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Hyperpigmentation

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2741. Skin pigmentary anomalies in a mosaic form of partial tetrasomy 3q Full Text available with Trip Pro

Skin pigmentary anomalies in a mosaic form of partial tetrasomy 3q 11182938 2000 11 16 2015 10 13 1468-6244 37 9 2000 Sep Journal of medical genetics J. Med. Genet. Skin pigmentary anomalies in a mosaic form of partial tetrasomy 3q. 723-5 Kroisel P M PM Petek E E Wagner K K eng Case Reports Comment Letter England J Med Genet 2985087R 0022-2593 IM J Med Genet. 1999 Mar;36(3):246-50 10204855 Child, Preschool Chromosome Aberrations Chromosomes, Human, Pair 3 genetics Humans Hyperpigmentation

2000 Journal of Medical Genetics

2742. Vasoproliferative tumours of the retina Full Text available with Trip Pro

were examined with a follow up period between 1 month and 6 years. Ophthalmological changes associated with VPTR were intraretinal and subretinal exudations (n=18), exudative detachments of the surrounding sensory retina (n=13), intraretinal and subretinal haemorrhages (n=10), exudative changes within the macula (n=10), hyperpigmentation of the retinal pigment epithelium at the border of the exudative retinal changes (n=9), and vitreous haemorrhages (n=4). Tumour biopsy was performed in two cases

2000 The British journal of ophthalmology

2743. Laugier-Hunziker syndrome: an important differential diagnosis for Peutz-Jeghers syndrome Full Text available with Trip Pro

Laugier-Hunziker syndrome: an important differential diagnosis for Peutz-Jeghers syndrome 12807976 2003 07 07 2008 11 20 1468-6244 40 6 2003 Jun Journal of medical genetics J. Med. Genet. Laugier-Hunziker syndrome: an important differential diagnosis for Peutz-Jeghers syndrome. e77 Lampe A K AK Hampton P J PJ Woodford-Richens K K Tomlinson I I Lawrence C M CM Douglas F S FS eng Case Reports Letter England J Med Genet 2985087R 0022-2593 IM Diagnosis, Differential Humans Hyperpigmentation

2003 Journal of Medical Genetics

2744. Tretinoin emollient cream 0.01% for the treatment of photoaged skin. (Abstract)

improvement in roughness, mottled hyperpigmentation, fine wrinkling, and lentigines at 24 and 48 weeks. More consistent improvement was seen on the forearms than on the face. Adverse experiences on the face in both treatment groups included dryness, peeling, and acne. No significant difference in reported adverse experiences was found between forearms in both treatment groups. On forearms, dermatitis was the most common adverse event. Tretinoin 0.01% was generally well tolerated, and skin irritation

1993 Cleveland Clinic journal of medicine Controlled trial quality: uncertain

2745. Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial. (Abstract)

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial. Melasma is a common disorder of cutaneous hyperpigmentation predominantly affecting the faces of women. Little is known about the aetiology of melasma, and treatment is frequently disappointing. Topical tretinoin is of benefit in treating other forms of hyperpigmentation, for example liver spots, and we therefore investigated its effectiveness in melasma. Thirty-eight women completed a randomized, vehicle

1993 The British journal of dermatology Controlled trial quality: uncertain

2746. Histological evaluation of the effect of 0.05% tretinoin in the treatment of photo damaged skin. Geographic differences in elastosis in baseline biopsies. (Abstract)

elastosis after 26 weeks application. Tretinoin cream appears effective in reversing epidermal atrophy and clinically diminishes fine wrinkling, mottled hyperpigmentation and skin roughness. Tretinoin cream may not offer a solution to the gross solar damage seen in the Australian population who have marked solar elastosis as a principal, clinical and histologic finding. However it is possible that dermal repair and reversal of solar elastosis may require topical application of tretinoin cream

1993 The Australasian journal of dermatology Controlled trial quality: uncertain

2747. Clinical and histologic evaluation of six erbium:YAG lasers for cutaneous resurfacing. (Abstract)

improvement than scarred skin. The most common postoperative side effect was hyperpigmentation, with all affected patients having either darker skin tones or preceding dermal inflammation. Three laser passes were needed to effect total epidermal ablation when using any one of the erbium:YAG systems.Equivalent clinical and histologic results were seen after each of the six erbium:YAG lasers studied. Erbium:YAG laser resurfacing can be used to significantly improve mild cutaneous photodamage and atrophic

1999 Lasers in surgery and medicine Controlled trial quality: uncertain

2748. Combined CO2/erbium:YAG laser resurfacing of peri-oral rhytides and side-by-side comparison with carbon dioxide laser alone. (Abstract)

was reduced on average from 7.2 to 6.0 days, and swelling was reduced from 6.3 to 6.0 days in patients receiving the combined procedure. No cases of permanent hyperpigmentation, hypopigmentation, or scarring occurred in any patients.The addition of the Er:YAG laser following CO2 laser resurfacing reduces the duration of crusting, swelling, and itching postoperatively. Medium to deep (Grade III) facial rhytids were improved by 70% with both procedures with no significant difference noted between techniques.

1999 Dermatologic Surgery Controlled trial quality: uncertain

2749. Laser scar revision: comparison study of 585-nm pulsed dye laser with and without intralesional corticosteroids. (Abstract)

before and after treatment was performed in four patients.All scars showed clinical improvement with increased pliability and decreased symptoms (pruritus) after each of the two treatments. Clinical improvement scores were not significantly better with the concomitant use of corticosteroids. Side effects were limited to mild purpura and transient hyperpigmentation. Decreased sclerosis was seen in scars after PDL treatment (with or without concomitant corticosteroids).Treatment of hypertrophic

2003 Dermatologic Surgery Controlled trial quality: uncertain

2750. Efficacy and safety of a new triple-combination agent for the treatment of facial melasma. (Abstract)

Efficacy and safety of a new triple-combination agent for the treatment of facial melasma. Treatment of melasma, a hyperpigmentation disorder, remains a challenge. The primary objective of two 8-week, multicenter, randomized, investigator-blind studies was to compare the efficacy and safety of a hydrophilic cream formulation containing tretinoin 0.05%, hydroquinone 4.0%, and fluocinolone acetonide 0.01% (RA+HQ+FA) with the dual-combination agents tretinoin plus hydroquinone (RA+HQ), tretinoin

2003 Cutis; cutaneous medicine for the practitioner Controlled trial quality: uncertain

2751. Comparative trial between sodium tetradecyl sulfate and glycerin in the treatment of telangiectatic leg veins. (Abstract)

had been already treated in a prior sclerotherapy session were randomly treated with either 0.25% STS or 72% glycerin solution. Patients were evaluated from 2 to 6 months postsclerotherapy for overall clinical improvement and incidence of adverse sequelae.Glycerin was comparable to STS in discomfort of injection but demonstrated a significant decrease in bruising, swelling, and postprocedural hyperpigmentation. Glycerin also demonstrated a better, more rapid clearance of treated

2003 Dermatologic Surgery Controlled trial quality: uncertain

2752. A clinical, prospective, randomized, double-blind trial comparing skin whitening complex with hydroquinone vs. placebo in the treatment of melasma. (Abstract)

A clinical, prospective, randomized, double-blind trial comparing skin whitening complex with hydroquinone vs. placebo in the treatment of melasma. To compare, in a double-blind, randomized, prospective study, the clinical improvement of hyperpigmentation in 30 patients with melasma using hydroquinone or skin whitening complex topically on one side of the face vs. a placebo cream on the other. The study was performed during the period November 2000 to March 2001 at the Federal University of São

2003 International journal of dermatology Controlled trial quality: uncertain

2753. Predictors of drusen reduction after subthreshold infrared (810 nm) diode laser macular grid photocoagulation for nonexudative age-related macular degeneration. (Abstract)

, and distribution of drusen, as well as focal hyperpigmentation) from two macula areas (central 1500 micro diameter, pericentral 1500 micro ring area) on stereo color photographs, the number of laser-induced lesions, and the area of laser induced retinal pigment epithelial (RPE) lesions on fluorescein angiography 3 months after treatment were studied as predictors of major drusen reduction (> or = 50% drusen reduction from baseline) 18 months after laser treatment. BCVA at baseline and 18 months later

2002 American journal of ophthalmology Controlled trial quality: uncertain

2754. Assessment of topical hypopigmenting agents on solar lentigines of Asian women. (Abstract)

showed a better although modest lightening effect when assessed by corneomelametry. The subclinical or faint mottled skin revealed by ultraviolet light examination better responded (p < 0.05) to treatments.Focal epidermal hyperpigmentation is better controlled by topical whitening agents when the increase in melanin content reflects a modest functional hyperactivity of melanocytes.Copyright 2002 S. Karger AG, Basel

2002 Dermatology (Basel, Switzerland) Controlled trial quality: uncertain

2755. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. (Abstract)

The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Cutaneous hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin colour. Thus, there is a need for the development of skin lightening agents. Niacinamide is a possible candidate.To investigate the effects of niacinamide on melanogenesis in vitro and on facial hyperpigmentation and skin colour in vivo in Japanese women.Melanin production was measured (...) in a purified mushroom tyrosinase assay, cultured melanocytes, a keratinocyte/melanocyte coculture model, and a pigmented reconstructed epidermis (PREP) model. The clinical trials included 18 subjects with hyperpigmentation who used 5% niacinamide moisturizer and vehicle moisturizer in a paired design, and 120 subjects with facial tanning who were assigned to two of three treatments: vehicle, sunscreen and 2% niacinamide + sunscreen. Changes in facial hyperpigmentation and skin colour were objectively

2002 The British journal of dermatology Controlled trial quality: uncertain

2756. Non-ablative cutaneous remodeling with a 1.45 microm mid-infrared diode laser: phase I. (Abstract)

mild and short-lived. There was a direct relationship between the degree of erythema and edema, and longer unopposed heating times. Mild hyperpigmentation occurred at only three treatment sites. Epidermal burns usually presented as immediate whitening in 11 of 60 one-pass sites and four of 16 two-pass sites. Whitening was associated with longer unopposed heating times. Atrophic, pitted scars occurred at two single-pass sites and three double-pass sites. Baseline biopsies demonstrated solar

2002 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology Controlled trial quality: uncertain

2757. Non-ablative cutaneous remodeling with a 1.45 microm mid-infrared diode laser: phase II. (Abstract)

2-3 days. Superficial, branny hyperpigmentation occurred in six patients at both treatment and control sides. This discoloration resolved within 1 week of treatment and left no residual pigment alterations. No whitening or residual scarring occurred. Rhytid scores improved from a baseline score of 2.3 to 1.8 at 6 months after treatment (p>0.05). Patient acceptance of the treatment was high, but most felt that there was little improvement of the treated rhytids.Although the 1.45 microm diode

2002 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology Controlled trial quality: uncertain

2758. Treatment of spider leg veins with the KTP (532 nm) laser--a prospective study. (Abstract)

session.Fifty-six patients completed the study. In group 1 (vascular diameter < or = 0.6 mm), spider leg veins were no longer visible in 33%; in 40%, a decrease in vascular diameter could be observed; in 27%, no change in size occurred. In group 2 (vascular diameter 0.7-1.0 mm), laser-treated spider leg veins were visible in all patients. Hyperpigmentation occurred in 13 patients.The KTP (532 nm) laser is an effective for treating spider leg veins having a vascular diameter under 0.7 mm.Copyright 2002 Wiley

2002 Lasers in surgery and medicine Controlled trial quality: uncertain

2759. Efficacy of 0.1% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trial. (Abstract)

, respectively. In the double-blind phase, 20 of 283 tazarotene-treated patients and 1 of 280 vehicle-treated patients discontinued treatment owing to adverse events.Once-daily application of 0.1% tazarotene cream or nonmedicated vehicle cream to the face for 24 weeks. Then, all continuing patients received treatment with 0.1% tazarotene cream for another 28 weeks.Primarily, fine wrinkling and mottled hyperpigmentation. Also, lentigines, elastosis, pore size, irregular depigmentation, tactile roughness (...) , coarse wrinkling, telangiectasia, actinic keratoses, overall integrated assessment of photodamage, global response to treatment, patients' overall assessment of photodamage, and plasma levels of tazarotenic acid.Compared with the vehicle, at week 24 tazarotene resulted in a significantly greater incidence of patients achieving treatment success (>or=50% global improvement) and at least a 1-grade improvement in fine wrinkling, mottled hyperpigmentation, lentigines, elastosis, pore size, irregular

2002 Archives of Dermatology Controlled trial quality: uncertain

2760. A clinical and histologic comparison of electrosurgical and carbon dioxide laser peels. (Abstract)

).This study was a matched clinical trial involving 9 subjects. Two strips (2 x 1 cm) of skin on the temple were alternately assigned to receive 2 passes with either the CO(2) laser (Silktouch mode, 260 handpiece, fluence 15 J/cm(2), 10 mm(2)) or the ESD (125 V = setting 4, 5 mm handpiece). Strips were wiped with moist gauze after the first pass, and 4-mm punch biopsy specimens were taken immediately and after 3 months. Clinical assessment of re-epithelialization, erythema, and hyperpigmentation was made

2001 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

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