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Hyperpigmentation

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61. Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation Full Text available with Trip Pro

Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation Polymyxin B is a polypeptide-antibiotic, primarily used for resistant Gram-negative infections, first obtained from bacterium Bacillus polymyxa in the late 1940s. Antibiotic spectrum are restricted to mainly gram negative bacterias like Enterobacter, E. coli, Klebsiella, Salmonella, Pasteurella, Bordetella, Shigella; and particularly organisms like Pseudomonas aeruginosa and Acinetobacter baumannii, which are extremely potent to acquire (...) excluded. An objective causality assessment reveals that, the cutaneous hyperpigmentation was possibly associated with Polymyxin B therapy, though further studies may be needed to explain the underlying mechanism.

2017 Journal of clinical and diagnostic research : JCDR

62. Minocycline-Induced Hyperpigmentation in a Patient Treated with Erlotinib for Non-Small Cell Lung Adenocarcinoma Full Text available with Trip Pro

Minocycline-Induced Hyperpigmentation in a Patient Treated with Erlotinib for Non-Small Cell Lung Adenocarcinoma While epidermal growth factor receptor (EGFR) inhibitors have improved progression-free survival in patients with non-small cell lung cancer (NSCLC), one of the most common adverse effects is papulopustular skin eruption, which is frequently severe enough to be treated with oral minocycline or doxycycline.We present a case of an 87-year-old man who developed a severe papulopustular (...) skin eruption secondary to erlotinib therapy for NSCLC. Control of the eruption with 100 mg of minocycline twice daily for 8 months eventually led to blue-gray skin hyperpigmentation. After 30 months, this side effect was recognized as minocycline drug deposition, which was confirmed with skin biopsy.Compliance with EGFR inhibitor therapy in NSCLC is often challenging due to common side effects, most notably cutaneous skin eruptions. Treatment of cutaneous toxicities is important to preserve

2017 Case reports in oncology

63. Bleomycin‐induced flagellate hyperpigmentation Full Text available with Trip Pro

Bleomycin‐induced flagellate hyperpigmentation A 27-year old male with Hodgkin's lymphoma was treated with combined chemotherapy that included bleomycin. He presented with pruritic erythematous, edematous linear lesions and was diagnosed to have flagellate hyperpigmentation, a rare side effect of bleomycin chemotherapy.

2017 Clinical Case Reports

64. p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation Full Text available with Trip Pro

p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation We previously reported that three point mutations in SASH1 and mutated SASH1 promote melanocyte migration in dyschromatosis universalis hereditaria (DUH) and a novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. However, the underlying mechanism of molecular regulation to cause this hyperpigmentation (...) disorder still remains unclear. In this study, we aimed to investigate the molecular mechanism undergirding hyperpigmentation in the dyschromatosis disorder. Our results revealed that SASH1 binds with MAP2K2 and is induced by p53-POMC-MC1R signal cascade to enhance the phosphorylation level of ERK1/2 and CREB. Moreover, increase in phosphorylated ERK1/2 and CREB levels and melanogenesis-specific molecules is induced by mutated SASH1 alleles. Together, our results suggest that a novel SASH1/MAP2K2

2017 Journal of cellular and molecular medicine

65. Treatment of Melasma and Post-Inflammatory Hyperpigmentation by a Picosecond 755-nm Alexandrite Laser in Asian Patients Full Text available with Trip Pro

Treatment of Melasma and Post-Inflammatory Hyperpigmentation by a Picosecond 755-nm Alexandrite Laser in Asian Patients The picosecond lasers have shown to effectively treat tattoo pigments that are intractable to previous multiple Q-switched (QS) laser treatments. Therefore we hypothesized that a picosecond laser would show better efficacy with minimal adverse events in the treatment of melasma and post-inflammatory hyperpigmentation (PIH) that are difficult to treat with conventional QS

2017 Annals of dermatology

66. Erythromelanosis follicularis faciei et colli with reticulated hyperpigmentation of the extremities Full Text available with Trip Pro

Erythromelanosis follicularis faciei et colli with reticulated hyperpigmentation of the extremities Erythromelanosis follicularis faciei et colli (EFFC) is a distinct, rare, and underdiagnosed condition of unknown etiology that is characterized by well-demarcated erythema, hyperpigmentation, and follicular papules. The pigmentation is usually on both maxillary, preauricular regions, and the cheeks. We report a case of a 12-year-old boy with EFFC that was associated with reticulated pigmentation

2017 Clinical Case Reports

67. CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation Full Text available with Trip Pro

CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation Casein kinase 1α (CK1α), a component of the β-catenin destruction complex, is a critical regulator of Wnt signaling; its ablation induces both Wnt and p53 activation. To characterize the role of CK1α (encoded by Csnk1a1) in skin physiology, we crossed mice harboring floxed Csnk1a1 with mice expressing K14-Cre-ERT2 to generate mice in which tamoxifen induces the deletion of Csnk1a1 exclusively (...) in keratinocytes [single-knockout (SKO) mice]. As expected, CK1α loss was accompanied by β-catenin and p53 stabilization, with the preferential induction of p53 target genes, but phenotypically most striking was hyperpigmentation of the skin, importantly without tumorigenesis, for at least 9 mo after Csnk1a1 ablation. The number of epidermal melanocytes and eumelanin levels were dramatically increased in SKO mice. To clarify the putative role of p53 in epidermal hyperpigmentation, we established K14-Cre-ERT2

2017 Proceedings of the National Academy of Sciences of the United States of America

68. Type 2 Minocycline-induced hyperpigmentation successfully treated with the novel 755 nm picosecond alexandrite laser – a case report Full Text available with Trip Pro

Type 2 Minocycline-induced hyperpigmentation successfully treated with the novel 755 nm picosecond alexandrite laser – a case report Minocycline therapy for acne vulgaris is associated with the occasional induction of various types of unsightly and often persistent hyperpigmentation, which is frequently resistant to hydroquinone treatment. Pigment-specific lasers have achieved some success with multiple treatment sessions. Recently, the picosecond domain 755 nm alexandrite laser (ps-Alex) has (...) was selected for the actual treatment (spot size, 2 mm; fluence, 6.37 J/cm2; pulsewidth, 750 ps) on one leg first, followed later by the contralateral leg.Rapid clearance of the pigmentation was noted after a single ps-Alex session on both limbs without prolonged post-inflammatory hyperpigmentation (PIH). At one year post-treatment, clearance had been maintained.Our results in this single case strongly suggest that the novel 755-nm ps-Alex laser is both safe and very effective for the treatment of type 2

2017 Laser therapy

69. Addison's Disease Caused by Tuberculosis with Atypical Hyperpigmentation and Active Pulmonary Tuberculosis Full Text available with Trip Pro

Addison's Disease Caused by Tuberculosis with Atypical Hyperpigmentation and Active Pulmonary Tuberculosis We herein report a case of Addison's disease caused by tuberculosis characterized by atypical hyperpigmentation, noted as exacerbation of the pigmentation of freckles and the occurrence of new freckles, that was diagnosed in the presence of active pulmonary tuberculosis. The clinical condition of the patient was markedly ameliorated by the administration of hydrocortisone and anti

2017 Internal Medicine

70. Psychosocial Impact of Postinflammatory Hyperpigmentation in Patients with Acne Vulgaris Full Text available with Trip Pro

Psychosocial Impact of Postinflammatory Hyperpigmentation in Patients with Acne Vulgaris Background: Acne vulgaris is a common, often socially distressing skin condition primarily seen in young adults. Quality of life studies have shown that people with acne are more introverted with increased social setting anxiety compared to a control group. Unfortunately, patients with acne may have residual postinflammatory hyperpigmentation, amplifying impaired psychosocial effects. Objective: To quantify (...) the impact of postinflammatory hyperpigmentation in patients with acne using a psychometric scale. Design: A clinic-based survey was conducted among US adults with facial acne and postinflammatory hyperpigmentation. Outcomes included age, race, gender, and acne-related quality of life. A board-certified dermatologist rated each patient's acne severity and postinflammatory hyperpigmentation. Setting: Dermatology clinic, Anheuser Busch Institute and Des Peres Hospital, Saint Louis, Missouri. Participants

2017 The Journal of clinical and aesthetic dermatology

71. Laugier-Hunziker syndrome: a case of asymptomatic mucosal and acral hyperpigmentation Full Text available with Trip Pro

Laugier-Hunziker syndrome: a case of asymptomatic mucosal and acral hyperpigmentation Laugier-Hunziker syndrome (LHS) is a rare condition characterized by acquired hyperpigmentation involving the lips, oral mucosa, acral surfaces, nails and perineum. While patients with LHS may manifest pigmentation in all of the aforementioned areas, most present with pigmentation localized to only a few of these anatomical sites. We herein report a patient exhibiting the characteristic pigment distribution (...) pattern associated with LHS. Since LHS is a diagnosis based on exclusion, we discuss the differential diagnosis of mucocutaneous hyperpigmentation. Due to the benign nature of the disease, it is critical to differentiate this disorder from conditions with similar mucocutaneous pigmentary changes with somatic abnormalities that require medical management. We also explore potential mechanisms that may explain the pathogenesis of LHS.

2017 Dermatology practical & conceptual

72. Serpentine supravenous hyperpigmentation Full Text available with Trip Pro

Serpentine supravenous hyperpigmentation Serpentine supravenous hyperpigmentation is a peculiar cutaneous eruption that follows the path of vein after intravenous injection of the chemotherapeutic agent. The lesions gradually resolve spontaneously if administration of the offending agent is stopped through the affected limb. Drugs such as 5-fluorouracil, docetaxel, vinorelbine, hydroxychloroquine, fotemustine, and minocycline are implicated.

2017 Clinical Case Reports

73. Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris

Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03361345 Recruitment

2017 Clinical Trials

74. Pharmacotherapy of post inflammatory hyperpigmentation: systematic review and meta analysis

Pharmacotherapy of post inflammatory hyperpigmentation: systematic review and meta analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

75. Ascorbic Acid Versus Diode Laser in the Treatment of Gingival Hyperpigmentation

Ascorbic Acid Versus Diode Laser in the Treatment of Gingival Hyperpigmentation Ascorbic Acid Versus Diode Laser in the Treatment of Gingival Hyperpigmentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Ascorbic Acid Versus Diode Laser in the Treatment of Gingival Hyperpigmentation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03252418 Recruitment Status : Completed First Posted : August 17, 2017 Last Update Posted : August 22, 2017 Sponsor: Ain Shams University Information provided by (Responsible

2017 Clinical Trials

76. Isolation and Characterization of Isofraxidin 7-<i>O</i>-(6'-<i>O</i>-<i>p</i>-Coumaroyl)-<i>β</i>-glucopyranoside from <i>Artemisia capillaris</i> Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo. Full Text available with Trip Pro

Isolation and Characterization of Isofraxidin 7-O-(6'-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo. Abnormalities in skin pigmentation can produce disorders such as albinism or melasma. There is a research need to discover novel compounds that safely and effectively regulate pigmentation. To identify novel modulators of pigmentation, we attempted to purify compounds (...) transcription factor (MITF) in melanocytes. Compared to the parent compound, isofraxidin, compound 1 produced greater effects on these pigmentation parameters. To validate compound 1 as a novel hyperpigmentation agent in vivo, we utilized the zebrafish vertebrate model. Zebrafish treated with compound 1 showed higher melanogenesis and increased tyrosinase activity. Compound 1 treated embryos had no developmental defects and displayed normal cardiac function, indicating that this compound enhanced

2017 Evidence-based Complementary and Alternative Medicine (eCAM)

77. Amyloidosis Cutis Dyschromica, a Rare Cause of Hyperpigmentation: A New Case and Literature Review. Full Text available with Trip Pro

Amyloidosis Cutis Dyschromica, a Rare Cause of Hyperpigmentation: A New Case and Literature Review. Amyloidosis cutis dyschromica is a rare form of primary cutaneous amyloidosis without systemic involvement and characterized by asymptomatic, progressive hyper- and hypopigmentation. We present the first case of a patient with amyloidosis cutis dyschromica diagnosed previously elsewhere as having Addison disease with generalized hyperpigmentation of the skin. This case suggests that in patients

2017 Pediatrics

78. Postinflammatory Hyperpigmentation

Postinflammatory Hyperpigmentation Postinflammatory Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Postinflammatory (...) Hyperpigmentation Postinflammatory Hyperpigmentation Aka: Postinflammatory Hyperpigmentation From Related Chapters II. Definition response to inflammation on dark skin III. Pathophysiology Common complication following or inflammation in darker skin type (3 to 6) Local inflammation results in prostaglandin, leukotriene and thromboxane release Epidermal s hypertrophy, synthesizing IV. Causes: Common precipitating lesions Inflammation Laser therapy or V. Signs Irregular, dark s and patches at sites of injury

2018 FP Notebook

79. Hyperpigmentation in Pregnancy

Hyperpigmentation in Pregnancy Hyperpigmentation in Pregnancy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperpigmentation (...) in Pregnancy Hyperpigmentation in Pregnancy Aka: Hyperpigmentation in Pregnancy , Chadwick's Sign , Linea Nigra II. Physiology stimulating hormone rises in early pregnancy Increased deposition III. Signs: General Scarred areas and nevi darken Pigmented areas become more pigmented Areola Axilla External genitalia Anal region Linea Nigra IV. Signs: Specific Chadwick's Sign Darkened vulva and vagina or ( ) Dark areas under eyes and bridge nose Linea Nigra Dark midline low Images: Related links to external

2018 FP Notebook

80. Diffuse Hyperpigmentation

Diffuse Hyperpigmentation Diffuse Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diffuse Hyperpigmentation Diffuse (...) Hyperpigmentation Aka: Diffuse Hyperpigmentation , Melanism , Diffuse Hypermelanosis , Melanosis From Related Chapters II. Causes Excessive deposition: Excessive s: Phototoxic III. Signs Diffuse brown discoloration of skin pigmentation Accentuated areas Palmar creases Recent scars Pressure points at elbow, knee, and knuckles IV. Differential Diagnosis Localized Lesions (increased or s) See See Diffuse skin changes See See See Images: Related links to external sites (from Bing) These images are a random sampling

2018 FP Notebook

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