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Hypertension Causes

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2. Treatment of Secondary Hypertension Due to Endocrine Causes

Treatment of Secondary Hypertension Due to Endocrine Causes XIV. Treatment of Secondary Hypertension Due to Endocrine Causes | Hypertension Canada Guidelines Subgroup Members: Ally P.H. Prebtani, MD; Gregory Kline, MD, Ernesto L. Schiffrin, MD PhD; Andrew Don-Wauchope, MD Central Review Committee: Stella S. Daskalopoulou, MD MSc DIC PhD (Chair); Kaberi Dasgupta, MD MSc; Kelly B. Zarnke, MD MSc; Kara Nerenberg, MD, MSc; Alexander A. Leung, MD MPH; Kevin C. Harris, MD MHSc; Kerry McBrien, MD MPH (...) ; Sonia Butalia, BSc MD MSc; Meranda Nakhla, MD MSc Co-Chairs: Doreen M. Rabi, MD MSc, Stella S. Daskalopoulou, MD MSc DIC PhD This information is based on the Hypertension Canada guidelines published in Nerenberg, Kara A. et al. Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children. . Recommendations Treatment of hyperaldosteronism and pheochromocytoma are outlined in , respectively. Background Treatment

2018 Hypertension Canada

3. Detection of Secondary Causes and Coexisting Diseases in Hypertensive Patients: OSA and PA Are the Common Causes Associated with Hypertension (PubMed)

Detection of Secondary Causes and Coexisting Diseases in Hypertensive Patients: OSA and PA Are the Common Causes Associated with Hypertension Since the control rate of blood pressure is lower in mainland China, the aim of this study is to investigate the proportion of secondary causes and coexisting diseases of hypertension in hypertensive patients.Data on consecutive patients with hypertension who visited the Hypertension Center. Diseases were detected using an established strict screening (...) protocol.Detection rate of secondary causes and coexisting diseases of hypertension was 39.5% among 3003 hypertensive patients. Obstructive sleep apnea (OSA) was the most common, accounting for 24.7% of patients, followed by primary aldosteronism (PA) (5.8%) and PA + OSA (4.9%). Endocrine hypertension accounted for 12.1% of patients, including 10.7% of patients with PA, 1.1% with hypothyroidism, 0.1% with pheochromocytoma, 0.1% with Cushing's syndrome, and 0.1% with hyperthyroidism, respectively. Those who smoke

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2017 BioMed research international

4. Associations of marital status with diabetes, hypertension, cardiovascular disease and all-cause mortality: A long term follow-up study. (PubMed)

Associations of marital status with diabetes, hypertension, cardiovascular disease and all-cause mortality: A long term follow-up study. To investigate the associations of marital status with major clinical outcomes including type 2 diabetes (T2D), hypertension, cardiovascular disease (CVD) and all-cause mortality.The study cohort (1999-2014) included 9,737 (45% male) Iranian adults with a mean age of 47.6 years. Marital status was defined as married versus never married, divorced and widowed (...) . The relationship between marital status and the four above mentioned outcomes were investigated using Cox regression models adjusted for the main confounders, specific to each outcome.After more than 12 years of follow-up, 1,889 (883 men) individuals developed hypertension, 1,038 (468 men) T2D, 1015 (597 men) CVD and 668 (409 men) all-cause mortality. Compared with married, being never married in men was associated with higher risk of hypertension [hazard ratio (HR): 1.55; 95% confidence interval (CI), 1.11

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2019 PLoS ONE

5. Whom should you test for secondary causes of hypertension?

Whom should you test for secondary causes of hypertension? Whom should you test for secondary causes of hypertension? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Whom should you test for secondary causes of hypertension? View/ Open Date 2014-01 Format Metadata Abstract Evidence-based answer: It’s recommended (...) that all children and adolescents with a new diagnosis of hypertension undergo renal ultrasound and laboratory evaluation for renal pathology (strength of recommendation [SOR]: C, consensus-based guidelines). Specific diagnostic tests are recommended for newly diagnosed patients who have suspicious clinical findings suggestive of a secondary cause of hypertension based on the initial history (excess daytime sleepiness, palpitations, tremor, sweating); physical examination (abdominal bruit, thyromegaly

2014 Clinical Inquiries

6. Bilateral renal artery stenosis as a cause of refractory intradialytic hypertension in a patient with end stage renal disease. (PubMed)

Bilateral renal artery stenosis as a cause of refractory intradialytic hypertension in a patient with end stage renal disease. We report a 61-year-old female with end-stage renal disease (ESRD) secondary to polycystic kidney disease (PKD) complicated by intradialytic hypertension (IDH). Increased sympathetic drive leading to increased stroke volume and/or vasoconstriction with an inappropriate increase in peripheral vascular resistance (PVR) has been postulated to be the cause of IDH.Attempts (...) to control her blood pressure by reducing her goal weight; increasing dialysis times/ frequency and decreasing her sodium concentrate in the dialysis fluid were unsuccessful. Acting upon literature evidence suggesting renovascular disease as a cause of IDH, we referred her to an interventional radiologist for evaluation of the renal arteries. Selective angiogram of both renal arteries revealed right sided atherosclerotic renal artery stenosis (RAS) treated with insertion of a balloon mounted 6 mm stent

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2019 BMC Nephrology

7. Is resistant hypertension an independent predictor of all-cause mortality in individuals with type 2 diabetes? A prospective cohort study. (PubMed)

Is resistant hypertension an independent predictor of all-cause mortality in individuals with type 2 diabetes? A prospective cohort study. Resistant hypertension is independently associated with an increased risk of death in the general hypertensive population. We assessed whether resistant hypertension is an independent predictor of all-cause mortality in individuals with type 2 diabetes from the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicentre Study.On 31 October 2015 (...) analyses were used to assess the association with all-cause mortality.Using the 130/80 mmHg targets for categorization, crude mortality rates and Kaplan-Meier estimates were highest among resistant hypertension participants, especially those with controlled resistant hypertension. As compared with resistant hypertension, risk for all-cause mortality was significantly lower for all the other groups, including individuals with controlled hypertension (hazard ratio 0.81 [95% confidence interval 0.74-0.89

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2019 BMC Medicine

8. Severe Arterial Hypertension from Cullin 3 Mutations Is Caused by Both Renal and Vascular Effects. (PubMed)

Severe Arterial Hypertension from Cullin 3 Mutations Is Caused by Both Renal and Vascular Effects. Mutations in four genes, WNK lysine deficient protein kinase 1 and 4 (WNK1 and WNK4), kelch like family member 3 (KLHL3), or Cullin 3 (CUL3), can result in familial hyperkalemic hypertension (FHHt), a rare Mendelian form of human arterial hypertension. Although all mutations result in an increased abundance of WNK1 or WNK4, all FHHt-causing CUL3 mutations, resulting in the skipping of exon 9, lead (...) involved in regulation of vascular tone, compared with aortas from control mice. We also observed increased RhoA abundance and t1/2 in Cul3∆9-expressing cells, caused by decreased ubiquitination.Mutations in Cul3 cause severe hypertension by affecting both renal and vascular function, the latter being associated with activation of RhoA.Copyright © 2019 by the American Society of Nephrology.

2019 Journal of the American Society of Nephrology

9. Unhealthy changes in eating habits cause acute onset hypertension in the normotensive community-dwelling elderly-3 years cohort study. (PubMed)

Unhealthy changes in eating habits cause acute onset hypertension in the normotensive community-dwelling elderly-3 years cohort study. The aim of this study was to determine what lifestyle changes can predict acute onset hypertension in the normotensive community-dwelling elderly.This study targeted elderly people enrolled in National Health Insurance in Fukushima Prefecture, Japan. The subjects were 24,490 people who took all of the specific health examination conducted by National Health (...) Insurance in fiscal years 2013, 2014, and 2015 continuously and had a recorded systolic blood pressure (BP) <130 mm Hg and diastolic BP <85 mm Hg in the first 2 fiscal years. We examined their lifestyle changes for the first 2 fiscal years using the questionnaires given at the health examination. Multivariate Poisson regression analysis was conducted to examine the relationship between new-onset hypertension observed at the last examination and unhealthy lifestyle changes.The mean age of the subjects

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2019 Medicine

10. A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report. (PubMed)

A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report. Secondary hypertension is a rare complication in pregnancy that causes poor outcomes, such as preeclampsia, premature delivery, intrauterine growth retardation, stillbirths, spontaneous abortion or intrauterine death. Cushing's disease caused by an adrenal adenoma is rare during pregnancy and may be overlooked by obstetricians and physicians, but can lead to hypertension, diabetes mellitus (...) and an increased risk of fetal and maternal morbidity. Approximately 200 cases have been reported in the literature. Here, we report the successful management of a pregnant patient with Cushing's syndrome due to an adrenal adenoma.The 35-year-old Chinese female had no individual or family medical history of hypertension, and did not exhibit chronic kidney disease, diabetes mellitus, autoimmune and common endocrine diseases. Her blood pressure was elevated from the 16th week of gestation and was not controlled

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2019 BMC Pregnancy and Childbirth

11. Correction to: Neonatal hypertension: cases, causes, and clinical approach. (PubMed)

Correction to: Neonatal hypertension: cases, causes, and clinical approach. The original version of this article unfortunately contained a mistake. Due to a production error, the wrong "Key summary points" were included. The correct key summary points are listed below.

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2019 Pediatric Nephrology

12. Diagnosis & Assessment of Hypertension - Renovascular Hypertension

treatment option for renovascular disease. However, early studies showed that revascularization led to cure of hypertension in only in a small number of patients. In the subgroup of patients who did not respond at all to revascularization, it is probable that the renal artery stenosis was not severe enough to cause renovascular hypertension. In those with only a partial response to revascularization, renal artery stenosis likely played only a partial role in the maintenance of hypertension (...) ). Fibromuscular dysplasia primarily affects younger (<40 year old) females. As the prevalence of hypertension below age 40 is relatively low, the presence of hypertension at this age more likely indicates either secondary form of hypertension and/or use of drugs/substances causing high blood pressure. In this situation, especially in the absence of an obvious contributor to early onset hypertension (such as obesity), testing for renovascular hypertension appears justified, as fibromuscular dysplasia

2018 Hypertension Canada

13. Diagnosis & Assessment of Hypertension - Endocrine Hypertension

A. Hyperaldosteronism: screening and diagnosis An excess of aldosterone as a cause for hypertension (primary aldosteronism) has traditionally been considered relatively rare (approximately 1% of hypertensive patients). However, recent studies using improved diagnostic methods have suggested that forms of hyperaldosteronism are much more prevalent, perhaps occurring in up to 15.5% of hypertensive patients and even 1.5% of normotensive subjects . Primary aldosteronism, is often caused by an aldosterone-producing (...) , and the need for multiple drug therapy . Blood pressure lowering responses to other potassium-sparing diuretics, ACEIs, ARBs and calcium channel blockers are modest-to-moderate . B. Pheochromocytoma and Paraganglioma: screening and diagnosis Pheochromocytomas and paragangliomas (PPGL) are an infrequent cause of hypertension (less than 0.3%) . The prevalence is greater among patients with adrenal incidentaloma (4%) . Because of the low incidence of pheochromocytoma/PPGL, the significant risk of severe

2018 Hypertension Canada

14. A rare cause of hypertension in pregnancy: Phaeochromocytoma (PubMed)

A rare cause of hypertension in pregnancy: Phaeochromocytoma A 26-year-old primigravida at 35 weeks' gestation was transferred to our institution from a regional hospital for management of presumed preeclampsia. Due to the labile nature of her hypertension, further investigation was undertaken which revealed a right-sided phaeochromocytoma. Alpha blockade was commenced, and an uncomplicated elective caesarean delivery was performed at 38 weeks' gestation under spinal anaesthetic. The patient (...) underwent an elective right laparoscopic adrenalectomy six weeks post-partum. This case highlights the importance of investigating young women for secondary causes of hypertension to avoid mislabelling as essential or gestational hypertension.

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2016 Obstetric medicine

15. Subacute right heart failure revealing three simultaneous causes of post‐embolic pulmonary hypertension in metastatic dissemination of breast cancer (PubMed)

Subacute right heart failure revealing three simultaneous causes of post‐embolic pulmonary hypertension in metastatic dissemination of breast cancer A 72-year-old woman with history of breast cancer only treated surgically was referred to our department for pulmonary hypertension (PH) suspicion. Echocardiogram revealed elevated right ventricular systolic pressure. Computed tomography (CT) angiogram showed no pulmonary embolism (PE), but lung scan revealed two ventilation-perfusion mismatch

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2016 ESC heart failure

16. Hypertension Canada's 2016 Canadian Hypertension Education Program guidelines for pharmacists: an update

, conducted in different settings, consistently reported that elevated nonfasting lipid panels were predictive of cardiovascular events, mor - tality and all-cause mortality. 38,39,42 Nonfasting lipid panel testing can also help alleviate the burden placed on laboratories with morning testing, reduce hypoglycemia in those with diabetes and improve patient adher - ence. 44-46 It can thus provide a practical option for individuals with hypertension. Health behaviour management Increasing dietary potassium (...) Hypertension Canada's 2016 Canadian Hypertension Education Program guidelines for pharmacists: an update CPJ/RPC • november / december 2016 • VOL 149, NO 6 337 © The Author(s) 2016 DOI: 10.1177/1715163516671747 Practice guidelines Peer-reviewed Practice guidelines * Peer-reviewed 671747 CPHXXX10.1177/1715163516671747C P J / R P CC P J / R P C research-article2016 Hypertension Canada’s 2016 Canadian Hypertension Education Program guidelines for pharmacists: An update Yazid N. Al Hamarneh, BSc

2016 CPG Infobase

17. Hypertension in pregnancy: diagnosis and management

oedema other signs of severe pre-eclampsia suspected fetal compromise Hypertension in pregnancy: diagnosis and management (NG133) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 17 of 54any other clinical signs that cause concern. [2019] [2019] 1.5.3 Consider using either the fullPIERS or PREP-S validated risk prediction models to help guide decisions about the most appropriate place of care (such as the need (...) Hypertension in pregnancy: diagnosis and management Hypertension in pregnancy: diagnosis Hypertension in pregnancy: diagnosis and management and management NICE guideline Published: 25 June 2019 www.nice.org.uk/guidance/ng133 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful consideration

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

18. Postoperative hemorrhage caused by portal hypertension associated with autoimmune pancreatitis: A case report. (PubMed)

Postoperative hemorrhage caused by portal hypertension associated with autoimmune pancreatitis: A case report. Autoimmune pancreatitis is a form of chronic pancreatitis, characterized by diffused enlargement of the pancreas and irregular narrowing of the main pancreatic duct. The theory that portal hypertension is associated with autoimmune pancreatitis has not been emphasized. In addition, only a few studies report that the gastrointestinal tract hemorrhage caused by portal hypertension (...) . After the surgery, the patient suffered twice from postoperative hemorrhage (9 and 16 mos).Postoperative hemorrhage, autoimmune pancreatitis.Electronic gastroscopy, exploratory laparotomy, and titanium clips were used simultaneously to stop the bleeding.The patient recovered well after the surgery.In this study, we present the case of repeated postoperative hemorrhage (9 and 16 mos). We discussed the correlation between postoperative hemorrhage and autoimmune pancreatitis, and the cause

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2018 Medicine

19. Dietary Approach to Stop Hypertension (DASH) diet and risk of renal function decline and all-cause mortality in renal transplant recipients. (PubMed)

Dietary Approach to Stop Hypertension (DASH) diet and risk of renal function decline and all-cause mortality in renal transplant recipients. Renal transplant recipients (RTR) are at risk of decline of graft function and premature mortality, with high blood pressure as an important risk factor for both. To study the association of the Dietary Approach to Stop Hypertension (DASH) diet with these adverse events, we conducted a prospective cohort study of adult RTR. Dietary data were collected (...) of the DASH score had lower risk of both renal function decline (hazard ratio [HR] = 0.57; 95% confidence interval [CI], 0.33-0.96, P = .03) and all-cause mortality (HR = 0.52; 95%CI, 0.32-0.83, P = .006) compared to the lowest tertile, independent of potential confounders. Adherence to a DASH-style diet is associated with lower risk of both renal function decline and all-cause mortality. These results suggest that a healthful diet might benefit long-term outcome in RTR.© 2018 The Authors. American

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2018 American Journal of Transplantation

20. Pulmonary Arterial Bypass Surgery for Fibrosing Mediastinitis Causing Severe Pulmonary Hypertension. (PubMed)

Pulmonary Arterial Bypass Surgery for Fibrosing Mediastinitis Causing Severe Pulmonary Hypertension. In this case report, we present a patient with mediastinal fibrosis. The mass lesion was expanding from the mediastinum to the cervical region and surrounding the major vascular structures. The patient has symptomatic dyspnea at rest and pulmonary hypertension due to stenosis of the bilateral main pulmonary arteries (PA). To decrease pulmonary artery pressure (PAP) and improve blood flow

2018 Annals of Thoracic Surgery

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