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Hyperpigmentation

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141. Atopic Dirty Neck or Acquired Atopic Hyperpigmentation? An Epidemiological and Clinical Study from the National Skin Centre in Singapore. (Abstract)

Atopic Dirty Neck or Acquired Atopic Hyperpigmentation? An Epidemiological and Clinical Study from the National Skin Centre in Singapore. 'Atopic dirty neck' is a poorly understood acquired hyperpigmentation in patients with atopic dermatitis (AD).To report a single-centre experience with synthesis of this entity's features.All patients with AD with dirty neck seen over a 5-month period at the National Skin Centre were invited to participate.Out of 544 AD patients examined, 78 (14.3%) had (...) acquired pigmentation of the neck. The majority had moderate-to-severe underlying eczema. Histopathology showed increased epidermal melanin and dermal melanophages, a thickened basement membrane and a dense superficial perivascular infiltrate.Acquired atopic hyperpigmentation has a high prevalence, particularly in adolescent Asian males. Clinico-pathological correlation suggests it results from both frictional melanosis and post-inflammatory hyperpigmentation. The rippled appearance and the onset

2014 Dermatology

142. Comparative study of treatment efficacy and the incidence of post-inflammatory hyperpigmentation with different degrees of irradiation using two different quality-switched lasers for removing solar lentigines on Asian skin. (Abstract)

Comparative study of treatment efficacy and the incidence of post-inflammatory hyperpigmentation with different degrees of irradiation using two different quality-switched lasers for removing solar lentigines on Asian skin. Quality-switched (QS) lasers are well-known effective treatment for removing solar lentigines. However, the high incidence of post-inflammatory hyperpigmentation (PIH) raises concern in darker skin types. This is the first study comparing efficacies and incidences of PIH

2014 Journal of the European Academy of Dermatology and Venereology : JEADV Controlled trial quality: uncertain

143. Metformin: a potential drug to treat hyperpigmentation disorders. Full Text available with Trip Pro

Metformin: a potential drug to treat hyperpigmentation disorders. Hyperpigmentation disorders are generally difficult to treat because of the limited availability of effective therapeutics with minimal side effects. In this issue, Lehraiki et al. report that metformin, an antidiabetic drug, inhibited melanogenesis, in vitro and in vivo, and they suggest that metformin may be used to treat hyperpigmentation disorders. This commentary reviews the molecular mechanisms through which metformin (...) inhibits melanogenesis and examines metformin as a potential drug to treat hyperpigmentation.

2014 Journal of Investigative Dermatology

144. Ginsenoside F1 attenuates hyperpigmentation in B16F10 melanoma cells by inducing dendrite retraction and activating Rho signaling. Full Text available with Trip Pro

Ginsenoside F1 attenuates hyperpigmentation in B16F10 melanoma cells by inducing dendrite retraction and activating Rho signaling. Ginsenoside F1 (GF1) is a metabolite produced by hydrolysis of the ginsenoside Re and Rg1 in Panax ginseng. According to various studies, high amounts of ginseng components are absorbed in the metabolized form, which are key constituents responsible for the biological effects of P. ginseng. Recently, GF1 was reported to have beneficial effects on skin. However

2014 Experimental Dermatology

145. Clinical efficacy and safety of 4-hexyl-1,3-phenylenediol for improving skin hyperpigmentation. (Abstract)

Clinical efficacy and safety of 4-hexyl-1,3-phenylenediol for improving skin hyperpigmentation. Hyperpigmentation disorders are of social and cosmetic concerns to many individuals due to their prevalent locations on highly visible parts of the body. Topical formulation containing hydroquinone is the most widely used remedy for the treatment of hyperpigmentation disorders. However, reports of side effects in long-term usage have raised concerns for its use in cosmetic products. Thus (...) , it is highly desirable to develop a safe and effective alternative to treat hyperpigmentation disorders. The objective of the current study is to investigate the de-pigmenting efficacy of 4-hexyl-1,3-phenylenediol in various in vitro models and in a randomized controlled clinical study. We showed that 4-hexyl-1,3-phenylenediol significantly reduced melanogenesis in primary human melanocytes, murine melanoma cells, and pigmented human epidermal equivalents. It was determined that the reduction

2014 Archives of dermatological research Controlled trial quality: uncertain

146. Esthetic treatment of gingival hyperpigmentation with Nd:YAG laser or scalpel technique: a 6-month RCT of patient and professional assessment. (Abstract)

Esthetic treatment of gingival hyperpigmentation with Nd:YAG laser or scalpel technique: a 6-month RCT of patient and professional assessment. This double-masked, randomized controlled trial with a split-mouth design aimed to compare patient- and professional-centered outcomes using different therapeutic approaches-neodymium-yttrium aluminum garnet (Nd:YAG) laser or scalpel technique-for gingival depigmentation. Patients presenting bilateral melanin gingival hyperpigmentation and who requested (...)  < 0.05). The Nd:YAG laser or the scalpel technique may be successfully used for the treatment of melanin gingival hyperpigmentation. However, the use of the Nd:YAG laser has presented advantages in terms of less discomfort/pain during the posttherapy period and a reduction of treatment chair time.

2014 Lasers in medical science Controlled trial quality: uncertain

147. Comparative Evaluation of Photoablative Efficacy of Er:YAG and Diode Laser for the Treatment of Gingival Hyperpigmentation. A Randomized Split-Mouth Clinical Trial. Full Text available with Trip Pro

Comparative Evaluation of Photoablative Efficacy of Er:YAG and Diode Laser for the Treatment of Gingival Hyperpigmentation. A Randomized Split-Mouth Clinical Trial. The use of lasers in periodontology is a matter of debate, mainly because of the lack of consensual therapeutic protocols. In this randomized, split-mouth trial, the clinical efficacy of two different photoablative dental lasers, erbium:yttrium-aluminum-garnet (Er:YAG) and diode, for the treatment of gingival hyperpigmentation (...) is compared.Twenty-one patients requiring treatment for mild-to-severe gingival hyperpigmentation were enrolled. Maxillary or mandibular left or right quadrants were randomly subjected to photoablative deepithelialization with either Er:YAG or diode laser. Masked clinical assessments of each laser quadrant were made at admission and days 7, 30, and 180 postoperatively by an independent observer. Histologic examination was performed before and soon after treatment and 6 months after irradiation. Patients also

2014 Journal of periodontology Controlled trial quality: uncertain

148. Postinflammatory Hyperpigmentation (Treatment)

Postinflammatory Hyperpigmentation (Treatment) Postinflammatory Hyperpigmentation Treatment & Management: Medical Care, Surgical Care, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTE5MS10cmVhdG1lbnQ= processing > Postinflammatory Hyperpigmentation Treatment & Management Updated: May 04, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Postinflammatory Hyperpigmentation Treatment Medical Care The treatment of postinflammatory hyperpigmentation (PIH) tends to be a difficult and prolonged process that often takes 6-12 months to achieve the desired results of depigmentation. Each of these treatment options potentially

2014 eMedicine.com

149. Postinflammatory Hyperpigmentation (Overview)

Postinflammatory Hyperpigmentation (Overview) Postinflammatory Hyperpigmentation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTE5MS1vdmVydmlldw== processing (...) > Postinflammatory Hyperpigmentation Updated: May 04, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Postinflammatory Hyperpigmentation Overview Background Postinflammatory hyperpigmentation (PIH) is a frequently encountered problem and represents the sequelae of various cutaneous disorders as well as therapeutic interventions. [ ] This acquired excess of pigment can be attributed to various preceding disease processes that affect

2014 eMedicine.com

150. Postinflammatory Hyperpigmentation (Follow-up)

Postinflammatory Hyperpigmentation (Follow-up) Postinflammatory Hyperpigmentation Treatment & Management: Medical Care, Surgical Care, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTE5MS10cmVhdG1lbnQ= processing > Postinflammatory Hyperpigmentation Treatment & Management Updated: May 04, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Postinflammatory Hyperpigmentation Treatment Medical Care The treatment of postinflammatory hyperpigmentation (PIH) tends to be a difficult and prolonged process that often takes 6-12 months to achieve the desired results of depigmentation. Each of these treatment options potentially

2014 eMedicine.com

151. Postinflammatory Hyperpigmentation (Diagnosis)

Postinflammatory Hyperpigmentation (Diagnosis) Postinflammatory Hyperpigmentation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTE5MS1vdmVydmlldw== processing (...) > Postinflammatory Hyperpigmentation Updated: May 04, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Postinflammatory Hyperpigmentation Overview Background Postinflammatory hyperpigmentation (PIH) is a frequently encountered problem and represents the sequelae of various cutaneous disorders as well as therapeutic interventions. [ ] This acquired excess of pigment can be attributed to various preceding disease processes that affect

2014 eMedicine.com

152. Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation. (Abstract)

Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation. Skin lightening preparations are used by people all over the world for a diverse range of dermatologic indications. Hydroquinone (HQ) is the gold standard and remains the only prescription product available in the United States for the treatment of generalized facial hyperpigmentation. Irritation and the risk of exogenous (...) and distribution. A single-center, double-blind comparison clinical study of 18 subjects was conducted to evaluate the efficacy of the product in reducing ultraviolet-induced hyperpigmentation. Test sites were irradiated with 1.0, 1.5, 2.0, and 2.5 minimal erythema doses. After 5 days, to allow for pigmentation development, the product or 4% HQ cream was applied to the respective test sites, once daily for 4 weeks. Chroma Meter measurements (L* brightness) and standardized digital photographs were taken

2013 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

153. Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation. (Abstract)

Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation. Skin lightening preparations are used by people all over the world for a diverse range of dermatologic indications. Hydroquinone (HQ) is the gold standard and remains the only prescription product available in the United States for the treatment of generalized facial hyperpigmentation. Irritation and the risk of exogenous (...) and distribution. A single-center, double-blind comparison clinical study of 18 subjects was conducted to evaluate the efficacy of the product in reducing ultraviolet-induced hyperpigmentation. Test sites were irradiated with 1.0, 1.5, 2.0, and 2.5 minimal erythema doses. After 5 days, to allow for pigmentation development, the product or 4% HQ cream was applied to the respective test sites, once daily for 4 weeks. Chroma Meter measurements (L* brightness) and standardized digital photographs were taken

2013 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

154. Secondary hyperpigmentation during interferon alfa treatment for chronic hepatitis C virus infection. Full Text available with Trip Pro

Secondary hyperpigmentation during interferon alfa treatment for chronic hepatitis C virus infection. Interferon alfa remains the central treatment for chronic hepatitis C virus (HCV) infection. Cases of cutaneous and mucous hyperpigmentations during interferon alfa treatment have been reported, but they are considered rare adverse effects.To study the clinical presentation and frequency of hyperpigmentation in patients receiving interferon alfa treatment for chronic HCV infection.Prospective (...) with hyperpigmentation. Hyperpigmentation of the oral mucous membrane, acquired longitudinal melononychia, and hyperpigmentation of the face were each observed in 7 patients (9%). All patients with hyperpigmentation of the skin had skin type III or IV and worked outside without sun protection. The intensity of pigmentation was reported to decrease progressively when interferon treatment was discontinued. Most patients with hyperpigmentation of the oral mucosa also had melanonychia. However, patients

2013 JAMA dermatology (Chicago, Ill.)

155. Hyperpigmentation: types, diagnostics and targeted treatment options. (Abstract)

Hyperpigmentation: types, diagnostics and targeted treatment options. Pigment formation is highly complex. It is involved in inflammation, sun protection and many other processes. For practical purposes, such as exposure time for sun tanning, six skin types are distinguished according to Fitzpatrick, listed in decreasing lightness. The hyperpigmentation commonly occurs in Fitzpatrick skin types III to VI and can have a considerable impact on quality of life.In this article we will give

2013 Journal of the European Academy of Dermatology and Venereology

156. A focused review on acne-induced and aesthetic procedure-related postinflammatory hyperpigmentation in Asians. Full Text available with Trip Pro

A focused review on acne-induced and aesthetic procedure-related postinflammatory hyperpigmentation in Asians. Postinflammatory hyperpigmentation (PIH) is a common consequence following cutaneous inflammation in dark-skinned individuals with Fitzpatrick skin phototypes (SPTs) III-VI. The exact pathogenesis of this condition is unknown, but is believed to be an integral part of the normal response of the skin to inflammatory stimuli. PIH can last from months to years and may significantly impair

2013 Journal of the European Academy of Dermatology and Venereology

157. 4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation. Full Text available with Trip Pro

4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation. Hyperpigmentary disorders like melasma, actinic and senile lentigines are a major cosmetic concern. Therefore, many topical products are available, containing various active ingredients aiming to reduce melanin production and distribution. The most prominent target for inhibitors of hyperpigmentation is tyrosinase, the key regulator of melanin production. Many inhibitors of tyrosinase (...) , 4-n-butylresorcinol reduced visibly the appearance of age spots, while the control spots showed no improvement. A second study showed that 4-butylresorcinol was more effective than 4-hexylresorcinol and 4-phenylethylresorcinol.The present in vitro and in vivo data prove the high inhibitory capacity of 4-n-butylresorcinol on human tyrosinase activity, exceeding by far the potency of hydroquinone, arbutin and kojic acid. The resulting clinical improvement of skin hyperpigmentations reveals 4-n

2013 Journal of the European Academy of Dermatology and Venereology

158. Diltiazem-Associated Hyperpigmentation Full Text available with Trip Pro

Diltiazem-Associated Hyperpigmentation 23846341 2014 08 12 2018 11 13 1525-1497 28 12 2013 Dec Journal of general internal medicine J Gen Intern Med Diltiazem-associated hyperpigmentation. 1676 10.1007/s11606-013-2530-1 Campbell Michelle M Wayne State University School of Medicine, Detroit, MI, USA. Ahluwalia Jesleen J Watson Alice C AC eng Case Reports Journal Article 2013 07 12 United States J Gen Intern Med 8605834 0884-8734 0 Antihypertensive Agents EE92BBP03H Diltiazem IM Antihypertensive (...) Agents adverse effects Diltiazem adverse effects Female Humans Hyperpigmentation chemically induced diagnosis Middle Aged 2012 11 15 2013 06 10 2013 01 31 2013 7 13 6 0 2013 7 13 6 0 2014 8 13 6 0 ppublish 23846341 10.1007/s11606-013-2530-1 PMC3832732 J Dermatol. 2010 Sep;37(9):807-11 20883365 Dermatol Online J. 2011;17(7):14 21810399 Cutis. 2010 Aug;86(2):82-4 20919601

2013 Journal of General Internal Medicine

159. Efficacy and Safety of Biocellulose Sheet Containing Anti-hyperpigmentation Agent ("Biocellulose Mask", "Farhorm®") in Patients Receiving Laser Treatment

Efficacy and Safety of Biocellulose Sheet Containing Anti-hyperpigmentation Agent ("Biocellulose Mask", "Farhorm®") in Patients Receiving Laser Treatment Efficacy and Safety of Biocellulose Sheet Containing Anti-hyperpigmentation Agent ("Biocellulose Mask", "Farhorm®") in Patients Receiving Laser Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail (...) Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy and Safety of Biocellulose Sheet Containing Anti-hyperpigmentation Agent ("Biocellulose Mask", "Farhorm®") in Patients Receiving Laser Treatment The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government

2013 Clinical Trials

160. Generalized hyperpigmentation in Wilson's disease: An unusual association Full Text available with Trip Pro

Generalized hyperpigmentation in Wilson's disease: An unusual association Wilson's disease, an autosomal recessive disorder of copper metabolism, most commonly presents either with hepatic or neurological features. But, it may sometimes have certain atypical presentations posing diagnostic difficulties. We report here a case of Wilson's disease presenting with generalized hyperpigmentation of skin who also developed neurological manifestations subsequently. We aim to highlight the importance (...) of keeping Wilson's disease as one of the differentials in patients who present with hyperpigmentation and neurological symptoms compatible with copper deposits in the central nervous system and proceed for investigations accordingly.

2013 Journal of neurosciences in rural practice

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