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Hyperpigmentation

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161. Familial Progressive Hyperpigmentation: A Case Report (PubMed)

Familial Progressive Hyperpigmentation: A Case Report Familial progressive hyperpigmentation (FPH) is a rare genodermatosis characterized by hyperpigmented patches in the skin and mucous membranes, present in early infancy, and increase in size and number with age. The genetic basis for FPH remains unknown. We report an unusual case of familial progressive hypermelanosis in a 17-year-old male patient with family history, who presented with a peculiar progressive oral pigmentation disorder

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2012 Case reports in dentistry

162. Familial glucocorticoid deficiency presenting with generalized hyperpigmentation in adolescence. Report of three siblings (PubMed)

Familial glucocorticoid deficiency presenting with generalized hyperpigmentation in adolescence. Report of three siblings Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterized by glucocorticoid deficiency, high ACTH levels and normal mineralocorticoid levels. FGD is caused due to defects in adrenocorticotropic hormone (ACTH) signaling. The defect can be caused by mutations in genes encoding the ACTH receptor (melanocortin 2 receptor) or its accessory (...) protein.Here we report three siblings with FGD. The second in order of siblings presented at an age of 15 years with history of diffuse hyperpigmentation since childhood. Their parents were non consanguineous. The patients were hyperpigmented and taller compared with their parents. None of the siblings had ambiguous genitalia or neurological abnormalities. There was no history of tuberculosis in the family. Biochemical investigations revealed low serum cortisol (<1 μg/dl) and elevated plasma ACTH (>1250 pg

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2012 Indian journal of endocrinology and metabolism

163. Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study. (PubMed)

Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study. Progressive cribriform and zosteriform hyperpigmentation (PCZH) is a disorder of pigmentation. Although several cases of PCZH have been reported, no clinicopathologic studies of the condition have been published in the English-language literature.The purpose of this study was to determine the clinical characteristics and histologic findings of PCZH.Between 1999 and 2009, 30 patients were diagnosed with PCZH

2012 International Journal of Dermatology

164. Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma. (PubMed)

Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma. Pyrostegia venusta is a native Brazilian plant which has a variety of uses in traditional folk medicine including the treatment of vitiligo. However, its effectiveness on melanogenesis is not yet elucidated.This study aimed to investigate the melanogenic activity of hydroalcoholic extracts from the leaves and flowers of P. venusta on murine B16F10 melanoma cells.Different concentrations

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2012 Journal of Ethnopharmacology

165. PDZK1 Upregulation in Estrogen-Related Hyperpigmentation in Melasma. (PubMed)

PDZK1 Upregulation in Estrogen-Related Hyperpigmentation in Melasma. The pathogenesis of melasma is unknown, although the potential role of estrogen has been considered. Microarray and real-time PCR analyses revealed that upregulation of PDZ domain protein kidney 1 (PDZK1) is clinically correlated with melasma. Although there has been no report that PDZK1 is involved in pigmentation and/or melanogenesis, PDZK1 expression can be induced by estrogen. In this study, the role of PDZK1 upregulation

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2012 Journal of Investigative Dermatology

166. Approaches to the evaluation of lip hyperpigmentation. (PubMed)

Approaches to the evaluation of lip hyperpigmentation. Hyperpigmentation of the lips is a common condition. It is associated with a wide variety of conditions that include physiologic changes, genodermatoses, inflammatory diseases, endocrinologic disorders, drugs and chemicals, benign and malignant neoplasm, and other non-melanotic conditions. The aim of this article is to provide a clinical approach to hyperpigmented lesions on the lips based on the extent of lesions, the age of onset

2012 International Journal of Dermatology

167. New horizons in treating disorders of hyperpigmentation in skin of color. (PubMed)

New horizons in treating disorders of hyperpigmentation in skin of color. Pigmentary abnormalities are among the most common reasons why patients with skin of color visit a dermatologist. Hydroquinone has been a cornerstone for the treatment of hyperpigmentation; however, concerns regarding adverse effects have prompted a search for alternative agents. Some promising topical treatments include soy, licorice, rucinol, mulberry, niacinamide, ellagic acid, resveratrol, and dioic acid. Oral agents (...) , primarily used for the prevention of postprocedural hyperpigmentation, include procyanidins, tranexamic acid, and Polypodium leucotomos. Advances in Q-switched lasers, intense pulse light, fractional photothermolysis, and the advent of tretinoin peeling add to the clinician's armamentarium for treating hyperpigmentation.Copyright © 2012 Elsevier Inc. All rights reserved.

2012 Seminars in Cutaneous Medicine and Surgery

168. Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation

Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01542138 Recruitment Status : Completed First Posted : March 2, 2012 Last Update Posted : November 29

2012 Clinical Trials

169. Tongue hyperpigmentation during hepatitis C treatment (PubMed)

Tongue hyperpigmentation during hepatitis C treatment 22451683 2012 11 28 2018 12 01 1488-2329 184 13 2012 Sep 18 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Tongue hyperpigmentation during hepatitis C treatment. 1498 10.1503/cmaj.111985 Bachmeyer Claude C Department of Internal Medicine, Tenon Hospital, Paris, France. claude.bachmeyer@tnn.aphp.fr Pellen Jean-Charles JC eng Case Reports Journal Article 2012 03 26 Canada CMAJ 9711805 0820-3946 (...) 0 Antiviral Agents 0 Interferon-alpha 0 Recombinant Proteins 3WJQ0SDW1A Polyethylene Glycols 49717AWG6K Ribavirin Q46947FE7K peginterferon alfa-2a AIM IM Antiviral Agents administration & dosage adverse effects therapeutic use Drug Therapy, Combination Female Hepatitis C drug therapy Humans Hyperpigmentation chemically induced pathology Interferon-alpha administration & dosage adverse effects therapeutic use Middle Aged Polyethylene Glycols administration & dosage adverse effects therapeutic use

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2012 CMAJ : Canadian Medical Association Journal

170. Oral Mucosa Hyperpigmentation

Oral Mucosa Hyperpigmentation Oral Mucosa Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Oral Mucosa (...) Hyperpigmentation Oral Mucosa Hyperpigmentation Aka: Oral Mucosa Hyperpigmentation , Melanin Pigmentation of Oral Mucosa From Related Chapters II. Causes May be associated with in autoimmune polyendocrinopathy- -ectodermal dystrophy syndrome Darker pigmentation related to ethnicity abuse 1 McCune-Albright Syndrome Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Oral Mucosa Hyperpigmentation." Click on the image (or right click) to open

2015 FP Notebook

171. Postinflammatory Hyperpigmentation

Postinflammatory Hyperpigmentation Postinflammatory Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Postinflammatory (...) Hyperpigmentation Postinflammatory Hyperpigmentation Aka: Postinflammatory Hyperpigmentation From Related Chapters II. Definition response to inflammation on dark skin III. Pathophysiology Common complication following or inflammation in darker skin type (3 to 6) Local inflammation results in prostaglandin, leukotriene and thromboxane release Epidermal s hypertrophy, synthesizing IV. Causes: Common precipitating lesions Inflammation Laser therapy or V. Signs Irregular, dark s and patches at sites of injury

2015 FP Notebook

172. Medication Causes of Hyperpigmentation

Medication Causes of Hyperpigmentation Medication Causes of Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Medication Causes of Hyperpigmentation Medication Causes of Hyperpigmentation Aka: Medication Causes of Hyperpigmentation , Hyperpigmentation Due to Medication , Drug Induced Hyperpigmentation From Related Chapters II. Causes ( ) Bismuth Bleomycin Busulfan Clofazimine Cyclophosphamide Daunorubicin Dibromomannitol Doxorubicin Gold Topical nitrogen mustard Phenothiazines Silver Zodovudine III. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2015 FP Notebook

173. Diffuse Hyperpigmentation

Diffuse Hyperpigmentation Diffuse Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diffuse Hyperpigmentation Diffuse (...) Hyperpigmentation Aka: Diffuse Hyperpigmentation , Melanism , Diffuse Hypermelanosis , Melanosis From Related Chapters II. Causes Excessive deposition: Excessive s: Phototoxic III. Signs Diffuse brown discoloration of skin pigmentation Accentuated areas Palmar creases Recent scars Pressure points at elbow, knee, and knuckles IV. Differential Diagnosis Localized Lesions (increased or s) See See Diffuse skin changes See See See Images: Related links to external sites (from Bing) These images are a random sampling

2015 FP Notebook

174. Hyperpigmentation

Hyperpigmentation Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation Hyperpigmentation Aka (...) : Hyperpigmentation From Related Chapters II. Causes: Hyperpigmentation Localized Lesions (increased or s) See See s Diffuse skin changes See See See See systemic causes below III. Causes: Systemic conditions with Hyperpigmentation Skin Endocrine and Metabolic See ( Deposition) Porphyria Hemosiderin deposition in Gastrointestinal Disease Whipple's Disease ( deposition) Genitalia Heller-Nelson Syndrome Hematology and Oncology Neoplasm Nutrition Starvation Medications and toxins See (increased s) Images: Related

2015 FP Notebook

175. Hyperpigmentation in Pregnancy

Hyperpigmentation in Pregnancy Hyperpigmentation in Pregnancy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation (...) in Pregnancy Hyperpigmentation in Pregnancy Aka: Hyperpigmentation in Pregnancy , Chadwick's Sign , Linea Nigra II. Physiology stimulating hormone rises in early pregnancy Increased deposition III. Signs: General Scarred areas and nevi darken Pigmented areas become more pigmented Areola Axilla External genitalia Anal region Linea Nigra IV. Signs: Specific Chadwick's Sign Darkened vulva and vagina or ( ) Dark areas under eyes and bridge nose Linea Nigra Dark midline low Images: Related links to external

2015 FP Notebook

176. Hyperpigmentation and atrophy. (PubMed)

Hyperpigmentation and atrophy. We suspected a malignancy, but a conversation with the patient provided a telling clue.

2012 Journal of Family Practice

177. Reduced WIF-1 Expression Stimulates Skin Hyperpigmentation in Patients with Melasma. (PubMed)

Reduced WIF-1 Expression Stimulates Skin Hyperpigmentation in Patients with Melasma. The expression of Wnt inhibitory factor-1 (WIF-1) gene, which was detected by a microarray analysis of hyperpigmented and normally pigmented skin sets of melasma patients, was significantly reduced in the hyperpigmented skin from melasma patients, but not in healthy controls, regardless of UV irradiation. Wnt signals regulate skin pigmentation; however, WIF-1 is expressed in cultured skin keratinocytes (...) and fibroblasts, but not in melanocytes. Therefore, we examined whether WIF-1 knockdown in neighboring keratinocytes and fibroblasts plays a role in melasma. Additionally, the effect of WIF-1 overexpression on the amelioration of hyperpigmentation was examined. WIF-1 knockdown, either in fibroblasts or in keratinocytes, significantly stimulated tyrosinase expression and melanosome transfer, whereas melanocytes with WIF-1 overexpression significantly reduced those parameters. The WIF-1 knockdown decreased

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2012 Journal of Investigative Dermatology

178. Efficacy and Safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for the Treatment of Acne and Acne-induced Post-inflammatory Hyperpigmentation in Patients with Skin of Color. (PubMed)

Efficacy and Safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for the Treatment of Acne and Acne-induced Post-inflammatory Hyperpigmentation in Patients with Skin of Color. To assess the efficacy and safety of a topical gel containing clindamycin 1.2% and tretinoin 0.025% for the treatment of acne and acne-induced postinflammatory hyperpigmentation (PIH) in darker skinned patients.Randomized, double-blind, placebo-controlled study.Two United States clinical sites.Thirty-three (...) patients 12 years of age or older with skin types IV to VI, mild-to-moderate facial acne, and PIH were enrolled.Patients applied clindamycin phosphate/tretinoin gel or a nonmedicated vehicle each evening and a sun protection factor 30 sunscreen daily. Changes in skin erythema and hyperpigmentation were measured using a chromameter and photographic images. Efficacy was assessed using the Evaluators Global Acne Severity Scale, lesion counts, Post-inflammatory Hyperpigmentation Severity Scales

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2012 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

179. A randomized control study of the prevention of hyperpigmentation post Q-switched Nd:YAG laser treatment of Hori nevus using topical fucidic acid plus betamethasone valerate cream versus fucidic acid cream. (PubMed)

A randomized control study of the prevention of hyperpigmentation post Q-switched Nd:YAG laser treatment of Hori nevus using topical fucidic acid plus betamethasone valerate cream versus fucidic acid cream. Post-inflammatory hyperpigmentation (PIH) after laser treatment of Hori nevus remains problematic. Prevention and treatment of PIH have limited success.To study the effects on hyperpigmentation using topical antibiotic alone versus combined antibiotic and betamethasone/valerate after 1064 nm

2012 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology Controlled trial quality: uncertain

180. Management of Gingival Hyperpigmentation by Semiconductor Diode Laser (PubMed)

Management of Gingival Hyperpigmentation by Semiconductor Diode Laser Gingival hyperpigmentation is caused by excessive deposition of melanin in the basal and suprabasal cell layers of the epithelium. Although melanin pigmentation of the gingiva is completely benign, cosmetic concerns are common, particularly in patients having a very high smile line (gummy smile). Various depigmentation techniques have been employed, such as scalpel surgery, gingivectomy, gingivectomy with free gingival

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2011 Journal of cutaneous and aesthetic surgery

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