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Hyperpigmentation

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2841. RALGA (Diacneal), a retinaldehyde and glycolic acid association and postinflammatory hyperpigmentation in acne--a review. (Abstract)

RALGA (Diacneal), a retinaldehyde and glycolic acid association and postinflammatory hyperpigmentation in acne--a review. Acne vulgaris affects 3 out of 4 adolescents and usually vanishes at the end of puberty with either no sequelae or mild to moderate sequelae, such as postinflammatory hyperpigmenation (PIH), which may result in psychological and emotional damages. The poor tolerability of the actual treatments (secondary inflammation) is a hindrance to therapy. Retinaldehyde (RAL

2005 Dermatology

2842. Topical methimazole as a new treatment for postinflammatory hyperpigmentation: report of the first case. (Abstract)

Topical methimazole as a new treatment for postinflammatory hyperpigmentation: report of the first case. We have previously shown that the peroxidase inhibitor methimazole (1-methyl-2-mercapto imidazole; MMI) is a noncytotoxic inhibitor of melanin production in cultured B16 melanocytes. It was further demonstrated that the topical application of 5% MMI on brown guinea pig skin for 6 weeks causes a significant reduction in the amount of epidermal melanin, resulting in visually recognizable (...) cutaneous depigmentation. Herein, we report a 27-year-old male with postinflammatory hyperpigmentation (due to acid burn), successfully treated with topical MMI as a new skin depigmenting agent. Topical 5% MMI caused a moderate to marked improvement of the hyperpigmented lesions within 6 weeks of once-daily application. Topical MMI was well tolerated by the patient and did not affect the level of serum thyroid hormones (free thyroxin, free triiodothyronine and the thyroid-stimulating hormone). Unlike

2005 Dermatology

2843. A new type of minocycline-induced cutaneous hyperpigmentation. (Abstract)

A new type of minocycline-induced cutaneous hyperpigmentation. Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline. Three distinct types of minocycline-induced cutaneous pigmentation have been described. Type I, blue-black pigmentation confined to sites of scarring or inflammation on the face; Type II, blue-grey circumscribed pigmentation of normal skin of the lower legs and forearms; and Type III, diffuse muddy brown (...) to be macrophages. Electron microscopy demonstrated electron-dense granules, free and membrane-bound, within macrophages and fibroblast-like cells. Energy-dispersive X-ray analysis confirmed the presence of calcium. Iron was absent. This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity. The pigment may be a drug metabolite-protein complex chelated with calcium, or an insoluble

2004 Clinical & Experimental Dermatology

2844. Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy. Full Text available with Trip Pro

Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy. Melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") can be considered as a melanoma-simulating type of acquired melanocytic nevus. We report on the morphologic changes of this type of melanocytic nevus over a 39-month period of dermoscopic follow-up.A 5-year-old girl had a 4-mm brown papule with a peripheral blue-black area on her right (...) upper arm. The eccentric focus of the hyperpigmentation corresponded dermoscopically to a blue-gray area of pigmentation associated with irregular brown-black globules or dots and partially with a superficial black network. After 39 months, a globular type of acquired melanocytic nevus was detectable, which clinically and dermoscopically appeared to be completely benign. A nearly identical situation was observed in 5 other melanocytic nevi, underlining the involution of the pigmented foci

2006 Archives of Dermatology

2845. Diltiazem induces severe photodistributed hyperpigmentation: case series, histoimmunopathology, management, and review of the literature. Full Text available with Trip Pro

Diltiazem induces severe photodistributed hyperpigmentation: case series, histoimmunopathology, management, and review of the literature. Diltiazem hydrochloride is a commonly prescribed benzothiazepine calcium channel blocker for the treatment of cardiovascular disease. Recently, 8 cases of diltiazem-induced photodistributed hyperpigmentation occurring predominantly in elderly African American women were reported. Here, we report occurrence for the first time in a light-skinned African (...) spectrum.Photospectrometry analysis revealed diltiazem could demonstrate a photosensitizing effect within the UV-B range. Discontinuation of therapy with diltiazem is the most effective modality in resolving hyperpigmentation. Avoidance of sun exposure and consistent use of sunscreens and sun-protective clothing are indicated for patients undergoing diltiazem therapy.

2006 Archives of Dermatology

2846. Progressive hyperpigmentation and generalized lentiginosis without associated systemic symptoms: a rare hereditary pigmentation disorder in south-east Germany. Full Text available with Trip Pro

Progressive hyperpigmentation and generalized lentiginosis without associated systemic symptoms: a rare hereditary pigmentation disorder in south-east Germany. Familial progressive hyperpigmentation is rarely described in the literature. We report on five patients from three different families presenting with a peculiar progressive pigmentary disorder. The patients show a progressive diffuse, partly blotchy, hyperpigmentation, intermixed with scattered small hypopigmented macules, a few large (...) hypopigmented areas, occasional café-au-lait spots and, most remarkably, a generalized lentiginosis. Histology revealed different degrees of basal layer hyperpigmentation and pigment incontinence, also in the spots appearing hypopigmented. Ultrastructural analysis showed a normal mode of Caucasian-like melanogenesis with varying content of regular melanosome complexes within the keratinocytes. All families are clustered in a small area around the town of Teublitz in south-east Germany with about 20,000

2004 Acta Dermato-Venereologica

2847. Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentation. (Abstract)

Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentation. Latin-Americans have a heterogeneous ancestry that is defined by their place of domicile, while Hispanics are defined as those persons of Spanish descent. These two groups have a diverse range of skin phototypes and pigmentation and are prone to an increased incidence of melasma and post-inflammatory hyperpigmentation. Little research has been conducted to evaluate the frequency, course (...) -inflammatory hyperpigmentation (PIH) following treatment should be considered.

2006 British Journal of Dermatology

2848. Minocycline-induced hyperpigmentation treated with a 755-nm Q-switched alexandrite laser. Full Text available with Trip Pro

Minocycline-induced hyperpigmentation treated with a 755-nm Q-switched alexandrite laser. Cutaneous pigmentation associated with minocycline therapy is an unusual adverse effect for which few successful treatments have been described. The pigment changes may persist for years, despite cessation of therapy, and is often cosmetically disfiguring, causing significant embarrassment and psychological depression in those affected. Few safe and effective treatments have been described in the past (...) ; however, recent pigment-specific laser technology has shown promise in the treatment of this condition.The objective was to describe a series of patients with minocycline-induced hyperpigmentation who were successfully treated with a 755-nm Q-switched alexandrite laser.Six patients with minocycline-induced hyperpigmentation on the face or legs were treated with a Q-switched alexandrite laser on a bimonthly basis until pigmentation was eradicated.Cutaneous pigmentation resolved completely in all

2004 Dermatologic Surgery

2849. Minocycline-induced hyperpigmentation masquerading as alkaptonuria in individuals with joint pain. (Abstract)

Minocycline-induced hyperpigmentation masquerading as alkaptonuria in individuals with joint pain. Alkaptonuria, a rare autosomal-recessive disorder caused by mutations in the HGD gene and a deficiency of homogentisate 1,2-dioxygenase, is characterized by accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue resulting in joint disease. Certain medications have been reported to cause cutaneous hyperpigmentation resembling that of alkaptonuria. We present 5 (...) based on normal urine HGA levels. All 5 patients were women who had taken minocycline for dermatologic or rheumatologic disorders for extended periods. Minocycline-induced hyperpigmentation should be considered in the differential diagnosis of ochronosis. This could be of increased significance now that minocycline and other tetracyclines have been proposed as therapeutic options for rheumatoid arthritis, bringing a new population of patients with ochronosis and arthritis to medical attention

2004 Arthritis and Rheumatism

2850. The frequency and distribution of minocycline induced hyperpigmentation in a rheumatoid arthritis population. (Abstract)

The frequency and distribution of minocycline induced hyperpigmentation in a rheumatoid arthritis population. Minocycline is particularly useful in patients with rheumatoid arthritis (RA) with previous major sepsis, where anti-tumor necrosis factor is relatively contraindicated. Pigmentation is a documented side effect, but predisposing factors in an RA population have not been established. We investigated minocycline induced pigmentation in a population with RA to determine whether skin type

2006 Journal of Rheumatology

2851. Post-inflammatory Hyperpigmentation of Skin

Post-inflammatory Hyperpigmentation of Skin Post-inflammatory Hyperpigmentation of Skin. Information | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Post-inflammatory Hyperpigmentation of Skin Authored by , Reviewed by | Last edited 10 Nov 2016 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors (...) and based on research evidence, UK and European Guidelines. You may find the article more useful, or one of our other . In this article In This Article Post-inflammatory Hyperpigmentation of Skin In this article Appearance Post-inflammatory hyperpigmentation occurs as brown macules or patches, often with a poorly defined border, irregular in outline and usually with little surface change [ ] . The basic mechanism in response to various triggers (see 'Aetiology', below) is melanosis of the epidermal

2008 Mentor

2852. Is there any information on hyperpigmentation, specifically poikiloderma of Civatte, and whether it is linked to perfume use?

Is there any information on hyperpigmentation, specifically poikiloderma of Civatte, and whether it is linked to perfume use? Is there any information on hyperpigmentation, specifically poikiloderma of Civatte, and whether it is linked to perfume use? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words (...) as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Is there any information on hyperpigmentation, specifically poikiloderma of Civatte, and whether it is linked to perfume use? eMedicine, an American

2003 TRIP Answers

2853. Glycolic acid peels for postinflammatory hyperpigmentation in black patients. A comparative study. (Abstract)

Glycolic acid peels for postinflammatory hyperpigmentation in black patients. A comparative study. Treatment of postinflammatory hyperpigmentation in patients of Fitzpatrick skin types IV, V, and VI is difficult. Glycolic acid peels are useful for pigment dyschromias in caucasians; however, there are no controlled studies examining their safety and efficacy in dark-complexioned individuals.To determine if serial glycolic acid peels provide additional improvement when compared with a topical (...) treatment groups demonstrated improvement, but the patients receiving the glycolic acid peels showed a trend toward more rapid and greater improvement. The peel group also experienced increased lightening of the normal skin.This pilot study demonstrates that serial glycolic acid peels provide an additional benefit, with minimal adverse effects, for the treatment of postinflammatory hyperpigmentation in dark-complexioned individuals.

1997 Dermatologic Surgery Controlled trial quality: uncertain

2854. Fluorescence photography in the evaluation of hyperpigmentation in photodamaged skin. (Abstract)

Fluorescence photography in the evaluation of hyperpigmentation in photodamaged skin. Treatment-related changes in hyperpigmentation are difficult to quantify with visible light photography, especially when the changes are subtle.Our purpose was to determine the utility and reliability of fluorescence photography to measure changes in mottled and diffuse hyperpigmentation.Thirty-two subjects, with mildly to moderately photodamaged skin, completed a 36-week, double-blind, vehicle-controlled (...) study of tretinoin cream 0.025%. Clinical evaluation of hyperpigmentation as well as standard flash photographs and fluorescence photographs were obtained at baseline and week 36.The fluorescence photographs were evaluated blindly and yielded macule counts that decreased significantly from baseline in tretinoin-treated subjects compared with vehicle-treated subjects (31% vs 11% decrease; p = 0.02). Diffuse hyperpigmentation, as evaluated from the fluorescence photographs, decreased 16% from baseline

1997 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

2855. Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. (Abstract)

Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. This multicenter, randomized, double-masked, parallel-group study assessed the efficacy, safety, and tolerability of azelaic acid 20% cream compared with those of its vehicle for the treatment of facial hyperpigmentation in darker-skinned patients (phototypes IV to VI). Following a 24-week treatment period, azelaic acid produced significantly greater decreases in pigmentary intensity than did vehicle (...) very satisfied or satisfied with their treatment. Also, more patients treated with azelaic acid than with vehicle rated their medication as being more effective or the same as past treatments. Thus azelaic acid is an effective and well-tolerated treatment for hyperpigmentation in darker-skinned patients.

1999 Clinical therapeutics Controlled trial quality: uncertain

2856. Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. (Abstract)

Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. This multicenter, randomized, double-masked, parallel-group, 24-week clinical study compared the efficacy of the combination of azelaic acid 20% cream and glycolic acid 15% or 20% lotion with hydroquinone 4% in the treatment of facial hyperpigmentation in darker-skinned patients. At week 24, overall improvement and reduction in lesion area (...) in the treatment of hyperpigmentation in darker-skinned patients, with only a slightly higher rate of mild local irritation. These findings suggest that the addition of glycolic acid to azelaic acid treatment for hyperpigmentation is an appropriate alternative in selected darker-skinned patients.

1999 Clinical therapeutics Controlled trial quality: uncertain

2857. Reversible hyperpigmentation associated with high dose hydroxyurea. Full Text available with Trip Pro

Reversible hyperpigmentation associated with high dose hydroxyurea. 2379018 1990 09 13 2018 11 13 0959-8138 300 6737 1990 Jun 02 BMJ (Clinical research ed.) BMJ Reversible hyperpigmentation associated with high dose hydroxyurea. 1468 Majumdar G G Department of Haematology, St Thomas's Hospital, London. Heard S E SE Slater N G NG eng Case Reports Journal Article England BMJ 8900488 0959-8138 X6Q56QN5QC Hydroxyurea AIM IM Humans Hydroxyurea administration & dosage adverse effects Male Middle Aged

1990 BMJ : British Medical Journal

2858. Effect of pretreatment on the incidence of hyperpigmentation following cutaneous CO2 laser resurfacing. (Abstract)

Effect of pretreatment on the incidence of hyperpigmentation following cutaneous CO2 laser resurfacing. Transient hyperpigmentation is the most common complication seen following cutaneous carbon dioxide (CO2) laser resurfacing.The purpose of this study was to determine whether the use of a topical skin lightening regimen prior to cutaneous laser resurfacing reduces the incidence of post-laser resurfacing hyperpigmentation.One hundred consecutive CO2 laser resurfacing patients (skin types I-III (...) ) were randomized to receive preoperative treatment with 10% glycolic acid cream twice daily (n=25), hydroquinone 4% cream qHS and tretinoin 0.025% cream twice daily (n=25) or no pretreatment (n=50, control) for at least 2 weeks. Clinical and photographic assessments were performed prior to laser resurfacing and at 4 and 12 weeks following treatment.There was no significant difference in the incidence of post-CO2 laser resurfacing hyperpigmentation between subjects who received pretreatment

1999 Dermatologic Surgery Controlled trial quality: uncertain

2859. Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. Full Text available with Trip Pro

Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. To quantify the 5-year risk of age-related macular degeneration (AMD) in eyes with different macular drusen characteristics (ie, size, type, location, and total area) or hyperpigmentation in a population-based cohort.The Blue Mountains Eye Study examined 3654 residents during 1992-1994; 2335 (75.1% of survivors) were reexamined during 1997-1999. Retinal photographs (...) neovascular or atrophic AMD lesions over 5 years. In right eyes, presence vs absence of the following macular signs predicted AMD: drusen that were 125 micro m or larger (13.9 vs 0.6%; age-adjusted RR, 5.7; 95% confidence interval [CI], 3.6-9.0), indistinct soft or reticular drusen (23.2% vs 0.4%; RR, 9.9; 95% CI, 6.4-15.4), total drusen area of half the disc area or more (31.4% vs 0.6%; RR, 13.5; 95% CI, 8.0-22.8), and hyperpigmentation (14.4% vs 0.5%; RR, 8.0; 95% CI, 5.4-11.9). After adjusting for age

2003 Archives of Ophthalmology

2860. Vaginal hyperpigmentation due to ochronosis. (Abstract)

Vaginal hyperpigmentation due to ochronosis. Ochronosis is a manifestation of alkaptonuria, a rare metabolic disorder. It results in the accumulation of pigment in connective tissues. After several years, ochronosis may produce a distinctive form of degenerative arthritis.Vaginal ochronosis was diagnosed in an asymptomatic elderly woman with vaginal hyperpigmentation and severe degenerative arthritis.Vaginal hyperpigmentation is a rare clinical finding that necessitates biopsy.

2003 Obstetrics and Gynecology

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