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Hyperpigmentation

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101. Cutaneous Hyperpigmentation in Megaloblastic Anemia: a Five Year Retrospective Review Full Text available with Trip Pro

Cutaneous Hyperpigmentation in Megaloblastic Anemia: a Five Year Retrospective Review Cutaneous hyperpigmentation is an often overlooked clinical sign in megaloblastic anemia (MA) which has been sporadically reported in the literature.We describe the bone marrow (BM) changes and clinicolaboratory characteristics of 25 of 198 adult cases (>16 years) with cutaneous hyperpigmentation who underwent BM evaluation for cytopenia (s).Twenty-one of 25 cases (84%) had MA, while MA without (...) hyperpigmentation occurred only in 12 of remainder 173 cases (P<0.001). Knuckle pad hyperpigmentation (KP) was noted in 16 (64%) cases; whereas 9 (36%) had diffuse brownish black discoloration (DP) of the palms and/or soles. Eighteen of 25 (72%) cases had pancytopenia (13 with KP) and 7 of 25 (28%) had bicytopenia (3 with KP). In addition, five cases (20%) presented with pyrexia. Of the 17 cases where data available, eleven were B12 deficient [<190 pg/ml; eight had severe deficiency (<100 pg/ml); ref.; 190

2016 Mediterranean journal of hematology and infectious diseases

102. Diffuse skin hyperpigmentation associated with chronic minocycline use in a patient with prosthetic joint infection Full Text available with Trip Pro

Diffuse skin hyperpigmentation associated with chronic minocycline use in a patient with prosthetic joint infection Cutaneous hyperpigmentation is a recognized adverse effect of chronic minocycline use occurring in up to 50% of patients. In this report we present a rare case of extensive skin hyperpigmentation involving both lower extremities in a patient receiving long term minocycline. The patient was receiving minocycline as suppression for chronic prosthetic joint infection. Risk factors

2016 IDCases

103. A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation Full Text available with Trip Pro

A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation p53-Transcriptional-regulated proteins interact with a large number of other signal transduction pathways in the cell, and a number of positive and negative autoregulatory feedback loops act upon the p53 response. P53 directly controls the POMC/α-MSH productions induced by ultraviolet (UV) and is associated with UV-independent pathological pigmentation. When identifying (...) at physiological and pathophysiological conditions. SASH1 is regulated by a novel p53/POMC/α-MSH/Gαs/SASH1 cascade to mediate melanogenesis. A novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. Our study demonstrates that a novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype.© 2016 The Authors. Journal of Cellular

2016 Journal of cellular and molecular medicine

104. Image Diagnosis: A Striking Bleomycin-Induced Skin Toxicity: Flagellate Hyperpigmentation Full Text available with Trip Pro

Image Diagnosis: A Striking Bleomycin-Induced Skin Toxicity: Flagellate Hyperpigmentation 28080950 2017 03 27 2019 02 26 1552-5775 21 2017 The Permanente journal Perm J Image Diagnosis: A Striking Bleomycin-Induced Skin Toxicity: Flagellate Hyperpigmentation. 16-001 10.7812/TPP/16-001 Hao Lin L Fellow in the Department of Hematology and Oncology at the University of Arkansas for Medical Sciences in Little Rock. lhao@uams.edu. Mahmoud Fade F Assistant Professor of Medicine in the Department (...) Drug Therapy, Combination Etoposide therapeutic use Humans Hyperpigmentation chemically induced Lymphadenopathy diagnostic imaging pathology Male Orchiectomy Teratoma diagnostic imaging pathology Testicular Neoplasms diagnostic imaging pathology surgery Tomography, X-Ray Computed Statement The author(s) have no conflicts of interest to disclose. 2017 1 13 6 0 2017 1 13 6 0 2017 3 28 6 0 ppublish 28080950 16-001 10.7812/TPP/16-001 PMC5224796 Int J Dermatol. 1999 Feb;38(2):140-1 10192167 Am J

2016 The Permanente journal

105. Postinflammatory hyperpigmentation after human cold pain testing Full Text available with Trip Pro

Postinflammatory hyperpigmentation after human cold pain testing Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by the accessibility and affordability of devices used to measure thermal sensitivity in humans. To address this gap, we developed an inexpensive method to measure cold pain thresholds in healthy (...) adult volunteers using dry ice and a thermode. However, early in preliminary testing, a subject presented with epidermal postinflammatory hyperpigmentation that lasted for >200 days. Although this response was unique among the small number of subjects in development of the assay, it raised questions as to the safety of the assay design.

2016 Pain Reports

106. An In Vivo Model for Postinflammatory Hyperpigmentation

An In Vivo Model for Postinflammatory Hyperpigmentation An In Vivo Model for Postinflammatory Hyperpigmentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An In Vivo Model for Postinflammatory (...) Hyperpigmentation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02905903 Recruitment Status : Unknown Verified February 2017 by Iltefat Hamzavi, Henry Ford Health System. Recruitment status was: Recruiting First Posted : September 19, 2016 Last Update Posted : February 23, 2017 Sponsor: Henry Ford Health

2016 Clinical Trials

107. A Comparative Study of Two Modalities, 4% Hydroquinone Versus 30% Salicylic Acid in Periorbital Hyperpigmentation and Assessment of Quality of Life Before and After Treatment. Full Text available with Trip Pro

A Comparative Study of Two Modalities, 4% Hydroquinone Versus 30% Salicylic Acid in Periorbital Hyperpigmentation and Assessment of Quality of Life Before and After Treatment. Periorbital hyperpigmentation (POH) is a common hyperpigmentary problem of the face, which can be psychologically distressing and it can influence an individual's quality of life. However, this condition has received less attention in literature.To study the clinico-etiological features and the effect of two therapeutic

2016 Indian journal of dermatology Controlled trial quality: uncertain

108. Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment. (Abstract)

Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment. Differences in cutaneous diseases in people of color call for nuanced evaluation and management. One of the most common dermatological complaints from patients with skin of color is dyspigmentation, particularly hyperpigmentation. The challenge for clinicians is to establish correct diagnoses along with consistently successful treatments to meet the needs of the increasingly diverse population served. This review (...) focuses on facial hyperpigmentation and outlines the most common skin disorders and treatment options.

2016 American journal of clinical dermatology

109. Comparative study of hydroquinone-free and hydroquinone-based hyperpigmentation regimens in treating facial hyperpigmentation and photoaging. (Abstract)

Comparative study of hydroquinone-free and hydroquinone-based hyperpigmentation regimens in treating facial hyperpigmentation and photoaging. Photoaged skin, characterized by mottled, irregular areas of pigmentation, is a common skin condition that is often difficult to treat. The areas of hypermelanosis are an aesthetic concern to subjects and may lead to social distress and quality of life issues. There are many commercial hyperpigmentation regimens marketed to lighten dark spots and improve (...) overall skin dyschromia. However, data to support efficacy of such kits are often lacking.This investigator-blinded, randomized trial was conducted to compare a new hydroquinone (HQ)-free hyperpigmentation regimen against a leading HQ-based hyperpigmentation regimen for the treatment of facial hyperpigmentation and photoaging.Subjects with mottled pigmentation and photodamaged facial skin were randomized to treatment with either the new 4-product (HQ-free) SkinMedica® Hyperpigmentation System (SKM

2013 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

110. Reliability assessment and validation of the postacne hyperpigmentation index (PAHPI), a new instrument to measure postinflammatory hyperpigmentation from acne vulgaris. (Abstract)

Reliability assessment and validation of the postacne hyperpigmentation index (PAHPI), a new instrument to measure postinflammatory hyperpigmentation from acne vulgaris. There are no validated outcome measures for postinflammatory hyperpigmentation (PIH).We sought to determine the reliability and validity of an outcome measure for PIH after acne in patients with skin of color.A postacne hyperpigmentation index (PAHPI) was developed. Six raters scored 21 patients with PIH twice. Reliability

2013 Journal of American Academy of Dermatology

111. An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits. (Abstract)

An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits. Acne vulgaris is a common condition that occurs in all skin types. Postinflammatory hyperpigmentation (PIH) is often associated with acne in patients of darker skin types, making it a common complaint in dermatology offices. Despite this, there is limited understanding of and effective treatment options for PIH.The study objective was to validate an in vivo

2015 British Journal of Dermatology

112. Antimelanogenic activity of a novel adamantyl benzylbenzamide derivative, AP736: a randomized, double-blind, vehicle-controlled comparative clinical trial performed in patients with hyperpigmentation during the summer. Full Text available with Trip Pro

Antimelanogenic activity of a novel adamantyl benzylbenzamide derivative, AP736: a randomized, double-blind, vehicle-controlled comparative clinical trial performed in patients with hyperpigmentation during the summer. AP736 is a novel compound with an adamantyl benzylbenzamide moiety that has shown antimelanogenic activity in melanocytes in vitro and in artificial skin equivalent through the inhibition of key melanogenic enzymes and suppression of the cAMP-phosphokinase A-cAMP response element (...) -binding protein signaling pathway. To estimate the clinical effectiveness of AP736 for the treatment of facial hyperpigmentation, we examined the efficacy and safety of a topical formulation containing AP736 compared with a vehicle formulation in human facial skin. To evaluate the degree of whitening when used in a real-life situation, subjects with hyperpigmentation conditions were selected and the trial was performed from mid-May to the end of June, when there are strong UV rays in Korea.Forty-eight

2015 International Journal of Dermatology Controlled trial quality: uncertain

113. Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature. (Abstract)

Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature. Inherited or acquired reticulate hyperpigmentation represents a heterogeneous group of infrequent dermatological conditions. The development of reticulate hyperpigmentation has so far been rarely reported to be associated with chemotherapeutic agents, including fluorouracil, bleomycin or a combination of cytarabine and idarubicin.We describe 5 cases of chemotherapy-related reticulate hyperpigmentation (...) . These features have been compared with the available data through a literature review.Reticulate hyperpigmentation is an underestimated but characteristic complication of chemotherapy. Neither specific management nor discontinuation of the chemotherapeutic regimen is required.© 2015 S. Karger AG, Basel.

2015 Dermatology

114. Cutaneous hyperpigmentation induced by doxycycline: a case series. (Abstract)

Cutaneous hyperpigmentation induced by doxycycline: a case series. Cutaneous hyperpigmentation is a well-known side effect of tetracyclines, but doxycycline-induced cutaneous hyperpigmentation has only been described in one patient with a therapeutic dosage of doxycycline, and in one patient using suprapharmacological doses. We describe four patients with cutaneous hyperpigmentation in previously unaffected skin, and speculate that this was due to treatment with doxycycline in therapeutic doses (...) . After cessation of therapy, the hyperpigmentation diminished in all four patients, illustrating the need for recognition and timely cessation of therapy.

2015 Netherlands Journal of Medicine

115. Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser

Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02492373 Recruitment Status : Completed First Posted : July 8, 2015 Last Update Posted : June 1, 2016 Sponsor

2015 Clinical Trials

116. Single blind, randomized, controlled trial of a lightening product with and without iontophoresis versus tretinoin and vehicle for hyperpigmentation. (Abstract)

Single blind, randomized, controlled trial of a lightening product with and without iontophoresis versus tretinoin and vehicle for hyperpigmentation. Hyperpigmentation is a common concern and has many causes including lentigines and melasma. Currently available topical products for hyperpigmentation are limited by their potential for irritation, lack of demonstrated efficacy or regulatory concerns.To compare the efficacy of a new skin lightening product with and without iontophoresis to a known (...) effective product (tretinoin) and placebo on hyperpigmentation caused by lentigines and/or melasma. Secondary objectives included an assessment of the product's effects on the appearance of rhytides and roughness.Eighty subjects were randomized into one of four treatment groups: proprietary lightening product, proprietary lightening product with iontophoresis, tretinoin 0.05% cream, or vehicle control. Seventy-four subjects completed all study visits. Blinded assessments of subjects were performed

2015 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

117. Evaluation of pain on use of electrosurgery and diode lasers in the management of gingival hyperpigmentation: A comparative study. Full Text available with Trip Pro

Evaluation of pain on use of electrosurgery and diode lasers in the management of gingival hyperpigmentation: A comparative study. Gingival depigmentation is a periodontal plastic surgical procedure whereby the gingival hyperpigmentation is removed by various techniques such as electrosurgery, cryosurgery, abrasion with diamond bur and lasers. The aim of this study was to determine the pain levels during the gingival depigmentation procedure using electrosurgery and lasers.Twenty patients, both (...) of hyperpigmentated gingival areas to create a confident and pleasant smile, which could be easily attained by using either electrosurgery or lasers. This study concluded that lasers produce lesser pain and discomfort compared with electrosurgery during gingival depigmentation.

2015 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

118. Long-term Multi-product Facial Regimen in Subjects with Moderate-to-severe Photodamage and Hyperpigmentation. (Abstract)

Long-term Multi-product Facial Regimen in Subjects with Moderate-to-severe Photodamage and Hyperpigmentation. Photoaged skin is primarily a result of chronic sun exposure. Irregular pigmentation and wrinkling are common clinical manifestations. Monotherapy with retinoids, growth factors, and skin lighteners have proven beneficial. However, long-term treatment with a multi-product facial regimen has not been assessed.This single-center clinical trial was conducted to assess the efficacy (...) and tolerance of a topical multi-product regimen when used by subjects with moderate-to-severe photodamage and hyperpigmentation on the face over a course of 24 weeks.Subjects were supplied with a six-product regimen to use on their face (cleanser, growth factor serum, skin brightener, moisturizer, retinol, and sunscreen). Products were used according to specific application instructions. Clinical grading and tolerability assessments were performed at baseline and at follow-up visits at Weeks 4,8,12,18

2015 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

119. Identification of tyrosinase inhibitors from traditional Chinese medicines for the management of hyperpigmentation Full Text available with Trip Pro

Identification of tyrosinase inhibitors from traditional Chinese medicines for the management of hyperpigmentation The inhibition of tyrosinase is the most effective method to decrease melanin synthesis during the process of pigmentation. We aimed to find compounds from traditional Chinese medicines (TCM) that are more effective than the most commonly used tyrosinase inhibitor, arbutin. First, we employed homology modeling to construct a tyrosinase-modeled structure, and structure-based virtual

2015 SpringerPlus

120. A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations. (Abstract)

A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations. Arbutin is one of the most effective lightening substances. Serratula quinquefolia is a new source of its β-anomer. The HPLC method showed that the solid content of this compound in the dried plant raw material accounts for 6.86%. The leaves of Serratula quinquefolia do not contain hydroquinone.To assess the efficacy of the aqueous extract from

2015 Journal of cosmetic dermatology Controlled trial quality: uncertain

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