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Hypersensitivity Reaction

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41. Allergic reaction to a green tattoo with nickel as a possible allergen. (Full text)

England Contact Dermatitis 7604950 0105-1873 allergic reaction allergy case report green hypersensitivity nickel pigment tattoo 2018 12 11 2019 01 15 2019 01 16 2019 1 22 6 0 2019 1 22 6 0 2019 1 22 6 0 aheadofprint 30663069 10.1111/cod.13226 (...) Allergic reaction to a green tattoo with nickel as a possible allergen. 30663069 2019 03 06 1600-0536 2019 Jan 21 Contact dermatitis Contact Derm. Allergic reaction to a green tattoo with nickel as a possible allergen. 10.1111/cod.13226 van der Bent Sebastiaan A S SAS Academic Tattoo Clinic Amsterdam, Department of Dermatology, Amsterdam University Medical Centre, Amsterdam, The Netherlands. Berg Tanja T Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany

2019 Contact Dermatitis PubMed abstract

42. Comparative epidemiology of suspected perioperative hypersensitivity reactions. (Full text)

Comparative epidemiology of suspected perioperative hypersensitivity reactions. Suspected perioperative hypersensitivity reactions are rare but contribute significantly to the morbidity and mortality of surgical procedures. Recent publications have highlighted the differences between countries concerning the respective risk of different drugs, and changes in patterns of causal agents and the emergence of new allergens. This review summarises recent information on the epidemiology (...) of perioperative hypersensitivity reactions, with specific consideration of differences between geographic areas for the most frequently involved offending agents.Copyright © 2019. Published by Elsevier Ltd.

2019 British Journal of Anaesthesia PubMed abstract

43. Prognostic value of hypersensitivity reactions on epidural steroid injection outcomes: a phenotypic signature? A prospective cohort study. (Full text)

Prognostic value of hypersensitivity reactions on epidural steroid injection outcomes: a phenotypic signature? A prospective cohort study. Studies have found that diffuse pain, indicative of central sensitization, portends poor interventional outcomes. Multiple chemical sensitivities are associated with signs of central sensitization. We sought to prospectively determine whether hypersensitivity reactions (HR) were associated with epidural steroid injection (ESI) outcomes.HR were classified

2019 Regional Anesthesia and Pain Medicine PubMed abstract

44. Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions. (Full text)

Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions. Grading schemes for severity of suspected allergic reactions have been applied to the perioperative setting, but there is no scoring system that estimates the likelihood that the reaction is an immediate hypersensitivity reaction. Such a score would be useful in evaluating current and proposed tests for the diagnosis of suspected perioperative immediate hypersensitivity reactions and culprit agents.We (...) process to devise a clinical scoring system for suspected perioperative immediate hypersensitivity reactions. This will enable objectivity and uniformity in the assessment of the sensitivity of diagnostic tests.Copyright © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

2019 British Journal of Anaesthesia PubMed abstract

45. An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions. (Full text)

An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions. Perioperative immediate hypersensitivity reactions are rare. Subsequent allergy investigation is complicated by multiple simultaneous drug exposures, the use of drugs with potent effects and the many differential diagnoses to hypersensitivity in the perioperative setting. The approach to the investigation of these complex reactions is not standardized and it is becoming increasingly apparent (...) that collaboration between experts in the field of allergy/immunology/dermatology and anaesthesiology is needed to provide the best possible care for these patients. The EAACI task force behind this position paper has therefore combined the expertise of allergists, immunologists and anaesthesiologists. The aims of this position paper are to provide recommendations for the investigation of immediate type perioperative hypersensitivity reactions and to provide practical information that can assist clinicians

2019 Allergy PubMed abstract

46. Hypersensitivity reactions to antiepileptic drugs in children. (Abstract)

. Sixty-six (66%) of 100 children had confirmed hypersensitivity reactions to AEDs. Fifty-nine children had positive patch test. No children had positive challenge tests. The most common AEDs causing hypersensitivity reactions were carbamazepine (45.4%), and lamotrigine (43.6%). Thirty-two children had positive tests for viruses or Mycoplasma pneumoniae and 9 of them had also a positive allergy work-up.Considering that there are not specific tests to distinguish between a viral infection (...) Hypersensitivity reactions to antiepileptic drugs in children. Antiepileptic drugs (AEDs) can cause hypersensitivity reactions in children. These reactions are mainly cutaneous, self-limiting and benign but life-threatening severe cutaneous adverse reactions can occur. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions, if a drug is taken at the same time. The aims of our study was to confirm or rule out the diagnosis of hypersensitivity reactions to AEDs

2019 Pediatric Allergy and Immunology

47. Immediate hypersensitivity reaction to human serum albumin in a child undergoing plasmapheresis. (Abstract)

Immediate hypersensitivity reaction to human serum albumin in a child undergoing plasmapheresis. Human serum albumin (HSA) is a commonly used colloid for volume expansion and albumin replacement and during plasmapheresis. Colloids are an uncommon cause of anaphylaxis, and cases of hypersensitivity reactions to HSA are extremely rare.A 10-year-old boy with chronic inflammatory demyelinating polyneuropathy was treated with plasmapheresis, with albumin as the replacement fluid. He developed (...) a severe reaction characterized by respiratory, gastrointestinal, and cutaneous symptoms.Skin testing to HSA was positive and resulted in objective systemic symptoms, suggesting an immediate hypersensitivity reaction to HSA.While colloids are an uncommon cause of immediate hypersensitivity reactions, they can lead to severe and potentially fatal reactions if not recognized and treated promptly.© 2019 AABB.

2019 Transfusion

48. Allergy-like reactions to methylene blue following laparoscopic chromopertubation: A systematic review of the literature. (Abstract)

of allergy-like reaction to methylene blue have been reported; these comprise two types: an allergic reaction and methemoglobinemia. In this study, a systematic literature review of allergy-like reactions caused by methylene blue dye following laparoscopic chromopertubation was conducted. A search was conducted in PUBMED, Web of Science, and Scopus from inception until June 2018, using the terms: "methylene blue", "complication", "allergic", "hypersensitive", "lung/pulmonary edema"," methemoglobinemia (...) Allergy-like reactions to methylene blue following laparoscopic chromopertubation: A systematic review of the literature. Methylene blue is commonly used as a tracer in sentinel lymph node mapping for many malignant diseases or chromopertubation during gynecologic laparoscopy. In contrast with other blue dyes such as patent blue V or isosulfan blue, methylene blue rarely causes an allergy-like reaction in patients undergoing sentinel lymph node mapping. However, in chromopertubation, some cases

2019 European journal of obstetrics, gynecology, and reproductive biology

49. Classification of hypersensitivity reactions. (Abstract)

Classification of hypersensitivity reactions. As the primary defense against pathogens, the immune system uses numerous strategies to ensure optimal protection for the host. When immune responses go awry, however, they can cause great damage. "Hypersensitivity" is a broad term used to describe an excessive and/or pathogenic immune response to either foreign or self antigens. Gell and Coombs were the first to categorize hypersensitivity reactions into 4 types according to pathophysiology

2019 Allergy and Asthma Proceedings

50. Beta-lactam allergy in the paediatric population

, children with true IgE-mediated allergy to penicillin medications are often advised to avoid all beta-lactam antibiotics, including cephalosporins, which is likely unnecessary in greater than 97% of those reporting penicillin allergies. Most patients can be safely treated with penicillin or amoxicillin if they do not have a history compatible with IgE-mediated or systemic, delayed reactions such as Stevens-Johnson syndrome (SJS), serum sickness-like reactions, drug reaction with eosinophilia (...) Beta-lactam allergy in the paediatric population Beta-lactam allergy is commonly diagnosed in paediatric patients, but over 90% of individuals reporting this allergy are able to tolerate the medications prescribed after evaluation by an allergist. Beta-lactam allergy labels are associated with negative clinical and administrative outcomes, including use of less desirable alternative antibiotics, longer hospitalizations, increasing antibiotic-resistant infections, and greater medical costs. Also

2020 Canadian Paediatric Society

51. Patch test reactions through the lens of dermoscopy: Further insights, particularly on weak allergic reactions. (Abstract)

Patch test reactions through the lens of dermoscopy: Further insights, particularly on weak allergic reactions. Distinguishing weak allergic reactions from irritant patch test reactions may be difficult.To describe the dermoscopic features of allergic reactions (especially weak allergic ones) and irritant patch test reactions and to assess the suitability of dermoscopy in supporting differential diagnosis.Eligible participants for this observational, cross-sectional study included consecutive (...) adult outpatients patch tested during a 12-month period, who developed any skin reaction. Healthy volunteers were patch tested with sodium lauryl sulfate as irritant controls. At the 72-hour reading, patch test reactions were recorded both with a digital camera and a digital dermoscopic system. For each reaction, clinical and dermoscopic variables were separately assessed, scored, and then compared.Erythema, vessels, and vesiculation were constant dermoscopic features of allergic reactions (n = 173

2019 Contact Dermatitis

52. Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo)

Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo) Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Allergic (...) Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo) (BdDAllergo) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03369509 Recruitment Status : Terminated (departure of the investigator from the CHU Grenoble Alpes) First Posted : December 12, 2017 Last Update Posted : February 6, 2019

2017 Clinical Trials

53. Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells (Full text)

Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells Glycyrrhizic acid (GA), the major bioactive triterpene glycoside of glycyrrhiza, has been shown to possess a wide range of pharmacological properties, including anti-inflammatory and anti-viral properties. However, few studies have examined the anti-allergic activity and exact mechanism of action of GA. In the present work, the anti-allergic activity and possible (...) mechanisms of action of GA on an immunoglobulin (Ig) E-mediated allergic reaction has been studied using three models of allergic reaction in vivo and in vitro. Active systemic allergic reaction in Balb/c mice showed that GA can suppress the increased level of IL-4 to restore the immune balance of TH1/TH2 cells in a dose-dependent manner. Additionally, GA attenuated significantly the B cells producing allergen-specific IgE and IgG1 partly because of the low levels of TH2 cytokines. Both passive cutaneous

2017 Scientific reports PubMed abstract

54. Biomarkers of severity and threshold of allergic reactions during oral peanut challenges. (Full text)

Biomarkers of severity and threshold of allergic reactions during oral peanut challenges. Oral food challenge (OFC) is the criterion standard to assess peanut allergy (PA), but it involves a risk of allergic reactions of unpredictable severity.Our aim was to identify biomarkers for risk of severe reactions or low dose threshold during OFC to peanut.We assessed Learning Early about Peanut Allergy study, Persistance of Oral Tolerance to Peanut study, and Peanut Allergy Sensitization study (...) participants by administering the basophil activation test (BAT) and the skin prick test (SPT) and measuring the levels of peanut-specific IgE, Arachis hypogaea 2-specific IgE, and peanut-specific IgG4, and we analyzed the utility of the different biomarkers in relation to PA status, severity, and threshold dose of allergic reactions to peanut during OFC.When a previously defined optimal cutoff was used, the BAT diagnosed PA with 98% specificity and 75% sensitivity. The BAT identified severe reactions

2020 Journal of Allergy and Clinical Immunology PubMed abstract

55. Identification of pigments related to allergic tattoo reactions in 104 human skin biopsies. (Full text)

Identification of pigments related to allergic tattoo reactions in 104 human skin biopsies. Red tattoos are prone to allergic reactions. The identity of the allergen(s) is mostly unknown.Chemical analysis of human skin biopsies from chronic allergic reactions in red tattoos to identify culprit pigment(s) and metals.One hundred four dermatome biopsies were analyzed by matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS) for identification of commonly used organic (...) % of the biopsies, no red pigment was detected. Element analysis indicated the presence of the sensitizers nickel and chromium.P.R. 22, P.R. 170, and P.R. 210 were identified as the prevailing pigments behind chronic allergic reactions in red tattoos. The epitope causing the reaction might be a pigment-degradation product. Metal contamination may derive from different sources, and its role in red tattoo allergy cannot be ascertained.© 2019 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.

2020 Contact Dermatitis PubMed abstract

56. Exercise-induced allergic reactions on desensitization to wheat after rush oral immunotherapy. (Abstract)

Exercise-induced allergic reactions on desensitization to wheat after rush oral immunotherapy. The effect of oral immunotherapy (OIT) on wheat allergy is promising in terms of the potential to obtain desensitization; however, the frequency of exercise-induced allergic reactions on desensitization (EIARDs) and the associated risk factors remain to be determined.Twenty-five patients underwent rush OIT for wheat allergy, and 21 achieved the full-dose intake of wheat products (5 g of wheat protein (...) frequently observed and remained for a long period after successful OIT for wheat allergy. None of the specific wheat components were found to contribute to EIARDs.© 2020 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.

2020 Allergy

57. Adverse cutaneous reaction to diabetic glucose sensors and insulin pumps: Irritant contact dermatitis or allergic contact dermatitis? (Abstract)

Adverse cutaneous reaction to diabetic glucose sensors and insulin pumps: Irritant contact dermatitis or allergic contact dermatitis? Adverse cutaneous reactions to diabetes medical devices (glucose sensors and insulin pumps) are described, notably allergic contact dermatitis (ACD) with isobornyl acrylate (IBOA) and N,N dimethylacrylamide (DMAA) as the main allergen.To determine if all cases of adverse cutaneous reactions observed with diabetes medical devices (ie FreeStyle Libre, Enlite (...) sensors or insulin pumps), referred to our department with suspected allergies are confirmed as ACD.Fifty-two patients who presented skin reactions to diabetes medical devices were patch tested with the European baseline series, a plastic and glues series, a (meth) acrylates series, a piece of the adhesive part of the device, as well as IBOA 0.1% and DMAA 0.1% pet.Seventeen patients had no positive reaction to IBOA nor to the adhesive part of the device; 11 of these also tested with DMAA with negative

2020 Contact Dermatitis

58. Dual transcriptomic and epigenomic study of reaction severity in peanut-allergic children. (Full text)

Dual transcriptomic and epigenomic study of reaction severity in peanut-allergic children. Unexpected allergic reactions to peanut are the most common cause of fatal food-related anaphylaxis. Mechanisms underlying the variable severity of peanut-allergic reactions remain unclear.We sought to expand mechanistic understanding of reaction severity in peanut allergy.We performed an integrated transcriptomic and epigenomic study of peanut-allergic children as they reacted in vivo during double-blind (...) , placebo-controlled peanut challenges. We integrated whole-blood transcriptome and CD4+ T-cell epigenome profiles to identify molecular signatures of reaction severity (ie, how severely a peanut-allergic child reacts when exposed to peanut). A threshold-weighted reaction severity score was calculated for each subject based on symptoms experienced during peanut challenge and the eliciting dose. Through linear mixed effects modeling, network construction, and causal mediation analysis, we identified

2020 Journal of Allergy and Clinical Immunology PubMed abstract

59. A Randomized Trial of Prophylactic Extended Carboplatin Infusion to Reduce Hypersensitivity Reactions in Recurrent Ovarian Cancer. (Full text)

A Randomized Trial of Prophylactic Extended Carboplatin Infusion to Reduce Hypersensitivity Reactions in Recurrent Ovarian Cancer. Hypersensitivity with repeated exposure to platinum agents is common and can preclude continued treatment, even in patients with disease that remains platinum sensitive. We sought to compare the effects of prophylactic, extended carboplatin infusion versus standard infusion on the rate of carboplatin hypersensitivity reactions (HSRs) in women with recurrent ovarian

2018 International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Controlled trial quality: uncertain PubMed abstract

60. Hypersensitivity reactions with prolonged infusions of beta-lactams? (Full text)

Hypersensitivity reactions with prolonged infusions of beta-lactams? 30195470 2018 12 23 1469-0691 25 1 2019 Jan Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Clin. Microbiol. Infect. Hypersensitivity reactions with prolonged infusions of β-lactams? 121-122 S1198-743X(18)30599-8 10.1016/j.cmi.2018.08.021 Fjeld H H Department of Pharmacology, RELIS Information Center and Department of Infection Prevention (...) , Oslo universitetssykehus, Oslo, Norway. Electronic address: hilde.fjeld@ous-hf.no. Stylianou E E Department of Pulmonary Diseases, Regional Unit for Asthma, Allergy and Hypersensitivity, Oslo universitetssykehus, Oslo, Norway. Electronic address: evasty@ous-hf.no. eng Letter 2018 09 07 England Clin Microbiol Infect 9516420 1198-743X 2018 07 04 2018 08 24 2018 08 25 2018 9 10 6 0 2018 9 10 6 0 2018 9 10 6 0 ppublish 30195470 S1198-743X(18)30599-8 10.1016/j.cmi.2018.08.021

2018 Clinical Microbiology and Infection PubMed abstract

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