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Hyperpigmentation

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2881. Hyperpigmentation associated with minocycline therapy Full Text available with Trip Pro

Hyperpigmentation associated with minocycline therapy 17261828 2007 04 03 2018 11 13 1488-2329 176 3 2007 Jan 30 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Hyperpigmentation associated with minocycline therapy. 321-2 Chatterjee Soumya S Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, Ohio, USA. eng Case Reports Journal Article Canada CMAJ 9711805 0820-3946 0 Anti-Bacterial Agents FYY3R43WGO (...) Minocycline AIM IM Anti-Bacterial Agents adverse effects Humans Hyperpigmentation chemically induced Male Middle Aged Minocycline adverse effects Scleroderma, Diffuse drug therapy 2007 1 31 9 0 2007 4 4 9 0 2007 1 31 9 0 ppublish 17261828 176/3/321 10.1503/cmaj.060866 PMC1780086 J Rheumatol. 2006 Jul;33(7):1254-7 16758512 Arthritis Rheum. 2004 Feb;50(2):553-7 14872498

2007 CMAJ : Canadian Medical Association Journal

2882. Intravenous vitamin C in the treatment of post-laser hyperpigmentation for melasma: A short report Full Text available with Trip Pro

Intravenous vitamin C in the treatment of post-laser hyperpigmentation for melasma: A short report Melasma is difficult to treat. Vitamin C, topical and by iontophoresis, has been shown to be useful. When lasers are used, there is a significant incidence of post-laser hyperpigmentation. There is no single established treatment for the latter. The case history of a 51-year-old Chinese woman is presented. Intravenous vitamin C appears to be useful in treating this complication.

2008 Journal of Cosmetic and Laser Therapy

2883. Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients? Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients? The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00172302 Recruitment Status : Unknown Verified May 2005 by National Taiwan University Hospital. Recruitment status was: Not yet

2005 Clinical Trials

2884. Post-inflammatory Hyperpigmentation of Skin

Post-inflammatory Hyperpigmentation of Skin Post-inflammatory Hyperpigmentation of Skin. Information | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Post-inflammatory Hyperpigmentation of Skin Authored by , Reviewed by | Last edited 10 Nov 2016 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors (...) and based on research evidence, UK and European Guidelines. You may find the article more useful, or one of our other . In this article In This Article Post-inflammatory Hyperpigmentation of Skin In this article Appearance Post-inflammatory hyperpigmentation occurs as brown macules or patches, often with a poorly defined border, irregular in outline and usually with little surface change [ ] . The basic mechanism in response to various triggers (see 'Aetiology', below) is melanosis of the epidermal

2008 Mentor

2885. Is there any information on hyperpigmentation, specifically poikiloderma of Civatte, and whether it is linked to perfume use?

Is there any information on hyperpigmentation, specifically poikiloderma of Civatte, and whether it is linked to perfume use? Is there any information on hyperpigmentation, specifically poikiloderma of Civatte, and whether it is linked to perfume use? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words (...) as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Is there any information on hyperpigmentation, specifically poikiloderma of Civatte, and whether it is linked to perfume use? eMedicine, an American

2003 TRIP Answers

2886. Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. Full Text available with Trip Pro

Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. To quantify the 5-year risk of age-related macular degeneration (AMD) in eyes with different macular drusen characteristics (ie, size, type, location, and total area) or hyperpigmentation in a population-based cohort.The Blue Mountains Eye Study examined 3654 residents during 1992-1994; 2335 (75.1% of survivors) were reexamined during 1997-1999. Retinal photographs (...) neovascular or atrophic AMD lesions over 5 years. In right eyes, presence vs absence of the following macular signs predicted AMD: drusen that were 125 micro m or larger (13.9 vs 0.6%; age-adjusted RR, 5.7; 95% confidence interval [CI], 3.6-9.0), indistinct soft or reticular drusen (23.2% vs 0.4%; RR, 9.9; 95% CI, 6.4-15.4), total drusen area of half the disc area or more (31.4% vs 0.6%; RR, 13.5; 95% CI, 8.0-22.8), and hyperpigmentation (14.4% vs 0.5%; RR, 8.0; 95% CI, 5.4-11.9). After adjusting for age

2003 Archives of Ophthalmology

2887. Vaginal hyperpigmentation due to ochronosis. (Abstract)

Vaginal hyperpigmentation due to ochronosis. Ochronosis is a manifestation of alkaptonuria, a rare metabolic disorder. It results in the accumulation of pigment in connective tissues. After several years, ochronosis may produce a distinctive form of degenerative arthritis.Vaginal ochronosis was diagnosed in an asymptomatic elderly woman with vaginal hyperpigmentation and severe degenerative arthritis.Vaginal hyperpigmentation is a rare clinical finding that necessitates biopsy.

2003 Obstetrics and Gynecology

2888. Aloesin inhibits hyperpigmentation induced by UV radiation. (Abstract)

Aloesin inhibits hyperpigmentation induced by UV radiation. Skin hyperpigmentation is caused by the overproduction of melanin pigment, which is synthesized by the action of tyrosinase. We recently reported that aloesin inhibits tyrosinase activity. The present study was undertaken to test the inhibitory effect of aloesin on pigmentation in human skin after UV radiation. Experimental subjects were UV-irradiated (210 mJ) on the inner forearm. UV-irradiated regions were assigned to four groups

2002 Clinical & Experimental Dermatology

2889. Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection. (Abstract)

Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection. Many types of skin disorders concomitantly occur with hepatitis C virus infection. These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN). To our knowledge, hyperpigmentation of the skin--and especially of the tongue--has not been reported so far. We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination (...) therapy with IFN and ribavirin. Immunohistochemical analysis of tongue biopsies confirmed the suspicion of melanin deposits in these areas of hyperpigmentation. We hypothesize that during interferon therapy, melanocytes may produce more melanin pigment in the presence of alpha-melanocyte stimulating hormone and sufficient amounts of tyrosine, leading to melanin deposits and clinical hyperpigmentation.

2003 British Journal of Dermatology

2890. Microabrasion versus microabrasion followed by 15% trichloroacetic acid for treatment of cutaneous hyperpigmentations in adult females. (Abstract)

Microabrasion versus microabrasion followed by 15% trichloroacetic acid for treatment of cutaneous hyperpigmentations in adult females. Cutaneous hyperpigmentations are common skin disorders that are often refractory to currently available treatments.To evaluate the efficacy of microabrasion alone or microabrasion with 15% trichloroacetic acid (TCA) for treatment of cutaneous hyperpigmentations.Twenty female patients were treated with microabrasion alone every 2 weeks (group 1), and 20 female (...) %). No unexpected or serious side effects were observed in either group.Microabrasion alone or microabrasion with 15% TCA is an effective, well-tolerated treatment for cutaneous hyperpigmentations.

2003 Dermatologic Surgery

2891. Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca plantaris. (Abstract)

Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca plantaris. Flagellate hyperpigmentation is a well-documented complication of systemic bleomycin sulfate therapy when using doses of 100 U or more as an antineoplastic agent. Two cases occurred after using systemic doses from 15 to 30 U injected intravenously or intrapleurally; however, it has not been described as a complication following intralesional treatment of verruca plantaris.We report a case (...) of flagellate hyperpigmentation after intralesional injection of 14 U of bleomycin for verrucae plantaris and review the literature associated with this cutaneous complication.Flagellate hyperpigmentation from extremely low doses of intralesional bleomycin is a previously undescribed complication. Although the mechanisms of reaction are not clearly understood, the clinician should be mindful of this uncommon complication.

2003 Archives of Dermatology

2892. The mechanism of epidermal hyperpigmentation in café-au-lait macules of neurofibromatosis type 1 (von Recklinghausen's disease) may be associated with dermal fibroblast-derived stem cell factor and hepatocyte growth factor. (Abstract)

The mechanism of epidermal hyperpigmentation in café-au-lait macules of neurofibromatosis type 1 (von Recklinghausen's disease) may be associated with dermal fibroblast-derived stem cell factor and hepatocyte growth factor. The mechanism of the accentuated melanization in café-au-lait macules (CALMs) in patients with neurofibromatosis type 1 (NF1; von Recklinghausen's disease) has not been elucidated.To clarify the mechanism involved in the hyperpigmentation of CALMs in NF1.Using enzyme-linked

2003 British Journal of Dermatology

2893. Reversible hyperpigmentation associated with high dose hydroxyurea. Full Text available with Trip Pro

Reversible hyperpigmentation associated with high dose hydroxyurea. 2379018 1990 09 13 2018 11 13 0959-8138 300 6737 1990 Jun 02 BMJ (Clinical research ed.) BMJ Reversible hyperpigmentation associated with high dose hydroxyurea. 1468 Majumdar G G Department of Haematology, St Thomas's Hospital, London. Heard S E SE Slater N G NG eng Case Reports Journal Article England BMJ 8900488 0959-8138 X6Q56QN5QC Hydroxyurea AIM IM Humans Hydroxyurea administration & dosage adverse effects Male Middle Aged

1990 BMJ : British Medical Journal

2894. Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. (Abstract)

Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. This multicenter, randomized, double-masked, parallel-group study assessed the efficacy, safety, and tolerability of azelaic acid 20% cream compared with those of its vehicle for the treatment of facial hyperpigmentation in darker-skinned patients (phototypes IV to VI). Following a 24-week treatment period, azelaic acid produced significantly greater decreases in pigmentary intensity than did vehicle (...) very satisfied or satisfied with their treatment. Also, more patients treated with azelaic acid than with vehicle rated their medication as being more effective or the same as past treatments. Thus azelaic acid is an effective and well-tolerated treatment for hyperpigmentation in darker-skinned patients.

1999 Clinical therapeutics Controlled trial quality: uncertain

2895. Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. (Abstract)

Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. This multicenter, randomized, double-masked, parallel-group, 24-week clinical study compared the efficacy of the combination of azelaic acid 20% cream and glycolic acid 15% or 20% lotion with hydroquinone 4% in the treatment of facial hyperpigmentation in darker-skinned patients. At week 24, overall improvement and reduction in lesion area (...) in the treatment of hyperpigmentation in darker-skinned patients, with only a slightly higher rate of mild local irritation. These findings suggest that the addition of glycolic acid to azelaic acid treatment for hyperpigmentation is an appropriate alternative in selected darker-skinned patients.

1999 Clinical therapeutics Controlled trial quality: uncertain

2896. Effect of pretreatment on the incidence of hyperpigmentation following cutaneous CO2 laser resurfacing. (Abstract)

Effect of pretreatment on the incidence of hyperpigmentation following cutaneous CO2 laser resurfacing. Transient hyperpigmentation is the most common complication seen following cutaneous carbon dioxide (CO2) laser resurfacing.The purpose of this study was to determine whether the use of a topical skin lightening regimen prior to cutaneous laser resurfacing reduces the incidence of post-laser resurfacing hyperpigmentation.One hundred consecutive CO2 laser resurfacing patients (skin types I-III (...) ) were randomized to receive preoperative treatment with 10% glycolic acid cream twice daily (n=25), hydroquinone 4% cream qHS and tretinoin 0.025% cream twice daily (n=25) or no pretreatment (n=50, control) for at least 2 weeks. Clinical and photographic assessments were performed prior to laser resurfacing and at 4 and 12 weeks following treatment.There was no significant difference in the incidence of post-CO2 laser resurfacing hyperpigmentation between subjects who received pretreatment

1999 Dermatologic Surgery Controlled trial quality: uncertain

2897. Fluorescence photography in the evaluation of hyperpigmentation in photodamaged skin. (Abstract)

Fluorescence photography in the evaluation of hyperpigmentation in photodamaged skin. Treatment-related changes in hyperpigmentation are difficult to quantify with visible light photography, especially when the changes are subtle.Our purpose was to determine the utility and reliability of fluorescence photography to measure changes in mottled and diffuse hyperpigmentation.Thirty-two subjects, with mildly to moderately photodamaged skin, completed a 36-week, double-blind, vehicle-controlled (...) study of tretinoin cream 0.025%. Clinical evaluation of hyperpigmentation as well as standard flash photographs and fluorescence photographs were obtained at baseline and week 36.The fluorescence photographs were evaluated blindly and yielded macule counts that decreased significantly from baseline in tretinoin-treated subjects compared with vehicle-treated subjects (31% vs 11% decrease; p = 0.02). Diffuse hyperpigmentation, as evaluated from the fluorescence photographs, decreased 16% from baseline

1997 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

2898. Glycolic acid peels for postinflammatory hyperpigmentation in black patients. A comparative study. (Abstract)

Glycolic acid peels for postinflammatory hyperpigmentation in black patients. A comparative study. Treatment of postinflammatory hyperpigmentation in patients of Fitzpatrick skin types IV, V, and VI is difficult. Glycolic acid peels are useful for pigment dyschromias in caucasians; however, there are no controlled studies examining their safety and efficacy in dark-complexioned individuals.To determine if serial glycolic acid peels provide additional improvement when compared with a topical (...) treatment groups demonstrated improvement, but the patients receiving the glycolic acid peels showed a trend toward more rapid and greater improvement. The peel group also experienced increased lightening of the normal skin.This pilot study demonstrates that serial glycolic acid peels provide an additional benefit, with minimal adverse effects, for the treatment of postinflammatory hyperpigmentation in dark-complexioned individuals.

1997 Dermatologic Surgery Controlled trial quality: uncertain

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