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Hyperpigmentation

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161. Hyperpigmentation in Pregnancy

Hyperpigmentation in Pregnancy Hyperpigmentation in Pregnancy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation (...) in Pregnancy Hyperpigmentation in Pregnancy Aka: Hyperpigmentation in Pregnancy , Chadwick's Sign , Linea Nigra II. Physiology stimulating hormone rises in early pregnancy Increased deposition III. Signs: General Scarred areas and nevi darken Pigmented areas become more pigmented Areola Axilla External genitalia Anal region Linea Nigra IV. Signs: Specific Chadwick's Sign Darkened vulva and vagina or ( ) Dark areas under eyes and bridge nose Linea Nigra Dark midline low Images: Related links to external

2015 FP Notebook

162. Diffuse Hyperpigmentation

Diffuse Hyperpigmentation Diffuse Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diffuse Hyperpigmentation Diffuse (...) Hyperpigmentation Aka: Diffuse Hyperpigmentation , Melanism , Diffuse Hypermelanosis , Melanosis From Related Chapters II. Causes Excessive deposition: Excessive s: Phototoxic III. Signs Diffuse brown discoloration of skin pigmentation Accentuated areas Palmar creases Recent scars Pressure points at elbow, knee, and knuckles IV. Differential Diagnosis Localized Lesions (increased or s) See See Diffuse skin changes See See See Images: Related links to external sites (from Bing) These images are a random sampling

2015 FP Notebook

163. Hyperpigmentation

Hyperpigmentation Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation Hyperpigmentation Aka (...) : Hyperpigmentation From Related Chapters II. Causes: Hyperpigmentation Localized Lesions (increased or s) See See s Diffuse skin changes See See See See systemic causes below III. Causes: Systemic conditions with Hyperpigmentation Skin Endocrine and Metabolic See ( Deposition) Porphyria Hemosiderin deposition in Gastrointestinal Disease Whipple's Disease ( deposition) Genitalia Heller-Nelson Syndrome Hematology and Oncology Neoplasm Nutrition Starvation Medications and toxins See (increased s) Images: Related

2015 FP Notebook

164. Medication Causes of Hyperpigmentation

Medication Causes of Hyperpigmentation Medication Causes of Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Medication Causes of Hyperpigmentation Medication Causes of Hyperpigmentation Aka: Medication Causes of Hyperpigmentation , Hyperpigmentation Due to Medication , Drug Induced Hyperpigmentation From Related Chapters II. Causes ( ) Bismuth Bleomycin Busulfan Clofazimine Cyclophosphamide Daunorubicin Dibromomannitol Doxorubicin Gold Topical nitrogen mustard Phenothiazines Silver Zodovudine III. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2015 FP Notebook

165. Oral Mucosa Hyperpigmentation

Oral Mucosa Hyperpigmentation Oral Mucosa Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Oral Mucosa (...) Hyperpigmentation Oral Mucosa Hyperpigmentation Aka: Oral Mucosa Hyperpigmentation , Melanin Pigmentation of Oral Mucosa From Related Chapters II. Causes May be associated with in autoimmune polyendocrinopathy- -ectodermal dystrophy syndrome Darker pigmentation related to ethnicity abuse 1 McCune-Albright Syndrome Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Oral Mucosa Hyperpigmentation." Click on the image (or right click) to open

2015 FP Notebook

166. Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation

Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01542138 Recruitment Status : Completed First Posted : March 2, 2012 Last Update Posted : November 29

2012 Clinical Trials

167. Efficacy and Safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for the Treatment of Acne and Acne-induced Post-inflammatory Hyperpigmentation in Patients with Skin of Color. Full Text available with Trip Pro

Efficacy and Safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for the Treatment of Acne and Acne-induced Post-inflammatory Hyperpigmentation in Patients with Skin of Color. To assess the efficacy and safety of a topical gel containing clindamycin 1.2% and tretinoin 0.025% for the treatment of acne and acne-induced postinflammatory hyperpigmentation (PIH) in darker skinned patients.Randomized, double-blind, placebo-controlled study.Two United States clinical sites.Thirty-three (...) patients 12 years of age or older with skin types IV to VI, mild-to-moderate facial acne, and PIH were enrolled.Patients applied clindamycin phosphate/tretinoin gel or a nonmedicated vehicle each evening and a sun protection factor 30 sunscreen daily. Changes in skin erythema and hyperpigmentation were measured using a chromameter and photographic images. Efficacy was assessed using the Evaluators Global Acne Severity Scale, lesion counts, Post-inflammatory Hyperpigmentation Severity Scales

2012 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

168. Tongue hyperpigmentation during hepatitis C treatment Full Text available with Trip Pro

Tongue hyperpigmentation during hepatitis C treatment 22451683 2012 11 28 2018 12 01 1488-2329 184 13 2012 Sep 18 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Tongue hyperpigmentation during hepatitis C treatment. 1498 10.1503/cmaj.111985 Bachmeyer Claude C Department of Internal Medicine, Tenon Hospital, Paris, France. claude.bachmeyer@tnn.aphp.fr Pellen Jean-Charles JC eng Case Reports Journal Article 2012 03 26 Canada CMAJ 9711805 0820-3946 (...) 0 Antiviral Agents 0 Interferon-alpha 0 Recombinant Proteins 3WJQ0SDW1A Polyethylene Glycols 49717AWG6K Ribavirin Q46947FE7K peginterferon alfa-2a AIM IM Antiviral Agents administration & dosage adverse effects therapeutic use Drug Therapy, Combination Female Hepatitis C drug therapy Humans Hyperpigmentation chemically induced pathology Interferon-alpha administration & dosage adverse effects therapeutic use Middle Aged Polyethylene Glycols administration & dosage adverse effects therapeutic use

2012 CMAJ : Canadian Medical Association Journal

169. Familial glucocorticoid deficiency presenting with generalized hyperpigmentation in adolescence. Report of three siblings Full Text available with Trip Pro

Familial glucocorticoid deficiency presenting with generalized hyperpigmentation in adolescence. Report of three siblings Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterized by glucocorticoid deficiency, high ACTH levels and normal mineralocorticoid levels. FGD is caused due to defects in adrenocorticotropic hormone (ACTH) signaling. The defect can be caused by mutations in genes encoding the ACTH receptor (melanocortin 2 receptor) or its accessory (...) protein.Here we report three siblings with FGD. The second in order of siblings presented at an age of 15 years with history of diffuse hyperpigmentation since childhood. Their parents were non consanguineous. The patients were hyperpigmented and taller compared with their parents. None of the siblings had ambiguous genitalia or neurological abnormalities. There was no history of tuberculosis in the family. Biochemical investigations revealed low serum cortisol (<1 μg/dl) and elevated plasma ACTH (>1250 pg

2012 Indian journal of endocrinology and metabolism

170. Synergistic Combination of an In-office Procedure and Home Regimen for the Treatment of Facial Hyperpigmentation Full Text available with Trip Pro

Synergistic Combination of an In-office Procedure and Home Regimen for the Treatment of Facial Hyperpigmentation Hyperpigmentation disorders, such as melasma and solar lentigines, pose a significant treatment challenge for most patients. Combining a series of in-office procedures, such as chemical peels and light- and laser-based treatments, with maintenance therapies have been shown to provide greater efficacy than one treatment alone. However, receiving multiple in-office procedures may (...) . Physician-graded overall improvement in hyperpigmentation, standardized photography, and patient satisfaction were evaluated at Weeks 4, 8, and 12. At Week 12, all eight patients demonstrated improvements of at least 25 percent in overall facial hyperpigmentation, with six of the patients demonstrating a 50- or 75-percent overall improvement. One hundred percent of the patients rated their experience with the novel treatment regimen as "excellent" or "good" reflecting high patient satisfaction

2012 The Journal of clinical and aesthetic dermatology

171. Familial Progressive Hyperpigmentation: A Case Report Full Text available with Trip Pro

Familial Progressive Hyperpigmentation: A Case Report Familial progressive hyperpigmentation (FPH) is a rare genodermatosis characterized by hyperpigmented patches in the skin and mucous membranes, present in early infancy, and increase in size and number with age. The genetic basis for FPH remains unknown. We report an unusual case of familial progressive hypermelanosis in a 17-year-old male patient with family history, who presented with a peculiar progressive oral pigmentation disorder

2012 Case reports in dentistry

172. Minocycline Hyperpigmentation Full Text available with Trip Pro

Minocycline Hyperpigmentation 22560532 2012 07 03 2013 12 13 1942-5546 87 5 2012 May Mayo Clinic proceedings Mayo Clin. Proc. Minocycline hyperpigmentation. e33 10.1016/j.mayocp.2012.02.013 Wetter David A DA Department of Dermatology, Mayo Clinic, Rochester, MN, USA. eng Case Reports Journal Article England Mayo Clin Proc 0405543 0025-6196 0 Anti-Bacterial Agents FYY3R43WGO Minocycline AIM IM Aged Anti-Bacterial Agents administration & dosage adverse effects Arthritis, Rheumatoid drug therapy (...) Humans Hyperpigmentation chemically induced diagnosis Male Minocycline administration & dosage adverse effects Risk Factors Skin drug effects 2012 02 27 2012 02 27 2012 5 8 6 0 2012 5 9 6 0 2012 7 4 6 0 ppublish 22560532 S0025-6196(12)00308-4 10.1016/j.mayocp.2012.02.013 PMC3498181

2012 Mayo Clinic Proceedings

173. Postinflammatory Hyperpigmentation After Skin Prick Testing Full Text available with Trip Pro

Postinflammatory Hyperpigmentation After Skin Prick Testing 23268476 2012 12 27 2019 02 11 1939-4551 5 5 2012 May The World Allergy Organization journal World Allergy Organ J Postinflammatory hyperpigmentation after skin prick testing. 57-8 10.1097/WOX.0b013e3182488069 Ludman Sian S Department of MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, King's College London, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Penagos

2012 The World Allergy Organization journal

174. Cyclophosphamide-induced nail hyperpigmentation in a child Full Text available with Trip Pro

Cyclophosphamide-induced nail hyperpigmentation in a child 22787324 2012 10 02 2018 11 13 1998-3662 22 2 2012 Mar Indian journal of nephrology Indian J Nephrol Cyclophosphamide-induced nail hyperpigmentation in a child. 149 10.4103/0971-4065.97144 Saha A A Department of Pediatrics, Division of Pediatric Nephrology, PGIMER and Associated Dr. RML Hospital, New Delhi, India. Arora N N Mehra N N Dubey N K NK eng Journal Article India Indian J Nephrol 8914356 0971-4065 2012 7 13 6 0 2012 7 13 6 0

2012 Indian Journal of Nephrology

175. Triple Combination and Glycolic Peels in Post-Acne Hyperpigmentation Full Text available with Trip Pro

Triple Combination and Glycolic Peels in Post-Acne Hyperpigmentation 22557866 2012 05 31 2018 11 13 0974-5157 5 1 2012 Jan Journal of cutaneous and aesthetic surgery J Cutan Aesthet Surg Triple combination and glycolic peels in post-acne hyperpigmentation. 60-1 10.4103/0974-2077.94335 Godse Kiran K Sakhia Jagdish J eng Letter India J Cutan Aesthet Surg 101525405 0974-2077 2012 5 5 6 0 2012 5 5 6 0 2012 5 5 6 1 ppublish 22557866 10.4103/0974-2077.94335 JCAS-5-60 PMC3339139 J Eur Acad Dermatol

2012 Journal of cutaneous and aesthetic surgery

176. A randomized control study of the prevention of hyperpigmentation post Q-switched Nd:YAG laser treatment of Hori nevus using topical fucidic acid plus betamethasone valerate cream versus fucidic acid cream. (Abstract)

A randomized control study of the prevention of hyperpigmentation post Q-switched Nd:YAG laser treatment of Hori nevus using topical fucidic acid plus betamethasone valerate cream versus fucidic acid cream. Post-inflammatory hyperpigmentation (PIH) after laser treatment of Hori nevus remains problematic. Prevention and treatment of PIH have limited success.To study the effects on hyperpigmentation using topical antibiotic alone versus combined antibiotic and betamethasone/valerate after 1064 nm

2012 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology Controlled trial quality: uncertain

177. Reduced WIF-1 Expression Stimulates Skin Hyperpigmentation in Patients with Melasma. Full Text available with Trip Pro

Reduced WIF-1 Expression Stimulates Skin Hyperpigmentation in Patients with Melasma. The expression of Wnt inhibitory factor-1 (WIF-1) gene, which was detected by a microarray analysis of hyperpigmented and normally pigmented skin sets of melasma patients, was significantly reduced in the hyperpigmented skin from melasma patients, but not in healthy controls, regardless of UV irradiation. Wnt signals regulate skin pigmentation; however, WIF-1 is expressed in cultured skin keratinocytes (...) and fibroblasts, but not in melanocytes. Therefore, we examined whether WIF-1 knockdown in neighboring keratinocytes and fibroblasts plays a role in melasma. Additionally, the effect of WIF-1 overexpression on the amelioration of hyperpigmentation was examined. WIF-1 knockdown, either in fibroblasts or in keratinocytes, significantly stimulated tyrosinase expression and melanosome transfer, whereas melanocytes with WIF-1 overexpression significantly reduced those parameters. The WIF-1 knockdown decreased

2012 Journal of Investigative Dermatology

178. Approaches to the evaluation of lip hyperpigmentation. (Abstract)

Approaches to the evaluation of lip hyperpigmentation. Hyperpigmentation of the lips is a common condition. It is associated with a wide variety of conditions that include physiologic changes, genodermatoses, inflammatory diseases, endocrinologic disorders, drugs and chemicals, benign and malignant neoplasm, and other non-melanotic conditions. The aim of this article is to provide a clinical approach to hyperpigmented lesions on the lips based on the extent of lesions, the age of onset

2012 International Journal of Dermatology

179. PDZK1 Upregulation in Estrogen-Related Hyperpigmentation in Melasma. Full Text available with Trip Pro

PDZK1 Upregulation in Estrogen-Related Hyperpigmentation in Melasma. The pathogenesis of melasma is unknown, although the potential role of estrogen has been considered. Microarray and real-time PCR analyses revealed that upregulation of PDZ domain protein kidney 1 (PDZK1) is clinically correlated with melasma. Although there has been no report that PDZK1 is involved in pigmentation and/or melanogenesis, PDZK1 expression can be induced by estrogen. In this study, the role of PDZK1 upregulation

2012 Journal of Investigative Dermatology

180. Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma. Full Text available with Trip Pro

Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma. Pyrostegia venusta is a native Brazilian plant which has a variety of uses in traditional folk medicine including the treatment of vitiligo. However, its effectiveness on melanogenesis is not yet elucidated.This study aimed to investigate the melanogenic activity of hydroalcoholic extracts from the leaves and flowers of P. venusta on murine B16F10 melanoma cells.Different concentrations

2012 Journal of Ethnopharmacology

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