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Hyperpigmentation

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161. Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone. (Abstract)

Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone. Hydroquinone (HQ) is the benchmark prescription agent for skin lightening. However, HQ use is recently banned in Europe and in parts of Asia because of potential long-term consequences, including carcinogenesis when orally consumed. This has resulted in development of alternative skin-lightening agents with comparable efficacy to HQ

2013 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

162. Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation. (Abstract)

Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation. Skin lightening preparations are used by people all over the world for a diverse range of dermatologic indications. Hydroquinone (HQ) is the gold standard and remains the only prescription product available in the United States for the treatment of generalized facial hyperpigmentation. Irritation and the risk of exogenous (...) and distribution. A single-center, double-blind comparison clinical study of 18 subjects was conducted to evaluate the efficacy of the product in reducing ultraviolet-induced hyperpigmentation. Test sites were irradiated with 1.0, 1.5, 2.0, and 2.5 minimal erythema doses. After 5 days, to allow for pigmentation development, the product or 4% HQ cream was applied to the respective test sites, once daily for 4 weeks. Chroma Meter measurements (L* brightness) and standardized digital photographs were taken

2013 Journal of drugs in dermatology : JDD

163. Facial hyperpigmentation: causes and treatment. Full Text available with Trip Pro

Facial hyperpigmentation: causes and treatment. By midcentury, the U.S.A. will be more ethnically and racially diverse. Skin of colour will soon constitute nearly one-half of the U.S. population, and a full understanding of skin conditions that affect this group is of great importance. Structural and functional differences in the skin, as well as the influence of cultural practices, produce variances in skin disease and presentation based on skin type. In the skin of colour population (...) , dyschromia is a growing concern, and a top chief complaint when patients present to the physician. A thorough understanding of the aetiology and management strategies of facial hyperpigmentation is of importance in caring for those afflicted and also in the development of new therapies. © 2013 The Authors BJD © 2013 British Association of Dermatologists.

2013 British Journal of Dermatology

164. Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Full Text available with Trip Pro

Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Axillary hyperpigmentation is a frequent cause of cosmetic consultations in dark-skinned women from tropical areas, including Latin America. Currently, there is no widely accepted treatment for the disorder, but it is usually treated with bleaching agents because it is considered a variant of inflammatory hyperpigmentation. The purpose of this study (...) was performed by histochemistry and immunohistochemistry, assisted by computerized morphometric analysis.Both niacinamide and desonide induced significant colorimetric improvement compared with placebo; however, desonide showed a better depigmenting effect than niacinamide. A good to excellent response was achieved in 24% of cases for niacinamide, 30% for desonide, and 6% for placebo. We observed a marked disruption of the basal membrane in axillary hyperpigmentation and an inflammatory infiltrate

2013 Clinical, cosmetic and investigational dermatology Controlled trial quality: uncertain

165. Mixed hyperpigmentation and hypopigmentation of iris and choroid in Chediak-Higashi syndrome. (Abstract)

Mixed hyperpigmentation and hypopigmentation of iris and choroid in Chediak-Higashi syndrome. An 8-year-old Taiwanese girl presented with hyperpigmentation and scattered hypopigmentation in her irides and choroids. Her skin showed hyperpigmentation with speckled hypopigmentation over cheeks and sun-exposed areas. Medical history was remarkable for frequent infectious episodes and lower extremity bruising. A peripheral blood smear revealed large inclusion bodies in the cytoplasm of neutrophils

2013 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

166. Pain and Hyperpigmentation of the Toes: A Quiz. Full Text available with Trip Pro

Pain and Hyperpigmentation of the Toes: A Quiz. 23756605 2014 09 11 2014 02 26 1651-2057 94 2 2014 Mar Acta dermato-venereologica Acta Derm. Venereol. Pain and hyperpigmentation of the toes: a quiz. Hyperpigmentation of the toes caused by millipedes. 253-4 10.2340/00015555-1645 Sampaio Felipe Maurício Soeiro FM Department of Dermatology, Oswaldo Cruz Foudation, 21940210 Rio de Janeiro, Brazil. felipemauricio@uol.com.br. Valviesse Vitor Ribeiro Gomes de Almeida VR Lyra-da-Silva Julia Ocampo JO (...) Mesquita Emerson Cicilini EC Brandão Luciana Gomes Pedro LG do Valle Antonio Carlos Francesconi AC eng Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 IM Animals Arthropods Bites and Stings complications Brazil Female Humans Hyperpigmentation etiology Pain etiology Toes Young Adult 2013 6 13 6 0 2013 6 13 6 0 2014 9 12 6 0 ppublish 23756605 10.2340/00015555-1645

2013 Acta Dermato-Venereologica

167. A Novel Germline KIT Mutation (p.L576P) in a Family Presenting With Juvenile Onset of Multiple Gastrointestinal Stromal Tumors, Skin Hyperpigmentations, and Esophageal Stenosis. (Abstract)

A Novel Germline KIT Mutation (p.L576P) in a Family Presenting With Juvenile Onset of Multiple Gastrointestinal Stromal Tumors, Skin Hyperpigmentations, and Esophageal Stenosis. Familial gastrointestinal stromal tumor (GIST) syndrome is a rare autosomal dominant genetic disorder. We report on a kindred in which 3 family members carry a germline mutation (c.1727T>C, p.L576P) in exon 11 of the KIT gene. This mutation was not reported so far in familial GISTs. Apart from multiple GISTs in 2

2013 American Journal of Surgical Pathology

168. Hyperpigmentation in Pregnancy

Hyperpigmentation in Pregnancy Hyperpigmentation in Pregnancy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation (...) in Pregnancy Hyperpigmentation in Pregnancy Aka: Hyperpigmentation in Pregnancy , Chadwick's Sign , Linea Nigra II. Physiology stimulating hormone rises in early pregnancy Increased deposition III. Signs: General Scarred areas and nevi darken Pigmented areas become more pigmented Areola Axilla External genitalia Anal region Linea Nigra IV. Signs: Specific Chadwick's Sign Darkened vulva and vagina or ( ) Dark areas under eyes and bridge nose Linea Nigra Dark midline low Images: Related links to external

2015 FP Notebook

169. Diffuse Hyperpigmentation

Diffuse Hyperpigmentation Diffuse Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diffuse Hyperpigmentation Diffuse (...) Hyperpigmentation Aka: Diffuse Hyperpigmentation , Melanism , Diffuse Hypermelanosis , Melanosis From Related Chapters II. Causes Excessive deposition: Excessive s: Phototoxic III. Signs Diffuse brown discoloration of skin pigmentation Accentuated areas Palmar creases Recent scars Pressure points at elbow, knee, and knuckles IV. Differential Diagnosis Localized Lesions (increased or s) See See Diffuse skin changes See See See Images: Related links to external sites (from Bing) These images are a random sampling

2015 FP Notebook

170. Hyperpigmentation

Hyperpigmentation Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation Hyperpigmentation Aka (...) : Hyperpigmentation From Related Chapters II. Causes: Hyperpigmentation Localized Lesions (increased or s) See See s Diffuse skin changes See See See See systemic causes below III. Causes: Systemic conditions with Hyperpigmentation Skin Endocrine and Metabolic See ( Deposition) Porphyria Hemosiderin deposition in Gastrointestinal Disease Whipple's Disease ( deposition) Genitalia Heller-Nelson Syndrome Hematology and Oncology Neoplasm Nutrition Starvation Medications and toxins See (increased s) Images: Related

2015 FP Notebook

171. Medication Causes of Hyperpigmentation

Medication Causes of Hyperpigmentation Medication Causes of Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Medication Causes of Hyperpigmentation Medication Causes of Hyperpigmentation Aka: Medication Causes of Hyperpigmentation , Hyperpigmentation Due to Medication , Drug Induced Hyperpigmentation From Related Chapters II. Causes ( ) Bismuth Bleomycin Busulfan Clofazimine Cyclophosphamide Daunorubicin Dibromomannitol Doxorubicin Gold Topical nitrogen mustard Phenothiazines Silver Zodovudine III. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2015 FP Notebook

172. Postinflammatory Hyperpigmentation

Postinflammatory Hyperpigmentation Postinflammatory Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Postinflammatory (...) Hyperpigmentation Postinflammatory Hyperpigmentation Aka: Postinflammatory Hyperpigmentation From Related Chapters II. Definition response to inflammation on dark skin III. Pathophysiology Common complication following or inflammation in darker skin type (3 to 6) Local inflammation results in prostaglandin, leukotriene and thromboxane release Epidermal s hypertrophy, synthesizing IV. Causes: Common precipitating lesions Inflammation Laser therapy or V. Signs Irregular, dark s and patches at sites of injury

2015 FP Notebook

173. Oral Mucosa Hyperpigmentation

Oral Mucosa Hyperpigmentation Oral Mucosa Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Oral Mucosa (...) Hyperpigmentation Oral Mucosa Hyperpigmentation Aka: Oral Mucosa Hyperpigmentation , Melanin Pigmentation of Oral Mucosa From Related Chapters II. Causes May be associated with in autoimmune polyendocrinopathy- -ectodermal dystrophy syndrome Darker pigmentation related to ethnicity abuse 1 McCune-Albright Syndrome Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Oral Mucosa Hyperpigmentation." Click on the image (or right click) to open

2015 FP Notebook

174. A randomized control study of the prevention of hyperpigmentation post Q-switched Nd:YAG laser treatment of Hori nevus using topical fucidic acid plus betamethasone valerate cream versus fucidic acid cream. (Abstract)

A randomized control study of the prevention of hyperpigmentation post Q-switched Nd:YAG laser treatment of Hori nevus using topical fucidic acid plus betamethasone valerate cream versus fucidic acid cream. Post-inflammatory hyperpigmentation (PIH) after laser treatment of Hori nevus remains problematic. Prevention and treatment of PIH have limited success.To study the effects on hyperpigmentation using topical antibiotic alone versus combined antibiotic and betamethasone/valerate after 1064 nm

2012 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology Controlled trial quality: uncertain

175. Reduced WIF-1 Expression Stimulates Skin Hyperpigmentation in Patients with Melasma. Full Text available with Trip Pro

Reduced WIF-1 Expression Stimulates Skin Hyperpigmentation in Patients with Melasma. The expression of Wnt inhibitory factor-1 (WIF-1) gene, which was detected by a microarray analysis of hyperpigmented and normally pigmented skin sets of melasma patients, was significantly reduced in the hyperpigmented skin from melasma patients, but not in healthy controls, regardless of UV irradiation. Wnt signals regulate skin pigmentation; however, WIF-1 is expressed in cultured skin keratinocytes (...) and fibroblasts, but not in melanocytes. Therefore, we examined whether WIF-1 knockdown in neighboring keratinocytes and fibroblasts plays a role in melasma. Additionally, the effect of WIF-1 overexpression on the amelioration of hyperpigmentation was examined. WIF-1 knockdown, either in fibroblasts or in keratinocytes, significantly stimulated tyrosinase expression and melanosome transfer, whereas melanocytes with WIF-1 overexpression significantly reduced those parameters. The WIF-1 knockdown decreased

2012 Journal of Investigative Dermatology

176. Approaches to the evaluation of lip hyperpigmentation. (Abstract)

Approaches to the evaluation of lip hyperpigmentation. Hyperpigmentation of the lips is a common condition. It is associated with a wide variety of conditions that include physiologic changes, genodermatoses, inflammatory diseases, endocrinologic disorders, drugs and chemicals, benign and malignant neoplasm, and other non-melanotic conditions. The aim of this article is to provide a clinical approach to hyperpigmented lesions on the lips based on the extent of lesions, the age of onset

2012 International Journal of Dermatology

177. PDZK1 Upregulation in Estrogen-Related Hyperpigmentation in Melasma. Full Text available with Trip Pro

PDZK1 Upregulation in Estrogen-Related Hyperpigmentation in Melasma. The pathogenesis of melasma is unknown, although the potential role of estrogen has been considered. Microarray and real-time PCR analyses revealed that upregulation of PDZ domain protein kidney 1 (PDZK1) is clinically correlated with melasma. Although there has been no report that PDZK1 is involved in pigmentation and/or melanogenesis, PDZK1 expression can be induced by estrogen. In this study, the role of PDZK1 upregulation

2012 Journal of Investigative Dermatology

178. Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma. Full Text available with Trip Pro

Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma. Pyrostegia venusta is a native Brazilian plant which has a variety of uses in traditional folk medicine including the treatment of vitiligo. However, its effectiveness on melanogenesis is not yet elucidated.This study aimed to investigate the melanogenic activity of hydroalcoholic extracts from the leaves and flowers of P. venusta on murine B16F10 melanoma cells.Different concentrations

2012 Journal of Ethnopharmacology

179. New horizons in treating disorders of hyperpigmentation in skin of color. (Abstract)

New horizons in treating disorders of hyperpigmentation in skin of color. Pigmentary abnormalities are among the most common reasons why patients with skin of color visit a dermatologist. Hydroquinone has been a cornerstone for the treatment of hyperpigmentation; however, concerns regarding adverse effects have prompted a search for alternative agents. Some promising topical treatments include soy, licorice, rucinol, mulberry, niacinamide, ellagic acid, resveratrol, and dioic acid. Oral agents (...) , primarily used for the prevention of postprocedural hyperpigmentation, include procyanidins, tranexamic acid, and Polypodium leucotomos. Advances in Q-switched lasers, intense pulse light, fractional photothermolysis, and the advent of tretinoin peeling add to the clinician's armamentarium for treating hyperpigmentation.Copyright © 2012 Elsevier Inc. All rights reserved.

2012 Seminars in Cutaneous Medicine and Surgery

180. Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study. (Abstract)

Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study. Progressive cribriform and zosteriform hyperpigmentation (PCZH) is a disorder of pigmentation. Although several cases of PCZH have been reported, no clinicopathologic studies of the condition have been published in the English-language literature.The purpose of this study was to determine the clinical characteristics and histologic findings of PCZH.Between 1999 and 2009, 30 patients were diagnosed with PCZH

2012 International Journal of Dermatology

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