucoma, Open-Angle Ocular Hypertension Eye Diseases Travoprost Antihypertensive Agents (...) Description Go to Brief Summary: The purpose of this study was to assess the efficacy and tolerability of TRAVATAN® Solution without benzalkonium chloride (BAK) in patients previously on latanoprost 0.005% or bimatoprost 0.01% ophthalmic solution monotherapy. Condition or disease Intervention/treatment Phase Open-Angle Glaucoma Ocular Hypertension Drug: Travoprost 0.004% Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 202

2011 Clinical Trials

34735. Parturient Microcirculation

of the microcirculation. In this study the investigators will compare the microcirculation, as seen with SDF imaging, of pregnant women to non-pregnant women. By improving the investigators understanding of maternal microcirculation the investigators are adding to the knowledge of how the pregnant body works. The investigators hope to then translate this knowledge into further studies to improve maternal and fetal outcomes through prevention and treatment of maternal low blood pressure caused by spinal anesthesia (...) )distributes blood to the organ tissues. The microcirculation can change blood flow and blood pressure. Microcirculation is involved in delivering oxygen and nutrients to your body, removing waste products, and regulating body temperature. The investigators current understanding of the microcirculation in pregnant women is limited. There is a device available that can measure microcirculation. It is known as Sidestream Dark Field (SDF) imaging. It is a special type of camera that captures pictures

2011 Clinical Trials

34736. Dasatinib in Advanced Squamous Cell Lung Cancer

or progressive brain metastases History of prior treatment with or allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib, nilotinib or imatinib Taking medications known to be potent CYP3A4 inhibitors Currently taking H2 inhibitors or proton pump inhibitors Currently taking drugs or have taken drugs in the past 7 days that are generally accepted to have a risk of causing Torsades de Pointes HIV positive Clinically uncontrolled hypertension (blood pressure > 160 (...) Phase 2 Detailed Description: Dasatinib will be taken orally, daily in cycles of 28 days. On the first day of study treatment and at 2 weeks, 4 weeks and then every 4 weeks subjects will have the following: Medical history and clinical exam Safety blood tests Measurement of Performance Status Review of pill log CT scans will be done every 8 weeks. In this research study, the investigators are looking at how well dasatinib works in treating squamous cell lung cancer. Dasatinib administered at 140mg

2011 Clinical Trials

34737. Bariatric Surgery, Arterial Stiffness and Target Organ Damage Study (BASTOD)

provided by (Responsible Party): University Hospital, Montpellier Study Details Study Description Go to Brief Summary: Introduction: Obesity is a major public health problem, associated with many morbidities, including metabolic and cardiovascular disease (CVD). High blood pressure (hypertension) is the most common comorbidity and one of the major risk factors for CVD and kidney failure. It has been described an almost linear relationship between body mass index (BMI) and the level of blood pressure (...) is becoming increasingly important in the management of obesity and the prevention of its comorbidities. It reduces all-cause as well as CV mortality. Bariatric surgery allows a resolution of the metabolic syndrome (in 2 out of 3 patients) and diabetes (in 5 out of 6 patients), but its effect on blood pressure remains inconstant and transient. The reasons for this limitation and the detailed effects of bariatric surgery on hemodynamics and arterial parameters have been poorly studied. Of note, a reduction

2011 Clinical Trials

34738. Efficacy Study of Epoetin Alfa in Friedreich Ataxia

Atassiche (AISA) Information provided by (Responsible Party): Alessandro Filla, Federico II University Study Details Study Description Go to Brief Summary: Friedreich's ataxia (FRDA) is a rare genetic disorder characterised by severe neurological disability and cardiomyopathy. Friedreich's ataxia is the consequence of frataxin deficiency. Although several drugs have been proposed, there is no available treatment. Four trials recently demonstrated that erythropoietin can increase the intracellular levels (...) of frataxin. The present project is aimed at testing a long term therapeutic approach using erythropoietin, which is an already available and commercialised drug. The study will test the effect of erythropoietin on exercise capacity, which is reduced in patients with FRDA. Additional objectives of the study will be the drug's safety and tolerability, and its effect on frataxin, blood vessel reactivity, heart functional indexes, and disease progression. Condition or disease Intervention/treatment Phase

2011 Clinical Trials

34739. Investigation of the Effect of Dietary Nitrate Treatment on Endothelial Function and Platelet Reactivity in Hypercholesterolemics.

within two months of commencing study or likely future use required during the study. Subjects with any acute infection, or significant trauma (burns, fractures). Subjects who have donated > 500mls blood within 56 days prior to study medication administration. Anaemia with Hb <10g/dl, or any other known blood disorder or significant illness that may affect platelet function, and coagulation. Known essential hypertension on antihypertensive medication is not a contraindication. History of malignancy (...) vegetables, including beetroot and the green leafy vegetables, possess high inorganic nitrate concentrations. The investigators recent evidence suggests that inorganic nitrate provides a source of gas called nitric oxide in the body that exerts a number of beneficial effects upon the heart and blood vessels . The investigators have previously shown that beetroot juice ingestion improves blood vessel (vascular endothelial) and platelet function in healthy volunteers. Studies by the investigators show

2011 Clinical Trials

34740. Extending the Time for Thrombolysis in Emergency Neurological Deficits

IIb - IIIa inhibitors within the past 72 hours. Prior use of single or dual agent oral platelet inhibitors (clopidogrel and/or low-dose aspirin) is permitted. Clinically significant hypoglycaemia. Uncontrolled hypertension defined by a blood pressure > 185 mmHg systolic or >110 mmHg diastolic on at least 2 separate occasions at least 10 minutes apart, or requiring aggressive treatment to reduce the blood pressure to within these limits. The definition of "aggressive treatment" is left (...) or MRI combined with >/=4 point deterioration in NIHSS within 36 hours of treatment). [ Time Frame: within 36 hours of intervention ] Death due to any cause [ Time Frame: 3 months ] Modified Rankin Scale (mRS) 0-1 at 3 months [ Time Frame: 3 months ] Categorical shift in mRS at 3 months [ Time Frame: 3 months ] NIHSS reduction 8 points or reaching 0-1 at 3 months [ Time Frame: 3 months ] Modified Rankin Scale (mRS) 0-2 at 3 months [ Time Frame: 3 months ] Eligibility Criteria Go to Information from

2011 Clinical Trials

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