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Hypersensitivity Reaction

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101. Comparison of Hypersensitivity Reactions to Carboplatin Retreatment in Gynecologic Cancer Patients between One and Two Hour Infusions: a Randomized Trial Study (PubMed)

Comparison of Hypersensitivity Reactions to Carboplatin Retreatment in Gynecologic Cancer Patients between One and Two Hour Infusions: a Randomized Trial Study Objective: To compare the incidence rate of carboplatin hypersensitivity reactions (HSRs) in gynecologic cancer patients receiving one-hour or two-hour carboplatin retreatment infusions. Setting: A Prospective Randomized Controlled Trial. Methods: Recurrent gynecologic cancer patients 25 to 80-years of age who were scheduled to receive

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2017 Asian Pacific journal of cancer prevention : APJCP Controlled trial quality: uncertain

102. Stinging insect hypersensitivity: Evaluation and management in children and youth

Stinging insect hypersensitivity: Evaluation and management in children and youth There are two types of IgE-mediated reactions to stinging insects: large local reactions and systemic reactions. Acute management of large local reactions is symptomatic and a patient history of a large local reaction does not indicate need for an epinephrine auto-injector or venom immunotherapy. By contrast, acute management of systemic reactions requires intramuscular epinephrine. Long-term management includes (...) prescribing an epinephrine auto-injector and consideration for venom immunotherapy by a paediatric allergist.  Keywords:   Allergy; Anaphylaxis; Large local reaction; Stinging insect; Venom immunotherapy 

2018 Canadian Paediatric Society

103. Hypersensitivity pneumonitis

. Immunological reaction to inhaled antigen is corroborative. No pathognomonic tests. Treatment involves avoidance of causative agent and use of corticosteroids. Definition Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, is the result of non-IgE mediated immunological inflammation. HP is caused by repeated inhalation of non-human protein, which can be of natural plant or animal origin or can be the result of a chemical conjugated to a human airway protein, such as albumin (...) Hypersensitivity pneumonitis Hypersensitivity pneumonitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Hypersensitivity pneumonitis Last reviewed: February 2019 Last updated: October 2017 Summary High index of suspicion of disease when evaluating individuals with interstitial lung disease or recurrent flu-like illness. History of exposure to organic dust: for example, birds, agricultural dusts, and moulds

2017 BMJ Best Practice

104. Adverse reactions to nonsteroidal anti-inflammatory drugs and hypersensitivity to lipid transfer proteins (PubMed)

Adverse reactions to nonsteroidal anti-inflammatory drugs and hypersensitivity to lipid transfer proteins 27605905 2016 09 08 2018 11 13 1642-395X 33 4 2016 Aug Postepy dermatologii i alergologii Postepy Dermatol Alergol Adverse reactions to nonsteroidal anti-inflammatory drugs and hypersensitivity to lipid transfer proteins. 309-10 10.5114/ada.2016.61608 Nucera Eleonora E Allergy Unit, Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, Rome, Italy. Di Rienzo Alessia A Allergy Unit

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2016 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

105. Amlodipine-induced hypersensitivity reaction mimicking CD30+ mycosis fungoides (PubMed)

Amlodipine-induced hypersensitivity reaction mimicking CD30+ mycosis fungoides 27570814 2016 08 29 2019 02 26 2352-5126 2 4 2016 Jul JAAD case reports JAAD Case Rep Amlodipine-induced hypersensitivity reaction mimicking CD30(+) mycosis fungoides. 320-2 10.1016/j.jdcr.2016.06.013 Gochoco Ashley A Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania. Jones Elizabeth E Department of Dermatology and Cutaneous Biology, Thomas Jefferson University (...) JAAD Case Rep 101665210 2352-5126 GVHD, graft-versus-host disease amlodipine cutaneous T-cell lymphoma drug reaction mycosis fungoides 2016 8 30 6 0 2016 8 30 6 0 2016 8 30 6 1 epublish 27570814 10.1016/j.jdcr.2016.06.013 S2352-5126(16)30063-7 PMC4992011 J Cutan Pathol. 2008 Apr;35(4):358-65 17976210 J Eur Acad Dermatol Venereol. 2008 Dec;22(12):1522-4 18452522 Eur J Dermatol. 2009 May-Jun;19(3):292-4 19336342 Clin Drug Investig. 2006;26(3):125-33 17163243 Arch Intern Med. 1989 Apr;149(4):829-32

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2016 JAAD Case Reports

106. Histopathologic Spectrum of Hypersensitivity Reactions Associated with anti-CD52 Therapy (Alemtuzumab) (PubMed)

Histopathologic Spectrum of Hypersensitivity Reactions Associated with anti-CD52 Therapy (Alemtuzumab) Alemtuzumab is a humanized monoclonal antibody directed against CD52, a cell surface antigen on B and T lymphocytes, and used to treat B-cell chronic lymphocytic leukemia and cutaneous T-cell lymphoma. Skin rash is a common adverse reaction following treatment with alemtuzumab. However, the clinicopathologic features and immunologic basis for the reaction have not been previously reported.Our (...) dermatitis with multifocal parakeratosis, endothelial activation and perivascular lymphocytic infiltrate. Eosinophils were not a prominent feature.We describe the clinicopathologic features of a novel hypersensitivity reaction to alemtuzumb, and hypothesize it may be due to an immunologic response precipitated by the persistence of resident memory T-cells (TRM ) in the skin. Our findings raise awareness for a novel reaction pattern and guide the histopathologic interpretation of lesions which may

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2016 Journal of cutaneous pathology

107. Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint? (PubMed)

Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint? Longevity and accumulation of multiple context-dependent signaling pathways of long-standing inflammation (antigen-load or oxidative stress) are the results of decreased/altered regulation of immunity and loss of control switch mechanisms that we defined as Yin and Yang of acute inflammation or immune surveillance. Chronic inflammation is initiated by immune disruptors-induced progressive changes in physiology (...) , generally categorized as 'mild' (e.g., increased allergies), 'moderate' (e.g., hypertension, colitis, gastritis, pancreatitis, emphysema) or 'severe' (e.g., accelerated neurodegenerative and autoimmune diseases or site-specific cancers and metastasis) are variations of hypersensitivity responses of tissues that are manifested as different diseases in immune-responsive or immune-privileged tissues. Continuous release/presence of low level histamine (subclinical) in circulation could contribute

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2016 Clinical and translational medicine

108. The influence of the carrier molecule on amoxicillin recognition by specific IgE in patients with immediate hypersensitivity reactions to betalactams (PubMed)

The influence of the carrier molecule on amoxicillin recognition by specific IgE in patients with immediate hypersensitivity reactions to betalactams The optimal recognition of penicillin determinants, including amoxicillin (AX), by specific IgE antibodies is widely believed to require covalent binding to a carrier molecule. The nature of the carrier and its contribution to the antigenic determinant is not well known. Here we aimed to evaluate the specific-IgE recognition of different AX (...) -derived structures. We studied patients with immediate hypersensitivity reactions to AX, classified as selective or cross-reactors to penicillins. Competitive immunoassays were performed using AX itself, amoxicilloic acid, AX bound to butylamine (AXO-BA) or to human serum albumin (AXO-HSA) in the fluid phase, as inhibitors, and amoxicilloyl-poli-L-lysine (AXO-PLL) in the solid-phase. Two distinct patterns of AX recognition by IgE were found: Group A showed a higher recognition of AX itself and AX

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2016 Scientific reports

109. Rare case of type I hypersensitivity reaction to sodium hypochlorite solution in a healthcare setting (PubMed)

Rare case of type I hypersensitivity reaction to sodium hypochlorite solution in a healthcare setting Sodium hypochlorite is a clear yellowish solution with a characteristic odour of chlorine and is commonly used as a disinfectant and a bleaching agent. It is used in various healthcare settings for its fast-acting and broad-spectrum antimicrobial activity. It is a known irritant and there are some reports that it can also cause allergic contact dermatitis of type IV hypersensitivity. We report (...) a case of work-related type I hypersensitivity to sodium hypochlorite, presenting with recurrent urticarial rash and a positive prick test reaction to this chemical. He was subsequently excused from further exposure with no further recurrences of the urticarial rash. To the best of our knowledge, this is the first such reported case due to work in the healthcare setting.2016 BMJ Publishing Group Ltd.

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2016 BMJ case reports

110. Utility of serum anti‐cetuximab immunoglobulin E levels to identify patients at a high risk of severe hypersensitivity reaction to cetuximab (PubMed)

Utility of serum anti‐cetuximab immunoglobulin E levels to identify patients at a high risk of severe hypersensitivity reaction to cetuximab Cetuximab is an anti-epidermal growth factor receptor antibody used for the treatment of metastatic colorectal cancer and head and neck cancer. Hypersensitivity reactions (HSRs) are associated with cetuximab use. The aim of the study was to evaluate the utility of anti-cetuximab immunoglobulin E (IgE) detection in order to identify patients at risk (...) % confidence interval, 2.4-45.6). Patients with severe HSRs had higher anti-cetuximab IgE levels than patients without reaction (median, 45 vs. 2 IgE arbitrary units, P = 0.006).Detection of pretreatment anti-cetuximab IgE is feasible and helpful to identify patients at risk of severe cetuximab-induced HSRs.© 2016 The British Pharmacological Society.

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2016 British journal of clinical pharmacology

111. Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions (PubMed)

Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions Adverse drug reactions adverse drug reaction (ADR) occur in approximately 17% of patients. Avoiding ADR is thus mandatory from both an ethical and an economic point of view. Whereas, pharmacogenetics changes of the pharmacokinetics may contribute to the explanation of some type A reactions, strong relationships of genetic markers has also been shown for drug hypersensitivity belonging to type B reactions. We present (...) the classifications of ADR, discuss genetic influences and focus on delayed-onset hypersensitivity reactions, i.e., drug-induced liver injury, drug-induced agranulocytosis, and severe cutaneous ADR. A guidance how to read and interpret the contingency table is provided as well as an algorithm whether and how a test for a pharmacogenetic biomarker should be conducted.

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2016 Frontiers in pharmacology

112. Circulating T cells to infliximab are detectable mainly in treated patients developing anti‐drug antibodies and hypersensitivity reactions (PubMed)

Circulating T cells to infliximab are detectable mainly in treated patients developing anti‐drug antibodies and hypersensitivity reactions Antibodies recognizing infliximab (IFX) may develop in a proportion of treated patients, leading to loss of response or hypersensitivity reactions (HRs). T cell response to IFX has been poorly investigated. This paper was addressed to detect IFX-specific T cells in treated patients with inflammatory diseases developing, or not, anti-drug antibodies (ADA

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2016 Clinical and experimental immunology

113. Methotrexate Hypersensitivity Reactions in Pediatrics: Evaluation and Management (PubMed)

Methotrexate Hypersensitivity Reactions in Pediatrics: Evaluation and Management Reports of hypersensitivity reactions (HSRs) to MTX are limited to single case studies. We retrospectively reviewed HSRs to MTX during a 12-year period in our tertiary care pediatric center. Seven patients were evaluated for HSRs to MTX. Skin testing was positive in one of the four patients tested. One patient underwent successful graded challenge to MTX. Seventeen desensitizations to MTX were successfully

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2016 Pediatric blood & cancer

114. Approach to hypersensitivity reactions from intravenous iron preparations. (PubMed)

Approach to hypersensitivity reactions from intravenous iron preparations. Hypersensitivity reactions (HSRs) to intravenous iron preparations (IVIPs) are well known. With newer preparations, HSRs have become rarer; however, severe reactions may still occur. We retrospectively reviewed records of patients evaluated for HSRs to IVIPs, to determine the safety of controlled re-administration (CRA). Allergological work-up included a detailed history, skin prick tests (SPTs) with IVIP, and basophil (...) activation tests (BATs) in some patients. CRA with an IVIP was carried out if indicated. Thirty-one patients with mild to severe reactions were evaluated. SPTs and BATs were negative in all patients tested. Eighteen CRAs in 15 patients were performed. Twelve patients tolerated the procedure, including three with a previous grade IV HSR. Two developed urticaria and one developed urticaria and dyspnea. The pathophysiology of HSRs to IVIPs remains currently unclear. SPTs and BATs provided no additional

2016 Allergy

115. Hypersensitivity reactions to metal implants: laboratory options. (PubMed)

Hypersensitivity reactions to metal implants: laboratory options. All implant compounds undergo an electrochemical process when in contact with biological fluids, as well as mechanical corrosion due to abrasive wear, with production of metal debris that may inhibit repair processes. None of the commonly-used methods can diagnose implant allergies when used singly, therefore a panel of tests should be performed on allergic patients as pre-operative screening, or when a postoperative metal (...) reactions and can confirm the diagnosis of hypersensitivity in patients with painful prostheses. The prevalence of a Th2-cytokine pattern may be used to identify predisposition to the development of allergic diseases, while the selective presence of osteoclastogenic cytokines may be used as predictor of a negative outcome in patients with painful prosthesis. The hypothesis of the prognostic value of these cytokines as early markers of aseptic loosening is attractive, but its confirmation would require

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2016 BMC Musculoskeletal Disorders

116. A novel risk score for prediction of hypersensitivity reactions in cancer patients receiving carboplatin: Retrospective observational analysis. (PubMed)

A novel risk score for prediction of hypersensitivity reactions in cancer patients receiving carboplatin: Retrospective observational analysis.

2016 Journal of Clinical Oncology

117. Severe Neck and Face Edema in an Adolescent-Delayed Hypersensitivity Reaction to Hair Dye. (PubMed)

Severe Neck and Face Edema in an Adolescent-Delayed Hypersensitivity Reaction to Hair Dye. Allergic contact reactions to hair dyes arise mostly due to sensitization to para-phenylenediamine (PPD). Para-phenylenediamine, a derivative of p-nitroanaline, is widely used as an oxydizable hair dye and is also found in black henna tattoo. Subsequent exposure to PPD may lead to delayed type IV hypersensitivity reaction manifesting as acute contact dermatitis. Here, a 15-year-old girl is presented, who (...) developed a hypersensitivity reaction after first exposure to hair dye. She was found to have been sensitized to PPD before, through application of black henna tatto.

2016 Pediatric Emergency Care

118. Adjunct histamine blockers as premedications to prevent carboplatin hypersensitivity reactions. (PubMed)

Adjunct histamine blockers as premedications to prevent carboplatin hypersensitivity reactions. The objective of this study was to evaluate the impact of premedications given as an adjunct to carboplatin on the incidence of hypersensitivity reactions in women with ovarian cancer. Medications of interest include a histamine1 (H1 ) and histamine2 (H2 ) blocker in addition to dexamethasone.This was a retrospective chart review evaluating the addition of an H1 and H2 blocker in addition (...) to dexamethasone as standard premedications on the incidence of carboplatin hypersensitivity reactions (CHRs) in women with ovarian cancer.The odds ratio for premedication use was 0.46 with a 95% confidence interval (0.17-1.27), suggesting that patients with premedication use had approximately half the risk of CHR compared with patients without premedication. The overall incidence of CHRs decreased from 7.9% at baseline to 3.2% after the addition of premedications. The incidence of CHRs was 5.2% in 58 patients

2016 Pharmacotherapy

119. In vitro tests for Drug Hypersensitivity Reactions. An ENDA/EAACI Drug Allergy Interest Group Position Paper. (PubMed)

In vitro tests for Drug Hypersensitivity Reactions. An ENDA/EAACI Drug Allergy Interest Group Position Paper. Drug hypersensitivity reactions (DHRs) are a matter of great concern, both for outpatient and in hospital care. The evaluation of these patients is complex, because in vivo tests have a suboptimal sensitivity and can be time-consuming, expensive and potentially risky, especially drug provocation tests. There are several currently available in vitro methods that can be classified (...) into two main groups: those that help to characterize the active phase of the reaction and those that help to identify the culprit drug. The utility of these in vitro methods depends on the mechanisms involved, meaning that they cannot be used for the evaluation of all types of DHRs. Moreover, their effectiveness has not been defined by a consensus agreement between experts in the field. Thus, the European Network on Drug Allergy and Drug Allergy Interest Group of the European Academy of Allergy

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2016 Allergy

120. Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10 years experience in allergy work-up. (PubMed)

Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10 years experience in allergy work-up. Non-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children (...) are labeled as 'drug allergic' after considering only the clinical history.To diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL METHODS: A prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma

2016 Pediatric Allergy and Immunology

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