How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,900 results for

Hyperpigmentation

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

281. Burns and scalds: Scenario: Management of non-complex burns and scalds

irregular pigmentation or hyperpigmentation. Arrange referral to: A specialist burns unit or seek specialist advice for any wound that is not improving as expected, or that has not healed within two weeks of the initial injury, depending on clinical judgement. A physiotherapist and/or occupational therapist if the person has hypertrophic scars or contractures which need support with maintaining movement and function. A skin camouflage service, if needed. Wound management Ensure a professional (...) application is based on the fact that symptoms such as itch typically peak at 2–6 months after injury. It may also reduce the risk of hypertrophic scarring, which may occur 4–6 weeks after injury to the deep dermis [ ; ]. The recommendation on the use of high factor sunblock is based on the fact that newly healed epidermis may have increased melanocyte activity if exposed to sunlight following a burn injury, causing permanent hyperpigmentation [ ]. Arranging referral or seeking specialist advice If a burn

2017 NICE Clinical Knowledge Summaries

283. CRACKCast E128 – Thyroid and Adrenal Disorders

characteristically have more pronounced clinical manifestations and skin hyperpigmentation. Measurement of cortisol in the ACTH stimulation test is the standard and most convenient method to assist in confirming the diagnosis. Refractory hypotension in the acutely ill patient may be the only clue to adrenal insufficiency and is readily treated with the IV administration of glucocorticoids (dexamethasone, 4 mg, or hydrocortisone, 100 mg). Rosen’s In Perspective Here’s the physiology of thyroid production (...) [12] List 5 causes of chronic primary adrenal insufficiency + 1 acute + 3 secondary The clinical manifestations are the result of primary adrenal failure or secondary adrenal disease from malfunction of the hypothalamic-pituitary-adrenal (HPA) axis in its production of adrenocorticotropic hormone (ACTH). Secondary causes are much more common than primary causes. Primary = high ACTH and low cortisol (get subsequent hyperpigmentation) Mild to moderate hyponatremia, with levels typically above 120

2017 CandiEM

284. CRACKCast E120 – Dermatologic presentations

in dermal-epidermal junction, often erythematous Hyperpigmentation Increase in melanin containing epidermal cells Lichenification Abnormally dense layer of keratinised epidermal cells [3] List systemic diseases that present with cutaneous signs for each of the following locations (table): ( See table 110.4 in Rosen’s 9 th edition) Generalized rash Head and neck Hands Legs Palms and Soles Infectious Secondary syphilis Hand foot and mouth disease (coxsackie) RMSF Kawasaki syndrome Aureus endocarditis

2017 CandiEM

285. Hepatitis C Virus Infection Care Pathway?A Report From the American Gastroenterological Association Institute HCV Care Pathway Work Group

digits, arthralgia, peripheral neuropathy Serum cryoblobulins, low C4, RFþ Skin biopsy showing leukocytoclastic vasculitis Mixed Cryoglobulinemia Mono/oligo-arthritis Non-erosive synovitis (x-ray) RFþ, anti-CCP-, Arthritis Xerostomia Xeroftalmia Schirmer’s testþ, mild salivary gland involvement Absent or low titer autoAntibody (ANA/ENA) Sicca Syndrome Skin hyperpigmentation, erosions at sun-exposed areas and bullae Elevated serum & urinary porphyrins, URO-D de?ciency Porphyria Cutanea Tarda

2017 American Gastroenterological Association Institute

286. Conjunctival pigmented lesions

melanocytosis hyperpigmentation of episclera as a result of an overpopulation of melanocytes, also occurring in uvea and skin (i.e., Naevus of Ota). Predisposes to melanoma. Naevus the most common conjunctival pigmented lesion: 52% of ocular pigmented lesions congenital or acquired cluster of naevus cells in the conjunctival epithelium, usually extending to substantia propria. Cysts are often present. Melanoma rare malignant tumour arising from naevus, PAM or de novo: 3-5% of ocular malignancies, incidence (...) *: Level of evidence=low, Strength of recommendation=strong) Congenital Ocular Melanocytosis Has potential for malignancy – refer. Is associated with malignant melanoma of the affected skin, orbit and uveal tract (fundoscopy with papillary dilatation is required). Also associated with hyperpigmentation elsewhere in the eye including the trabeculum (regular monitoring for glaucoma required) (GRADE*: Level of evidence=low, Strength of recommendation=strong) Naevus Generally requires no treatment

2018 College of Optometrists

288. Diagnosis and management of iliofemoral deep vein thrombosis: clinical practice guideline

telangiectasias, varicose veins, erythema, hyperpigmentation, dependent cyanosis and venous ulcers, as defined in the Villalta score of the CaVenT study. 8,58 Prevention of post-thrombotic syndrome Initial RCTs of compression therapy for the prevention of post-thrombotic syndrome in patients with proximal DVT (including iliofem- oral DVT) yielded conflicting results, but were hindered by lack of a placebo control, small numbers of patients, single-centre recruitment and open-label design. 59–62 The recent SOX

2015 CPG Infobase

289. Chinese expert consensus on clinical prevention and treatment of scar+ Full Text available with Trip Pro

Chinese expert consensus on clinical prevention and treatment of scar+ Following injury, Asian skin has a tendency toward hyperpigmentation and scar formation than Caucasians. A standardized algorithm tailored to Asian patients, especially Chinese patients, is in great demand. Twelve independent, self-selected academic and military physicians from the department of burn/trauma, plastic surgery and dermatology with extensive experience in treating scars were assembled on January 17, 2015

2018 Burns & trauma

290. A case of exogenous ochronosis associated with hydroxychloroquine Full Text available with Trip Pro

A case of exogenous ochronosis associated with hydroxychloroquine Exogenous ochronosis is characterized by hyperpigmented skin lesions that arise in association with local suppression of homogentisic acid oxidase enzyme. Although it generally develops in association with topical application of chemical agents, it can occasionally develop in association with antimalarial drugs. Here we present the case of a patient with rheumatoid arthritis who developed hyperpigmentation on the face and neck (...) regions during hydroxychloroquine treatment. Hydroxychloroquine is being widely used in rheumatology practice, and cutaneous hyperpigmentation may develop as an adverse effect. In the present case, we emphasize the potential underlying mechanisms through which it may cause cutaneous hyperpigmentation and determine the clinical and histopathological findings of exogenous ochronosis.

2018 European journal of rheumatology

291. Post Thrombotic Syndrome (PTS)

are aggravated by standing or walking and improve with resting, leg elevation and lying down. TABLE 1: TYPICAL CLINICAL FEATURES OF THE POST-THROMBOTIC SYNDROME LEG SYMPTOMS SIGNS Heaviness or fatigue Edema Pain Peri-malleolar telangiectasiae Swelling Venous ectasia, varicose veins Itching Hyperpigmentation Cramps Redness Paresthesia Dependent cyanosis Bursting pain on walking (venous claudication) Lipodermatosclerosis Symptom pattern: Worse with activity, standing, walking; better with rest, recumbency (...) and swelling associated with acute DVT to resolve, hence a diagnosis of PTS should be deferred until after the acute phase (i.e. 3-6 months) has passed. ? Symptoms of PTS usually occur within 3-6 months after DVT, but can occur up to 2 years after DVT. TABLE 2: VILLALTA PTS SCALE CRITERIA USED TO DIAGNOSE PTS ? 5 symptoms (pain, cramps, heaviness, pruritus, paresthesia) ? 6 signs (edema, skin induration, hyperpigmentation, venous ectasia, redness, pain during calf compression) ? Each symptom and sign rated

2015 Thrombosis Interest Group of Canada

293. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. (Abstract)

Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. Topical niacinamide and N-acetyl glucosamine (NAG) each individually inhibit epidermal pigmentation in cell culture. In small clinical studies, niacinamide-containing and NAG-containing formulations reduced the appearance of hyperpigmentation.To assess the effect of a combination

2010 The British journal of dermatology Controlled trial quality: uncertain

294. Ipsilateral areolar hyperpigmentation following unilateral application of estradiol spray. (Abstract)

Ipsilateral areolar hyperpigmentation following unilateral application of estradiol spray. A 48 year old postmenopausal female noted hyperpigmentation of the left areola 3 months after beginning estradiol spray to her left forearm. She then applied the spray to the right forearm instead until the areolae were the same color again and then applied 1 spray to each forearm thereafter.Copyright © 2010 Mosby, Inc. All rights reserved.

2010 American Journal of Obstetrics and Gynecology

295. Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo. (Abstract)

Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo. Cutaneous pigmentation is regulated by a complex melanogenic network in which both keratinocytes and fibroblasts synthesize growth factors and cytokines. Solar lentigo (SL) is characterized by hyperpigmented lesions occurring on photodamaged skin areas. Despite the association of SL to ultraviolet (UV) exposure, the mechanisms underlying the development of these spots are not completely defined.To (...) analyse the involvement of the fibroblast-derived growth factors, hepatocyte growth factor (HGF), keratinocyte growth factor (KGF) and stem cell factor (SCF) in SL hyperpigmentation; to evaluate whether the photoageing process occurring in fibroblasts could be responsible for the altered expression of these cytokines; and to investigate a new possible role of KGF in regulating pigmentation through the specific induction of melanogenic cytokines by keratinocytes.We performed immunohistochemical

2010 British Journal of Dermatology

296. Application of a combined sulphorhodamine B and melanin assay to the evaluation of Chinese medicines and their constituent compounds for hyperpigmentation treatment. (Abstract)

Application of a combined sulphorhodamine B and melanin assay to the evaluation of Chinese medicines and their constituent compounds for hyperpigmentation treatment. To investigate the efficacy of traditional Chinese medicine (TCM) in the treatment of hyperpigmentation problems, extracts of herbs selected based on traditional Chinese medical literature were screened.Forty extracts were extracted from 10 selected herbs using hexane, dichloromethane, methanol and water. They were then screened

2010 Journal of Ethnopharmacology

297. The quantitative evaluation of online haemodiafiltration effect on skin hyperpigmentation. Full Text available with Trip Pro

The quantitative evaluation of online haemodiafiltration effect on skin hyperpigmentation. Skin pigmentation is a common problem for dialysis patients, but little is known about the factor responsible for the colour intensity. Middle-molecular-weight (MMW) substances have been suggested to be responsible for the skin colour. Several papers have reported that β(2)-microglobulin (β(2)-MG) correlates with the skin colour, and haemodiafiltration (HDF) is effective to reduce the skin (...) hyperpigmentation. However, a quantitative skin colour follow-up on patients treated with online haemodiafiltration (online HDF) has not been performed.Sixty-one patients were enrolled in this study. Quantification of skin colour was done using a reflected light colorimeter. Among them, 51 patients were under haemodialysis (HD), and the other 10 patients were under online HDF. Follow-ups to estimate the skin colour change were performed for 6 months. Among 10 patients under online HDF, four patients were also

2010 Transplantation

298. Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Novel Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. (Abstract)

Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Novel Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. 20629692 2011 03 30 2011 02 14 1524-4725 36 9 2010 Sep Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Commentary: treatment of facial postinflammatory hyperpigmentation with facial acne in Asian patients using a novel Q-switched neodymium-doped yttrium aluminum garnet (...) laser. 1381 10.1111/j.1524-4725.2010.01644.x Metelitsa Andrei I AI SkinCare Physicians, Chestnut Hill, Massachusetts, USA. eng Comment Journal Article 2010 07 09 United States Dermatol Surg 9504371 1076-0512 IM Dermatol Surg. 2010 Sep;36(9):1374-80 20629693 Acne Vulgaris complications surgery Dermatitis etiology Face Humans Hyperpigmentation etiology surgery Lasers, Solid-State therapeutic use Skin Diseases etiology surgery 2010 7 16 6 0 2010 7 16 6 0 2011 3 31 6 0 ppublish 20629692 DSU1644 10.1111

2010 Dermatologic Surgery

299. Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. (Abstract)

Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. Postinflammatory hyperpigmentation (PIH) due to facial acne commonly occurs in Fitzpatrick skin types IV to VI and can have a considerable effect on quality of life. The sequelae in terms of pigmentation are often the main reason for consulting a dermatologist and take precedence over the acne itself.The purpose of this study was to evaluate

2010 Dermatologic Surgery

300. Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial. Full Text available with Trip Pro

with dermatologic procedures. The current study was designed to evaluate solar lentigo hyperpigmentation, skin architecture and clinician and patient assessments comparing a dermocosmetic lightening product (active) with a moisturizing product (control) according to clinical, digital and subjective analyses in 72 lesions over 12-month follow up period. Statistically significant differences were observed between the lesions treated with the active compared to the control in terms of papillary brightness (p (...) to clinical, digital and subjective analyses in reducing lesion hyperpigmentation, stabilizing the lesion skin architecture and increasing patient satisfaction compared to the control in a cohort of 36 subjects, over a 12-month period. Beside demonstrating the efficacy of this topical lightening product, we propose a "destructuring score", which improves the robustness of solar lentigo's evaluation, and can be used in future studies to standardize the quantitative comparisons of different treatment

2019 PLoS ONE Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>