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Hyperpigmentation

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81. Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment. (PubMed)

Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment. Differences in cutaneous diseases in people of color call for nuanced evaluation and management. One of the most common dermatological complaints from patients with skin of color is dyspigmentation, particularly hyperpigmentation. The challenge for clinicians is to establish correct diagnoses along with consistently successful treatments to meet the needs of the increasingly diverse population served. This review (...) focuses on facial hyperpigmentation and outlines the most common skin disorders and treatment options.

2016 American journal of clinical dermatology

82. Postinflammatory Hyperpigmentation Associated with Treatment of Solar Lentigines using a Q-Switched 532-nm Nd: YAG Laser: A Multicenter Survey. (PubMed)

Postinflammatory Hyperpigmentation Associated with Treatment of Solar Lentigines using a Q-Switched 532-nm Nd: YAG Laser: A Multicenter Survey. To characterize the risk factors of Korean patients for postinflammatory hyperpigmentation (PIH) during treatment of solar lentigines using a Q-switched 532-nm Nd: YAG (QS 532 NY) laser.The present retrospective multicenter study was conducted at the dermatology clinics of five tertiary hospitals in Korea. Between October 2007 and January 2013, 516

2016 Journal of Dermatological Treatment

83. Edema, Hyperpigmentation, Induration: 3 Skin Signs Heralding Danger in Patients on Maintenance Hemodialysis. (PubMed)

Edema, Hyperpigmentation, Induration: 3 Skin Signs Heralding Danger in Patients on Maintenance Hemodialysis. Skin changes are common in patients on dialysis. This study focused on putative associations of specific skin findings with comorbidities and mortality.We performed a retrospective analysis of data from 508 patients on maintenance hemodialysis therapy in 7 centers in the German State of North Rhine Westphalia. Data had been collected by interview, from patient files, and from targeted (...) physical examination in an earlier prospective study screening hemodialysis patients for the presence of nephrogenic systemic fibrosis. While on dialysis, patients' extremities had been examined for any of the following: edematous skin at the lower extremities, hyperpigmentation, induration, and xerosis cutis. Our present data analyses focused on associated mortality and comorbidities.Five hundred eight patients (median age 71 years, range 20.0-95.9; n = 292 men) had agreed to participate

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2016 Medicine

84. Hyperpigmentation following the Blaschko's lines: a subtle cutaneous manifestation of Turner syndrome with complex mosaicism. (PubMed)

Hyperpigmentation following the Blaschko's lines: a subtle cutaneous manifestation of Turner syndrome with complex mosaicism. 27106053 2017 09 18 2017 09 18 1365-2133 175 6 2016 Dec The British journal of dermatology Br. J. Dermatol. Hyperpigmentation following the Blaschko's lines: a subtle cutaneous manifestation of Turner syndrome with complex mosaicism. 1379-1381 10.1111/bjd.14688 Deza G G Department of Dermatology, Department of Pathology, Hospital del Mar - Parc de Salut Mar, Barcelona (...) , Spain. Cancer Research Programme, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. Gilaberte M M Department of Dermatology, Department of Pathology, Hospital del Mar - Parc de Salut Mar, Barcelona, Spain. Pujol R M RM Department of Dermatology, Department of Pathology, Hospital del Mar - Parc de Salut Mar, Barcelona, Spain. eng Case Reports Letter 2016 10 07 England Br J Dermatol 0004041 0007-0963 IM Child, Preschool Female Humans Hyperpigmentation etiology pathology Mosaicism

2016 British Journal of Dermatology

85. Association of hyperpigmentations of the skin and drug use: a systematic review. (PubMed)

Association of hyperpigmentations of the skin and drug use: a systematic review. Part of the acquired hyperpigmentations of the skin are interpreted as adverse effect of drugs. However, systematic studies are rare in the literature, as case reports have predominantly been published. The present systematic review attempts to provide a contribution to the body of evidence for a causal relation.The reports on an association of hyperpigmentation and drugs from 1970 until April 2016 found in Medline (...) and EMBASE were rated according to the SIGN grading system for clinical studies.A total of 352 evaluated publications were found, which mainly consist of reports of single cases, only a small number of larger case series were available. Case-control-studies and randomized controlled studies have rarely been found. The level of evidence for a causal relation to hyperpigmentation is low for the major part of drugs as quoted in order to the Anatomical Therapeutic Chemical Classification System with Defined

2016 Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

86. Minocycline-Induced Cutaneous Hyperpigmentation in an Orthopedic Patient Population (PubMed)

Minocycline-Induced Cutaneous Hyperpigmentation in an Orthopedic Patient Population Background.  The objectives of this study were to estimate the incidence and evaluate risk factors for development of minocycline-induced cutaneous hyperpigmentation in patients with orthopedic infections. Methods.  Patients with orthopedic infections evaluated at Mayo Clinic (Rochester, MN) and treated with minocycline from 1 January 2002 to 31 December 2011 were retrospectively identified. Long-term (...) minocycline suppression was defined as daily minocycline use for at least 3 months. A proportional hazards model was used to evaluate potential risk factors. Results.  Of 291 patients receiving long-term minocycline suppression, 54% (156 of 291) developed hyperpigmentation after a mean follow-up of 4.8 years (range, 0.3-13.2 years); 88% involved blue-gray pigmentation of normal skin that appeared most commonly in the lower (75%) and upper extremities (44%). The mean duration of minocycline therapy before

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2016 Open forum infectious diseases

87. Tigecycline Induced Hyperpigmentation of the Skin (PubMed)

Tigecycline Induced Hyperpigmentation of the Skin 27011952 2016 03 25 2018 11 13 2328-8957 3 1 2016 Jan Open forum infectious diseases Open Forum Infect Dis Tigecycline Induced Hyperpigmentation of the Skin. ofw033 10.1093/ofid/ofw033 Vandecasteele S J SJ Departments of Nephrology and Infectious Diseases. De Ceulaer J J Maxillofacial Surgery. Wittouck E E Dermatology , AZ Sint-Jan Brugge-Oostende AV , Belgium. eng Journal Article 2016 02 17 United States Open Forum Infect Dis 101637045 2328

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2016 Open forum infectious diseases

88. HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample (PubMed)

HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample Objective. The aim of the study was to determine the prevalence of HIV-associated oral mucosal melanin hyperpigmentation (HIV-OMH) in a specific population of HIV-seropositive South Africans and to analyse the associations between HIV-OMH clinical features and the demographic and immunological characteristics of the study cohort. Material and Methods. This cross-sectional study included

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2016 AIDS research and treatment

89. Periorbital Hyperpigmentation in Patients with Xanthelasma Palpebrarum: An Interesting Observation (PubMed)

Periorbital Hyperpigmentation in Patients with Xanthelasma Palpebrarum: An Interesting Observation Background: Xanthelasma palpebrarum refers to xanthomas that occur more often near the inner canthus of the eyelid. Periorbital hyperpigmentation presents as a dark area surrounding the eyelids. Objective: In the present study, the authors examined the prevalence and the associated factors of periorbital hyperpigmentation among patients with xanthelasma. Methods: One hundred and fourteen patients (...) with xanthelasma palpebrarum were examined for the presence of dark circles. Detailed questionnaires regarding the history of diabetes, hypothyroidism, smoking status, and weight were completed by all patients. They were also tested for serum lipids (cholesterol, low-density lipoprotein, triglycerides, apolipoprotein A and apolipoprotein B). Results: From the 114 patients with xanthelasma, 94 (82.4%) were diagnosed with periorbital hyperpigmentation. At the time of the survey, 46 patients were smokers (48.9

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2016 The Journal of clinical and aesthetic dermatology

90. Cutaneous Hyperpigmentation in Megaloblastic Anemia: a Five Year Retrospective Review (PubMed)

Cutaneous Hyperpigmentation in Megaloblastic Anemia: a Five Year Retrospective Review Cutaneous hyperpigmentation is an often overlooked clinical sign in megaloblastic anemia (MA) which has been sporadically reported in the literature.We describe the bone marrow (BM) changes and clinicolaboratory characteristics of 25 of 198 adult cases (>16 years) with cutaneous hyperpigmentation who underwent BM evaluation for cytopenia (s).Twenty-one of 25 cases (84%) had MA, while MA without (...) hyperpigmentation occurred only in 12 of remainder 173 cases (P<0.001). Knuckle pad hyperpigmentation (KP) was noted in 16 (64%) cases; whereas 9 (36%) had diffuse brownish black discoloration (DP) of the palms and/or soles. Eighteen of 25 (72%) cases had pancytopenia (13 with KP) and 7 of 25 (28%) had bicytopenia (3 with KP). In addition, five cases (20%) presented with pyrexia. Of the 17 cases where data available, eleven were B12 deficient [<190 pg/ml; eight had severe deficiency (<100 pg/ml); ref.; 190

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2016 Mediterranean journal of hematology and infectious diseases

91. Postinflammatory Hyperpigmentation

Postinflammatory Hyperpigmentation Postinflammatory Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Postinflammatory (...) Hyperpigmentation Postinflammatory Hyperpigmentation Aka: Postinflammatory Hyperpigmentation From Related Chapters II. Definition response to inflammation on dark skin III. Pathophysiology Common complication following or inflammation in darker skin type (3 to 6) Local inflammation results in prostaglandin, leukotriene and thromboxane release Epidermal s hypertrophy, synthesizing IV. Causes: Common precipitating lesions Inflammation Laser therapy or V. Signs Irregular, dark s and patches at sites of injury

2018 FP Notebook

92. Oral Mucosa Hyperpigmentation

Oral Mucosa Hyperpigmentation Oral Mucosa Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Oral Mucosa (...) Hyperpigmentation Oral Mucosa Hyperpigmentation Aka: Oral Mucosa Hyperpigmentation , Melanin Pigmentation of Oral Mucosa From Related Chapters II. Causes May be associated with in autoimmune polyendocrinopathy- -ectodermal dystrophy syndrome Darker pigmentation related to ethnicity abuse 1 McCune-Albright Syndrome Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Oral Mucosa Hyperpigmentation." Click on the image (or right click) to open

2018 FP Notebook

93. Hyperpigmentation in Pregnancy

Hyperpigmentation in Pregnancy Hyperpigmentation in Pregnancy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation (...) in Pregnancy Hyperpigmentation in Pregnancy Aka: Hyperpigmentation in Pregnancy , Chadwick's Sign , Linea Nigra II. Physiology stimulating hormone rises in early pregnancy Increased deposition III. Signs: General Scarred areas and nevi darken Pigmented areas become more pigmented Areola Axilla External genitalia Anal region Linea Nigra IV. Signs: Specific Chadwick's Sign Darkened vulva and vagina or ( ) Dark areas under eyes and bridge nose Linea Nigra Dark midline low Images: Related links to external

2018 FP Notebook

94. Hyperpigmentation

Hyperpigmentation Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation Hyperpigmentation Aka (...) : Hyperpigmentation From Related Chapters II. Causes: Hyperpigmentation Localized Lesions (increased or s) See See s Diffuse skin changes See See See See systemic causes below III. Causes: Systemic conditions with Hyperpigmentation Skin Endocrine and Metabolic See ( Deposition) Porphyria Hemosiderin deposition in Gastrointestinal Disease Whipple's Disease ( deposition) Genitalia Heller-Nelson Syndrome Hematology and Oncology Neoplasm Nutrition Starvation Medications and toxins See (increased s) Images: Related

2018 FP Notebook

95. Medication Causes of Hyperpigmentation

Medication Causes of Hyperpigmentation Medication Causes of Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Medication Causes of Hyperpigmentation Medication Causes of Hyperpigmentation Aka: Medication Causes of Hyperpigmentation , Hyperpigmentation Due to Medication , Drug Induced Hyperpigmentation From Related Chapters II. Causes ( ) Bismuth Bleomycin Busulfan Clofazimine Cyclophosphamide Daunorubicin Dibromomannitol Doxorubicin Gold Topical nitrogen mustard Phenothiazines Silver Zodovudine III. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2018 FP Notebook

96. Diffuse Hyperpigmentation

Diffuse Hyperpigmentation Diffuse Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diffuse Hyperpigmentation Diffuse (...) Hyperpigmentation Aka: Diffuse Hyperpigmentation , Melanism , Diffuse Hypermelanosis , Melanosis From Related Chapters II. Causes Excessive deposition: Excessive s: Phototoxic III. Signs Diffuse brown discoloration of skin pigmentation Accentuated areas Palmar creases Recent scars Pressure points at elbow, knee, and knuckles IV. Differential Diagnosis Localized Lesions (increased or s) See See Diffuse skin changes See See See Images: Related links to external sites (from Bing) These images are a random sampling

2018 FP Notebook

97. Treatment of Persistent Facial Postinflammatory Hyperpigmentation With Novel Pulse-in-Pulse Mode Intense Pulsed Light. (PubMed)

Treatment of Persistent Facial Postinflammatory Hyperpigmentation With Novel Pulse-in-Pulse Mode Intense Pulsed Light. Postinflammatory hyperpigmentation (PIH) is an acquired hypermelanosis induced by various causes including inflammatory dermatoses, injury, or cosmetic procedures, such as lasers or chemical peels, and it tends to affect dark-skinned people with greater frequency and severity. There are a variety of treatment options for PIH, including topical agents, chemical peels, laser

2016 Dermatologic Surgery

98. Image Diagnosis: A Striking Bleomycin-Induced Skin Toxicity: Flagellate Hyperpigmentation (PubMed)

Image Diagnosis: A Striking Bleomycin-Induced Skin Toxicity: Flagellate Hyperpigmentation 28080950 2017 03 27 2019 02 26 1552-5775 21 2017 The Permanente journal Perm J Image Diagnosis: A Striking Bleomycin-Induced Skin Toxicity: Flagellate Hyperpigmentation. 16-001 10.7812/TPP/16-001 Hao Lin L Fellow in the Department of Hematology and Oncology at the University of Arkansas for Medical Sciences in Little Rock. lhao@uams.edu. Mahmoud Fade F Assistant Professor of Medicine in the Department (...) Drug Therapy, Combination Etoposide therapeutic use Humans Hyperpigmentation chemically induced Lymphadenopathy diagnostic imaging pathology Male Orchiectomy Teratoma diagnostic imaging pathology Testicular Neoplasms diagnostic imaging pathology surgery Tomography, X-Ray Computed Statement The author(s) have no conflicts of interest to disclose. 2017 1 13 6 0 2017 1 13 6 0 2017 3 28 6 0 ppublish 28080950 16-001 10.7812/TPP/16-001 PMC5224796 Int J Dermatol. 1999 Feb;38(2):140-1 10192167 Am J

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2016 The Permanente journal

99. A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation (PubMed)

A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation p53-Transcriptional-regulated proteins interact with a large number of other signal transduction pathways in the cell, and a number of positive and negative autoregulatory feedback loops act upon the p53 response. P53 directly controls the POMC/α-MSH productions induced by ultraviolet (UV) and is associated with UV-independent pathological pigmentation. When identifying (...) at physiological and pathophysiological conditions. SASH1 is regulated by a novel p53/POMC/α-MSH/Gαs/SASH1 cascade to mediate melanogenesis. A novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. Our study demonstrates that a novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype.© 2016 The Authors. Journal of Cellular

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2016 Journal of cellular and molecular medicine

100. Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation (PubMed)

Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation Hyperpigmentation caused by melanin overproduction is a major skin disorder in humans. Inhibition of tyrosinase, a key regulator of melanin production, has been used as an effective strategy to treat hyperpigmentation. In this study, we investigated the use of solid lipid nanoparticles (SLNs) as a highly effective and nontoxic means to deliver (...) -induced melanogenesis, resulting in no change in the skin color of C57BL/6 mouse, compared with that observed in an MHY solution-treated group and an untreated control group. The antimelanogenic effect of MHY-SLNs was further confirmed through Fontana-Masson staining. Importantly, MHY-SLNs did not induce any toxic effects in the L929 cell line. Overall, these data indicate that MHY-SLNs show promise in the topical treatment of hyperpigmentation.

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2016 Drug design, development and therapy

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