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19,182 results for

Hypersensitivity Reaction

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19141. Hypersensitivity reactions after respiratory sensitization: effect of intranasal peptides containing T-cell epitopes. (PubMed)

Hypersensitivity reactions after respiratory sensitization: effect of intranasal peptides containing T-cell epitopes. The intranasal administration of peptides containing T-cell epitopes has been shown to inhibit T-cell and antibody responses of mice injected with allergen, but responses to respiratory sensitization might be regulated differently.This study was designed to examine the effect of intranasal peptide on antigen-induced lung inflammatory responses and delayed hypersensitivity after (...) , and delayed hypersensitivity responses were measured on the basis of ear swelling.Delayed hypersensitivity reactions were induced in mice treated with intranasal peptide, and large reactions were found in mice given intranasal peptide and sensitized with intranasal Der p 1 and adjuvant. Mice pretreated with peptide and sensitized with Der p 1 had an increased lymphocytic infiltration after allergen-specific challenge, as measured by means of bronchoalveolar lavage and shown histologically

2002 Journal of Allergy and Clinical Immunology

19142. "Not so immediate" hypersensitivity--the danger of biphasic anaphylactic reactions. (PubMed)

"Not so immediate" hypersensitivity--the danger of biphasic anaphylactic reactions. To assess how commonly clinically significant biphasic anaphylactic reactions occur after apparently successful treatment of an anaphylactic reaction. Cases were analysed to determine whether there were any markers that would allow early identification of patients who would subsequently develop a biphasic response.Retrospective review of case notes of 34 patients admitted for observation after an anaphylactic (...) reaction that had required treatment with adrenaline.Six patients (18%) had biphasic reactions. No clinical features on initial presentation identified those likely to have a biphasic response. These patients however required significantly more adrenaline to ameliorate their initial symptoms (p = 0.03) compared with those having a simple uniphasic reaction.Biphasic anaphylactic reactions occur frequently. There are no clinical features that allow identification of patients likely to have a biphasic

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1998 Journal of accident & emergency medicine

19143. Kinetics of cellular infiltration and cytokine production during the efferent phase of a delayed-type hypersensitivity reaction. (PubMed)

Kinetics of cellular infiltration and cytokine production during the efferent phase of a delayed-type hypersensitivity reaction. Cell-mediated immunity is a primary host resistance mechanism against many infectious organisms and is responsible for leucocyte recruitment to the infection site. Delayed-type hypersensitivity (DTH) reactions are in vivo correlates of cell-mediated immunity and have long been used to assess the level of cell-mediated immune (CMI) responsiveness to specific antigens (...) . It has been difficult to study the kinetics of cellular influx and cytokine composition at the site of an on-going CMI reaction. Consequently, knowledge of the sequential events occurring during the efferent phase of a CMI response is incomplete. Here we report on the use of a gelatin sponge model for evaluating the progression of events during the effector phase of a DTH reaction to antigens of the mycotic organism Cryptococcus neoformans. Previously, we have shown that 24 hr after antigen injection

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1997 Immunology

19144. Hypersensitivity reaction to balsalazide (PubMed)

Hypersensitivity reaction to balsalazide 10698880 2000 03 28 2018 11 13 0959-8138 320 7235 2000 Mar 04 BMJ (Clinical research ed.) BMJ Hypersensitivity reaction to balsalazide. 613 Adhiyaman V V Withybush General Hospital, Haverfordwest, Pembrokeshire SA61 2PZ. Vaishnavi A A Froese S S eng Case Reports Journal Article England BMJ 8900488 0959-8138 0 Aminosalicylic Acids 0 Anti-Ulcer Agents 0 Phenylhydrazines 4Q81I59GXC Mesalamine P80AL8J7ZP balsalazide AIM IM Aminosalicylic Acids adverse (...) effects Anti-Ulcer Agents adverse effects Drug Hypersensitivity etiology Female Humans Mesalamine Middle Aged Phenylhydrazines 2000 3 4 9 0 2000 4 1 9 0 2000 3 4 9 0 ppublish 10698880 PMC27304 Br Med J. 1977 Nov 5;2(6096):1188-9 22375 Am J Gastroenterol. 1988 Jan;83(1):15-9 2892391 BMJ. 1992 Jul 18;305(6846):159 1515833 Am J Gastroenterol. 1990 Mar;85(3):332-3 2309693 Am J Gastroenterol. 1989 Jan;84(1):85-6 2563191

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2000 BMJ : British Medical Journal

19145. Hypersensitivity reaction to balsalazide (PubMed)

Hypersensitivity reaction to balsalazide 11532843 2001 09 27 2018 11 13 0959-8138 323 7311 2001 Sep 01 BMJ (Clinical research ed.) BMJ Drug points: Hypersensitivity reaction to balsalazide. 489 Adhiyaman V V Withybush General Hospital, Haverfordwest, Pembrokeshire SA61 2PZ. Vaishnavi A A Froese S S eng Case Reports Journal Article England BMJ 8900488 0959-8138 0 Aminosalicylic Acids 0 Anti-Ulcer Agents 0 Phenylhydrazines 4Q81I59GXC Mesalamine P80AL8J7ZP balsalazide AIM IM Aminosalicylic Acids (...) adverse effects Anti-Ulcer Agents adverse effects Drug Hypersensitivity etiology Female Humans Mesalamine Middle Aged Pericarditis chemically induced Phenylhydrazines 2001 9 5 10 0 2001 9 28 10 1 2001 9 5 10 0 ppublish 11532843 PMC48136 Br Med J. 1977 Nov 5;2(6096):1188-9 22375 Am J Gastroenterol. 1988 Jan;83(1):15-9 2892391 BMJ. 1992 Jul 18;305(6846):159 1515833 Am J Gastroenterol. 1990 Mar;85(3):332-3 2309693 Am J Gastroenterol. 1989 Jan;84(1):85-6 2563191

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2001 BMJ : British Medical Journal

19146. Pathogenesis of necrotising enteritis with special reference to intestinal hypersensitivity reactions. (PubMed)

Pathogenesis of necrotising enteritis with special reference to intestinal hypersensitivity reactions. The aetiological aspects of 83 sporadic cases of necrotising enteritis (NE) have been studied. Of 56 cases in which histology of the intestine was possible, eight showed appearances (oedema and local eosinophilia) suggestive of a type I hypersensitivity reaction, while in 37 the appearances were suggestive of a type III reaction. We suggest that these reactions, which were more common (...) in children and young adults, were initiating factors in the intestinal necrosis. The type III reactions (submucosal arteritis, fibrinoid necrosis of arteriolar walls, intramural and perivascular infiltration with polymorphonuclear, mononuclear, and eosinophil cells, and submucous oedema) were in seven cases accompanied by extraintestinal lesions (hypercellularity of glomeruli, amorphous material in the Bowman's capsular space, tubular casts, mononuclear cell infiltration into the hepatic portal tracts

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1980 Gut

19147. Penicillin allergy: anti-penicillin IgE antibodies and immediate hypersensitivity skin reactions employing major and minor determinants of penicillin. (PubMed)

Penicillin allergy: anti-penicillin IgE antibodies and immediate hypersensitivity skin reactions employing major and minor determinants of penicillin. 300 children considered to have had adverse reactions to penicillin were examined. Informed consent was obtained from the parents. Skin tests were conducted by the scratch/prick and intradermal techniques, using benzylpenicilloyl polylysine conjugate and a mixture of minor determinants of penicillin. Specific anti-penicillin IgE antibodies were (...) estimated by the radioallergosorbent test. There was a good correlation between the two methods. The overall frequency of positive tests was 19%. 11 children showed cutaneous reactivity only to the minor determinants mixture. Positive results were found more often in those with accelerated adverse reactions, particularly anaphylaxis, serum sickness, angio-oedema, or urticaria. The validity of penicillin-negative results was confirmed by drug challenge in 56 subjects, only 2 of whom showed a slight skin

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1980 Archives of Disease in Childhood

19148. Delayed hypersensitivity reactions to Listeria monocytogenes in rats decomplemented with cobra factor and in C5-deficient mice. (PubMed)

Delayed hypersensitivity reactions to Listeria monocytogenes in rats decomplemented with cobra factor and in C5-deficient mice. The in vivo effect of cobra factor (CoF), the complement-activating protein of cobra (Naja naja) venom, was investigated, using quantifiable assays for localization of labelled donor lymphoblasts and of host macrophages in intraperitoneal and subcutaneous sites of injection of antigens from Listeria monocytogenes. Both commercially available (Cordis) and highly (...) immunospecific reaction. The effect of CoF on macrophages may be direct, or via depletion of complement components acting on macrophages, such as factor B and/or C3 or fragments thereof. It does not seem to involve the terminal complement components, C5--C9, since neither delayed-type hypersensitivity (DTH) nor cellular resistance to Listeria was reduced in C5-deficient mice when compared with C5-sufficient congenic controls.

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1981 Immunology

19149. Suppression of antibody-mediated accumulation of eosinophils in chronic inflammatory lesions by concomitant delayed hypersensitivity reactions. (PubMed)

Suppression of antibody-mediated accumulation of eosinophils in chronic inflammatory lesions by concomitant delayed hypersensitivity reactions. Studies were carried out in order to explain the often small contribution of eosinophils to immunologically mediated chronic inflammatory reactions. A chronic inflammation model was used in which large numbers of eosinophils accumulated in the peritoneal injections with PPD or ovalbumin (OA). Eosinophil accumulation could be strongly suppressed by pre (...) -immunization with a mycobacteria-containing adjuvant, which induces delayed hypersensitivity to the stimulating antigen. Suppression of OA-induced eosinophil accumulation could be obtained in a non-specific way by concomitant delayed hypersensitivity reactions to PPD. The absence o eosinophil accumulation was not related to a lack of relevant antibodies. Histological studies suggested that similar numbers of basophils were locally available in both non-pre-immunized and pre-immunized groups to allow

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1980 Immunology

19150. Lymphocyte subsets and their proliferation in a model for a delayed-type hypersensitivity reaction in the skin. (PubMed)

Lymphocyte subsets and their proliferation in a model for a delayed-type hypersensitivity reaction in the skin. A delayed-type hypersensitivity (DTH) reaction was induced in the skin of young pigs, by local injection of phytohaemagglutinin, and evaluation was carried out on the resulting accumulation of lymphocyte subsets and lymphocyte production by incorporation of bromodeoxyuridine in the skin and the draining lymph node. There was a rapid increase in mononuclear cells, which were found (...) in clusters around venules. These included very few B lymphocytes, and CD8+ lymphocytes far outnumbered CD4+ cells. Underlining the importance of determining absolute numbers, the relative and absolute numbers of lymphocyte subsets showed quite different patterns during the development of the skin reaction. Lymphocytes in the normal skin incorporated the DNA precursor bromodeoxyuridine at higher rates than have been found for peripheral lymphoid organs. After intradermal phytohaemagglutinin injections

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1990 Immunology

19151. D-penicillamine-induced enhancement of the delayed hypersensitivity reaction in guinea-pigs. (PubMed)

D-penicillamine-induced enhancement of the delayed hypersensitivity reaction in guinea-pigs. Intraperitoneal gelatin sponge implants were used in guinea-pigs to examine the effect of D-penicillamine on the delayed hypersensitivity reaction in vivo. When it was administered daily in a dose of 200 mg/kg for 14 days before sensitisation or for 14 or 30 days before challenge, D-penicillamine increased the number of exudate cells during the onset of the delayed hypersensitivity reaction. About 20

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1982 Annals of the Rheumatic Diseases

19152. Immediate food hypersensitivity reactions on the first known exposure to the food. (PubMed)

Immediate food hypersensitivity reactions on the first known exposure to the food. We report 8 infants with immediate hypersensitivity reactions to foods (milk, egg, or peanut), occurring at the first-known exposure. Each developed symptoms within the first hour, but these generally settled within 2 hours. Sensitisation to the food concerned was demonstrated by positive immediate allergen skin prick tests in every case. Symptoms experienced included irritability, erythematous rash, urticaria (...) , angio-oedema, vomiting, rhinorrhoea, and cough. Five infants were being followed prospectively and 4 were clinically tolerant of the food by age 16 months. The most likely route of sensitisation was via breast milk. None of the infants experienced similar reactions while being breast fed, suggesting that the reaction was dose dependent. As 5 out of a group of 80 infants being followed prospectively developed an immediate reaction at their first known exposure to a food, this appeared

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1983 Archives of Disease in Childhood

19153. Prolonged reduction in basophil counts at cutaneous basophil hypersensitivity reaction sites challenged with antigen. (PubMed)

Prolonged reduction in basophil counts at cutaneous basophil hypersensitivity reaction sites challenged with antigen. Previous studies have shown that injection of antigen into 24 hr cutaneous basophil hypersensitivity (CBH) reaction sites results in immediate degranulation of local basophils and release of mediators, such as histamine, that increase vascular permeability. In the current study, cell counts were made at these antigen-challenged CBH sites, 4, 8 and 24 hr later, and demonstrated

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1982 Immunology

19154. Modification of delayed-type hypersensitivity reactions to ovalbumin in cyclosporin A-treated guinea-pigs. (PubMed)

Modification of delayed-type hypersensitivity reactions to ovalbumin in cyclosporin A-treated guinea-pigs. Cyclosporin A (Cs A) administered daily (25 mg/kg per os) to outbred guinea-pigs for 2 weeks following immunization with ovalbumin (OVA; CsA 0-13) caused profound suppression of 14-day delayed-type hypersensitivity (DTH) skin reactions. Very marked impairment of DTH was also found when Cs A was given for the first time 24 hr before skin testing and at 6 and 24 hr thereafter. In contrast (...) interfere with the generation of a population of suppressor cells which regulate DTH reactions in the guinea-pig.

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1983 Immunology

19155. The mediation of tissue eosinophilia in hypersensitivity reactions. III. Separation of two different delayed eosinophil chemotactic factors and transfer of these factors by serum or cells from sensitized guinea-pigs. (PubMed)

The mediation of tissue eosinophilia in hypersensitivity reactions. III. Separation of two different delayed eosinophil chemotactic factors and transfer of these factors by serum or cells from sensitized guinea-pigs. Two different eosinophil chemotactic factors (delayed ECF-a and ECF-b) were isolated from the delayed phase (24 hr old) of eosinophil-rich inflammatory reaction sites induced by DNP-ascaris extract, which could be separated by DEAE-Sephadex. Both the factors were thermolabile (56

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1983 Immunology

19156. The mediation of tissue eosinophilia in hypersensitivity reactions. IV. Production of delayed eosinophil chemotactic factor-a by peritoneal exudate cells from sensitized guinea-pigs in vitro. (PubMed)

The mediation of tissue eosinophilia in hypersensitivity reactions. IV. Production of delayed eosinophil chemotactic factor-a by peritoneal exudate cells from sensitized guinea-pigs in vitro. An eosinophil chemotactic factor (ECF) was produced in the cell-free culture supernatants (CFS) of peritoneal exudate cells (PEC) from guinea-pigs immunized with dinitrophenyl derivatives of ascaris extract (DNP-As), when stimulated by the antigen in vitro without activation by immune complexes. A 2 or 6

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1983 Immunology

19157. Lymphocyte chemotaxis in inflammation. VIII. Demonstration of lymphocyte chemotactic lymphokines in PPD-induced delayed hypersensitivity skin reaction site in the guinea-pig. (PubMed)

Lymphocyte chemotaxis in inflammation. VIII. Demonstration of lymphocyte chemotactic lymphokines in PPD-induced delayed hypersensitivity skin reaction site in the guinea-pig. The experiments were carried out to clarify whether lymphocyte chemotactic factors (LCFs) derived from activated lymphocytes, i.e. lymphocyte chemotactic lymphokines would exist in delayed-type hypersensitivity (DTH) reaction sites in guinea-pigs. To analyse the problem, we attempted to use an immunoadsorbent column (...) conjugated with respective antibodies against LCFs (LCF-b, LCF-c and LCF-d) isolated from purified protein derivative (PPD)-induced DTH skin reaction sites in guinea-pigs. The chemotactic activity of culture supernatants from PPD- or concanavalin A (Con A)-stimulated lymph node (LN) cells was decreased to about 50% by the immunoadsorbent column with anti-LCF-c antibody or anti-LCF-d antibody, while its activity was little or not influenced by the columns with anti-LCF-b, anti-IgG or anti-IgM antibody

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1984 Immunology

19158. Lymphocyte chemotaxis in inflammation. VII. Isolation and purification of chemotactic factors for T lymphocytes from PPD-induced delayed hypersensitivity skin reaction site in the guinea-pig. (PubMed)

Lymphocyte chemotaxis in inflammation. VII. Isolation and purification of chemotactic factors for T lymphocytes from PPD-induced delayed hypersensitivity skin reaction site in the guinea-pig. Four types of lymphocyte chemotactic factor (LCF-a, -b, -c and -d) could be isolated from extract of 24-hr-old delayed-type hypersensitivity (DTH) skin reaction sites induced with purified protein derivative (PPD) in guinea-pigs by gel filtration on Sephadex G-100 followed by chromatography with DEAE

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1984 Immunology

19159. Selective chemotaxis of Ia antigen-positive blood monocytes in response to a macrophage chemotactic lymphokine extractable from PPD-induced delayed hypersensitivity reaction site in guinea-pigs. (PubMed)

Selective chemotaxis of Ia antigen-positive blood monocytes in response to a macrophage chemotactic lymphokine extractable from PPD-induced delayed hypersensitivity reaction site in guinea-pigs. Intraperitoneal injection of 10 micrograms PPD into BCG-immunized guinea-pigs induced enrichment of Ia-positive macrophages in the peritoneal exudates and Ia-positive monocytes in the peripheral blood. The peritoneal fluids (PF) free of exudate cells exhibited distinct macrophage chemotactic activity (...) (MCA). Most of the MCA were absorbed by the antibody to macrophage chemotactic factor c (MCF-c), which was isolated as a complex of macrophage chemotactic lymphokine (mol. wt. 12,500) and serum protein (as a carrier protein) from skin site of PPD-induced delayed-type hypersensitivity (DTH) reaction in guinea-pigs and highly purified. The PF and MCF-c selectively attracted Ia-positive blood monocytes rather than Ia-negative monocytes, while MCF-a and -b, which were also isolated from the same skin

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1984 Immunology

19160. Fibronectin deposition in delayed-type hypersensitivity. Reactions of normals and a patient with afibrinogenemia. (PubMed)

Fibronectin deposition in delayed-type hypersensitivity. Reactions of normals and a patient with afibrinogenemia. During development of delayed hypersensitivity (DH) skin reactions, fibronectin accumulates in two distinct sites: (a) the dermal interstitium in a pattern similar to fibrin and with a time course similar to that of fibrin deposition and mononuclear cell infiltration, and (b) blood vessel walls in a pattern suggestive of basement membrane staining and with a time course similar (...) to that of endothelial cell proliferation. In vitro fibronectin can bind to monocytes or endothelial cells and simultaneously bind to fibrin or collagen matrices; by such interaction in vivo it may affect cell migration or proliferation. Thus, fibronectin deposition in DH reactions may facilitate cell-matrix interactions; however, the possibility exists that extravascular fibronectin accumulation may be only secondary to interstitial fibrin clot formation, and that blood vessel-associated fibronectin may be only

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1984 Journal of Clinical Investigation

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