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Hyperpigmentation

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121. Evaluation of pain on use of electrosurgery and diode lasers in the management of gingival hyperpigmentation: A comparative study. (Full text)

Evaluation of pain on use of electrosurgery and diode lasers in the management of gingival hyperpigmentation: A comparative study. Gingival depigmentation is a periodontal plastic surgical procedure whereby the gingival hyperpigmentation is removed by various techniques such as electrosurgery, cryosurgery, abrasion with diamond bur and lasers. The aim of this study was to determine the pain levels during the gingival depigmentation procedure using electrosurgery and lasers.Twenty patients, both (...) of hyperpigmentated gingival areas to create a confident and pleasant smile, which could be easily attained by using either electrosurgery or lasers. This study concluded that lasers produce lesser pain and discomfort compared with electrosurgery during gingival depigmentation.

2015 Journal of Indian Society of Periodontology Controlled trial quality: uncertain PubMed abstract

122. Long-term Multi-product Facial Regimen in Subjects with Moderate-to-severe Photodamage and Hyperpigmentation. (Abstract)

Long-term Multi-product Facial Regimen in Subjects with Moderate-to-severe Photodamage and Hyperpigmentation. Photoaged skin is primarily a result of chronic sun exposure. Irregular pigmentation and wrinkling are common clinical manifestations. Monotherapy with retinoids, growth factors, and skin lighteners have proven beneficial. However, long-term treatment with a multi-product facial regimen has not been assessed.This single-center clinical trial was conducted to assess the efficacy (...) and tolerance of a topical multi-product regimen when used by subjects with moderate-to-severe photodamage and hyperpigmentation on the face over a course of 24 weeks.Subjects were supplied with a six-product regimen to use on their face (cleanser, growth factor serum, skin brightener, moisturizer, retinol, and sunscreen). Products were used according to specific application instructions. Clinical grading and tolerability assessments were performed at baseline and at follow-up visits at Weeks 4,8,12,18

2015 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

123. Identification of tyrosinase inhibitors from traditional Chinese medicines for the management of hyperpigmentation (Full text)

Identification of tyrosinase inhibitors from traditional Chinese medicines for the management of hyperpigmentation The inhibition of tyrosinase is the most effective method to decrease melanin synthesis during the process of pigmentation. We aimed to find compounds from traditional Chinese medicines (TCM) that are more effective than the most commonly used tyrosinase inhibitor, arbutin. First, we employed homology modeling to construct a tyrosinase-modeled structure, and structure-based virtual

2015 SpringerPlus PubMed abstract

124. A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations. (Abstract)

A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations. Arbutin is one of the most effective lightening substances. Serratula quinquefolia is a new source of its β-anomer. The HPLC method showed that the solid content of this compound in the dried plant raw material accounts for 6.86%. The leaves of Serratula quinquefolia do not contain hydroquinone.To assess the efficacy of the aqueous extract from

2015 Journal of cosmetic dermatology Controlled trial quality: uncertain

125. Pernicious anaemia presenting as hyperpigmentation. (Abstract)

Pernicious anaemia presenting as hyperpigmentation. An adult East Asian woman presented with sudden onset of hyperpigmented macules on her oral mucosal surfaces, palms and soles, in association with hypoguesia and loss of weight. This was found to be associated with underlying severe vitamin B12 deficiency secondary to pernicious anaemia. © 2015 British Association of Dermatologists.

2015 Clinical & Experimental Dermatology

126. A Case of Hyper Immunoglobulin-E Syndrome Associated with Scrotal Tongue and Intraoral Hyperpigmentation (Full text)

A Case of Hyper Immunoglobulin-E Syndrome Associated with Scrotal Tongue and Intraoral Hyperpigmentation 26120195 2015 06 29 2018 11 13 1998-3611 60 3 2015 May-Jun Indian journal of dermatology Indian J Dermatol A Case of Hyper Immunoglobulin-E Syndrome Associated with Scrotal Tongue and Intraoral Hyperpigmentation. 324 10.4103/0019-5154.156483 Patil Subha V SV Department of Dermatology, Dr. D. Y. Patil Medical College and Hospital, Pimpri, India. E-mail: patilsubha23@gmail.com. Sharma Yugal K

2015 Indian journal of dermatology PubMed abstract

127. Benign dermoscopic parallel ridge pattern in plantar hyperpigmentation due to capecitabine (Full text)

Benign dermoscopic parallel ridge pattern in plantar hyperpigmentation due to capecitabine We report the case of a 37-year-old woman (phototype II) who presented at our outpatient clinic with a two-month history of hyperpigmented plantar macules. Medical history revealed that the patient had taken capecitabine in the past three months as adjuvant chemotherapy for recurrent breast cancer. Dermoscopic examination of the plantar macules showed parallel ridge pattern with pigmentation (...) in the furrows without obliteration of eccrine gland apertures. Besides in acral melanoma, parallel ridge pattern can also be observed in benign plantar lesions, such as congenital or acquired acral nevi, subcorneal hemorrhage, dye-related pigmentation and drug-induced hyperpigmentation, especially in patients with phototypes III-VI. The few reported cases of capecitabine-induced hyperpigmentation have been associated with hand and foot syndrome in patients with phototypes IV-V and palmar as well as plantar

2015 Dermatology practical & conceptual PubMed abstract

128. Hyperpigmentation Results in Aberrant Immune Development in Silky Fowl (Gallus gallus domesticus Brisson) (Full text)

Hyperpigmentation Results in Aberrant Immune Development in Silky Fowl (Gallus gallus domesticus Brisson) The Silky Fowl (SF) is known for its special phenotypes and atypical distribution of melanocytes among internal organs. Although the genes associated with melanocyte migration have been investigated substantially, there is little information on the postnatal distribution of melanocytes in inner organs and the effect of hyperpigmentation on the development of SF. Here, we analyzed melanocyte (...) and apoptosis-associated Bax and Bcl-2 proteins indicated that apoptosis is involved in degeneration of the thymus and bursa of Fabricius. Therefore, these results suggest that hyperpigmentation in SF may have a close relationship with immune development in SF, which can provide an important animal model to investigate the roles of melanocyte.

2015 PloS one PubMed abstract

129. Aesthetic Management of Gum Hyperpigmentation by a Simple Technique (Full text)

Aesthetic Management of Gum Hyperpigmentation by a Simple Technique 25949028 2015 05 07 2018 11 13 0974-2077 8 1 2015 Jan-Mar Journal of cutaneous and aesthetic surgery J Cutan Aesthet Surg Aesthetic management of gum hyperpigmentation by a simple technique. 64-6 10.4103/0974-2077.155095 Singhal Anshul A Department of Periodontology, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India E-mail: deepa_arun@rediffmail.com. Deepa Dhruvakumar D Department of Periodontology, Subharti

2015 Journal of cutaneous and aesthetic surgery PubMed abstract

130. H Syndrome; a Multifaceted Histiocytic Disorder with Hyperpigmentation and Hypertrichosis. (Full text)

H Syndrome; a Multifaceted Histiocytic Disorder with Hyperpigmentation and Hypertrichosis. 26015165 2016 08 12 2015 11 04 1651-2057 95 8 2015 Nov Acta dermato-venereologica Acta Derm. Venereol. H syndrome: a multifaceted histiocytic disorder with hyperpigmentation and hypertrichosis. 1021-3 10.2340/00015555-2145 Tekin Burak B Department of Dermatology, Marmara University School of Medicine, 34899 Istanbul, Turkey. burak.tekin@marmara.edu.tr. Atay Zeynep Z Ergun Tulin T Can Meryem M Tuney Davut (...) D Babay Sofia S Turan Serap S Bereket Abdullah A Zlotogorski Abraham A Molho-Pessach Vered V eng Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 0 Nucleoside Transport Proteins 0 SLC29A3 protein, human IM Adult Child Hearing Loss, Sensorineural genetics Histiocytes pathology Humans Hyperpigmentation genetics pathology Hypertrichosis genetics pathology Male Nucleoside Transport Proteins genetics Phenotype Syndrome 2015 5 28 6 0 2015 5 28 6 0 2016 8 16 6 0 ppublish

2015 Acta Dermato-Venereologica PubMed abstract

131. Comparison of Nd:YAG Laser and Surgical Stripping for Treatment of Gingival Hyperpigmentation: A Clinical Trial. (Abstract)

Comparison of Nd:YAG Laser and Surgical Stripping for Treatment of Gingival Hyperpigmentation: A Clinical Trial. The objective of this study is to evaluate and compare surgical stripping and neodymium-doped: yttrium, aluminum garnet (Nd:YAG) laser techniques for gingival depigmentation and to evaluate their effect on repigmentation.Gingival depigmentation is often associated with repigmentation. Recurrence of pigmentation differs according to different treatment modalities.In this study, 40 (...) maxillary sites from 20 patients presenting bilateral melanin gingival hyperpigmentation were selected. Contralateral quadrants in the maxilla were randomly assigned to receive Nd:YAG laser at 3 W, 30 mJ per pulse, with contact mode, and with a handpiece with a 300 μm diameter optic fiber and surgical stripping. Plaque index, Dummett Oral Pigmentation Index (DOPI), Hedin melanin index, size of pigmented area, time interval and extent of repigmentation, time taken for each of the procedures, assessment

2015 Photomedicine and laser surgery Controlled trial quality: uncertain

132. Efficacy and tolerability of two commercial hyperpigmentation kits in the treatment of facial hyperpigmentation and photo-aging. (Abstract)

Efficacy and tolerability of two commercial hyperpigmentation kits in the treatment of facial hyperpigmentation and photo-aging. Hyperpigmentary disorders are common aesthetic skin conditions that can be very concerning to patients and both challenging and time-consuming for the physician to treat. Several companies commercialize hyperpigmentation kits for the lightening of dark spots and improvement of overall skin dyschromia. Unfortunately, clinical data from controlled studies to support (...) the efficacy and tolerability of these kits are typically lacking.This investigator-blinded, randomized trial was undertaken to compare two commercial hyperpigmentation systems (kits) used for the treatment of facial hyperpigmentation and photo-aging.Female subjects with at least mild facial hyperpigmentation and photo-aging were randomized to treatment with either the four product SkinMedica (SKM) regimen or the 7-product Obagi (OMP) regimen. Evaluations were conducted at baseline, 4, 8, and 12 weeks

2012 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

133. Comparative study of treatment efficacy and the incidence of post-inflammatory hyperpigmentation with different degrees of irradiation using two different quality-switched lasers for removing solar lentigines on Asian skin. (Abstract)

Comparative study of treatment efficacy and the incidence of post-inflammatory hyperpigmentation with different degrees of irradiation using two different quality-switched lasers for removing solar lentigines on Asian skin. Quality-switched (QS) lasers are well-known effective treatment for removing solar lentigines. However, the high incidence of post-inflammatory hyperpigmentation (PIH) raises concern in darker skin types. This is the first study comparing efficacies and incidences of PIH

2014 Journal of the European Academy of Dermatology and Venereology : JEADV Controlled trial quality: uncertain

134. Generalised hyperpigmentation caused by ectopic adrenocorticotropic hormone syndrome with recurrent thymic neuroendocrine carcinoma. (Abstract)

Generalised hyperpigmentation caused by ectopic adrenocorticotropic hormone syndrome with recurrent thymic neuroendocrine carcinoma. Ectopic adrenocorticotropic hormone (ACTH) syndrome is a rare cause of generalised hyperpigmentation. The clinical features are due to the excessive ectopic secretion of adenocorticotropin by diverse neuroendocrine or non-endocrine tumours. Here, we describe a rare case of ectopic ACTH syndrome developing from recurring thymic neuroendocrine carcinoma, which first (...) presented as generalised hyperpigmentation. © 2014 The Australasian College of Dermatologists.

2014 Australasian Journal of Dermatology

135. Atopic Dirty Neck or Acquired Atopic Hyperpigmentation? An Epidemiological and Clinical Study from the National Skin Centre in Singapore. (Abstract)

Atopic Dirty Neck or Acquired Atopic Hyperpigmentation? An Epidemiological and Clinical Study from the National Skin Centre in Singapore. 'Atopic dirty neck' is a poorly understood acquired hyperpigmentation in patients with atopic dermatitis (AD).To report a single-centre experience with synthesis of this entity's features.All patients with AD with dirty neck seen over a 5-month period at the National Skin Centre were invited to participate.Out of 544 AD patients examined, 78 (14.3%) had (...) acquired pigmentation of the neck. The majority had moderate-to-severe underlying eczema. Histopathology showed increased epidermal melanin and dermal melanophages, a thickened basement membrane and a dense superficial perivascular infiltrate.Acquired atopic hyperpigmentation has a high prevalence, particularly in adolescent Asian males. Clinico-pathological correlation suggests it results from both frictional melanosis and post-inflammatory hyperpigmentation. The rippled appearance and the onset

2014 Dermatology

136. Clinical efficacy and safety of 4-hexyl-1,3-phenylenediol for improving skin hyperpigmentation. (Abstract)

Clinical efficacy and safety of 4-hexyl-1,3-phenylenediol for improving skin hyperpigmentation. Hyperpigmentation disorders are of social and cosmetic concerns to many individuals due to their prevalent locations on highly visible parts of the body. Topical formulation containing hydroquinone is the most widely used remedy for the treatment of hyperpigmentation disorders. However, reports of side effects in long-term usage have raised concerns for its use in cosmetic products. Thus (...) , it is highly desirable to develop a safe and effective alternative to treat hyperpigmentation disorders. The objective of the current study is to investigate the de-pigmenting efficacy of 4-hexyl-1,3-phenylenediol in various in vitro models and in a randomized controlled clinical study. We showed that 4-hexyl-1,3-phenylenediol significantly reduced melanogenesis in primary human melanocytes, murine melanoma cells, and pigmented human epidermal equivalents. It was determined that the reduction

2014 Archives of dermatological research Controlled trial quality: uncertain

137. Metformin: a potential drug to treat hyperpigmentation disorders. (Full text)

Metformin: a potential drug to treat hyperpigmentation disorders. Hyperpigmentation disorders are generally difficult to treat because of the limited availability of effective therapeutics with minimal side effects. In this issue, Lehraiki et al. report that metformin, an antidiabetic drug, inhibited melanogenesis, in vitro and in vivo, and they suggest that metformin may be used to treat hyperpigmentation disorders. This commentary reviews the molecular mechanisms through which metformin (...) inhibits melanogenesis and examines metformin as a potential drug to treat hyperpigmentation.

2014 Journal of Investigative Dermatology PubMed abstract

138. Ginsenoside F1 attenuates hyperpigmentation in B16F10 melanoma cells by inducing dendrite retraction and activating Rho signaling. (Abstract)

Ginsenoside F1 attenuates hyperpigmentation in B16F10 melanoma cells by inducing dendrite retraction and activating Rho signaling. Ginsenoside F1 (GF1) is a metabolite produced by hydrolysis of the ginsenoside Re and Rg1 in Panax ginseng. According to various studies, high amounts of ginseng components are absorbed in the metabolized form, which are key constituents responsible for the biological effects of P. ginseng. Recently, GF1 was reported to have beneficial effects on skin. However

2014 Experimental Dermatology

139. Esthetic treatment of gingival hyperpigmentation with Nd:YAG laser or scalpel technique: a 6-month RCT of patient and professional assessment. (Abstract)

Esthetic treatment of gingival hyperpigmentation with Nd:YAG laser or scalpel technique: a 6-month RCT of patient and professional assessment. This double-masked, randomized controlled trial with a split-mouth design aimed to compare patient- and professional-centered outcomes using different therapeutic approaches-neodymium-yttrium aluminum garnet (Nd:YAG) laser or scalpel technique-for gingival depigmentation. Patients presenting bilateral melanin gingival hyperpigmentation and who requested (...)  < 0.05). The Nd:YAG laser or the scalpel technique may be successfully used for the treatment of melanin gingival hyperpigmentation. However, the use of the Nd:YAG laser has presented advantages in terms of less discomfort/pain during the posttherapy period and a reduction of treatment chair time.

2014 Lasers in medical science Controlled trial quality: uncertain

140. Comparative Evaluation of Photoablative Efficacy of Er:YAG and Diode Laser for the Treatment of Gingival Hyperpigmentation. A Randomized Split-Mouth Clinical Trial. (Full text)

Comparative Evaluation of Photoablative Efficacy of Er:YAG and Diode Laser for the Treatment of Gingival Hyperpigmentation. A Randomized Split-Mouth Clinical Trial. The use of lasers in periodontology is a matter of debate, mainly because of the lack of consensual therapeutic protocols. In this randomized, split-mouth trial, the clinical efficacy of two different photoablative dental lasers, erbium:yttrium-aluminum-garnet (Er:YAG) and diode, for the treatment of gingival hyperpigmentation (...) is compared.Twenty-one patients requiring treatment for mild-to-severe gingival hyperpigmentation were enrolled. Maxillary or mandibular left or right quadrants were randomly subjected to photoablative deepithelialization with either Er:YAG or diode laser. Masked clinical assessments of each laser quadrant were made at admission and days 7, 30, and 180 postoperatively by an independent observer. Histologic examination was performed before and soon after treatment and 6 months after irradiation. Patients also

2014 Journal of periodontology Controlled trial quality: uncertain PubMed abstract

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