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Hyperpigmentation

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101. Mitten-Line Hyperpigmentation of an Infant Full Text available with Trip Pro

Mitten-Line Hyperpigmentation of an Infant 27746653 2018 11 13 1013-9087 28 5 2016 Oct Annals of dermatology Ann Dermatol Mitten-Line Hyperpigmentation of an Infant. 653-654 Park Jin J Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea.; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea. Park Su-Kyung SK Department of Dermatology, Chonbuk National

2016 Annals of dermatology

102. Unusual case of hyperpigmentation secondary to irinotecan Full Text available with Trip Pro

Unusual case of hyperpigmentation secondary to irinotecan 27793873 2017 03 06 2018 12 02 1757-790X 2016 2016 Oct 28 BMJ case reports BMJ Case Rep Unusual case of hyperpigmentation secondary to irinotecan. bcr2016217545 10.1136/bcr-2016-217545 Nestor Laura Aisling LA Department of Dermatology, Adelaide and Meath Hospital, Tallaght, Ireland. Flint Stephen S Department of Oral Medicine and Dentistry, Dublin Dental School and Hospital, Dublin, Ireland. Galvin Sheila S Department of Oral Medicine (...) & dosage Colorectal Neoplasms therapy Drug Eruptions etiology Female Humans Hyperpigmentation chemically induced Irinotecan Middle Aged Mouth Mucosa Nails Neoplasm Recurrence, Local drug therapy Conflicts of Interest: None declared. 2016 10 30 6 0 2017 3 7 6 0 2016 10 30 6 0 epublish 27793873 bcr-2016-217545 10.1136/bcr-2016-217545 PMC5093355 Drug Discov Today Dis Mech. 2008;5(2):e189-e199 19578486 J Pharm Bioallied Sci. 2015 Aug;7(Suppl 2):S403-8 26538887

2016 BMJ case reports

103. Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation Full Text available with Trip Pro

Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation Hyperpigmentation caused by melanin overproduction is a major skin disorder in humans. Inhibition of tyrosinase, a key regulator of melanin production, has been used as an effective strategy to treat hyperpigmentation. In this study, we investigated the use of solid lipid nanoparticles (SLNs) as a highly effective and nontoxic means to deliver (...) -induced melanogenesis, resulting in no change in the skin color of C57BL/6 mouse, compared with that observed in an MHY solution-treated group and an untreated control group. The antimelanogenic effect of MHY-SLNs was further confirmed through Fontana-Masson staining. Importantly, MHY-SLNs did not induce any toxic effects in the L929 cell line. Overall, these data indicate that MHY-SLNs show promise in the topical treatment of hyperpigmentation.

2016 Drug design, development and therapy

104. Minocycline-Induced Cutaneous Hyperpigmentation in an Orthopedic Patient Population Full Text available with Trip Pro

Minocycline-Induced Cutaneous Hyperpigmentation in an Orthopedic Patient Population Background.  The objectives of this study were to estimate the incidence and evaluate risk factors for development of minocycline-induced cutaneous hyperpigmentation in patients with orthopedic infections. Methods.  Patients with orthopedic infections evaluated at Mayo Clinic (Rochester, MN) and treated with minocycline from 1 January 2002 to 31 December 2011 were retrospectively identified. Long-term (...) minocycline suppression was defined as daily minocycline use for at least 3 months. A proportional hazards model was used to evaluate potential risk factors. Results.  Of 291 patients receiving long-term minocycline suppression, 54% (156 of 291) developed hyperpigmentation after a mean follow-up of 4.8 years (range, 0.3-13.2 years); 88% involved blue-gray pigmentation of normal skin that appeared most commonly in the lower (75%) and upper extremities (44%). The mean duration of minocycline therapy before

2016 Open forum infectious diseases

105. Tigecycline Induced Hyperpigmentation of the Skin Full Text available with Trip Pro

Tigecycline Induced Hyperpigmentation of the Skin 27011952 2016 03 25 2018 11 13 2328-8957 3 1 2016 Jan Open forum infectious diseases Open Forum Infect Dis Tigecycline Induced Hyperpigmentation of the Skin. ofw033 10.1093/ofid/ofw033 Vandecasteele S J SJ Departments of Nephrology and Infectious Diseases. De Ceulaer J J Maxillofacial Surgery. Wittouck E E Dermatology , AZ Sint-Jan Brugge-Oostende AV , Belgium. eng Journal Article 2016 02 17 United States Open Forum Infect Dis 101637045 2328

2016 Open forum infectious diseases

106. HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample Full Text available with Trip Pro

HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample Objective. The aim of the study was to determine the prevalence of HIV-associated oral mucosal melanin hyperpigmentation (HIV-OMH) in a specific population of HIV-seropositive South Africans and to analyse the associations between HIV-OMH clinical features and the demographic and immunological characteristics of the study cohort. Material and Methods. This cross-sectional study included

2016 AIDS research and treatment

107. Periorbital Hyperpigmentation in Patients with Xanthelasma Palpebrarum: An Interesting Observation Full Text available with Trip Pro

Periorbital Hyperpigmentation in Patients with Xanthelasma Palpebrarum: An Interesting Observation Background: Xanthelasma palpebrarum refers to xanthomas that occur more often near the inner canthus of the eyelid. Periorbital hyperpigmentation presents as a dark area surrounding the eyelids. Objective: In the present study, the authors examined the prevalence and the associated factors of periorbital hyperpigmentation among patients with xanthelasma. Methods: One hundred and fourteen patients (...) with xanthelasma palpebrarum were examined for the presence of dark circles. Detailed questionnaires regarding the history of diabetes, hypothyroidism, smoking status, and weight were completed by all patients. They were also tested for serum lipids (cholesterol, low-density lipoprotein, triglycerides, apolipoprotein A and apolipoprotein B). Results: From the 114 patients with xanthelasma, 94 (82.4%) were diagnosed with periorbital hyperpigmentation. At the time of the survey, 46 patients were smokers (48.9

2016 The Journal of clinical and aesthetic dermatology

108. Cutaneous Hyperpigmentation in Megaloblastic Anemia: a Five Year Retrospective Review Full Text available with Trip Pro

Cutaneous Hyperpigmentation in Megaloblastic Anemia: a Five Year Retrospective Review Cutaneous hyperpigmentation is an often overlooked clinical sign in megaloblastic anemia (MA) which has been sporadically reported in the literature.We describe the bone marrow (BM) changes and clinicolaboratory characteristics of 25 of 198 adult cases (>16 years) with cutaneous hyperpigmentation who underwent BM evaluation for cytopenia (s).Twenty-one of 25 cases (84%) had MA, while MA without (...) hyperpigmentation occurred only in 12 of remainder 173 cases (P<0.001). Knuckle pad hyperpigmentation (KP) was noted in 16 (64%) cases; whereas 9 (36%) had diffuse brownish black discoloration (DP) of the palms and/or soles. Eighteen of 25 (72%) cases had pancytopenia (13 with KP) and 7 of 25 (28%) had bicytopenia (3 with KP). In addition, five cases (20%) presented with pyrexia. Of the 17 cases where data available, eleven were B12 deficient [<190 pg/ml; eight had severe deficiency (<100 pg/ml); ref.; 190

2016 Mediterranean journal of hematology and infectious diseases

109. Diffuse skin hyperpigmentation associated with chronic minocycline use in a patient with prosthetic joint infection Full Text available with Trip Pro

Diffuse skin hyperpigmentation associated with chronic minocycline use in a patient with prosthetic joint infection Cutaneous hyperpigmentation is a recognized adverse effect of chronic minocycline use occurring in up to 50% of patients. In this report we present a rare case of extensive skin hyperpigmentation involving both lower extremities in a patient receiving long term minocycline. The patient was receiving minocycline as suppression for chronic prosthetic joint infection. Risk factors

2016 IDCases

110. A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation Full Text available with Trip Pro

A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation p53-Transcriptional-regulated proteins interact with a large number of other signal transduction pathways in the cell, and a number of positive and negative autoregulatory feedback loops act upon the p53 response. P53 directly controls the POMC/α-MSH productions induced by ultraviolet (UV) and is associated with UV-independent pathological pigmentation. When identifying (...) at physiological and pathophysiological conditions. SASH1 is regulated by a novel p53/POMC/α-MSH/Gαs/SASH1 cascade to mediate melanogenesis. A novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. Our study demonstrates that a novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype.© 2016 The Authors. Journal of Cellular

2016 Journal of cellular and molecular medicine

111. Image Diagnosis: A Striking Bleomycin-Induced Skin Toxicity: Flagellate Hyperpigmentation Full Text available with Trip Pro

Image Diagnosis: A Striking Bleomycin-Induced Skin Toxicity: Flagellate Hyperpigmentation 28080950 2017 03 27 2019 02 26 1552-5775 21 2017 The Permanente journal Perm J Image Diagnosis: A Striking Bleomycin-Induced Skin Toxicity: Flagellate Hyperpigmentation. 16-001 10.7812/TPP/16-001 Hao Lin L Fellow in the Department of Hematology and Oncology at the University of Arkansas for Medical Sciences in Little Rock. lhao@uams.edu. Mahmoud Fade F Assistant Professor of Medicine in the Department (...) Drug Therapy, Combination Etoposide therapeutic use Humans Hyperpigmentation chemically induced Lymphadenopathy diagnostic imaging pathology Male Orchiectomy Teratoma diagnostic imaging pathology Testicular Neoplasms diagnostic imaging pathology surgery Tomography, X-Ray Computed Statement The author(s) have no conflicts of interest to disclose. 2017 1 13 6 0 2017 1 13 6 0 2017 3 28 6 0 ppublish 28080950 16-001 10.7812/TPP/16-001 PMC5224796 Int J Dermatol. 1999 Feb;38(2):140-1 10192167 Am J

2016 The Permanente journal

112. Postinflammatory hyperpigmentation after human cold pain testing Full Text available with Trip Pro

Postinflammatory hyperpigmentation after human cold pain testing Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by the accessibility and affordability of devices used to measure thermal sensitivity in humans. To address this gap, we developed an inexpensive method to measure cold pain thresholds in healthy (...) adult volunteers using dry ice and a thermode. However, early in preliminary testing, a subject presented with epidermal postinflammatory hyperpigmentation that lasted for >200 days. Although this response was unique among the small number of subjects in development of the assay, it raised questions as to the safety of the assay design.

2016 Pain Reports

113. An In Vivo Model for Postinflammatory Hyperpigmentation

An In Vivo Model for Postinflammatory Hyperpigmentation An In Vivo Model for Postinflammatory Hyperpigmentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An In Vivo Model for Postinflammatory (...) Hyperpigmentation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02905903 Recruitment Status : Unknown Verified February 2017 by Iltefat Hamzavi, Henry Ford Health System. Recruitment status was: Recruiting First Posted : September 19, 2016 Last Update Posted : February 23, 2017 Sponsor: Henry Ford Health

2016 Clinical Trials

114. A Comparative Study of Two Modalities, 4% Hydroquinone Versus 30% Salicylic Acid in Periorbital Hyperpigmentation and Assessment of Quality of Life Before and After Treatment. Full Text available with Trip Pro

A Comparative Study of Two Modalities, 4% Hydroquinone Versus 30% Salicylic Acid in Periorbital Hyperpigmentation and Assessment of Quality of Life Before and After Treatment. Periorbital hyperpigmentation (POH) is a common hyperpigmentary problem of the face, which can be psychologically distressing and it can influence an individual's quality of life. However, this condition has received less attention in literature.To study the clinico-etiological features and the effect of two therapeutic

2016 Indian journal of dermatology Controlled trial quality: uncertain

115. Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment. (Abstract)

Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment. Differences in cutaneous diseases in people of color call for nuanced evaluation and management. One of the most common dermatological complaints from patients with skin of color is dyspigmentation, particularly hyperpigmentation. The challenge for clinicians is to establish correct diagnoses along with consistently successful treatments to meet the needs of the increasingly diverse population served. This review (...) focuses on facial hyperpigmentation and outlines the most common skin disorders and treatment options.

2016 American journal of clinical dermatology

116. Comparative study of hydroquinone-free and hydroquinone-based hyperpigmentation regimens in treating facial hyperpigmentation and photoaging. (Abstract)

Comparative study of hydroquinone-free and hydroquinone-based hyperpigmentation regimens in treating facial hyperpigmentation and photoaging. Photoaged skin, characterized by mottled, irregular areas of pigmentation, is a common skin condition that is often difficult to treat. The areas of hypermelanosis are an aesthetic concern to subjects and may lead to social distress and quality of life issues. There are many commercial hyperpigmentation regimens marketed to lighten dark spots and improve (...) overall skin dyschromia. However, data to support efficacy of such kits are often lacking.This investigator-blinded, randomized trial was conducted to compare a new hydroquinone (HQ)-free hyperpigmentation regimen against a leading HQ-based hyperpigmentation regimen for the treatment of facial hyperpigmentation and photoaging.Subjects with mottled pigmentation and photodamaged facial skin were randomized to treatment with either the new 4-product (HQ-free) SkinMedica® Hyperpigmentation System (SKM

2013 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

117. Reliability assessment and validation of the postacne hyperpigmentation index (PAHPI), a new instrument to measure postinflammatory hyperpigmentation from acne vulgaris. (Abstract)

Reliability assessment and validation of the postacne hyperpigmentation index (PAHPI), a new instrument to measure postinflammatory hyperpigmentation from acne vulgaris. There are no validated outcome measures for postinflammatory hyperpigmentation (PIH).We sought to determine the reliability and validity of an outcome measure for PIH after acne in patients with skin of color.A postacne hyperpigmentation index (PAHPI) was developed. Six raters scored 21 patients with PIH twice. Reliability

2013 Journal of American Academy of Dermatology

118. An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits. (Abstract)

An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits. Acne vulgaris is a common condition that occurs in all skin types. Postinflammatory hyperpigmentation (PIH) is often associated with acne in patients of darker skin types, making it a common complaint in dermatology offices. Despite this, there is limited understanding of and effective treatment options for PIH.The study objective was to validate an in vivo

2015 British Journal of Dermatology

119. Antimelanogenic activity of a novel adamantyl benzylbenzamide derivative, AP736: a randomized, double-blind, vehicle-controlled comparative clinical trial performed in patients with hyperpigmentation during the summer. Full Text available with Trip Pro

Antimelanogenic activity of a novel adamantyl benzylbenzamide derivative, AP736: a randomized, double-blind, vehicle-controlled comparative clinical trial performed in patients with hyperpigmentation during the summer. AP736 is a novel compound with an adamantyl benzylbenzamide moiety that has shown antimelanogenic activity in melanocytes in vitro and in artificial skin equivalent through the inhibition of key melanogenic enzymes and suppression of the cAMP-phosphokinase A-cAMP response element (...) -binding protein signaling pathway. To estimate the clinical effectiveness of AP736 for the treatment of facial hyperpigmentation, we examined the efficacy and safety of a topical formulation containing AP736 compared with a vehicle formulation in human facial skin. To evaluate the degree of whitening when used in a real-life situation, subjects with hyperpigmentation conditions were selected and the trial was performed from mid-May to the end of June, when there are strong UV rays in Korea.Forty-eight

2015 International Journal of Dermatology Controlled trial quality: uncertain

120. Cutaneous hyperpigmentation induced by doxycycline: a case series. (Abstract)

Cutaneous hyperpigmentation induced by doxycycline: a case series. Cutaneous hyperpigmentation is a well-known side effect of tetracyclines, but doxycycline-induced cutaneous hyperpigmentation has only been described in one patient with a therapeutic dosage of doxycycline, and in one patient using suprapharmacological doses. We describe four patients with cutaneous hyperpigmentation in previously unaffected skin, and speculate that this was due to treatment with doxycycline in therapeutic doses (...) . After cessation of therapy, the hyperpigmentation diminished in all four patients, illustrating the need for recognition and timely cessation of therapy.

2015 Netherlands Journal of Medicine

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