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Hyperpigmentation

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341. Café noir spots: A Feature of Familial Progressive Hyper- and Hypopigmentation. (Abstract)

Café noir spots: A Feature of Familial Progressive Hyper- and Hypopigmentation. Familial progressive hyper- and hypopigmentation (FPHH) is a rare genodermatosis characterized by multiple café au lait spots and hypopigmented ash-leaf macules intermingled with blotchy hyperpigmentation (1,2). Herein, we describe a Turkish FPHH patient with café-noir spots. A 16-year-old male presented to our Pediatric Dermatology Clinic, with extensive hyperpigmentation, irregular brown patches, and hypopigmented

2019 Journal of the European Academy of Dermatology and Venereology

342. UV-sensitive syndrome: Whole exome sequencing identified a nonsense mutation in the gene UVSSA in two consanguineous pedigrees from Pakistan. Full Text available with Trip Pro

UV-sensitive syndrome: Whole exome sequencing identified a nonsense mutation in the gene UVSSA in two consanguineous pedigrees from Pakistan. UV-sensitive syndrome (UVSS) is a rare autosomal recessive genodermatosis characterised by photosensitivity, and hyperpigmentation, freckling, and dryness of sun exposed areas. In contrast to other photosensitivity disorders, affected patients show no predisposition to cutaneous melanoma or neurological dysfunction. UVSS results from a defect

2019 Journal of dermatological science

343. Reflectance confocal microscopy and dermoscopy aid in evaluating repigmentation within or adjacent to lentigo maligna melanoma surgical scars. (Abstract)

in the study cohort. Twenty-one patients had biopsy-confirmed recurrent LM/LMM; the remainder had pigmented actinic keratosis (n = 4) or hyperpigmentation/solar lentigo (n = 5). RCM had sensitivity of 95.24% (95% CI, 76.18-99.88%), specificity of 77.7% (95% CI, 39.99-97.19%), positive predictive value of 90.91% (95% CI, 74.58-97.15%) and negative predictive value of 87.5% (95% CI, 50.04-98.0%). The most common dermoscopic feature observed among patients with recurrent LM/LMM was focal homogeneous

2019 Journal of the European Academy of Dermatology and Venereology

344. The effect of human umbilical cord blood-derived mesenchymal stem cell media containing serum on recovery after laser treatment: A double-blinded, randomized, split-face controlled study. (Abstract)

The effect of human umbilical cord blood-derived mesenchymal stem cell media containing serum on recovery after laser treatment: A double-blinded, randomized, split-face controlled study. Ablative CO2 fractional laser (AFL) is a common cosmetic procedure to improve skin laxity. However, due to prolonged downtime and the risk of postinflammatory hyperpigmentation, laser-assisted delivery of active ingredients as post-laser treatment has gained interest in past years. Among various active

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

345. Patient-Reported Outcomes in Acne Patients With Skin of Color Using Adapalene 0.3%-Benzoyl Peroxide 2.5%: A Prospective Real-World Study (Abstract)

(GAI), postinflammatory hyperpigmentation (PIH; if present at baseline), and safety. Results: Fifty subjects were enrolled: 20 Asians, 17 black/African-Americans, and 13 Latin-Americans. Most had FST IV (74%) or V (22%), with moderate (70%; IGA 3) or severe (30%; IGA 4) acne. At week 16, 77% of subjects were satisfied or very satisfied with treatment, 56% of subjects had an IGA of 0 or 1 (clear/almost clear), and 87% had a good to excellent improvement in GAI. QoL improved throughout the study

2019 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

346. A randomized study to evaluate the efficacy and effectiveness of two sunscreen formulations on Indian skin types IV and V with pigmentation irregularities. Full Text available with Trip Pro

enrolled adult men and women (18-45 years) with Fitzpatrick skin phototypes IV (28° < individual typological angle <10°) and V (10° < individual typological angle < -30°) with pigmentary abnormalities seen on the face in adults (actinic lentigines and postinflammatory hyperpigmentation), who did not use sunscreens. Participants were randomized (1:1) to either of the two marketed sunscreen products, Product A (sun protection factor 50 PA+++) or Product B (sun protection factor 19 PA+++), applied twice

2019 Indian journal of dermatology, venereology and leprology Controlled trial quality: uncertain

347. Novel topical dermal repair: A clinical analysis. (Abstract)

Fitzpatrick skin types were randomized to receive either the topical anti-wrinkle cream (AM cream) only or the AM cream and the topical evening DNA repair serum (PM serum) for 16 weeks. Subjects noted their subjective improvement in wrinkles, pore size, hyperpigmentation, and overall skin quality. Two blinded physicians evaluated the appearance of wrinkles pre- and postapplication of the AM cream.Participants who applied the AM cream only reported subjective improvement in wrinkles and overall quality

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

348. Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split (Abstract)

evaluate the efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese (experimental cream) versus 0.02% Triamcinolone acetonide (TA) cream in decreasing adverse effects and downtime after FrCO2 laser, with wound healing improvement and prevention of certain steroid-related side effects like postinflammatory hyperpigmentation (PIH).We conducted a double-blinded, split face, randomized controlled trial in 20 subjects receiving FrCO2 laser on both sides

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

349. Comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans. Full Text available with Trip Pro

for the treatment of neck hyperpigmentation associated with AN was performed. M index measured by a narrowband reflectance spectrophotometer and both investigator's global evaluation (IGE) and parent's global evaluation (PGE) scales were used to evaluate efficacy.There was no statistically significant difference between 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of AN-associated hyperpigmentation (P = 0.56). Mean differences in M indices between week 0 and week 8 of 0.1% adapalene and 0.025

2019 Pediatric dermatology Controlled trial quality: uncertain

350. Treatment of Moderate-to-severe Facial Acne Vulgaris with Solid-state Fractional 589/1,319-nm Laser. (Abstract)

acne lesions were reduced by 2.5 (-23.1%) on the treatment side and increased by 1.1 (+11.1%) on the control side. No patients experienced bruising, edema, hyperpigmentation or scarring. At the conclusion of the study, 77.8 percent of the patients reported overall satisfaction. Conclusion: This unique combination of lasers appears to be safe in patients with Fitzpatrick Skin Type IV, and might be useful in treating moderate-to-severe acne vulgaris.

2019 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

351. Analysis of the effect of different doses of oral tranexamic acid on melasma: a multicentre prospective study. (Abstract)

Analysis of the effect of different doses of oral tranexamic acid on melasma: a multicentre prospective study. Melasma is pale brown to dark brown hyperpigmentation of the facial skin that commonly affects women of reproductive age. Treatment methods for melasma include oral and topical use of vitamin C, hydroquinone ointment, and laser treatment, with unsatisfactory results. Tranexamic acid (TA) has been shown to be effective against melasma, however, the optimal dose has not been

2019 European journal of dermatology : EJD Controlled trial quality: uncertain

352. Long-pulsed Nd: YAG Laser and Intense Pulse Light-755 nm for Idiopathic Facial Hirsutism: A Comparative Study. Full Text available with Trip Pro

%, perifollicular edema and hyperpigmentation in 13.33% each. In Group B, erythema was seen in 50% patients, perifollicular edema in 16.67% and hyperpigmentation in 38.89% patients.Long-pulsed Nd: YAG Laser (1064 nm) is better than IPL-755 nm in terms of safety and effectiveness in the management of idiopathic facial hirsutism.

2019 Journal of cutaneous and aesthetic surgery Controlled trial quality: uncertain

353. Fractional CO2 laser versus combined platelet-rich plasma and fractional CO2 laser in treatment of acne scars: Image analysis system evaluation. (Abstract)

and skin texture were reported by the patients. Although 70% of our patients were of a dark skin type, no hyperpigmentation was reported.The combined use of fractional CO2 laser and PRP achieved better results. It reduced the downtime of the fractional CO2 laser. The use of the skin analysis camera provided an objective assessment of the results.© 2019 Wiley Periodicals, Inc.

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

354. Gamma Knife radiosurgery for the treatment of Nelson's syndrome: a multicenter, international study. (Abstract)

Gamma Knife radiosurgery for the treatment of Nelson's syndrome: a multicenter, international study. Nelson's syndrome is a rare and challenging neuroendocrine disorder, and it is associated with elevated adrenocorticotrophic hormone (ACTH) level, skin hyperpigmentation, and pituitary adenoma growth. Management options including resection and medical therapy are traditional approaches. Ionizing radiation in the form of Gamma Knife radiosurgery (GKRS) is also being utilized to treat Nelson's

2019 Journal of Neurosurgery

355. Noncultured Extracted Hair Follicle Outer Root Sheath Cell Suspension versus Noncultured Epidermal Cell Suspension in the Treatment of Stable Vitiligo. Full Text available with Trip Pro

. In NCES group, 10% showed excellent pigmentation, 10% good pigmentation, 40% fair, and 40% poor pigmentation. This difference was not statistically significant. Excellent color match was observed in 80% of NCORSHFS and in 70% of NCES. Donor area complications were absent in NCORSHFS group, whereas in NCES, mild scarring in 20% and hyperpigmentation in 40% of patients was observed. The difference in patients' satisfaction between the two groups was not statistically significant.Both NCORSHFS and NCES

2019 Journal of cutaneous and aesthetic surgery Controlled trial quality: uncertain

356. Home vs hospital narrowband UVB treatment by a hand-held unit for new-onset vitiligo: A pilot randomized controlled study. (Abstract)

reduced to the greatest degree at week 8 for all patients in both groups. Adverse events, such as painful erythema, burning, blistering, and excessive hyperpigmentation, were more frequently observed in the home-based treatment group than in the hospital-based treatment group. The cost of phototherapy in hospital exceeded the cost of home phototherapy after 7 weeks of treatment.Home NB-UVB phototherapy treatment was as effective as treatment in hospital, but exhibited cost-effective and a better

2019 Photodermatology, photoimmunology & photomedicine Controlled trial quality: uncertain

357. Outcomes and Prognostic Factors In African American / Black Patients With Mycosis Fungoides And Sézary Syndrome: Retrospective Analysis Of 157 Patients From A Referral Cancer Center. (Abstract)

/SS.Clinical features and follow-up data were analyzed in 157 self-identified AA/black patients seen between 1994-2018.We included 122 patients with early-stage MF and 35 patients with advanced-stage disease (median follow-up of 25 months). >80% of the patients who died from disease or progressed presented with erythema/hyperpigmentation without hypopigmentation. Patients presenting with hypopigmentation, either as the sole manifestation or in combination with other lesions, had better overall survival (P

2019 Journal of American Academy of Dermatology

358. Development and accuracy of an artificial intelligence algorithm for acne grading from smartphone photographs. Full Text available with Trip Pro

Development and accuracy of an artificial intelligence algorithm for acne grading from smartphone photographs. We developed an artificial intelligence algorithm (AIA) for smartphones to determine the severity of facial acne using the GEA scale and to identify different types of acne lesion (comedonal, inflammatory) and postinflammatory hyperpigmentation (PIHP) or residual hyperpigmentation. Overall, 5972 images (face, right and left profiles) obtained with smartphones (IOS and/or Android) from

2019 Experimental Dermatology

359. The efficacy and safety of microneedle monopolar radiofrequency for the treatment of periorbital wrinkles. (Abstract)

treated with a short microneedle (SMN, 0.8 mm) were compared, significant improvement in the VISIA wrinkle score was observed only in those treated with the LMN. No serious adverse events, including scarring and postinflammatory hyperpigmentation, occurred. Conclusions: We demonstrated the efficacy and safety of the microneedle monopolar RF device in treating periorbital wrinkles. The LMN was superior to the SMN in reducing VISIA wrinkle score.

2019 Journal of Dermatological Treatment

360. Cutaneous Disorders Associated with Castleman's Disease. Full Text available with Trip Pro

(paraneoplastic pemphigus, xanthogranulomas), cytokine-related (vasculitis-like lesion, cherry angioma, hyperpigmentation), and non-specific (pruritus). This study builds on previous case reports of cutaneous disorders in Castleman's disease and proposes a new classification system.

2019 Acta Dermato-Venereologica

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