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Hyperpigmentation

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61. Bleomycin‐induced flagellate hyperpigmentation (PubMed)

Bleomycin‐induced flagellate hyperpigmentation A 27-year old male with Hodgkin's lymphoma was treated with combined chemotherapy that included bleomycin. He presented with pruritic erythematous, edematous linear lesions and was diagnosed to have flagellate hyperpigmentation, a rare side effect of bleomycin chemotherapy.

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2017 Clinical Case Reports

62. p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation (PubMed)

p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation We previously reported that three point mutations in SASH1 and mutated SASH1 promote melanocyte migration in dyschromatosis universalis hereditaria (DUH) and a novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. However, the underlying mechanism of molecular regulation to cause this hyperpigmentation (...) disorder still remains unclear. In this study, we aimed to investigate the molecular mechanism undergirding hyperpigmentation in the dyschromatosis disorder. Our results revealed that SASH1 binds with MAP2K2 and is induced by p53-POMC-MC1R signal cascade to enhance the phosphorylation level of ERK1/2 and CREB. Moreover, increase in phosphorylated ERK1/2 and CREB levels and melanogenesis-specific molecules is induced by mutated SASH1 alleles. Together, our results suggest that a novel SASH1/MAP2K2

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2017 Journal of cellular and molecular medicine

63. Laugier-Hunziker syndrome: a case of asymptomatic mucosal and acral hyperpigmentation (PubMed)

Laugier-Hunziker syndrome: a case of asymptomatic mucosal and acral hyperpigmentation Laugier-Hunziker syndrome (LHS) is a rare condition characterized by acquired hyperpigmentation involving the lips, oral mucosa, acral surfaces, nails and perineum. While patients with LHS may manifest pigmentation in all of the aforementioned areas, most present with pigmentation localized to only a few of these anatomical sites. We herein report a patient exhibiting the characteristic pigment distribution (...) pattern associated with LHS. Since LHS is a diagnosis based on exclusion, we discuss the differential diagnosis of mucocutaneous hyperpigmentation. Due to the benign nature of the disease, it is critical to differentiate this disorder from conditions with similar mucocutaneous pigmentary changes with somatic abnormalities that require medical management. We also explore potential mechanisms that may explain the pathogenesis of LHS.

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2017 Dermatology practical & conceptual

64. Psychosocial Impact of Postinflammatory Hyperpigmentation in Patients with Acne Vulgaris (PubMed)

Psychosocial Impact of Postinflammatory Hyperpigmentation in Patients with Acne Vulgaris Background: Acne vulgaris is a common, often socially distressing skin condition primarily seen in young adults. Quality of life studies have shown that people with acne are more introverted with increased social setting anxiety compared to a control group. Unfortunately, patients with acne may have residual postinflammatory hyperpigmentation, amplifying impaired psychosocial effects. Objective: To quantify (...) the impact of postinflammatory hyperpigmentation in patients with acne using a psychometric scale. Design: A clinic-based survey was conducted among US adults with facial acne and postinflammatory hyperpigmentation. Outcomes included age, race, gender, and acne-related quality of life. A board-certified dermatologist rated each patient's acne severity and postinflammatory hyperpigmentation. Setting: Dermatology clinic, Anheuser Busch Institute and Des Peres Hospital, Saint Louis, Missouri. Participants

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2017 The Journal of clinical and aesthetic dermatology

65. Serpentine supravenous hyperpigmentation (PubMed)

Serpentine supravenous hyperpigmentation Serpentine supravenous hyperpigmentation is a peculiar cutaneous eruption that follows the path of vein after intravenous injection of the chemotherapeutic agent. The lesions gradually resolve spontaneously if administration of the offending agent is stopped through the affected limb. Drugs such as 5-fluorouracil, docetaxel, vinorelbine, hydroxychloroquine, fotemustine, and minocycline are implicated.

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2017 Clinical Case Reports

66. Erythromelanosis follicularis faciei et colli with reticulated hyperpigmentation of the extremities (PubMed)

Erythromelanosis follicularis faciei et colli with reticulated hyperpigmentation of the extremities Erythromelanosis follicularis faciei et colli (EFFC) is a distinct, rare, and underdiagnosed condition of unknown etiology that is characterized by well-demarcated erythema, hyperpigmentation, and follicular papules. The pigmentation is usually on both maxillary, preauricular regions, and the cheeks. We report a case of a 12-year-old boy with EFFC that was associated with reticulated pigmentation

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2017 Clinical Case Reports

67. Treatment of oral hyperpigmentation and gummy smile using lasers and role of plasma as a novel treatment technique in dentistry: An introductory review (PubMed)

Treatment of oral hyperpigmentation and gummy smile using lasers and role of plasma as a novel treatment technique in dentistry: An introductory review Gingival hyperpigmentation and the condition known as gummy smile are very common dental cosmetic problems. Gingival hyperpigmentation arises due to the excess presence of melanin in certain regions of the gums. In the case of gummy smile, more than the required amount of gingival tissue is exposed upon smiling. An aesthetically pleasing smile (...) should expose only a negligible amount of gingival tissue. Gummy smile and gingival hyperpigmentation can have detrimental effects on the aesthetic quality of a smile, and thereby a wide variety of treatment options must be taken into consideration depending patient outcome objectives. The use of a laser as a treatment modality is considered to be a promising option for such cases. We aim to explain the effects of using a laser on the gingiva and discuss the advantages and disadvantages of this type

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2017 Oncotarget

68. Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation (PubMed)

Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation Polymyxin B is a polypeptide-antibiotic, primarily used for resistant Gram-negative infections, first obtained from bacterium Bacillus polymyxa in the late 1940s. Antibiotic spectrum are restricted to mainly gram negative bacterias like Enterobacter, E. coli, Klebsiella, Salmonella, Pasteurella, Bordetella, Shigella; and particularly organisms like Pseudomonas aeruginosa and Acinetobacter baumannii, which are extremely potent to acquire (...) excluded. An objective causality assessment reveals that, the cutaneous hyperpigmentation was possibly associated with Polymyxin B therapy, though further studies may be needed to explain the underlying mechanism.

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2017 Journal of clinical and diagnostic research : JCDR

69. CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation (PubMed)

CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation Casein kinase 1α (CK1α), a component of the β-catenin destruction complex, is a critical regulator of Wnt signaling; its ablation induces both Wnt and p53 activation. To characterize the role of CK1α (encoded by Csnk1a1) in skin physiology, we crossed mice harboring floxed Csnk1a1 with mice expressing K14-Cre-ERT2 to generate mice in which tamoxifen induces the deletion of Csnk1a1 exclusively (...) in keratinocytes [single-knockout (SKO) mice]. As expected, CK1α loss was accompanied by β-catenin and p53 stabilization, with the preferential induction of p53 target genes, but phenotypically most striking was hyperpigmentation of the skin, importantly without tumorigenesis, for at least 9 mo after Csnk1a1 ablation. The number of epidermal melanocytes and eumelanin levels were dramatically increased in SKO mice. To clarify the putative role of p53 in epidermal hyperpigmentation, we established K14-Cre-ERT2

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2017 Proceedings of the National Academy of Sciences of the United States of America

70. Addison's Disease Caused by Tuberculosis with Atypical Hyperpigmentation and Active Pulmonary Tuberculosis (PubMed)

Addison's Disease Caused by Tuberculosis with Atypical Hyperpigmentation and Active Pulmonary Tuberculosis We herein report a case of Addison's disease caused by tuberculosis characterized by atypical hyperpigmentation, noted as exacerbation of the pigmentation of freckles and the occurrence of new freckles, that was diagnosed in the presence of active pulmonary tuberculosis. The clinical condition of the patient was markedly ameliorated by the administration of hydrocortisone and anti

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2017 Internal Medicine

71. Type 2 Minocycline-induced hyperpigmentation successfully treated with the novel 755 nm picosecond alexandrite laser – a case report (PubMed)

Type 2 Minocycline-induced hyperpigmentation successfully treated with the novel 755 nm picosecond alexandrite laser – a case report Minocycline therapy for acne vulgaris is associated with the occasional induction of various types of unsightly and often persistent hyperpigmentation, which is frequently resistant to hydroquinone treatment. Pigment-specific lasers have achieved some success with multiple treatment sessions. Recently, the picosecond domain 755 nm alexandrite laser (ps-Alex) has (...) was selected for the actual treatment (spot size, 2 mm; fluence, 6.37 J/cm2; pulsewidth, 750 ps) on one leg first, followed later by the contralateral leg.Rapid clearance of the pigmentation was noted after a single ps-Alex session on both limbs without prolonged post-inflammatory hyperpigmentation (PIH). At one year post-treatment, clearance had been maintained.Our results in this single case strongly suggest that the novel 755-nm ps-Alex laser is both safe and very effective for the treatment of type 2

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2017 Laser therapy

72. Skin Hyperpigmentation as the Presenting Symptom of Subacute Combined Degeneration of the Spinal Cord (PubMed)

Skin Hyperpigmentation as the Presenting Symptom of Subacute Combined Degeneration of the Spinal Cord Vitamin B12 deficiency results in hematological, neurological, and rarely dermatological complications. Subacute combined degeneration of the cord is one of the neurological complications, and usually the presenting symptom is paresthesia. Herein, we report a case of a 46-year-old man with subacute combined degeneration presenting with knuckle hyperpigmentation.

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2017 Case reports in neurological medicine

73. Treatment of Postinflammatory Hyperpigmentation With a Combination of Glycolic Acid Peels and a Topical Regimen in Dark-Skinned Patients: A Comparative Study. (PubMed)

Treatment of Postinflammatory Hyperpigmentation With a Combination of Glycolic Acid Peels and a Topical Regimen in Dark-Skinned Patients: A Comparative Study. Facial postinflammatory hyperpigmentation (PIH) is challenging to manage in patients with skin of color because of the risk of subsequent treatment-related hyperpigmentation.To evaluate the safety and efficacy of combining glycolic acid (GA) peels with a modified Kligman formula (MKF) containing hydroquinone 2%, tretinoin 0.05 (...) %, and hydrocortisone 1% for the treatment of facial PIH in Indian patients.Thirty Indian patients (Fitzpatrick skin Types III-V) with facial PIH were randomly assigned to 2 groups of 15 each. One group received serial GA peels combined with an intervening topical regimen containing MKF. The other group received MKF alone. Results were evaluated by a clinical investigator at baseline and at the end of 21 weeks (3 weeks after treatment completion) using an objective scoring system, the Hyperpigmentation Area

2017 Dermatologic Surgery Controlled trial quality: uncertain

74. An Unusual Case of Facial Hyperpigmentation Solved on Histopathology (PubMed)

An Unusual Case of Facial Hyperpigmentation Solved on Histopathology 27790561 2018 11 13 2249-782X 10 9 2016 Sep Journal of clinical and diagnostic research : JCDR J Clin Diagn Res An Unusual Case of Facial Hyperpigmentation Solved on Histopathology. WL01-WL02 Agarwal Kiran K Director Professor, Department of Pathology, Lady Hardinge Medical College , New Delhi, India . Puri Vandana V Assistant Professor, Department of Pathology, Lady Hardinge Medical College , New Delhi, India . Goel Ruchika

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2016 Journal of clinical and diagnostic research : JCDR

75. Postinflammatory hyperpigmentation after human cold pain testing (PubMed)

Postinflammatory hyperpigmentation after human cold pain testing Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by the accessibility and affordability of devices used to measure thermal sensitivity in humans. To address this gap, we developed an inexpensive method to measure cold pain thresholds in healthy (...) adult volunteers using dry ice and a thermode. However, early in preliminary testing, a subject presented with epidermal postinflammatory hyperpigmentation that lasted for >200 days. Although this response was unique among the small number of subjects in development of the assay, it raised questions as to the safety of the assay design.

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2016 Pain Reports

76. Minocycline-induced Hyperpigmentation (PubMed)

Minocycline-induced Hyperpigmentation 27173498 2019 01 28 2019 01 28 1525-1497 32 1 2017 01 Journal of general internal medicine J Gen Intern Med Minocycline-induced Hyperpigmentation. 133 10.1007/s11606-016-3735-x Judson Timothy T Department of Internal Medicine, University of California, San Francisco, CA, USA. Mihara Kip K Emergency Department, San Francisco VA Medical Center, 4150 Clement Street, Mail code 111A3, San Francisco, CA, 94121, USA. Kip.mihara@va.gov. Department of Internal (...) Medicine, University of California, San Francisco, CA, USA. Kip.mihara@va.gov. eng Case Reports Journal Article 2016 05 12 United States J Gen Intern Med 8605834 0884-8734 0 Anti-Bacterial Agents FYY3R43WGO Minocycline IM Aged Anti-Bacterial Agents administration & dosage adverse effects Diagnosis, Differential Drug-Related Side Effects and Adverse Reactions diagnosis etiology Humans Hyperpigmentation chemically induced diagnosis Male Minocycline administration & dosage adverse effects Patient Care

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2016 Journal of General Internal Medicine

77. Mitten-Line Hyperpigmentation of an Infant (PubMed)

Mitten-Line Hyperpigmentation of an Infant 27746653 2018 11 13 1013-9087 28 5 2016 Oct Annals of dermatology Ann Dermatol Mitten-Line Hyperpigmentation of an Infant. 653-654 Park Jin J Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea.; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea. Park Su-Kyung SK Department of Dermatology, Chonbuk National

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2016 Annals of dermatology

78. Unusual case of hyperpigmentation secondary to irinotecan (PubMed)

Unusual case of hyperpigmentation secondary to irinotecan 27793873 2017 03 06 2018 12 02 1757-790X 2016 2016 Oct 28 BMJ case reports BMJ Case Rep Unusual case of hyperpigmentation secondary to irinotecan. bcr2016217545 10.1136/bcr-2016-217545 Nestor Laura Aisling LA Department of Dermatology, Adelaide and Meath Hospital, Tallaght, Ireland. Flint Stephen S Department of Oral Medicine and Dentistry, Dublin Dental School and Hospital, Dublin, Ireland. Galvin Sheila S Department of Oral Medicine (...) & dosage Colorectal Neoplasms therapy Drug Eruptions etiology Female Humans Hyperpigmentation chemically induced Irinotecan Middle Aged Mouth Mucosa Nails Neoplasm Recurrence, Local drug therapy Conflicts of Interest: None declared. 2016 10 30 6 0 2017 3 7 6 0 2016 10 30 6 0 epublish 27793873 bcr-2016-217545 10.1136/bcr-2016-217545 PMC5093355 Drug Discov Today Dis Mech. 2008;5(2):e189-e199 19578486 J Pharm Bioallied Sci. 2015 Aug;7(Suppl 2):S403-8 26538887

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2016 BMJ case reports

79. An In Vivo Model for Postinflammatory Hyperpigmentation

An In Vivo Model for Postinflammatory Hyperpigmentation An In Vivo Model for Postinflammatory Hyperpigmentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An In Vivo Model for Postinflammatory (...) Hyperpigmentation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02905903 Recruitment Status : Unknown Verified February 2017 by Iltefat Hamzavi, Henry Ford Health System. Recruitment status was: Recruiting First Posted : September 19, 2016 Last Update Posted : February 23, 2017 Sponsor: Henry Ford Health

2016 Clinical Trials

80. Laser Treatments for Postinflammatory Hyperpigmentation: A Systematic Review. (PubMed)

Laser Treatments for Postinflammatory Hyperpigmentation: A Systematic Review. Lasers are gaining interest as a treatment option for postinflammatory hyperpigmentation (PIH) but can pose a clinical dilemma given the risk for laser-induced or exacerbated PIH.To assess the clinical evidence for the use of lasers in the treatment of PIH.A systematic review was performed by searching PubMed databases from January 1, 1990, through May 31, 2016. Included studies involved laser treatment for PIH

2016 JAMA dermatology

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