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Hyperpigmentation

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262. Interventions for acne scars. (Full text)

and placebo (RR 1.03, 95% CI 0.10 to 11.10; n = 147; low-quality evidence).For our outcome 'Investigator-assessed short-term adverse events', fractional laser (6/32) was associated with a reduced risk of hyperpigmentation than non-fractional non-ablative laser (10/32) in one study (RR 0.60, 95% CI 0.25 to 1.45; n = 64; very low-quality evidence); chemical peeling was associated with increased risk of hyperpigmentation (6/12) compared to skin needling (0/15) in one study (RR 16.00, 95% CI 0.99 to 258.36; n

2016 Cochrane PubMed abstract

263. Diagnosis and management of iliofemoral deep vein thrombosis: clinical practice guideline

telangiectasias, varicose veins, erythema, hyperpigmentation, dependent cyanosis and venous ulcers, as defined in the Villalta score of the CaVenT study. 8,58 Prevention of post-thrombotic syndrome Initial RCTs of compression therapy for the prevention of post-thrombotic syndrome in patients with proximal DVT (including iliofem- oral DVT) yielded conflicting results, but were hindered by lack of a placebo control, small numbers of patients, single-centre recruitment and open-label design. 59–62 The recent SOX

2015 CPG Infobase

264. Chinese expert consensus on clinical prevention and treatment of scar+ (Full text)

Chinese expert consensus on clinical prevention and treatment of scar+ Following injury, Asian skin has a tendency toward hyperpigmentation and scar formation than Caucasians. A standardized algorithm tailored to Asian patients, especially Chinese patients, is in great demand. Twelve independent, self-selected academic and military physicians from the department of burn/trauma, plastic surgery and dermatology with extensive experience in treating scars were assembled on January 17, 2015

2018 Burns & trauma PubMed abstract

265. A case of exogenous ochronosis associated with hydroxychloroquine (Full text)

A case of exogenous ochronosis associated with hydroxychloroquine Exogenous ochronosis is characterized by hyperpigmented skin lesions that arise in association with local suppression of homogentisic acid oxidase enzyme. Although it generally develops in association with topical application of chemical agents, it can occasionally develop in association with antimalarial drugs. Here we present the case of a patient with rheumatoid arthritis who developed hyperpigmentation on the face and neck (...) regions during hydroxychloroquine treatment. Hydroxychloroquine is being widely used in rheumatology practice, and cutaneous hyperpigmentation may develop as an adverse effect. In the present case, we emphasize the potential underlying mechanisms through which it may cause cutaneous hyperpigmentation and determine the clinical and histopathological findings of exogenous ochronosis.

2018 European journal of rheumatology PubMed abstract

267. Varicose veins

) are intradermal veins that are less than 1 mm in diameter. Reticular veins are permanently dilated intradermal veins that range between 1–3 mm in diameter. They may be tortuous but are usually asymptomatic. Assess for any , including: Skin changes — look for hyperpigmentation (brown-red discolouration caused by haemosiderin deposition), venous eczema (itchy, red, scaly, and/or flaky skin which may have blisters and crusts on the surface), lipodermatosclerosis (painful, hardened, tight skin), and atrophie

2019 NICE Clinical Knowledge Summaries

268. Leg ulcer - venous

, resulting in enlarged veins, oedema, and venous skin changes (hyperpigmentation, , , and ). As the condition of the skin and subcutaneous tissue worsens, it becomes increasingly vulnerable to ulceration. Risk factors for developing venous leg ulcers include [ ; ; ; ; ; ; ] : Increasing age. Obesity. Immobility. Limited range of ankle function. Previous ulcer. Personal or family history of varicose veins. Personal history of deep vein thrombosis. Female sex. Multiple pregnancies. Arteriovenous fistula (...) of ulceration, malodour, and increased exudate. Examine both legs for signs of venous insufficiency, including: Pitting oedema — rule out non-venous causes of oedema, such as heart failure and chronic kidney disease. See the CKS topics on and . Skin changes — look for hyperpigmentation (brown-red discolouration caused by haemosiderin deposition), venous eczema (itchy, red, scaly, and/or flaky skin which may have blisters and crusts on the surface), lipodermatosclerosis (painful, hardened, tight skin

2019 NICE Clinical Knowledge Summaries

269. Post Thrombotic Syndrome (PTS)

are aggravated by standing or walking and improve with resting, leg elevation and lying down. TABLE 1: TYPICAL CLINICAL FEATURES OF THE POST-THROMBOTIC SYNDROME LEG SYMPTOMS SIGNS Heaviness or fatigue Edema Pain Peri-malleolar telangiectasiae Swelling Venous ectasia, varicose veins Itching Hyperpigmentation Cramps Redness Paresthesia Dependent cyanosis Bursting pain on walking (venous claudication) Lipodermatosclerosis Symptom pattern: Worse with activity, standing, walking; better with rest, recumbency (...) and swelling associated with acute DVT to resolve, hence a diagnosis of PTS should be deferred until after the acute phase (i.e. 3-6 months) has passed. ? Symptoms of PTS usually occur within 3-6 months after DVT, but can occur up to 2 years after DVT. TABLE 2: VILLALTA PTS SCALE CRITERIA USED TO DIAGNOSE PTS ? 5 symptoms (pain, cramps, heaviness, pruritus, paresthesia) ? 6 signs (edema, skin induration, hyperpigmentation, venous ectasia, redness, pain during calf compression) ? Each symptom and sign rated

2015 Thrombosis Interest Group of Canada

270. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. (Abstract)

Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. Topical niacinamide and N-acetyl glucosamine (NAG) each individually inhibit epidermal pigmentation in cell culture. In small clinical studies, niacinamide-containing and NAG-containing formulations reduced the appearance of hyperpigmentation.To assess the effect of a combination

2010 The British journal of dermatology Controlled trial quality: uncertain

271. Ipsilateral areolar hyperpigmentation following unilateral application of estradiol spray. (Abstract)

Ipsilateral areolar hyperpigmentation following unilateral application of estradiol spray. A 48 year old postmenopausal female noted hyperpigmentation of the left areola 3 months after beginning estradiol spray to her left forearm. She then applied the spray to the right forearm instead until the areolae were the same color again and then applied 1 spray to each forearm thereafter.Copyright © 2010 Mosby, Inc. All rights reserved.

2010 American Journal of Obstetrics and Gynecology

272. Application of a combined sulphorhodamine B and melanin assay to the evaluation of Chinese medicines and their constituent compounds for hyperpigmentation treatment. (Abstract)

Application of a combined sulphorhodamine B and melanin assay to the evaluation of Chinese medicines and their constituent compounds for hyperpigmentation treatment. To investigate the efficacy of traditional Chinese medicine (TCM) in the treatment of hyperpigmentation problems, extracts of herbs selected based on traditional Chinese medical literature were screened.Forty extracts were extracted from 10 selected herbs using hexane, dichloromethane, methanol and water. They were then screened

2010 Journal of Ethnopharmacology

273. Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo. (Abstract)

Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo. Cutaneous pigmentation is regulated by a complex melanogenic network in which both keratinocytes and fibroblasts synthesize growth factors and cytokines. Solar lentigo (SL) is characterized by hyperpigmented lesions occurring on photodamaged skin areas. Despite the association of SL to ultraviolet (UV) exposure, the mechanisms underlying the development of these spots are not completely defined.To (...) analyse the involvement of the fibroblast-derived growth factors, hepatocyte growth factor (HGF), keratinocyte growth factor (KGF) and stem cell factor (SCF) in SL hyperpigmentation; to evaluate whether the photoageing process occurring in fibroblasts could be responsible for the altered expression of these cytokines; and to investigate a new possible role of KGF in regulating pigmentation through the specific induction of melanogenic cytokines by keratinocytes.We performed immunohistochemical

2010 British Journal of Dermatology

274. Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Novel Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. (Abstract)

Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Novel Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. 20629692 2011 03 30 2011 02 14 1524-4725 36 9 2010 Sep Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Commentary: treatment of facial postinflammatory hyperpigmentation with facial acne in Asian patients using a novel Q-switched neodymium-doped yttrium aluminum garnet (...) laser. 1381 10.1111/j.1524-4725.2010.01644.x Metelitsa Andrei I AI SkinCare Physicians, Chestnut Hill, Massachusetts, USA. eng Comment Journal Article 2010 07 09 United States Dermatol Surg 9504371 1076-0512 IM Dermatol Surg. 2010 Sep;36(9):1374-80 20629693 Acne Vulgaris complications surgery Dermatitis etiology Face Humans Hyperpigmentation etiology surgery Lasers, Solid-State therapeutic use Skin Diseases etiology surgery 2010 7 16 6 0 2010 7 16 6 0 2011 3 31 6 0 ppublish 20629692 DSU1644 10.1111

2010 Dermatologic Surgery

275. Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. (Abstract)

Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. Postinflammatory hyperpigmentation (PIH) due to facial acne commonly occurs in Fitzpatrick skin types IV to VI and can have a considerable effect on quality of life. The sequelae in terms of pigmentation are often the main reason for consulting a dermatologist and take precedence over the acne itself.The purpose of this study was to evaluate

2010 Dermatologic Surgery

276. The quantitative evaluation of online haemodiafiltration effect on skin hyperpigmentation. (Full text)

The quantitative evaluation of online haemodiafiltration effect on skin hyperpigmentation. Skin pigmentation is a common problem for dialysis patients, but little is known about the factor responsible for the colour intensity. Middle-molecular-weight (MMW) substances have been suggested to be responsible for the skin colour. Several papers have reported that β(2)-microglobulin (β(2)-MG) correlates with the skin colour, and haemodiafiltration (HDF) is effective to reduce the skin (...) hyperpigmentation. However, a quantitative skin colour follow-up on patients treated with online haemodiafiltration (online HDF) has not been performed.Sixty-one patients were enrolled in this study. Quantification of skin colour was done using a reflected light colorimeter. Among them, 51 patients were under haemodialysis (HD), and the other 10 patients were under online HDF. Follow-ups to estimate the skin colour change were performed for 6 months. Among 10 patients under online HDF, four patients were also

2010 Transplantation PubMed abstract

277. Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial. (Full text)

with dermatologic procedures. The current study was designed to evaluate solar lentigo hyperpigmentation, skin architecture and clinician and patient assessments comparing a dermocosmetic lightening product (active) with a moisturizing product (control) according to clinical, digital and subjective analyses in 72 lesions over 12-month follow up period. Statistically significant differences were observed between the lesions treated with the active compared to the control in terms of papillary brightness (p (...) to clinical, digital and subjective analyses in reducing lesion hyperpigmentation, stabilizing the lesion skin architecture and increasing patient satisfaction compared to the control in a cohort of 36 subjects, over a 12-month period. Beside demonstrating the efficacy of this topical lightening product, we propose a "destructuring score", which improves the robustness of solar lentigo's evaluation, and can be used in future studies to standardize the quantitative comparisons of different treatment

2019 PLoS ONE Controlled trial quality: uncertain PubMed abstract

278. Systematic review and meta-analysis of safety and efficacy of high-intensity focused ultrasound (HIFU) for face and neck rejuvenation. (Abstract)

of 5 maximum score, for objective improvement score and subjective satisfaction score, respectively. Meta-analysis of mean pain score, assessed by a 0-10 Likert score, was 4.2 (95% CI 4.27-5.19). Edema and erythema showed considerable heterogeneity, and no hyperpigmentation was reported by included studies. Included studies used multiple and different outcome variables with different scoring at various time points. Long follow-up was not reported by majority of studies. HIFU is safe procedure

2020 Lasers in medical science

279. Role of bioactive compounds and other metabolites from mushrooms against skin disorders- a systematic review assessing their cosmeceutical and nutricosmetic outcomes. (Abstract)

, antimicrobial, anti-tyrosinase, anti-elastase and anti-collagenase activities. These metabolites can be utilised as ingredients to suppress the severity of inflammatory skin diseases, offer photoprotection to the skin and correct hyperpigmentation. However, studies regarding the molecular mechanism behind the mentioned bioactivities are still lacking. Challenges associated with the use of mushroom extracts and their associated metabolites as cosmeceutical and nutricosmetic ingredients include several steps

2020 Current Medicinal Chemistry

280. Topical Treatments for Melasma: A Systematic Review of Randomized Controlled Trials (Abstract)

Topical Treatments for Melasma: A Systematic Review of Randomized Controlled Trials Background: Melasma is an acquired skin disease characterized by symmetric hyperpigmentation on sun-exposed areas, particularly on the face. Recently, there has been tremendous scientific interest in novel, safe, and effective topical agents to manage melasma. Objective: To evaluate topical treatments for melasma and provide evidence-based recommendations for clinical use and further research. Methods: We

2020 Journal of drugs in dermatology : JDD

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