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Hypersensitivity Reaction

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121. Suspected perioperative allergic reactions: nomenclature and terminology. (Abstract)

Suspected perioperative allergic reactions: nomenclature and terminology. Standardising nomenclature facilitates diagnostic and therapeutic algorithms, improves comparisons of data in scientific research and reduces misunderstanding. Here, we propose a nomenclature for suspected perioperative allergic reactions.Copyright © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

2019 British Journal of Anaesthesia

122. Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations. Full Text available with Trip Pro

Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations. Suspected perioperative allergic reactions are rare but can be life-threatening. The diagnosis is difficult to make in the perioperative setting, but prompt recognition and correct treatment is necessary to ensure a good outcome. A group of 26 international experts in perioperative allergy (anaesthesiologists, allergists, and immunologists) contributed to a modified (...) Delphi consensus process, which covered areas such as differential diagnosis, management during and after anaphylaxis, allergy investigations, and plans for a subsequent anaesthetic. They were asked to rank the appropriateness of statements related to the immediate management of suspected perioperative allergic reactions. Statements were selected to represent areas where there is a lack of consensus in existing guidelines, such as dosing of epinephrine and fluids, the management of impending cardiac

2019 British Journal of Anaesthesia

123. Allergic reaction to platelet-rich plasma (PRP): Case report. Full Text available with Trip Pro

Allergic reaction to platelet-rich plasma (PRP): Case report. In the recent years, growing interest is focused on the use of platelet-rich plasma (PRP) in wound healing and tissue regeneration. There are a number of papers regarding the usefulness of PRP in the healing of ulcerations, skin injures, bone loss or distraction osteogenesis. Most authors emphasize the safety of PRP usage due to its authogenic nature.We present a case of a 14 -year-old boy admitted to our department due to simple (...) (Clemastinum)-both antihistaminic drugs.All symptoms withdrew and the patient was released home after 4 days. The patient is in 6 years follow-up without any symptoms of allergic disease.Our case shows that safety of use of PRP is not absolutely sure. The pure autologous tissue is safe, but preparation for its use can substantially decrease this safety. In our patient, only limited skin reaction to calcium citrate was observed, but general reaction leading to anaphylactic shock cannot be excluded. In order

2019 Medicine

124. Thimerosal induces skin pseudo-allergic reaction via Mas-related G-protein coupled receptor B2. Full Text available with Trip Pro

Thimerosal induces skin pseudo-allergic reaction via Mas-related G-protein coupled receptor B2. Thimerosal has been used as a preservative in many products which may cause contact dermatitis. It is the second most common allergen in positive patch test reactions, though being a clinical irrelevant allergen. Thimerosal-induced contact dermatitis is generally considered to be a delayed-type hypersensitivity reaction, but it is difficult to explain the fact that most patients develop an allergic (...) reaction upon first encounter with thimerosal. Recent studies have demonstrated the association between Mas-related G protein coupled receptor X2 (MRGPRX2) and pseudo-allergic reactions which occur at the first contact with stimulation. This suggests the possibility that thimerosal may cause contact dermatitis via MRGPRX2 mediated mechanism.To investigate the role of Mas-related G-protein coupled receptor B2 (MrgprB2)/MRGPRX2 in contact dermatitis induced by thimerosal.Thimerosal induced pseudo

2019 Journal of dermatological science

125. Sensitivity and specificity of passive immune-basophil activation test to detect allergic transfusion reactions. (Abstract)

Sensitivity and specificity of passive immune-basophil activation test to detect allergic transfusion reactions. The basophil activation test (BAT), performed with patient blood samples and supernatants from transfused blood, was developed to elucidate the mechanistic relationship between transfusion and the resultant allergic transfusion reactions (ATRs). This test cannot be performed on myelosuppressed patients and neonates because of the absence of basophils. Therefore, we devised (...) the passive immune basophil activation test (pi-BAT) using patients' plasma and residual transfused blood as sources of immunoglobulin E and allergen, respectively, and the basophils of healthy volunteers served as a source of the responder cells. The sensitivity and specificity of the pi-BAT, however, remained largely unknown.In this study, the pi-BAT was performed on 31 patients with nonhemolytic transfusion reactions including nine non-ATR and 22 ATR (12 mild and 10 moderate-to-severe) cases to examine

2019 Transfusion

126. Investigation of factors associated with allergic transfusion reaction due to platelet transfusion and the efficacy of platelets resuspended in BRS-A in adult patients. (Abstract)

Investigation of factors associated with allergic transfusion reaction due to platelet transfusion and the efficacy of platelets resuspended in BRS-A in adult patients. Although allergic transfusion reactions (ATRs) resulting from platelet concentrate (PC) are a common adverse reaction, the mechanism underlying ATRs has not been fully elucidated. Plasma-replaced PC suspended in bicarbonate Ringer's solution and anticoagulant citrate dextrose solution A (RPC-B) is effective for preventing ATRs

2019 Transfusion

127. Comment on "Calcium preparations do not inhibit allergic reactions: a randomized controlled trial". Full Text available with Trip Pro

Comment on "Calcium preparations do not inhibit allergic reactions: a randomized controlled trial". 28984281 2019 01 17 2019 01 17 1897-9483 127 9 2017 09 29 Polish archives of internal medicine Comment on "Calcium preparations do not inhibit allergic reactions: a randomized controlled trial". 577-578 10.20452/pamw.4105 Bodzenta-Łukaszyk Anna A Łukaszyk Mateusz M eng Editorial Comment 2017 09 29 Poland Pol Arch Intern Med 101700960 0032-3772 0 Calcium, Dietary IM Pol Arch Intern Med. 2017 Sep (...) 29;127(9):582-588 28724883 Calcium, Dietary Humans Hypersensitivity 2017 10 7 6 0 2017 10 7 6 0 2019 1 18 6 0 ppublish 28984281 10.20452/pamw.4105

2019 Polish archives of internal medicine Controlled trial quality: predicted high

128. Systemic reaction rates with omalizumab, subcutaneous immunotherapy, and combination therapy in children with allergic asthma. (Abstract)

Systemic reaction rates with omalizumab, subcutaneous immunotherapy, and combination therapy in children with allergic asthma. Background: For children with moderate-to-severe persistent allergic asthma, omalizumab is effective. However, it is expensive, and there are no current guidelines for discontinuation. Subcutaneous immunotherapy (SCIT) is the only approach that can provide persistent beneficial effects after treatment is discontinued. However, SCIT is contraindicated in poorly (...) controlled asthma. Therefore, we performed, to our knowledge, the first U.S. study that exclusively compared the safety of omalizumab, SCIT, and combination (omalizumab and SCIT) therapy in children with allergic asthma. Objective: We hypothesize that the systemic reaction (SR) rates in children who receive combination therapy are comparable with omalizumab alone. Methods: We performed a retrospective study of children ages 6-18 years old with allergic asthma who, from July 2010 to June 2017, received

2019 Allergy and Asthma Proceedings

129. Concomitant contact-allergic reactions to iodopropynyl butylcarbamate and iodine. (Abstract)

Concomitant contact-allergic reactions to iodopropynyl butylcarbamate and iodine. Iodopropynyl butylcarbamate (IPBC) is a broad-spectrum preservative for use in several product types, including cosmetics in which its concentrations have been limited by EU legislation because of concerns related to its iodine content and release, and risk of subsequent overdose.To report about concomitant patch-test reactions observed with iodine and IPBC in patients sensitized to iodine-containing (...) antiseptics.Between 2012 and 2018, 7 patients, six from Belgium and one from France, two suffering from acute dermatitis during surgical interventions, four from dermatitis due to wound treatment, and one from occupational dermatitis, were shown to be sensitized to iodine and/or povidone-iodine (PVP-I) which were considered relevant for their dermatitis. All patients were coincidentally also patch-tested with IPBC.All patients presented positive patch-test reactions to several other allergens, including IPBC

2019 Contact Dermatitis

130. The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions: current status. Full Text available with Trip Pro

The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions: current status. Suspected perioperative allergic reactions are often severe. To avoid potentially life-threatening re-exposure to the culprit drug, establishing a firm diagnosis and identifying the culprit is crucial. Drug provocation tests are considered the gold standard in drug allergy investigation but have not been recommended in the investigation of perioperative allergy (...) anaesthesiologists and allergists with experience in perioperative allergy investigation. In addition, 19 participating centres in the International Suspected Perioperative Allergic Reaction Group were surveyed on the use of provocation testing in perioperative allergy investigation. A response was received from 13 centres in eight European countries, New Zealand, and the USA. Also, 21 centres from the Australian and New Zealand Anaesthetic Allergy Group were surveyed. Two centres performed provocation routinely

2019 British Journal of Anaesthesia

131. Epicutaneous Exposure to Peanut Oil Induces Systemic and Pulmonary Allergic Reaction in Mice. (Abstract)

Epicutaneous Exposure to Peanut Oil Induces Systemic and Pulmonary Allergic Reaction in Mice. The prevalence of peanut allergy (PA) is constantly on the rise. Atopic dermatitis (AD) is a major risk factor for developing food allergy. Some bath oils and skin creams used for treating AD contain peanut oil, and it has been suggested that exposure to peanut allergens through a disrupted skin barrier is a potential cause of PA. Our aim was to investigate whether application of peanut oil (...) to irritated skin causes a systemic or respiratory allergic response to peanuts in an animal model.BALB/c mice underwent epicutaneous sensitization with either peanut oil (PM, n = 9) or phosphate buffered solution (controls, n = 9) daily for 5 consecutive days. Ten days after the last exposure the mice were challenged with intranasal peanut protein for 5 consecutive days. Bronchial alveolar lavage fluid was collected for cellular studies and measurement of cytokine levels. Sera were collected

2019 International Archives of Allergy and Immunology

132. Investigation of the factors that determine the severity of allergic reactions to Hymenoptera venoms. (Abstract)

Investigation of the factors that determine the severity of allergic reactions to Hymenoptera venoms. Introduction: Many risk factors that facilitate venom allergy and increase systemic reaction severity have been described in various studies, but the data are limited regarding this issue. We aimed to evaluate the impact of total immunoglobulin E (tIgE), specific IgE, and tryptase levels on the severity of systemic reactions in patients with a history of allergic reactions to Hymenoptera stings (...) . Method: Eighty-two patients with a history of allergic reaction to Hymenoptera venom admitted to our outpatient clinic between March 2016 and August 2017 were included. Venom-specific IgE (Apis mellifera and Vespula vulgaris), total IgE, and basal tryptase levels were measured. Skin-prick tests were performed with inhalant allergens. The levels of specific IgE, total IgE, and tryptase were compared between patients with large local reactions and systemic reactions, and the relation

2019 Allergy and Asthma Proceedings

133. Calcium preparations do not inhibit allergic reactions: a randomized controlled trial. Full Text available with Trip Pro

Calcium preparations do not inhibit allergic reactions: a randomized controlled trial. INTRODUCTION Massive consumption of dietary supplements, including vitamins and minerals, has recently become a serious health issue in Europe. Their use may negatively affect the pharmacological activity of various medications, including antiallergic drugs. Calcium preparations are commonly used in some European countries as a popular remedy for allergy‑related skin reactions, such as itching, erythema (...) , and wheals, as well as insect bites. However, so far there have been no reliable studies to prove their action.  OBJECTIVES The aim of this randomized, double‑blind, placebo‑controlled study was to investigate the efficacy of calcium salts in allergic reactions, using an allergen‑induced skin prick test (SPT).  PATIENTS AND METHODS Forty adult volunteers with allergic rhinoconjunctivitis or asthma (or both) were recruited to receive oral calcium carbonate (1000 mg) or placebo 3 times a day for 3 days

2019 Polish archives of internal medicine Controlled trial quality: predicted high

134. Identifying and managing patients at risk of severe allergic reactions to food: Report from two iFAAM workshops. (Abstract)

Identifying and managing patients at risk of severe allergic reactions to food: Report from two iFAAM workshops. Food allergy affects a small but important number of children and adults. Much of the morbidity associated with food allergy is driven by the fear of a severe reaction and fatalities continue to occur. Foods are the commonest cause of anaphylaxis. One of the aims of the European Union-funded Integrated Approaches to Food Allergen and Allergy Risk Management (iFAAM) project (...) was to improve the identification and management of children and adults at risk of experiencing a severe reaction. A number of interconnected studies within the project have focused on quantifying the severity of allergic reactions; the impact of food matrix, immunological factors on severity of reactions; the impact of co-factors such as medications on the severity of reactions; utilizing single-dose challenges to understand threshold and severity of reactions; and community studies to understand

2019 Clinical and Experimental Allergy

135. Allergen immunotherapy: definition, indications, and reactions. (Abstract)

Allergen immunotherapy: definition, indications, and reactions. Specific allergen immunotherapy is the administration of increasing amounts of specific allergens to which the patient has type I immediate hypersensitivity. It is a disease-modifying therapy, indicated for the treatment of allergic rhinitis, allergic conjunctivitis, allergic asthma, and Hymenoptera hypersensitivity. Specific immunoglobulin E (IgE) antibodies for appropriate allergens for immunotherapy must be documented (...) . Indications for allergen immunotherapy include (1) inadequate symptom control despite pharmacotherapy and avoidance measures; (2) a desire to reduce the morbidity from allergic rhinitis and/or asthma, or reduce the risk of anaphylaxis from a future insect sting; (3) when the patient experiences undesirable adverse effects from pharmacotherapy; and (4) when avoidance is not possible. Several studies reported that immunotherapy in allergic rhinitis seems to prevent the development of new allergic

2019 Allergy and Asthma Proceedings

136. Prophylactic 3-hour graduated infusion schedule minimizes risk of carboplatin hypersensitivity reactions - A prospective study. (Abstract)

Prophylactic 3-hour graduated infusion schedule minimizes risk of carboplatin hypersensitivity reactions - A prospective study. Aim of this study was observation of hypersensitivity reaction (HSR) frequency by using a 3-hour graduated infusion protocol with appropriate premedication as a prophylactic measure in patients with gynecological cancer receiving carboplatin retreatment in second line or above. None of the patients had experienced HSRs to platinum previously.All the patients (...) ) or combination regime (401cycles). HSRs were recorded in only 11cycles (1.8%) in a total of 11 patients. While 8 of these patients had grade 1or 2 reactions (8.1%), only 3 patients had grade 3 reactions (3%). After pause in the infusion and complete resolution of HSR symptoms, an attempt of retreatment using this infusion protocol with extra premedication was successful in 6 of these patients without any reoccurrence of HSRs.In this prospective study, we report that prophylactic 3-hour graduated infusion

2017 Gynecologic Oncology

137. Are metals involved in tattoo-related hypersensitivity reactions? A case report. (Abstract)

Are metals involved in tattoo-related hypersensitivity reactions? A case report. Allergic reactions to tattoos are not uncommon. However, identification of the culprit allergen(s) remains challenging.We present a patient with papulo-nodular infiltration of 20-year-old tattoos associated with systemic symptoms that disappeared within a week after surgical removal of metal osteosynthesis implants from his spine. We aimed to explore the causal relationship between the metal implants (...) with an extract of the implants and metallic Ti on the tattooed skin evoked flare-up of the symptoms.The patient's hypersensitivity reaction and its spontaneous remission after removal of the implants indicate that Ti, possibly along with some of the other metals detected, could have played a major role in this particular case of tattoo-related allergy.© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2017 Contact Dermatitis

138. Evaluation of periprocedural hypersensitivity reactions. (Abstract)

Evaluation of periprocedural hypersensitivity reactions. Identifying the cause of periprocedural hypersensitivity reactions (HSRs) remains challenging because of the multitude of medications involved. Antibiotics are the most common cause in the United States, whereas neuromuscular blocking agents are most common in Europe.To identify causative agents for periprocedural HSRs.This study was a 7-year retrospective medical record review of patients evaluated between December 2009 and January 2017 (...) at a drug allergy center in Bronx, New York for periprocedural HSRs, defined as occurring soon before, during, or soon after a medical procedure or operation with or without general anesthesia. Demographics, description of historical HSRs, results of testing to potential causative medications, and tolerance of subsequent anesthesia were reviewed.Thirty-four patients completed a comprehensive evaluation. Skin testing identified an IgE-mediated cause in 22 patients (64.7%). The most common causative class

2017 Asthma & Immunology

139. Allergy-like Immediate Reactions with Herbal Medicines in Children: A Retrospective Study Using Data from VigiBase<sup>®</sup>. (Abstract)

Allergy-like Immediate Reactions with Herbal Medicines in Children: A Retrospective Study Using Data from VigiBase®. The use of herbal medicines in children and the general population is continually on the rise with an overall herbal lifetime and current use ranging between 0.8%-85.5% and 2.2%-8.9%, respectively. Although acute hypersensitivity reactions are generally considered to be rare, little knowledge exists on the frequency and type of these reactions especially in specific (...) adverse reactions reported in association with herbal medicine in children. Among those, 79 cases with 107 allergy-like reactions met our inclusion criteria. The most commonly reported WHO-ART terms were urticaria or rash/rash erythematous (59.8%), and allergic reaction (8.4%). The most frequently reported suspected herbal medicines were mixed herbal products (51.4%), Hedera helix (15.0%), and Echinacea purpurea (5.6%). Most frequent routes of administration were oral (75.9%), topical (8.9

2017 Pediatric Allergy and Immunology

140. Expression of CD73 slows down migration of skin dendritic cells, affecting the sensitization phase of contact hypersensitivity reactions in mice. Full Text available with Trip Pro

Expression of CD73 slows down migration of skin dendritic cells, affecting the sensitization phase of contact hypersensitivity reactions in mice. Application of haptens to the skin induces release of immune stimulatory ATP into the extracellular space. This "danger" signal can be converted to immunosuppressive adenosine (ADO) by the action of the ectonucleotidases CD39 and CD73, expressed by skin and immune cells. Thus, the expression and regulation of CD73 by skin derived cells may have (...) crucial influence on the outcome of contact hypersensitivity (CHS) reactions.To investigate the role of CD73 expression during 2,4,6-trinitrochlorobenzene (TNCB) induced CHS reactions.Wild type (wt) and CD73 deficient mice were subjected to TNCB induced CHS. In the different mouse strains the resulting ear swelling reaction was recorded along with a detailed phenotypic analysis of the skin migrating subsets of dendritic cells (DC).In CD73 deficient animals the motility of DC was higher as compared

2017 Journal of dermatological science

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