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Hypersensitivity Reaction

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121. Outcomes of corticosteroid prophylaxis for hypersensitivity reactions to low osmolar contrast media in high-risk patients. (PubMed)

Outcomes of corticosteroid prophylaxis for hypersensitivity reactions to low osmolar contrast media in high-risk patients. Corticosteroid prophylaxis has been widely adopted for the prevention of acute allergic-like reactions to iodinated contrast media, but its use is still controversial because there is no strong evidence supporting its efficacy before administration of nonionic low osmolar contrast media (LOCM).To assess the outcomes of premedication in patients with previous acute allergic (...) -like reactions to LOCM in clinical practice.A retrospective study was performed on 322 high-risk patients who were reexposed to LOCM after premedication composed of antihistamines and/or systemic corticosteroids because of a previous history of acute allergic-like reactions to LOCM.After premedication, 275 patients (85.4%) did not experience any reaction, but 47 patients (14.6%) still experienced a breakthrough reaction. The premedication rate and amount of corticosteroid administered were

2016 Asthma & Immunology

122. Down-regulation of CD62L shedding in T cells by CD39<sup>+</sup> regulatory T cells leads to defective sensitization in contact hypersensitivity reactions. (PubMed)

Down-regulation of CD62L shedding in T cells by CD39+ regulatory T cells leads to defective sensitization in contact hypersensitivity reactions. Injection of regulatory T cells (Tregs) followed by sensitization with 2,4,6-trinitrochlorobenzene induced a transient increase in size and cellularity of skin-draining lymph nodes (LNs) in mice. This led us to hypothesize that Tregs may affect the trafficking of T cells from and to peripheral LNs. Two to three hours after sensitization, we

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2016 Journal of Investigative Dermatology

123. Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies. (PubMed)

Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies. Due to the increase in utilization of chemotherapies and antibodies, drug hypersensitivity reactions have increased dramatically worldwide, preventing the use of first-line therapies and impacting patients' survival and quality of life. Some of the more frequently used medications in cancer include taxanes for ovarian, lung, breast (...) , Wegener's granulomatosis, microscopic polyangiitis, ankylosing spondylitis, plaque psoriasis, and asthma. Neoplastic diseases include non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and colorectal, breast, gastric, and lung cancer. The clinical presentation of drug hypersensitivity reactions ranges from mild cutaneous reactions to life-threatening symptoms including anaphylaxis. Rapid drug desensitization (RDD) has become a groundbreaking approach to the management of immediate drug

2016 Clinical Reviews in Allergy & Immunology

124. Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions. (PubMed)

Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions. It is hypothesised that associations between adverse drug reactions and specific alleles of the human leukocyte antigens arise due to specific interactions between the human leukocyte antigen molecules and the causative drug that stimulate immune responses targeting drug exposed tissues. To date this has only been definitively demonstrated for abacavir, an antiretroviral that causes a systemic adverse drug (...) reaction, abacavir hypersensitivity syndrome, solely in HLA-B*57:01+ individuals. Whilst this has informed the modification of abacavir to remove immunogenicity, there remains an imperative to define other interactions between drugs and specific HLA in order to understand the scope of interactions that can drive T cell mediated drug hypersensitivity. Here we review the current state of understanding of these interactions.Copyright © 2016 Elsevier Ltd. All rights reserved.

2016 Current opinion in immunology

125. Respiratory Hypersensitivity Reactions to NSAIDs in Europe: The Global Allergy and Asthma Network (GA<sup>2</sup> LEN) Survey. (PubMed)

Respiratory Hypersensitivity Reactions to NSAIDs in Europe: The Global Allergy and Asthma Network (GA2 LEN) Survey. Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most prevalent drugs inducing hypersensitivity reactions. The aim of this analysis was to estimate the prevalence of NSAID-induced respiratory symptoms in population across Europe and to assess its association with upper and lower respiratory tract disorders.The GA2 LEN survey was conducted in 22 centers in 15 (...) European countries. Each of 19 centers selected random samples of 5000 adults aged 15-74 from their general population, and in three centers (Athens, Munich, Oslo), a younger population was sampled. Questionnaires including questions about age, gender, presence of symptoms of asthma, allergic rhinitis, chronic rhinosinusitis, smoking status, and history of NSAID-induced hypersensitivity reactions were sent to participants by mail. Totally, 62 737 participants completed the questionnaires.The mean

2016 Allergy

126. In vitro rapid diagnostic tests for severe drug hypersensitivity reactions in children. (PubMed)

In vitro rapid diagnostic tests for severe drug hypersensitivity reactions in children. Previous reports have demonstrated the utility of T-cell proliferation and cytokine release assays as in vitro diagnostic tests for drug causation in drug hypersensitivity reactions (DHR). However, data from pediatric populations are scarce compared with data in adults.To compare the lymphocyte proliferation assay (LPA) with combination cytokine assays in the pediatric population and to identify its

2016 Asthma & Immunology

127. Effect of Prophylactic Extended-Infusion Carboplatin on Incidence of Hypersensitivity Reactions in Patients with Ovarian, Fallopian Tube, or Peritoneal Carcinomas. (PubMed)

Effect of Prophylactic Extended-Infusion Carboplatin on Incidence of Hypersensitivity Reactions in Patients with Ovarian, Fallopian Tube, or Peritoneal Carcinomas. To determine whether extended-infusion carboplatin, initiated at approximately the eighth cumulative carboplatin cycle and prior to development of carboplatin hypersensitivity, reduces the incidence of carboplatin hypersensitivity reactions in patients with ovarian, fallopian tube, or peritoneal cancer.Retrospective chart (...) cycle and prior to development of a hypersensitivity reaction (extended-infusion group [total of 1527 carboplatin cycles]).Baseline characteristics were similar between the groups, except significantly more patients in the extended-infusion group received triple premedication therapy prior to infusion (p<0.001). Hypersensitivity reactions occurred in 64 patients (40%) who received standard-infusion carboplatin and 40 patients (24.2%) who received extended-infusion carboplatin (p=0.0027). The median

2016 Pharmacotherapy

128. Immunoglobulin E-Mediated Hypersensitivity Reaction to Ketamine. (PubMed)

Immunoglobulin E-Mediated Hypersensitivity Reaction to Ketamine. Ketamine is a commonly used analgesic agent in the management of both acute and chronic pain. While dose-dependent side effects are well described, allergy to ketamine is extremely rare.A 41-year-old woman with chronic pelvic pain and previous ketamine exposure developed a widespread urticarial rash and mild perioral edema following the initiation of a ketamine infusion. The infusion was ceased and the patient was treated (...) with oral antihistamine, with rapid resolution of symptoms. Serum tryptase levels were elevated at 2 and 6 hours after the infusion was ceased, and subsequent intradermal skin testing supported the diagnosis of type I hypersensitivity reaction to ketamine.This case represents a likely immunoglobulin E-mediated type I hypersensitivity reaction to ketamine, supported by elevated tryptase levels and positive intradermal skin testing. The interpretation of these results and likely mechanism

2016 Pain Practice

129. Phenotypical characterization of children with hypersensitivity reactions to NSAIDs. (PubMed)

Phenotypical characterization of children with hypersensitivity reactions to NSAIDs. Non-steroidal anti-inflammatory drugs (NSAIDs) are the main cause of drug-induced hypersensitivity in children. Many classifications have been proposed, focusing on adults. So far, no large study has deeply investigated a pediatric cohort. The aim of the present study was to describe a population of NSAID hypersensitive patients reporting a reaction during their childhood and to verify whether it is possible (...) in children.The current ENDA classification does not seem to be adapted for pediatric patients; a modified version does. Our study could help allergists better understand the differences between adults and children in developing hypersensitivity reactions to NSAIDs, but further large-scale prospective longitudinal analyses are required to validate this new classification.© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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2016 Pediatric Allergy and Immunology

130. Antibiotics are the Most Commonly Identified Cause of Perioperative Hypersensitivity Reactions (PubMed)

Antibiotics are the Most Commonly Identified Cause of Perioperative Hypersensitivity Reactions Hypersensitivity reactions (HSRs) during the perioperative period are unpredictable and can be life threatening. Prospective studies for the evaluation of perioperative HSRs are lacking, and data on causative agents vary between different studies.The objective of this study was to prospectively determine the success of a comprehensive allergy evaluation plan for patients with HSRs during anesthesia

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2016 The journal of allergy and clinical immunology. In practice

131. Immunization against an IL-6 peptide induces anti-IL-6 antibodies and modulates the Delayed-Type Hypersensitivity reaction in cynomolgus monkeys (PubMed)

Immunization against an IL-6 peptide induces anti-IL-6 antibodies and modulates the Delayed-Type Hypersensitivity reaction in cynomolgus monkeys Interleukin-6 (IL-6) overproduction has been involved in the pathogenesis of several chronic inflammatory diseases and the administration of an anti-IL-6 receptor monoclonal antibody has been proven clinically efficient to treat them. However, the drawbacks of monoclonal antibodies have led our group to develop an innovative anti-IL-6 strategy using (...) an important decrease of the cumulative inflammatory score following a delayed-type hypersensitivity reaction induced by the Tetanus vaccine compared to control groups (minus 57,9%, P = 0.014). These findings are highly significant because the immunizing IL-6 peptide used in this study is identical in humans and in monkeys and this novel anti-IL-6 strategy could thus represent a promising alternative to monoclonal antibodies.

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2016 Scientific reports

132. Hypersensitivity reactions associated with L-asparaginase administration in 142 dogs and 68 cats with lymphoid malignancies: 2007–2012 (PubMed)

Hypersensitivity reactions associated with L-asparaginase administration in 142 dogs and 68 cats with lymphoid malignancies: 2007–2012 Clinically significant hypersensitivity reactions (HSRs) to the chemotherapy drug L-asparaginase are reported in humans and dogs, but frequency in small animals is not well-defined. This study retrospectively evaluated the frequency of HSR to L-asparaginase given by IM injection to dogs and cats with lymphoid malignancies. The medical records of all dogs (...) and cats treated with at least 1 dose of L-asparaginase chemotherapy over a 5-year period were reviewed. A total of 370 doses of L-asparaginase were administered to the dogs, with 88 of 142 dogs receiving multiple doses, and 6 dogs experiencing an HSR. A total of 197 doses were administered to the cats, with 33 of 68 cats receiving multiple doses, and no cats experiencing an HSR. Hypersensitivity reactions were documented in 4.2% of dogs, and in association with 1.6% of L-asparaginase doses

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2016 The Canadian Veterinary Journal

133. Systemic hypersensitivity reaction to Omnipaque radiocontrast medium: a case of mini‐DRESS (PubMed)

Systemic hypersensitivity reaction to Omnipaque radiocontrast medium: a case of mini‐DRESS Drug reaction with eosinophilia and systemic symptoms (DRESS) is a delayed drug reaction defined by physical signs and laboratory parameters. Mini-DRESS is a new entity, in cases that display some but not all features of DRESS. Cases of mini-DRESS have a less protracted course, and respond well to systemic corticosteroid treatment.

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2016 Clinical Case Reports

134. A novel approach to predict cetuximab‐induced hypersensitivity reaction: detection of drug‐specific IgE on basophils (PubMed)

A novel approach to predict cetuximab‐induced hypersensitivity reaction: detection of drug‐specific IgE on basophils Cetuximab is remarkable for the relatively high rate and severity of hypersensitivity reactions (HR) being reported in the literature. Screening for cetuximab-specific IgE in serum via immunoassay has been found to be useful in preventing HR; however, these tests are known to have a low positive predictive rate. In an attempt to remedy this, we evaluated the interaction

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2016 Cancer medicine

135. Potential Mechanisms for IgG4 Inhibition of Immediate Hypersensitivity Reactions (PubMed)

Potential Mechanisms for IgG4 Inhibition of Immediate Hypersensitivity Reactions IgG4 is the least abundant IgG subclass in human serum, representing less than 5% of all IgG. Increases in IgG4 occur following chronic exposure to antigen and are generally associated with states of immune tolerance. In line with this, IgG4 is regarded as an anti-inflammatory antibody with a limited ability to elicit effective immune responses. Furthermore, IgG4 attenuates allergic responses by inhibiting (...) the activity of IgE. The mechanism by which IgG4 inhibits IgE-mediated hypersensitivity has been investigated using a variety of model systems leading to two proposed mechanisms. First by sequestering antigen, IgG4 can function as a blocking antibody, preventing cross-linking of receptor bound IgE. Second IgG4 has been proposed to co-stimulate the inhibitory IgG receptor FcγRIIb, which can negatively regulate FcεRI signaling and in turn inhibit effector cell activation. Recent advances in our understanding

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2016 Current Allergy and Asthma Reports

136. CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model (PubMed)

CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model Interaction of CD200 with its receptor CD200R has an immunoregulatory role and attenuates various types of neuroinflammatory diseases.Immunofluorescence staining, western blot analysis, and RT-PCR were used to investigate the modulatory effects of CD200 fusion protein (CD200Fc) on activation of microglia and astrocytes as well (...) cerebrospinal fluid or CD200Fc.Seven days from sCCI operation and 5 h from intrathecal application, CD200Fc reduced mechanical and thermal hypersensitivity when compared with control animals. Simultaneously, CD200Fc attenuated activation of glial cells and decreased proinflammatory and increased anti-inflammatory cytokine messenger RNA (mRNA) levels. Administration of CD200Fc also diminished elevation of CD200 and CD200R proteins as a concomitant reaction of the modulatory system to increased

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2016 Journal of neuroinflammation

137. The N-terminal fragment of the tomato torrado virus RNA1-encoded polyprotein induces a hypersensitive response (HR)-like reaction in Nicotiana benthamiana (PubMed)

The N-terminal fragment of the tomato torrado virus RNA1-encoded polyprotein induces a hypersensitive response (HR)-like reaction in Nicotiana benthamiana The hypersensitive response (HR) is a defence reaction observed during incompatible plant-pathogen interactions in plants infected with a wide range of fungi, bacteria and viruses. Here, we show that an N-terminal polyprotein fragment encoded by tomato torrado virus RNA1, located between the first ATG codon and the protease cofactor (ProCo (...) ) motif, induces an HR-like reaction in Nicotiana benthamiana. Agrobacterium tumefaciens-mediated transient expression of the first 105 amino acids (the calculated molecular weight of the fragment was ca. 11.33 kDa, hereafter refered to as the 11K domain) from ToTV RNA1 induced an HR-like phenotype in infiltrated leaves. To investigate whether the 11K domain could influence the virulence and pathogenicity of a recombinant virus, we created a potato virus X (PVX) with the 11K coding sequence inserted

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2016 Archives of Virology

138. Hypersensitivity Reaction

Hypersensitivity Reaction Hypersensitivity Reaction Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hypersensitivity Reaction (...) Hypersensitivity Reaction Aka: Hypersensitivity Reaction , Gell and Coombs Classification , Coombs and Gell Classification , Type 1 Hypersensitivity , Immediate Hypersensitivity Reaction , Type 2 Hypersensitivity , Cytotoxic Antibody Reaction , Type 3 Hypersensitivity , Immune Complex Reaction , Type 4 Hypersensitivity , Delayed-Type Hypersensitivity , Type 5 Hypersensitivity , Stimulatory Hypersensitivity II. Definition Categories of Hypersensitivity Response III. Type 1: Immediate Hypersensitivity Reaction

2018 FP Notebook

139. Immediate hypersensitivity reactions to ibuprofen and other arylpropionic acid derivatives. (PubMed)

Immediate hypersensitivity reactions to ibuprofen and other arylpropionic acid derivatives. Although ibuprofen and other arylpropionic acid derivatives (APs) are the most common medicines involved in hypersensitivity drug reactions (HDRs) to NSAIDs, no patient series studies have been performed regarding immediate selective reactions (SRs) to these drugs.To characterize patients with immediate selective HDRs to ibuprofen and other APs through clinical history and challenge.Subjects who (...) as selective immediate hypersensitivity reactors by both clinical history and challenge. A selective response to naproxen and dexketoprofen with tolerance to ibuprofen was found in 16 of 20 cases. Significant differences in serum tryptase levels were observed between 2 and 24 h in the 11 cases that were studied further.Within the group of patients with HDRs to NSAIDs, APs can induce immediate SRs. Within this group, selective responses to a single drug or responders to several APs may exist, suggesting

2016 Allergy

140. Successful rapid subcutaneous desensitization to Anakinra in a case of delayed-type hypersensitivity reaction. (PubMed)

Successful rapid subcutaneous desensitization to Anakinra in a case of delayed-type hypersensitivity reaction. 26852184 2017 06 13 2017 08 17 1365-2133 174 6 2016 Jun The British journal of dermatology Br. J. Dermatol. Successful rapid subcutaneous desensitization to anakinra in a case of delayed-type hypersensitivity reaction. 1417-8 10.1111/bjd.14454 Leroy V V Department of Dermatology and Paediatric Dermatology, National Reference Center for Rare Skin Disorders, Hôpital Saint-André (...) -André, University of Bordeaux, 1 Rue Jean Burguet, 33075, Bordeaux CEDEX, France. INSERM U1035, University of Bordeaux, Bordeaux, France. eng Case Reports Letter 2016 03 20 England Br J Dermatol 0004041 0007-0963 0 Antirheumatic Agents 0 Interleukin 1 Receptor Antagonist Protein IM Adult Antirheumatic Agents administration & dosage adverse effects Drug Administration Schedule Drug Eruptions etiology Female Humans Hypersensitivity, Delayed chemically induced Interleukin 1 Receptor Antagonist Protein

2016 British Journal of Dermatology

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