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Hypertension Causes

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1. Impact of early initiation of antihypertensive medications for patients with hypertension or elevated blood pressure. (Abstract)

Impact of early initiation of antihypertensive medications for patients with hypertension or elevated blood pressure. The 2017 American College of Cardiology/American Heart Association High Blood Pressure Guidelines lowered high blood pressure (BP) threshold, recommending earlier treatment to prevent cardiovascular disease. This study estimated the impact of initiating early antihypertensive medications on the risk of acute myocardial infarction (AMI), stroke, death, and on healthcare costs (...) in patients potentially qualifying for antihypertensive treatment under the 2017 guidelines.High-risk patients qualifying for antihypertensive medications under the 2017 guidelines were identified using Optum data. Patients with a diagnosis of elevated BP were also assumed eligible for hypertension treatment under the new guidelines. Patients were defined to have initiated early treatment if they initiated treatment before experiencing a cardiovascular event postdiagnosis.A total of 916 633 patients met

2019 Journal of Hypertension

2. Care of the older person: Antihypertensive medications may reduce the risk of dementia in older African–Americans with hypertension Full Text available with Trip Pro

Antihypertensive medications may reduce the risk of dementia in older African–Americans with hypertension Tomas Welsh 1 , 2 , 3 , Jane Masoli 4 , 5 Statistics from Altmetric.com Commentary on: Murray MD, Hendrie HC, Lane KA, et al. Antihypertensive Medication and Dementia Risk in Older Adult African Americans with Hypertension: A Prospective Cohort Study. J Gen Intern Med . 2018 Apr;33:455–462. Implications for practice and research Treatment for hypertension to target blood pressure in community-dwelling (...) antihypertensive use and incident dementia should adopt an approach which avoids these complexities. Context High blood pressure is very common amongst older adults, 1 with blood pressure increasing into middle age and then falling towards the end of … Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many

2018 Evidence-Based Nursing

3. High Blood Pressure in Paediatric Patients With Sleep Disorder Breathing.

will be available (measurements just before the surgery / control group) that will be compared with the measurements of those same patients six months after the surgery (treatment group). This measure allows having control values without preventing the treatment of any patient and without causing delays in the application of the same linked to the study Masking: None (Open Label) Primary Purpose: Other Official Title: Prevalence of High Blood Pressure in Paediatric Patients With Sleep Disorder Breathing (...) High Blood Pressure in Paediatric Patients With Sleep Disorder Breathing. High Blood Pressure in Paediatric Patients With Sleep Disorder Breathing. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. High Blood

2018 Clinical Trials

4. Randomised controlled trial: In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120?mm?Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from

Randomised controlled trial: In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120?mm?Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120 mm Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from any cause | BMJ (...) OR managers of institutional accounts Username * Password * your user name or password? You are here In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120 mm Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from any cause Article Text Therapeutics/Prevention Randomised controlled trial In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure

2016 Evidence-Based Medicine

5. Correlation among high salt intake, blood pressure variability, and target organ damage in patients with essential hypertension: Study protocol clinical trial (SPIRIT compliant). Full Text available with Trip Pro

Correlation among high salt intake, blood pressure variability, and target organ damage in patients with essential hypertension: Study protocol clinical trial (SPIRIT compliant). Essential hypertension is a multifactorial disease, which is affected by genetic and environmental factors, and can cause diseases such as cerebrovascular disease, heart failure, coronary heart disease, and chronic renal failure. High salt intake is a risk factor for hypertension, stroke, and cardiovascular disease (...) . Blood pressure variability (BPV) is a reliable independent predictor of cardiovascular events and death. At present, there are few studies about the correlation among high salt intake, BPV, and target organ damage (TOD) in patients with hypertension.The purpose of this study is to compare 24-hour urine sodium excretion, BPV, carotid intima-media thickness, left ventricular mass index, and serum creatinine or endogenous creatinine clearance rate. To clarify the relationship between high salt load

2020 Medicine

6. Cohort study: ACE inhibitors in African Americans with hypertension associated with worse outcomes as compared to other antihypertensives

Article Text Prognosis Cohort study ACE inhibitors in African Americans with hypertension associated with worse outcomes as compared to other antihypertensives Lars H Lund 1 , 2 Statistics from Altmetric.com Commentary on : Bangalore S , Ogedegbe G , Gyamfi J , et al . Outcomes with angiotensin-converting enzyme inhibitors vs other antihypertensive agents in hypertensive blacks . Context Hypertension affects one-third of the world's population and remains a leading cause of myocardial infarction (...) , stroke, heart failure, renal failure and death. Although hypertension control has improved, 1 the prevalence is increasing due to an ageing population, rising obesity and a shift towards western lifestyles and disease patterns in low-income and middle-income countries. Hypertension is now also a major contributor to heart failure in low-income countries. 2 Furthermore, control of blood pressure (<140/90 mm Hg) is achieved in only half of patients. 1 In the recent landmark Systolic Blood Pressure

2016 Evidence-Based Medicine

7. Benefit of antihypertensive therapy for mild-to-moderate chronic hypertension during pregnancy remains uncertain

of Maternal- Fetal Medicine (SMFM). 1 For women with persistent chronic hypertension with systolic blood pressure (BP)160 mm Hg or diastolic BP>105 mm Hg, antihypertensive therapy is recommen- ded. Treatment bene?t for mild-to- moderate hypertension (de?ned as systolicBP140mm Hgbut 56%ineachgroupwerekepton antihypertensive therapy at randomiza- tion (10-12% on at least 2 drugs), 14% had prior severe hypertension, and only 35% were enrolled<21 weeks of gesta- tion. Although the study was well con- ducted (...) Benefit of antihypertensive therapy for mild-to-moderate chronic hypertension during pregnancy remains uncertain SMFM Statement: bene?t of antihypertensive therapy or mild-to- moderate chronic hypertension during pregnancy remains uncertain SMFM Publications Committee C hronic hypertension is present in up to 5% of pregnant women and constitutes a major cause of ma- ternal and neonatal morbidity and mortality. 1-4 To mitigate these sequelae, antihypertensive treatment is often pre

2015 Society for Maternal-Fetal Medicine

8. Antihypertensive Activity of <i>Leersia hexandra</i> Sw. (Poaceae) Aqueous Extract on Ethanol-Induced Hypertension in Wistar Rat. Full Text available with Trip Pro

pressure (MAP) and heart rate of normotensive rats. The administration of the extract (100 and 200 mg/kg) or nifedipine caused a significant decrease of MAP compared to hypertensive rats. Ethanol induced a significant increase of lipid profile, the atherogenic index, creatinine, and transaminase activities. Ethanol also induced a significant decrease in serum HDL-cholesterol and antioxidant markers evaluated. Treatment of hypertensive rats with L. hexandra or nifedipine significantly improved lipid (...) Antihypertensive Activity of Leersia hexandra Sw. (Poaceae) Aqueous Extract on Ethanol-Induced Hypertension in Wistar Rat. Leersia hexandra (L. hexandra) is used in traditional medicine to treat many diseases including hypertension. This study aimed to evaluate the curative effects of the aqueous extract of L. hexandra on hypertension. Hypertension was induced in rats by oral administration of ethanol (5 g/kg/day) for five weeks. The animals were divided into 2 groups: one group of 5

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

9. Intervention for High-normal or Borderline-elevated Blood Pressure in Adults With Type 2 Diabetes

Status : Not yet recruiting First Posted : August 29, 2017 Last Update Posted : January 12, 2018 See Sponsor: Jiyan Chen Information provided by (Responsible Party): Jiyan Chen, Guangdong General Hospital Study Details Study Description Go to Brief Summary: Lowering of blood pressure (BP) in high-risk hypertensive individuals reduces major adverse cardiovascular (CV) events. Diabetic patients with hypertension benefit from BP lowering treatment. The present trial,IPAD in brief, is a randomized (...) Intervention for High-normal or Borderline-elevated Blood Pressure in Adults With Type 2 Diabetes Intervention for High-normal or Borderline-elevated Blood Pressure in Adults With Type 2 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2017 Clinical Trials

10. Atlantoaxial Misalignment Causes High Blood Pressure in Rats: A Novel Hypertension Model Full Text available with Trip Pro

Atlantoaxial Misalignment Causes High Blood Pressure in Rats: A Novel Hypertension Model Atlantoaxial disorders are often correlated with hypertension in practice. In order to study the relationship between atlantoaxial disorder and hypertension, we attempted to construct an animal model. In this work, we presented an animal model where their atlantoaxial joints were misaligned. We investigated the changes of blood pressure before and after treatments of the modeled rats. We had the following (...) , we concluded that we successfully constructed cervical atlantoaxial disorder models in rats that showed hypertension symptom. However, the underlying mechanism connecting atlantoaxial disorder and hypertension still requires further study.

2017 BioMed research international

11. Hypertension Canada’s 2020 comprehensive guidelines for the prevention, diagnosis, risk assessment, and treatment of hypertension in adults and children

, angiotensin converting enzyme inhibitor; AHA-ACC, American Heart Association-American College of Cardiology; ARB, angiotensin receptor blocker; BP, blood pressure; CCB, calcium channel blocker; DBP, diastolic blood pressure; ESH, European Society of Hypertension; HBPM, home blood pressure monitoring; SBP, systolic blood pressure. Table 6. Blood pressure thresholds for diagnosis of resistant hypertension Description BP threshold Diabetes Systolic BP> 130 mm Hg or diastolic BP> 80 mm Hg High cardiovascular (...) 25, 2019. After the discussions, the guidelines were further revised and ?nalized for anelectronic vote by all 81 members of the HCGC, with > 70% support required for approval of each new guideline. Guidelines for the diagnosis, assessment, prevention, and treatment of hyper- tension in adults and children are published separately. 10 Key Messages Resistant hypertension (RHT) is de?ned as blood pressure (BP) above target despite 3 or more BP- lowering drugs at optimal doses preferably including

2020 CPG Infobase

12. Dose-Related Antihypertensive Properties and the Corresponding Mechanisms of a Chicken Foot Hydrolysate in Hypertensive Rats Full Text available with Trip Pro

Dose-Related Antihypertensive Properties and the Corresponding Mechanisms of a Chicken Foot Hydrolysate in Hypertensive Rats The antihypertensive properties of different doses of a chicken foot hydrolysate, Hpp11 and the mechanisms involved in this effect were investigated. Spontaneously hypertensive rats (SHR) were administered water, Captopril (50 mg/kg) or Hpp11 at different doses (25, 55 and 85 mg/kg), and the systolic blood pressure (SBP) was recorded. The SBP of normotensive Wistar-Kyoto (...) (WKY) rats administered water or Hpp11 was also recorded. Additionally, plasmatic angiotensin-converting enzyme (ACE) activity was determined in the SHR administered Hpp11. Moreover, the relaxation caused by Hpp11 in isolated aortic rings from Sprague-Dawley rats was evaluated. Hpp11 exhibited antihypertensive activity at doses of 55 and 85 mg/kg, with maximum activity 6 h post-administration. At this time, no differences were found between these doses and Captopril. Initial SBP values of 55 and 85

2018 Nutrients

13. Long-term effects of antihypertensive therapy on cardiovascular events and new-onset diabetes mellitus in high-risk hypertensive patients in Japan. (Abstract)

Long-term effects of antihypertensive therapy on cardiovascular events and new-onset diabetes mellitus in high-risk hypertensive patients in Japan. During the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial, patients with hypertension who received amlodipine had similar cardiovascular risks as those who received candesartan. We conducted a post-trial study, the Candesartan Antihypertensive Survival Evaluation in Japan 10-year follow-up (CASE-J 10). This study aimed (...) %), and when adjusted for clinical factors, candesartan remained an independent predictor for NOD prevention (hazard ratioadj = 0.71, 95% CI 0.52-0.98).With more than 28 385 patient-years follow-up, we demonstrated that candesartan and amlodipine were comparable in reducing cardiovascular events in patients with high-risk hypertension. Additionally, our results may support candesartan's superiority in reducing NOD incidence compared with amlodipine even after the long-term follow-up.

2018 Journal of Hypertension

14. Age- and sex- specific all-cause mortality risk greatest in metabolic syndrome combinations with elevated blood pressure from 7 U.S. cohorts. Full Text available with Trip Pro

Age- and sex- specific all-cause mortality risk greatest in metabolic syndrome combinations with elevated blood pressure from 7 U.S. cohorts. The association between metabolic syndrome (MetS) and all-cause mortality is well established but it is unclear if there are differences in mortality risk among the 32 possible MetS combinations. Hence, the purpose of this study is to evaluate the associations between different MetS combinations and its individual components with all-cause mortality (...) were not associated with mortality (p>0.05).In a large U.S. population, different combinations of MetS components vary substantially in their associations with all-cause mortality. Men, women and younger individuals with MetS combinations including elevated blood pressure had stronger associations with greater mortality risk, with minimal associations between MetS and mortality risk in older adults. Thus, we suggest that future algorithms may wish to consider differential weighting of these common

2019 PLoS ONE

16. High-intensity interval training lowers blood pressure and improves apelin and NOx plasma levels in older treated hypertensive individuals. (Abstract)

High-intensity interval training lowers blood pressure and improves apelin and NOx plasma levels in older treated hypertensive individuals. Hypertension is the major risk factor for cardiovascular diseases and is one of the primary causes of morbidity and mortality worldwide. Apelin levels and NO bioavailability are impaired in older hypertensive patients. Exercise is an effective intervention for treating hypertension. Our purpose was to evaluate the effect of high-intensity interval training (...) on blood pressure, apelin, and NOx plasma levels in older treated hypertensive individuals. Thirty treated hypertensive subjects (61.70 ± 5.78 years, 17 males, 13 females) were randomly divided into 6 weeks of high-intensity interval training (n = 15) and control (n = 15). The exercise training was conducted for three 35-min sessions a week (1.5-min interval at 85-90% of heart rate reserve [HRR] and 2 min active phase at 50-55% of HRR). Assessment of plasma apelin, nitrite/nitrate (NOx), and endothelin

2018 Journal of physiology and biochemistry Controlled trial quality: uncertain

17. Upward Shift and Steepening of the Blood Pressure Response to Exercise in Hypertensive Subjects at High Altitude Full Text available with Trip Pro

Upward Shift and Steepening of the Blood Pressure Response to Exercise in Hypertensive Subjects at High Altitude Acute exposure to high-altitude hypobaric hypoxia induces a blood pressure rise in hypertensive humans, both at rest and during exercise. It is unclear whether this phenomenon reflects specific blood pressure hyperreactivity or rather an upward shift of blood pressure levels. We aimed at evaluating the extent and rate of blood pressure rise during exercise in hypertensive subjects (...) acutely exposed to high altitude, and how these alterations can be counterbalanced by antihypertensive treatment.Fifty-five subjects with mild hypertension, double-blindly randomized to placebo or to a fixed-dose combination of an angiotensin-receptor blocker (telmisartan 80 mg) and a calcium-channel blocker (nifedipine slow release 30 mg), performed a cardiopulmonary exercise test at sea level and after the first night's stay at 3260 m altitude. High-altitude exposure caused both an 8 mm Hg upward

2018 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease Controlled trial quality: uncertain

18. A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety

A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information (...) . Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety (PRECISION) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing

2018 Clinical Trials

19. This Study Tests the Safety of Inhaled BAY1237592, How the Drug is Tolerated and How it Effects Patients With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH) and Chronic Thromboemb

This Study Tests the Safety of Inhaled BAY1237592, How the Drug is Tolerated and How it Effects Patients With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH) and Chronic Thromboemb This Study Tests the Safety of Inhaled BAY1237592, How the Drug is Tolerated and How it Effects Patients With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH (...) With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) (ATMOS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2018 Clinical Trials

20. Treatment of Secondary Hypertension Due to Endocrine Causes

be performed only done after biochemical confirmation of disease. v. Definitive treatment is with surgical resection. Preoperative planning is recommended for blood pressure control and volume expansion: α-blockade should be started 10-14 days preoperatively. Typical options include oral phenoxybenzamine (a long-acting, non-selective, irreversible α-blocker), prazosin, or doxazosin. Other anti-hypertensives may be added as necessary but diuretics should be avoided if possible. Oral β-blockers may (...) Treatment of Secondary Hypertension Due to Endocrine Causes XIV. Treatment of Secondary Hypertension Due to Endocrine Causes | Hypertension Canada Guidelines Subgroup Members: Ally P.H. Prebtani, MD; Gregory Kline, MD, Ernesto L. Schiffrin, MD PhD; Andrew Don-Wauchope, MD Central Review Committee: Stella S. Daskalopoulou, MD MSc DIC PhD (Chair); Kaberi Dasgupta, MD MSc; Kelly B. Zarnke, MD MSc; Kara Nerenberg, MD, MSc; Alexander A. Leung, MD MPH; Kevin C. Harris, MD MHSc; Kerry McBrien, MD MPH

2018 Hypertension Canada

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