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Hyperpigmentation

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361. Treatment of periorbital dark circles: Comparative study of carboxy therapy vs chemical peeling vs mesotherapy. Full Text available with Trip Pro

Treatment of periorbital dark circles: Comparative study of carboxy therapy vs chemical peeling vs mesotherapy. Evaluation and comparison of the efficacy and safety of 3 different modalities of treatment for dark circles that function via different modes of action.In total, 45 female patients with periorbital hyperpigmentation were randomly selected to participate from those attending the outpatient dermatology clinic of Al-Zahraa University Hospital within a 6-month period. Patients were

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

362. Nitrogen plasma skin regeneration for the treatment of mild-to-moderate periorbital wrinkles: A prospective, randomized, controlled evaluator-blinded trial. Full Text available with Trip Pro

satisfaction score to favor the nitrogen plasma treatment group than the control group (P < 0.001). The short-term adverse effects included erythema, scaling, temporary hyperpigmentation, pruritus, and dryness.Nitrogen plasma skin regeneration is effective and safe for the treatment of mild-to-moderate periorbital wrinkles and darkening.© 2018 Wiley Periodicals, Inc.

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

363. Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study. Full Text available with Trip Pro

Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study. Melasma is a highly prevalent hyperpigmentation disorder with a high relapsing rate and a negative impact on the psychological state of the affected patients. The exact pathogenesis of melasma is not completely elucidated; however, ultraviolet induced oxidative stress has an important role in its pathogenesis. Silymarin, antioxidant drug, reduces the harmful effects of solar ultraviolet radiation

2019 Journal of cosmetic dermatology

364. Novel Tretinoin 0.05% Lotion for Once-Daily Treatment of Moderate-to-Severe Acne Vulgaris in a Hispanic Population (Abstract)

% lotion was lower than in the overall study population; the most frequently were application site pain (2.0%), dryness (1.4%), and erythema (1.2%). Local cutaneous safety and tolerability assessments were generally mild-to-moderate at baseline and improved by week 12. There were slight transient increases in scaling and burning over the first four weeks. Hyperpigmentation severity reduced progressively with treatment. Conclusions: Tretinoin 0.05% lotion was significantly more effective than its

2019 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

365. Comparison between topical recombinant human epidermal growth factor and Aloe vera gel in combination with ablative fractional carbon dioxide laser as treatment for striae alba: A randomized double-blind trial. (Abstract)

satisfaction with the AFXL-rhEGF-treated side, which showed significantly greater marked improvement (at 50%) than the AFXL-Aloe-treated side at 6 months after the final treatment (P = 0.034). Post-inflammatory hyperpigmentation (PIH) occurred in 95.8% of participants, which decreased after 6 months compared with baseline. Both treatments improved melanin variation at 6 months after the final treatment, although without significant difference from pretreatment between both groups. Skin biopsy revealed

2019 Lasers in surgery and medicine Controlled trial quality: uncertain

366. Efficacy and safety of picosecond 755-nm alexandrite laser with diffractive lens array for non-ablative rejuvenation in Chinese skin. Full Text available with Trip Pro

. No significant improvements wer--e observed in pore size, rhytides, or skin laxity. The mean pain score was 5.1 ± 2 and mean heat sensation was 3.6 ± 2.1. Expected transient erythema and edema occurred in 95.3% (102/107) and 1.9% (2/108) of treatments, respectively, and resolved in hours. No incidences of post-inflammatory hyperpigmentation (PIH) were noted at the 1, 2, and 3 month visits.The 755-nm picosecond laser with DLA is a safe and effective non-ablative modality for targeting facial skin texture

2019 Lasers in surgery and medicine Controlled trial quality: uncertain

367. Comparative Evaluation of Clinical Outcomes of Laser Skin Resurfacing Using an Ultra-Pulse Carbon Dioxide Laser and Manual Dermabrasion Using a Medium-Grit Drywall Sand Screen for Scar Revision in Adults: A Split-Scar Prospective Study. (Abstract)

the Manchester scar rating scale at the end of the first month, third month, and sixth month.This study showed that both methods were effective in improving the appearance of the postsurgical and post-traumatic scars. No significant difference was found between them (P = .978). Hyperpigmentation occurred in 4 scars in both the half treated with manual dermabrasion and the half treated with laser resurfacing; however, it had resolved by the end of the sixth month in all 4 scars.CO2 laser resurfacing

2019 Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons Controlled trial quality: uncertain

368. Comparison of a picosecond alexandrite laser versus a Q-switched alexandrite laser for the treatment of nevus of Ota: A randomized, split-lesion, controlled trial. (Abstract)

5.61 vs QSAL 6.40). Patients were more satisfied with PSAL than QSAL (Likert scale, 4.5 vs 4.0). Occurrences of postinflammatory hyperpigmentation (PSAL 26% vs QSAL 34%) and hypopigmentation (PSAL 21% vs QSAL 47%) were also lower in PSAL than QSAL arm.Lack of objective assessments and outcome measures.PSAL demonstrated better clinical results and fewer adverse events than QSAL for the treatment of nevus of Ota.Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All

2019 Journal of American Academy of Dermatology Controlled trial quality: uncertain

369. How hormones may modulate human skin pigmentation in melasma: an in vitro perspective. Full Text available with Trip Pro

hypothesize that in predisposed persons, sex steroid hormones initiate hyperpigmentation in melasma by amplifying the effects of UV on melanogenesis via direct effects on melanocytes or indirect effects via keratinocytes and on the transfer of melanosomes. They also help to sustain hyperpigmentation by increasing the number of blood vessels and, in turn, the level of endothelin-1.© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2019 Experimental Dermatology

370. Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology. Full Text available with Trip Pro

effective for treating many hyperpigmented lesions such as lentigos, dermal hypermelanocytosis or heavy metal depositions. In the other hand, they have to be considered with great caution for other disorders, such as café au lait macules, melasma or postinflammatory hyperpigmentation. After making the correct diagnosis, if lasers or IPLS are indicated, the optimal wavelengths and parameters will be chosen taking into account the skin phototype, origin and depth of the target pigments.Although

2019 Journal of the European Academy of Dermatology and Venereology

371. Pigmentation Disorders in the Elderly. (Abstract)

Pigmentation Disorders in the Elderly. Aging skin is subject to morphological change due to both intrinsic (skin tone, genetics, endogenous hormones) and extrinsic (chronic sun exposure, medications, exogenous pigments) factors. The broad spectrum of transformation includes both hypo- and hyperpigmentation. Although cutaneous pigmentary disorders are common in younger individuals, certain disorders are more prevalent in the geriatric population. This article reviews the epidemiology

2019 Drugs & Aging

372. Identification of small peptides and glycinamide that inhibit melanin synthesis using a positional scanning synthetic peptide combinatorial library. (Abstract)

Identification of small peptides and glycinamide that inhibit melanin synthesis using a positional scanning synthetic peptide combinatorial library. Antimelanogenic peptides are potentially useful to treat hyperpigmentation, but many peptides have limited application because of high cost and/or low activity.To identify small and potent peptide inhibitors of cellular melanin synthesis useful for cosmetic and medical applications.A positional scanning synthetic tetrapeptide combinatorial library (...) element binding protein, protein levels of microphthalmia-associated transcription factor and tyrosinase, L-tyrosine hydroxylase activity of tyrosinase, and the melanin levels in stimulated cells.Small peptides, including glycinamide and tryptophanyl glycinamide, are potent antimelanogenic agents with potential value for the treatment of skin hyperpigmentation. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 British Journal of Dermatology

373. DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo. Full Text available with Trip Pro

1; p<0.01), retinoic acid (7 versus 2; p<0.05), and placebo (7 versus 3; p<0.05), which correlates with clinical improvement. DNMT3b was not overexpressed in lesional skin but reduced in all groups.We found DNA hypermethylation in melasma lesions. Environmental factors such as solar radiation may induce cellular changes that trigger hyperpigmentation through the activation of pathways regulated by epigenetic modifications. However, limiting or decreasing DNA methylation through sunscreen

2019 BioMed research international Controlled trial quality: uncertain

374. Combination of Hydroquinone and Fractional CO Full Text available with Trip Pro

Combination of Hydroquinone and Fractional CO Melasma is a chronic hyperpigmentation skin disorder mainly affecting women in the reproductive age. Available treatments for melasma do not lead to long-term satisfactory results.This study aimed to compare the efficacy of fractional CO2 laser in combination with topical therapy to topical therapy alone.Forty women with bilateral melasma were studied in this randomized single-blinded clinical trial. Each side of the face was randomly allotted (...) to either topical hydroquinone 4% or combination of topical hydroquinone 4% and fractional CO2 laser. Patients received three sessions of laser therapy at 3-week intervals. Hydroquinone 4% application on both sides maintained for 3 months after the last laser session. The clinical improvement (darkness [D] and homogeneity [H] of hyperpigmentation) was measured by a blinded main investigator and an outcome assessor. Furthermore, improvement was assessed by physician's global assessment (PGA) and patient

2019 Indian journal of dermatology Controlled trial quality: uncertain

375. Efficacy of mesotherapy with tranexamic acid and ascorbic acid with and without glutathione in treatment of melasma: A split face comparative trial. (Abstract)

Efficacy of mesotherapy with tranexamic acid and ascorbic acid with and without glutathione in treatment of melasma: A split face comparative trial. Melasma is a prevalent annoying skin hyperpigmentation disorder that commonly involves reproductive-aged females. Variety of treatments with controversial results has been recommended. The aim of the current study was to evaluate combination therapy of tranexamic acid (TA) and vitamin C with and without glutathione with mesotherapy technique

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

376. Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris: assessment of safety and tolerability in subgroups. (Abstract)

Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris: assessment of safety and tolerability in subgroups. Topical tretinoin's role in acne has been established through evidence-based guidelines. Cutaneous irritation and potential to cause or exacerbate postinflammatory hyperpigmentation (PIH) may limit use.Evaluate safety and tolerability of novel polymeric formulation of tretinoin 0.05% lotion in moderate-to-severe acne.One thousand six hundred

2019 Journal of Dermatological Treatment Controlled trial quality: uncertain

377. Efficacy of bleomycin application on periungual warts after treatment with ablative carbon dioxide fractional laser: a pilot study. (Abstract)

% improvement). The warts clearing completely did not recur over the follow-up period of 6 months. No significant long-term adverse effects occurred. One lesion showed postinflammatory hyperpigmentation, resolving within 1 month; five patients (29%) had short-term localized moderate pain after treatment.Bleomycin solution after ablative fractional CO2 laser is effective and safe to treat periungual warts. Further large controlled studies are necessary to validate effectiveness and find an optimal regimen.

2019 Journal of Dermatological Treatment

378. Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis: Intrafamilial overlap of phenotypes in patients with the same KRT14 frameshift variant. (Abstract)

are an an- or hypohidrosis as well as a reticular pattern of hyperpigmentation of the skin (Table 1). Furthermore, most patients reveal a palmoplantar keratoderma (PPK), a hypo- to aplasia of dermatoglyphics, and an onychodystrophy. Single patients show non-scarring blisters on hand and feet during the first years of life. Debated differences between NFJS and DPR are fading of the reticular hyperpigmentation and defects on teeth and enamel in patients with NFJS whereas partial noncicatricial alopecia of the scalp

2019 British Journal of Dermatology

379. UV irradiation-induced DNA hypomethylation around WNT1 gene: implications for solar lentigines. (Abstract)

UV irradiation-induced DNA hypomethylation around WNT1 gene: implications for solar lentigines. Wnt/β-catenin signaling promotes melanogenesis in melanocytes and also induces melanocytogenesis from melanocyte stem cells (McSCs). Previous study reported that WNT1, a ligand which activates Wnt/β-catenin signaling pathway, was more highly expressed in the epidermis at SLs than in normal skin areas, suggesting that WNT1 causes hyperpigmentation. To elucidate the mechanism by which WNT1 expression

2019 Experimental Dermatology

380. Fargesin inhibits melanin synthesis in murine malignant and immortalized melanocytes by regulating PKA/CREB and P38/MAPK signaling pathways. Full Text available with Trip Pro

enzymes.These results show that fargesin can function as an anti-melanogenic agent, at least in part, by inhibiting PKA/CREB and p38/MAPK signaling pathways. Therefore, fargesin and its derivatives may potentially be used for preventing hyperpigmentation disorders in the future.Copyright © 2019. Published by Elsevier B.V.

2019 Journal of dermatological science

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