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Hyperpigmentation

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101. Hyperpigmentation in a middle aged woman: a common yet underdiagnosed condition (PubMed)

Hyperpigmentation in a middle aged woman: a common yet underdiagnosed condition 27406454 2016 07 13 2018 11 13 2000-9666 6 3 2016 Journal of community hospital internal medicine perspectives J Community Hosp Intern Med Perspect Hyperpigmentation in a middle aged woman: a common yet underdiagnosed condition. 31544 10.3402/jchimp.v6.31544 Melnick Stephen S Department of Internal Medicine, Reading Health System, West Reading, PA, USA; Stephen.melnick2@readinghealth.org. Lohani Saroj S Department

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2016 Journal of community hospital internal medicine perspectives

102. A Comparative Study of Two Modalities, 4% Hydroquinone Versus 30% Salicylic Acid in Periorbital Hyperpigmentation and Assessment of Quality of Life Before and After Treatment. (PubMed)

A Comparative Study of Two Modalities, 4% Hydroquinone Versus 30% Salicylic Acid in Periorbital Hyperpigmentation and Assessment of Quality of Life Before and After Treatment. Periorbital hyperpigmentation (POH) is a common hyperpigmentary problem of the face, which can be psychologically distressing and it can influence an individual's quality of life. However, this condition has received less attention in literature.To study the clinico-etiological features and the effect of two therapeutic

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2016 Indian journal of dermatology Controlled trial quality: uncertain

103. The comparison between modified kligman formulation versus kligman formulation and intense pulsed light in the treatment of the post-burn hyperpigmentation. (PubMed)

The comparison between modified kligman formulation versus kligman formulation and intense pulsed light in the treatment of the post-burn hyperpigmentation. Post inflammatory hyperpigmentation (PIH) is a common problem occurs following many dermatologic diseases and medical interventions. Different modalities including topical agents, lasers and intense pulsed light (IPL) are suggested for treatment of the post-burn PIH. In the current study, we evaluated the efficacy of IPL plus modified

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2016 Advanced biomedical research Controlled trial quality: uncertain

104. Reliability assessment and validation of the postacne hyperpigmentation index (PAHPI), a new instrument to measure postinflammatory hyperpigmentation from acne vulgaris. (PubMed)

Reliability assessment and validation of the postacne hyperpigmentation index (PAHPI), a new instrument to measure postinflammatory hyperpigmentation from acne vulgaris. There are no validated outcome measures for postinflammatory hyperpigmentation (PIH).We sought to determine the reliability and validity of an outcome measure for PIH after acne in patients with skin of color.A postacne hyperpigmentation index (PAHPI) was developed. Six raters scored 21 patients with PIH twice. Reliability

2013 Journal of American Academy of Dermatology

105. Comparative study of hydroquinone-free and hydroquinone-based hyperpigmentation regimens in treating facial hyperpigmentation and photoaging. (PubMed)

Comparative study of hydroquinone-free and hydroquinone-based hyperpigmentation regimens in treating facial hyperpigmentation and photoaging. Photoaged skin, characterized by mottled, irregular areas of pigmentation, is a common skin condition that is often difficult to treat. The areas of hypermelanosis are an aesthetic concern to subjects and may lead to social distress and quality of life issues. There are many commercial hyperpigmentation regimens marketed to lighten dark spots and improve (...) overall skin dyschromia. However, data to support efficacy of such kits are often lacking.This investigator-blinded, randomized trial was conducted to compare a new hydroquinone (HQ)-free hyperpigmentation regimen against a leading HQ-based hyperpigmentation regimen for the treatment of facial hyperpigmentation and photoaging.Subjects with mottled pigmentation and photodamaged facial skin were randomized to treatment with either the new 4-product (HQ-free) SkinMedica® Hyperpigmentation System (SKM

2013 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

106. Cutaneous hyperpigmentation induced by doxycycline: a case series. (PubMed)

Cutaneous hyperpigmentation induced by doxycycline: a case series. Cutaneous hyperpigmentation is a well-known side effect of tetracyclines, but doxycycline-induced cutaneous hyperpigmentation has only been described in one patient with a therapeutic dosage of doxycycline, and in one patient using suprapharmacological doses. We describe four patients with cutaneous hyperpigmentation in previously unaffected skin, and speculate that this was due to treatment with doxycycline in therapeutic doses (...) . After cessation of therapy, the hyperpigmentation diminished in all four patients, illustrating the need for recognition and timely cessation of therapy.

2015 Netherlands Journal of Medicine

107. Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser

Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02492373 Recruitment Status : Completed First Posted : July 8, 2015 Last Update Posted : June 1, 2016 Sponsor

2015 Clinical Trials

108. An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits. (PubMed)

An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits. Acne vulgaris is a common condition that occurs in all skin types. Postinflammatory hyperpigmentation (PIH) is often associated with acne in patients of darker skin types, making it a common complaint in dermatology offices. Despite this, there is limited understanding of and effective treatment options for PIH.The study objective was to validate an in vivo

2015 British Journal of Dermatology

109. Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature. (PubMed)

Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature. Inherited or acquired reticulate hyperpigmentation represents a heterogeneous group of infrequent dermatological conditions. The development of reticulate hyperpigmentation has so far been rarely reported to be associated with chemotherapeutic agents, including fluorouracil, bleomycin or a combination of cytarabine and idarubicin.We describe 5 cases of chemotherapy-related reticulate hyperpigmentation (...) . These features have been compared with the available data through a literature review.Reticulate hyperpigmentation is an underestimated but characteristic complication of chemotherapy. Neither specific management nor discontinuation of the chemotherapeutic regimen is required.© 2015 S. Karger AG, Basel.

2015 Dermatology

110. Identification of tyrosinase inhibitors from traditional Chinese medicines for the management of hyperpigmentation (PubMed)

Identification of tyrosinase inhibitors from traditional Chinese medicines for the management of hyperpigmentation The inhibition of tyrosinase is the most effective method to decrease melanin synthesis during the process of pigmentation. We aimed to find compounds from traditional Chinese medicines (TCM) that are more effective than the most commonly used tyrosinase inhibitor, arbutin. First, we employed homology modeling to construct a tyrosinase-modeled structure, and structure-based virtual

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2015 SpringerPlus

111. Hyperpigmentation Results in Aberrant Immune Development in Silky Fowl (Gallus gallus domesticus Brisson) (PubMed)

Hyperpigmentation Results in Aberrant Immune Development in Silky Fowl (Gallus gallus domesticus Brisson) The Silky Fowl (SF) is known for its special phenotypes and atypical distribution of melanocytes among internal organs. Although the genes associated with melanocyte migration have been investigated substantially, there is little information on the postnatal distribution of melanocytes in inner organs and the effect of hyperpigmentation on the development of SF. Here, we analyzed melanocyte (...) and apoptosis-associated Bax and Bcl-2 proteins indicated that apoptosis is involved in degeneration of the thymus and bursa of Fabricius. Therefore, these results suggest that hyperpigmentation in SF may have a close relationship with immune development in SF, which can provide an important animal model to investigate the roles of melanocyte.

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2015 PloS one

112. Benign dermoscopic parallel ridge pattern in plantar hyperpigmentation due to capecitabine (PubMed)

Benign dermoscopic parallel ridge pattern in plantar hyperpigmentation due to capecitabine We report the case of a 37-year-old woman (phototype II) who presented at our outpatient clinic with a two-month history of hyperpigmented plantar macules. Medical history revealed that the patient had taken capecitabine in the past three months as adjuvant chemotherapy for recurrent breast cancer. Dermoscopic examination of the plantar macules showed parallel ridge pattern with pigmentation (...) in the furrows without obliteration of eccrine gland apertures. Besides in acral melanoma, parallel ridge pattern can also be observed in benign plantar lesions, such as congenital or acquired acral nevi, subcorneal hemorrhage, dye-related pigmentation and drug-induced hyperpigmentation, especially in patients with phototypes III-VI. The few reported cases of capecitabine-induced hyperpigmentation have been associated with hand and foot syndrome in patients with phototypes IV-V and palmar as well as plantar

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2015 Dermatology practical & conceptual

113. A Case of Hyper Immunoglobulin-E Syndrome Associated with Scrotal Tongue and Intraoral Hyperpigmentation (PubMed)

A Case of Hyper Immunoglobulin-E Syndrome Associated with Scrotal Tongue and Intraoral Hyperpigmentation 26120195 2015 06 29 2018 11 13 1998-3611 60 3 2015 May-Jun Indian journal of dermatology Indian J Dermatol A Case of Hyper Immunoglobulin-E Syndrome Associated with Scrotal Tongue and Intraoral Hyperpigmentation. 324 10.4103/0019-5154.156483 Patil Subha V SV Department of Dermatology, Dr. D. Y. Patil Medical College and Hospital, Pimpri, India. E-mail: patilsubha23@gmail.com. Sharma Yugal K

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2015 Indian journal of dermatology

114. Pernicious anaemia presenting as hyperpigmentation. (PubMed)

Pernicious anaemia presenting as hyperpigmentation. An adult East Asian woman presented with sudden onset of hyperpigmented macules on her oral mucosal surfaces, palms and soles, in association with hypoguesia and loss of weight. This was found to be associated with underlying severe vitamin B12 deficiency secondary to pernicious anaemia. © 2015 British Association of Dermatologists.

2015 Clinical & Experimental Dermatology

115. Aesthetic Management of Gum Hyperpigmentation by a Simple Technique (PubMed)

Aesthetic Management of Gum Hyperpigmentation by a Simple Technique 25949028 2015 05 07 2018 11 13 0974-2077 8 1 2015 Jan-Mar Journal of cutaneous and aesthetic surgery J Cutan Aesthet Surg Aesthetic management of gum hyperpigmentation by a simple technique. 64-6 10.4103/0974-2077.155095 Singhal Anshul A Department of Periodontology, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India E-mail: deepa_arun@rediffmail.com. Deepa Dhruvakumar D Department of Periodontology, Subharti

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2015 Journal of cutaneous and aesthetic surgery

116. H Syndrome; a Multifaceted Histiocytic Disorder with Hyperpigmentation and Hypertrichosis. (PubMed)

H Syndrome; a Multifaceted Histiocytic Disorder with Hyperpigmentation and Hypertrichosis. 26015165 2016 08 12 2015 11 04 1651-2057 95 8 2015 Nov Acta dermato-venereologica Acta Derm. Venereol. H syndrome: a multifaceted histiocytic disorder with hyperpigmentation and hypertrichosis. 1021-3 10.2340/00015555-2145 Tekin Burak B Department of Dermatology, Marmara University School of Medicine, 34899 Istanbul, Turkey. burak.tekin@marmara.edu.tr. Atay Zeynep Z Ergun Tulin T Can Meryem M Tuney Davut (...) D Babay Sofia S Turan Serap S Bereket Abdullah A Zlotogorski Abraham A Molho-Pessach Vered V eng Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 0 Nucleoside Transport Proteins 0 SLC29A3 protein, human IM Adult Child Hearing Loss, Sensorineural genetics Histiocytes pathology Humans Hyperpigmentation genetics pathology Hypertrichosis genetics pathology Male Nucleoside Transport Proteins genetics Phenotype Syndrome 2015 5 28 6 0 2015 5 28 6 0 2016 8 16 6 0 ppublish

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2015 Acta Dermato-Venereologica

117. Evaluation of pain on use of electrosurgery and diode lasers in the management of gingival hyperpigmentation: A comparative study. (PubMed)

Evaluation of pain on use of electrosurgery and diode lasers in the management of gingival hyperpigmentation: A comparative study. Gingival depigmentation is a periodontal plastic surgical procedure whereby the gingival hyperpigmentation is removed by various techniques such as electrosurgery, cryosurgery, abrasion with diamond bur and lasers. The aim of this study was to determine the pain levels during the gingival depigmentation procedure using electrosurgery and lasers.Twenty patients, both (...) of hyperpigmentated gingival areas to create a confident and pleasant smile, which could be easily attained by using either electrosurgery or lasers. This study concluded that lasers produce lesser pain and discomfort compared with electrosurgery during gingival depigmentation.

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2015 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

118. Long-term Multi-product Facial Regimen in Subjects with Moderate-to-severe Photodamage and Hyperpigmentation. (PubMed)

Long-term Multi-product Facial Regimen in Subjects with Moderate-to-severe Photodamage and Hyperpigmentation. Photoaged skin is primarily a result of chronic sun exposure. Irregular pigmentation and wrinkling are common clinical manifestations. Monotherapy with retinoids, growth factors, and skin lighteners have proven beneficial. However, long-term treatment with a multi-product facial regimen has not been assessed.This single-center clinical trial was conducted to assess the efficacy (...) and tolerance of a topical multi-product regimen when used by subjects with moderate-to-severe photodamage and hyperpigmentation on the face over a course of 24 weeks.Subjects were supplied with a six-product regimen to use on their face (cleanser, growth factor serum, skin brightener, moisturizer, retinol, and sunscreen). Products were used according to specific application instructions. Clinical grading and tolerability assessments were performed at baseline and at follow-up visits at Weeks 4,8,12,18

2015 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

119. Single blind, randomized, controlled trial of a lightening product with and without iontophoresis versus tretinoin and vehicle for hyperpigmentation. (PubMed)

Single blind, randomized, controlled trial of a lightening product with and without iontophoresis versus tretinoin and vehicle for hyperpigmentation. Hyperpigmentation is a common concern and has many causes including lentigines and melasma. Currently available topical products for hyperpigmentation are limited by their potential for irritation, lack of demonstrated efficacy or regulatory concerns.To compare the efficacy of a new skin lightening product with and without iontophoresis to a known (...) effective product (tretinoin) and placebo on hyperpigmentation caused by lentigines and/or melasma. Secondary objectives included an assessment of the product's effects on the appearance of rhytides and roughness.Eighty subjects were randomized into one of four treatment groups: proprietary lightening product, proprietary lightening product with iontophoresis, tretinoin 0.05% cream, or vehicle control. Seventy-four subjects completed all study visits. Blinded assessments of subjects were performed

2015 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

120. Comparison of Nd:YAG Laser and Surgical Stripping for Treatment of Gingival Hyperpigmentation: A Clinical Trial. (PubMed)

Comparison of Nd:YAG Laser and Surgical Stripping for Treatment of Gingival Hyperpigmentation: A Clinical Trial. The objective of this study is to evaluate and compare surgical stripping and neodymium-doped: yttrium, aluminum garnet (Nd:YAG) laser techniques for gingival depigmentation and to evaluate their effect on repigmentation.Gingival depigmentation is often associated with repigmentation. Recurrence of pigmentation differs according to different treatment modalities.In this study, 40 (...) maxillary sites from 20 patients presenting bilateral melanin gingival hyperpigmentation were selected. Contralateral quadrants in the maxilla were randomly assigned to receive Nd:YAG laser at 3 W, 30 mJ per pulse, with contact mode, and with a handpiece with a 300 μm diameter optic fiber and surgical stripping. Plaque index, Dummett Oral Pigmentation Index (DOPI), Hedin melanin index, size of pigmented area, time interval and extent of repigmentation, time taken for each of the procedures, assessment

2015 Photomedicine and laser surgery Controlled trial quality: uncertain

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