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Hyperpigmentation

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2881. Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. (Abstract)

Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. This multicenter, randomized, double-masked, parallel-group study assessed the efficacy, safety, and tolerability of azelaic acid 20% cream compared with those of its vehicle for the treatment of facial hyperpigmentation in darker-skinned patients (phototypes IV to VI). Following a 24-week treatment period, azelaic acid produced significantly greater decreases in pigmentary intensity than did vehicle (...) very satisfied or satisfied with their treatment. Also, more patients treated with azelaic acid than with vehicle rated their medication as being more effective or the same as past treatments. Thus azelaic acid is an effective and well-tolerated treatment for hyperpigmentation in darker-skinned patients.

1999 Clinical therapeutics Controlled trial quality: uncertain

2882. Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. (Abstract)

Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. This multicenter, randomized, double-masked, parallel-group, 24-week clinical study compared the efficacy of the combination of azelaic acid 20% cream and glycolic acid 15% or 20% lotion with hydroquinone 4% in the treatment of facial hyperpigmentation in darker-skinned patients. At week 24, overall improvement and reduction in lesion area (...) in the treatment of hyperpigmentation in darker-skinned patients, with only a slightly higher rate of mild local irritation. These findings suggest that the addition of glycolic acid to azelaic acid treatment for hyperpigmentation is an appropriate alternative in selected darker-skinned patients.

1999 Clinical therapeutics Controlled trial quality: uncertain

2883. Reversible hyperpigmentation associated with high dose hydroxyurea. (Full text)

Reversible hyperpigmentation associated with high dose hydroxyurea. 2379018 1990 09 13 2018 11 13 0959-8138 300 6737 1990 Jun 02 BMJ (Clinical research ed.) BMJ Reversible hyperpigmentation associated with high dose hydroxyurea. 1468 Majumdar G G Department of Haematology, St Thomas's Hospital, London. Heard S E SE Slater N G NG eng Case Reports Journal Article England BMJ 8900488 0959-8138 X6Q56QN5QC Hydroxyurea AIM IM Humans Hydroxyurea administration & dosage adverse effects Male Middle Aged

1990 BMJ : British Medical Journal PubMed abstract

2884. Effect of pretreatment on the incidence of hyperpigmentation following cutaneous CO2 laser resurfacing. (Abstract)

Effect of pretreatment on the incidence of hyperpigmentation following cutaneous CO2 laser resurfacing. Transient hyperpigmentation is the most common complication seen following cutaneous carbon dioxide (CO2) laser resurfacing.The purpose of this study was to determine whether the use of a topical skin lightening regimen prior to cutaneous laser resurfacing reduces the incidence of post-laser resurfacing hyperpigmentation.One hundred consecutive CO2 laser resurfacing patients (skin types I-III (...) ) were randomized to receive preoperative treatment with 10% glycolic acid cream twice daily (n=25), hydroquinone 4% cream qHS and tretinoin 0.025% cream twice daily (n=25) or no pretreatment (n=50, control) for at least 2 weeks. Clinical and photographic assessments were performed prior to laser resurfacing and at 4 and 12 weeks following treatment.There was no significant difference in the incidence of post-CO2 laser resurfacing hyperpigmentation between subjects who received pretreatment

1999 Dermatologic Surgery Controlled trial quality: uncertain

2885. Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. (Full text)

Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. To quantify the 5-year risk of age-related macular degeneration (AMD) in eyes with different macular drusen characteristics (ie, size, type, location, and total area) or hyperpigmentation in a population-based cohort.The Blue Mountains Eye Study examined 3654 residents during 1992-1994; 2335 (75.1% of survivors) were reexamined during 1997-1999. Retinal photographs (...) neovascular or atrophic AMD lesions over 5 years. In right eyes, presence vs absence of the following macular signs predicted AMD: drusen that were 125 micro m or larger (13.9 vs 0.6%; age-adjusted RR, 5.7; 95% confidence interval [CI], 3.6-9.0), indistinct soft or reticular drusen (23.2% vs 0.4%; RR, 9.9; 95% CI, 6.4-15.4), total drusen area of half the disc area or more (31.4% vs 0.6%; RR, 13.5; 95% CI, 8.0-22.8), and hyperpigmentation (14.4% vs 0.5%; RR, 8.0; 95% CI, 5.4-11.9). After adjusting for age

2003 Archives of Ophthalmology PubMed abstract

2886. Vaginal hyperpigmentation due to ochronosis. (Abstract)

Vaginal hyperpigmentation due to ochronosis. Ochronosis is a manifestation of alkaptonuria, a rare metabolic disorder. It results in the accumulation of pigment in connective tissues. After several years, ochronosis may produce a distinctive form of degenerative arthritis.Vaginal ochronosis was diagnosed in an asymptomatic elderly woman with vaginal hyperpigmentation and severe degenerative arthritis.Vaginal hyperpigmentation is a rare clinical finding that necessitates biopsy.

2003 Obstetrics and Gynecology

2887. Aloesin inhibits hyperpigmentation induced by UV radiation. (Abstract)

Aloesin inhibits hyperpigmentation induced by UV radiation. Skin hyperpigmentation is caused by the overproduction of melanin pigment, which is synthesized by the action of tyrosinase. We recently reported that aloesin inhibits tyrosinase activity. The present study was undertaken to test the inhibitory effect of aloesin on pigmentation in human skin after UV radiation. Experimental subjects were UV-irradiated (210 mJ) on the inner forearm. UV-irradiated regions were assigned to four groups

2002 Clinical & Experimental Dermatology

2888. Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection. (Abstract)

Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection. Many types of skin disorders concomitantly occur with hepatitis C virus infection. These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN). To our knowledge, hyperpigmentation of the skin--and especially of the tongue--has not been reported so far. We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination (...) therapy with IFN and ribavirin. Immunohistochemical analysis of tongue biopsies confirmed the suspicion of melanin deposits in these areas of hyperpigmentation. We hypothesize that during interferon therapy, melanocytes may produce more melanin pigment in the presence of alpha-melanocyte stimulating hormone and sufficient amounts of tyrosine, leading to melanin deposits and clinical hyperpigmentation.

2003 British Journal of Dermatology

2889. Microabrasion versus microabrasion followed by 15% trichloroacetic acid for treatment of cutaneous hyperpigmentations in adult females. (Abstract)

Microabrasion versus microabrasion followed by 15% trichloroacetic acid for treatment of cutaneous hyperpigmentations in adult females. Cutaneous hyperpigmentations are common skin disorders that are often refractory to currently available treatments.To evaluate the efficacy of microabrasion alone or microabrasion with 15% trichloroacetic acid (TCA) for treatment of cutaneous hyperpigmentations.Twenty female patients were treated with microabrasion alone every 2 weeks (group 1), and 20 female (...) %). No unexpected or serious side effects were observed in either group.Microabrasion alone or microabrasion with 15% TCA is an effective, well-tolerated treatment for cutaneous hyperpigmentations.

2003 Dermatologic Surgery

2890. Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca plantaris. (Abstract)

Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca plantaris. Flagellate hyperpigmentation is a well-documented complication of systemic bleomycin sulfate therapy when using doses of 100 U or more as an antineoplastic agent. Two cases occurred after using systemic doses from 15 to 30 U injected intravenously or intrapleurally; however, it has not been described as a complication following intralesional treatment of verruca plantaris.We report a case (...) of flagellate hyperpigmentation after intralesional injection of 14 U of bleomycin for verrucae plantaris and review the literature associated with this cutaneous complication.Flagellate hyperpigmentation from extremely low doses of intralesional bleomycin is a previously undescribed complication. Although the mechanisms of reaction are not clearly understood, the clinician should be mindful of this uncommon complication.

2003 Archives of Dermatology

2891. The mechanism of epidermal hyperpigmentation in café-au-lait macules of neurofibromatosis type 1 (von Recklinghausen's disease) may be associated with dermal fibroblast-derived stem cell factor and hepatocyte growth factor. (Abstract)

The mechanism of epidermal hyperpigmentation in café-au-lait macules of neurofibromatosis type 1 (von Recklinghausen's disease) may be associated with dermal fibroblast-derived stem cell factor and hepatocyte growth factor. The mechanism of the accentuated melanization in café-au-lait macules (CALMs) in patients with neurofibromatosis type 1 (NF1; von Recklinghausen's disease) has not been elucidated.To clarify the mechanism involved in the hyperpigmentation of CALMs in NF1.Using enzyme-linked

2003 British Journal of Dermatology

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