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Hypersensitivity Reaction

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141. Role of Histamine Release Test for the Evaluation of Patients with Immediate Hypersensitivity Reactions to Clavulanic Acid. (PubMed)

Role of Histamine Release Test for the Evaluation of Patients with Immediate Hypersensitivity Reactions to Clavulanic Acid. Immediate hypersensitivity reactions to clavulanic acid (CLV) seem to be on the increase. Diagnosis is mainly based on skin testing and the drug provocation test (DPT), procedures that are not risk free. The aim of this study was to evaluate whether the histamine release test (HRT) could help evaluate patients with selective hypersensitivity to CLV.Eighteen patients (...) with immediate selective hypersensitivity reactions to CLV (positive skin tests to CLV but negative to the major and minor determinants of benzylpenicillin and amoxicillin; negative DPT to benzylpenicillin and amoxicillin) and 21 controls with tolerance to CLV were included. Direct and passive HRT, using patient whole blood or 'IgE-stripped' donor blood sensitized by patient serum, respectively, were performed by stimulating the blood with CLV, and basophil histamine release was detected by fluorometric

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2016 International Archives of Allergy and Immunology

142. Evaluation of Lymphocyte Transformation Test Results in Patients with Delayed Hypersensitivity Reactions following the Use of Anticonvulsant Drugs. (PubMed)

Evaluation of Lymphocyte Transformation Test Results in Patients with Delayed Hypersensitivity Reactions following the Use of Anticonvulsant Drugs. Administration of the anticonvulsant drugs phenobarbital, phenytoin, carbamazepine and lamotrigine can be associated with severe hypersensitivity reactions. The lymphocyte transformation test (LTT) is a method to determine which drug has caused the hypersensitivity reaction. This study was done to evaluate the results of LTT in patients with delayed (...) hypersensitivity reactions following the administration of anticonvulsants.Twenty-four patients with hypersensitivity reactions, e.g. drug-induced hypersensitivity syndrome/drug rash and eosinophilia with systemic symptoms (DIHS/DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), following the administration of anticonvulsant drugs, and 24 patients who had used anticonvulsant drugs but did not have hypersensitivity reactions (the control group) were included in this study. Peripheral

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2016 International Archives of Allergy and Immunology

143. Genetic risk factors for antiepileptic drug-induced hypersensitivity reactions in Israeli populations. (PubMed)

Genetic risk factors for antiepileptic drug-induced hypersensitivity reactions in Israeli populations. The human leukocyte antigen (HLA) alleles B*15:02 and A*31:01 have been identified as predictive markers of adverse cutaneous effects of carbamazepine and phenytoin in Asian and North European populations, respectively. Our aim was to estimate the distribution of these alleles in Jewish and Arab populations in Israel. The HLA-B*15:02 and HLA-A*31:01 carrier rate was estimated based on data

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2016 Epilepsia

144. Hypersensitivity reaction associated with subcutaneous glargine insulin therapy in a cat (PubMed)

Hypersensitivity reaction associated with subcutaneous glargine insulin therapy in a cat A 14-year-old, domestic shorthair cat was treated for transient diabetes mellitus for 3 months with glargine insulin, which was discontinued when the diabetes mellitus resolved. Approximately 36 months later the diabetes mellitus recurred and glargine insulin was restarted. Within 2-3 mins of the first injection the cat collapsed, developed profuse vomiting and diarrhea, as well as facial swelling (...) and diffuse erythema. A hypersensitivity reaction was suspected and the cat was treated with antihistamines, aggressive fluid therapy and gastrointestinal support. The cat made a full recovery and was discharged 3 days later. Six months later the cat re-presented for relapse of its diabetes mellitus and an intradermal skin challenge with 1:20 diluted insulin was performed confirming a hypersensitivity to glargine. The cat continues to be well regulated on porcine zinc insulin without any hypersensitivity

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2016 JFMS Open Reports

145. Identification of MHC Haplotypes Associated with Drug-Induced Hypersensitivity Reactions in Cynomolgus Monkeys (PubMed)

Identification of MHC Haplotypes Associated with Drug-Induced Hypersensitivity Reactions in Cynomolgus Monkeys Drug-induced hypersensitivity reactions can significantly impact drug development and use. Studies to understand risk factors for drug-induced hypersensitivity reactions have identified genetic association with specific human leukocyte antigen (HLA) alleles. Interestingly, drug-induced hypersensitivity reactions can occur in nonhuman primates; however, association between drug-induced (...) hypersensitivity reactions and major histocompatibility complex (MHC) alleles has not been described. In this study, tissue samples were collected from 62 cynomolgus monkeys from preclinical studies in which 9 animals had evidence of drug-induced hypersensitivity reactions. Microsatellite analysis was used to determine MHC haplotypes for each animal. A total of 7 haplotypes and recombinant MHC haplotypes were observed, with distribution frequency comparable to known MHC I allele frequency in cynomolgus monkeys

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2016 Toxicologic Pathology

146. Role of CCL7 in Type I Hypersensitivity Reactions in Murine Experimental Allergic Conjunctivitis (PubMed)

Role of CCL7 in Type I Hypersensitivity Reactions in Murine Experimental Allergic Conjunctivitis Molecules that are necessary for ocular hypersensitivity reactions include the receptors CCR1 and CCR3; CCL7 is a ligand for these receptors. Therefore, we explored the role of CCL7 in mast cell activity and motility in vitro and investigated the requirement for CCL7 in a murine model of IgE-mediated allergic conjunctivitis. For mast cells treated with IgE and Ag, the presence of CCL7 (...) understanding of the role of CCL7 in mediating ocular hypersensitivity reactions will provide insights into mast cell function and novel treatments for allergic ocular diseases.Copyright © 2017 by The American Association of Immunologists, Inc.

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2016 The Journal of Immunology Author Choice

147. Metal Hypersensitivity Reactions to Orthopedic Implants (PubMed)

Metal Hypersensitivity Reactions to Orthopedic Implants Total hip and knee replacement surgery using metal alloy devices is common. Type IV allergic reactions to these implants occur, though infrequently. While uncommon, peri-implant metal allergic reactions may cause significant morbidity for the affected individual-including aseptic loosening, pseudotumor formation and frank device failure. It is challenging to predict who will have these reactions, even in those with established pre-implant

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2016 Dermatology and therapy

148. Daclatasvir and Asunaprevir Combination Therapy-induced Hepatitis and Cholecystitis with Coagulation Disorder due to Hypersensitivity Reactions (PubMed)

Daclatasvir and Asunaprevir Combination Therapy-induced Hepatitis and Cholecystitis with Coagulation Disorder due to Hypersensitivity Reactions A 70-year-old woman with chronic hepatitis C was admitted to our hospital due to liver injury, cholecystitis, and disseminated intravascular coagulation with a fever and skin rash. She had been on a combination regimen of daclatasvir and asunaprevir for 2 weeks of a 24-week regimen. Because of the symptoms, laboratory findings, results of a drug-induced

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2016 Internal Medicine

149. Prevalence of HLA-B*5701 and Its Relationship with Abacavir Hypersensitivity Reaction in Iranian HIV-Infected Patients (PubMed)

Prevalence of HLA-B*5701 and Its Relationship with Abacavir Hypersensitivity Reaction in Iranian HIV-Infected Patients Hypersensitivity reaction (HSR) is a major adverse effect of abacavir (ABC), which occurs in 5-8% of Caucasians. The relationship between Human Leukocyte Antigen (HLA) and ABC HSR has been reported in various populations. It has been proposed to administer ABC only to HLA-B*5701 negative patients to avoid this reaction. The purpose of this study was to assess the prevalence

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2016 Tanaffos

150. Could aluminum be a new hidden allergen in type 1 hypersensitivity reactions when used as a drug additive? (PubMed)

Could aluminum be a new hidden allergen in type 1 hypersensitivity reactions when used as a drug additive? 27512363 2016 08 11 2018 11 13 1642-395X 33 3 2016 Jun Postepy dermatologii i alergologii Postepy Dermatol Alergol Could aluminum be a new hidden allergen in type 1 hypersensitivity reactions when used as a drug additive? 243-5 10.5114/ada.2016.60620 Kutlu Ali A Department of Allergy and Immunology, GATA Haydarpasa Training Hospital, Istanbul, Turkey. Ucar Ramazan R Department of Clinical

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2016 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

151. Involvement of Histamine and RhoA/ROCK in Penicillin Immediate Hypersensitivity Reactions (PubMed)

Involvement of Histamine and RhoA/ROCK in Penicillin Immediate Hypersensitivity Reactions The mechanism of penicillin immediate hypersensitivity reactions has not been completely elucidated. These reactions are generally considered to be mediated by IgE, but penicillin-specific IgE could not be detected in most cases. This study demonstrated that penicillin was able to cause vascular hyperpermeability in a mouse model mimicking clinical symptoms of penicillin immediate hypersensitivity (...) of the endothelial monolayer. Activation of the RhoA/ROCK signaling pathway was observed in ears and lungs of mice and in endothelial cells after treatment with penicillin. Both an anti-histamine agent and a ROCK inhibitor attenuated penicillin immediate hypersensitivity reactions in mice. This study presents a novel mechanism of penicillin immediate hypersensitivity reactions and suggests a potential preventive approach against these reactions.

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2016 Scientific reports

152. Draft Genome Sequences of Two Novel Pseudomonas Strains Exhibiting Differential Hypersensitivity Reactions on Tobacco and Corn Seedlings (PubMed)

Draft Genome Sequences of Two Novel Pseudomonas Strains Exhibiting Differential Hypersensitivity Reactions on Tobacco and Corn Seedlings Two novel Pseudomonas strains (S1E40 and S3E12) isolated from corn roots are antagonistic to Rhizoctonia solani and exhibit differential hypersensitivity reactions on tobacco and corn seedlings. We report here the draft genome sequences of strains S1E40 and S3E12, consisting of 6.98 and 7.06 Mb with 6,150 and 6,129 predicted protein-coding sequences

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2016 Genome Announcements

153. A joint allergist/cardiologist classification for thienopyridines hypersensitivity reactions based on their symptomatic patterns and its impact on the management strategies. (PubMed)

A joint allergist/cardiologist classification for thienopyridines hypersensitivity reactions based on their symptomatic patterns and its impact on the management strategies. The role and importance of thienopyridines such as ticlopidine, clopidogrel, and prasugrel is well-established for several indications, ranging from prevention of acute coronary syndromes to percutaneous coronary interventions, where the dual antiplatelet therapy represents the gold standard to avoid denovo coronary (...) stenosis. However, there is a significant cohort of patients with coronary artery disease who may manifest hypersensitivity reactions to thienopyridines. The examination of the various case reports from medical literature leads to identify mainly four clinical patterns of hypersensitivity to thienopyridines which involves more frequently cutaneous, hematologic, and articular tissues, therefore the kind and predominance of clinical symptoms may determine a different clinical approach to overcome

2016 International journal of cardiology

154. Hypersensitivity and immunologic reactions to biologics: opportunities for the allergist. (PubMed)

Hypersensitivity and immunologic reactions to biologics: opportunities for the allergist. There has been a great expanse in the use of biological agents during the past decade. However, there are significant differences between biologics and typical pharmaceutical drugs. This review focuses on 3 separate types of adverse reactions to biologics, namely high cytokine reactions, hypersensitivity reactions, and secondary immunodeficiency.A PubMed literature search restricted to the previous 10 (...) antibody desensitization.A phase 1 clinical trial using a humanized anti-CD28 monoclonal antibody (TGN1412) caused severe cytokine storm reactions in all 6 subjects, resulting in multiorgan failure. Omalizumab has been reported to cause anaphylaxis in fewer than 0.1% of patients, many with delayed reactions. The mechanism for this anaphylactic reaction is unclear. Rituximab has been associated with hypogammaglobulinemia, serum sickness-like reactions, and anaphylaxis. Rapid drug desensitizations

2016 Asthma & Immunology

155. Persistent Skin Reactions and Aluminium Hypersensitivity Induced by Childhood Vaccines. (PubMed)

Persistent Skin Reactions and Aluminium Hypersensitivity Induced by Childhood Vaccines. There is increasing awareness of reactions to vaccination that include persistent skin reactions. We present here a retrospective investigation of long-lasting skin reactions and aluminium hypersensitivity in children, based on medical records and questionnaires sent to the parents. In the 10-year period 2003 to 2013 we identified 47 children with persistent skin reactions caused by childhood vaccinations (...) . Most patients had a typical presentation of persisting pruritic subcutaneous nodules. Five children had a complex diagnostic process involving paediatricians, orthopaedics and plastic surgeons. Two patients had skin biopsies performed from their skin lesions, and 2 patients had the nodules surgically removed. Forty-two children had a patch-test performed with 2% aluminium chloride hexahydrate in petrolatum and 39 of them (92%) had a positive reaction. The persistent skin reactions were treated

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2016 Acta Dermato-Venereologica

156. Severe Agranulocytosis in Two Patients with Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms. (PubMed)

Severe Agranulocytosis in Two Patients with Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms. 27025798 2017 01 16 2017 05 05 1651-2057 96 6 2016 08 23 Acta dermato-venereologica Acta Derm. Venereol. Severe Agranulocytosis in Two Patients with Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms. 842-3 10.2340/00015555-2420 Kato Miyuki M Department of Dermatology, Kyorin University School of Medicine, 6-20-2 (...) Shinkawa Mitaka, Tokyo 181-8611, Japan. Kano Yoko Y Sato Yohei Y Shiohara Tetsuo T eng Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 0 Anti-Inflammatory Agents, Non-Steroidal 0 Antimetabolites 3XC8GUZ6CB Sulfasalazine 63CZ7GJN5I Allopurinol IM Aged Aged, 80 and over Agranulocytosis diagnosis therapy Allopurinol adverse effects Anti-Inflammatory Agents, Non-Steroidal adverse effects Antimetabolites adverse effects Drug Hypersensitivity Syndrome diagnosis therapy Eosinophilia

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2016 Acta Dermato-Venereologica

157. Intravenous versus oral dexamethasone for prophylaxis of paclitaxel-associated hypersensitivity reaction in patients with primary ovarian, fallopian tube and peritoneal cancer: A double-blind randomized controlled trial. (PubMed)

Intravenous versus oral dexamethasone for prophylaxis of paclitaxel-associated hypersensitivity reaction in patients with primary ovarian, fallopian tube and peritoneal cancer: A double-blind randomized controlled trial. To compare the efficacies and side effects of intravenous and oral dexamethasone (IV-D and PO-D) for paclitaxel-associated hypersensitivity reaction (P-HSR) prophylaxis in patients with primary ovarian, fallopian tube and peritoneal carcinomas (POC/PFTC/PPC) receiving a first

2016 Asia-Pacific journal of clinical oncology Controlled trial quality: predicted high

158. Management of Cancer Medication-Related Infusion Reactions

the first day of administration. 8 Management of Cancer Medication-Related Infusion Reactions 7 Hypersensitivity reactions (HSRs) are a subset of IRs that occur at doses normally tolerated by patients and are not consistent with a known toxicity of the drug. 2 HSRs can be divided into subtypes as defined by Gell and Coombs, depending on the mechanism of reaction. • Type I reactions are those mediated by immunoglobulin E (IgE) antibodies, and include anaphylaxis, a type of systemic HSR that is severe (...) Management of Cancer Medication-Related Infusion Reactions Management of Cancer Medication- Related Infusion Reactions Care has been taken in the preparation of the information contained in this report. Nonetheless, any person seeking to apply or consult the report is expected to use independent medical judgment in the context of individual clinical circumstances or seek out the supervision of a qualified clinician. Cancer Care Ontario makes no representation or guarantees of any kind

2019 Cancer Care Ontario

159. CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis

CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis - CanadiEM CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis In , by Chris Lipp October 19, 2017 This episode of CRACKCast covers Rosen’s Chapter 119 (109 in 9th), Allergy, Hypersensitivity, Angioedema, and Anaphylaxis. Patients suffering from acute allergic reactions, anaphylaxis, and angioedema are amongst the most unstable (...) patients presenting to the ED. With proper management, however, these patients can be efficiently managed and discharged with relative ease. Shownotes – Also check out EMCases Rapid Review video on Rosen’s in Perspective This chapter covers disease states in which the immune system overreacts against typically harmless agents. These hypersensitivity reactions are manifested in clinical symptoms ranging from mildly inconvenient to fatal. For practical purposes, let’s define some terms: Allergy Used

2017 CandiEM

160. Pacing as a Treatment for Reflex-Mediated (Vasovagal, Situational, or Carotid Sinus Hypersensitivity) Syncope: A Systematic Review for the 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American Coll

caused by stroke, and 1 by cancer. Search Terms and Date: syncope, faint, carotid sinus hypersensitivity, carotid sinus syndrome, loss of consciousness - LOC, tLOC, vasovagal attack, vasovagal response, vasovagal reaction, vasovagal episode, vasovagal syndrome, vasovagal collapse, pacemaker, pacing, cardiac resynchronization therapy, CRT device, implantable cardiac device, cardiovascular implantable electronic device, cardiac implantable device; October 7, 2015. ATP indicates adenosine triphosphate (...) Pacing as a Treatment for Reflex-Mediated (Vasovagal, Situational, or Carotid Sinus Hypersensitivity) Syncope: A Systematic Review for the 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American Coll Pacing as a Treatment for Reflex-Mediated (Vasovagal, Situational, or Carotid Sinus Hypersensitivity) Syncope: A Systematic Review for the 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report

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2017 American Heart Association

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