How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,900 results for

Hyperpigmentation

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

201. Tegafur-induced acral hyperpigmentation Full Text available with Trip Pro

Tegafur-induced acral hyperpigmentation Tegafur is a prodrug of 5-fluorouracil (5-FU) with a similar spectrum of antitumor activity. It is used in the treatment of advanced gastrointestinal neoplasms. Over 5-FU, tegafur has the advantage of oral administration and less hematologic toxicity. Gastrointestinal toxicity is its main dose-limiting factor. The cutaneous adverse effects of tegafur include mucositis, photosensitivity, diffuse or nail-restricted hyperpigmentation, palmoplantar (...) erythrodysesthesia syndrome, palmoplantar keratoderma, sclerodactyly and Raynaud phenomenon. We report here the case of a patient who developed acral hyperpigmentation during treatment with tegafur.

2011 Dermatology Reports

202. Hyperpigmentation in human solar lentigo is promoted by heparanase-induced loss of heparan sulfate chains at the dermal-epidermal junction. (Abstract)

Hyperpigmentation in human solar lentigo is promoted by heparanase-induced loss of heparan sulfate chains at the dermal-epidermal junction. Skin pigmentation induced by ultraviolet B radiation is caused in part by inflammation mediated by cytokines secreted from keratinocytes and fibroblasts in the irradiated area. Heparanase is also activated in the irradiated skin, and this leads to loss of heparan sulfate at the dermal-epidermal junction (DEJ), resulting in uncontrolled diffusion of heparan

2011 Journal of dermatological science

203. Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. (Abstract)

Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis and sequela of a variety of inflammatory skin conditions. PIH can have a negative impact on a patient's quality of life, particularly for darker-skinned patients. Studies show that dyschromias, including PIH, are one of the most common presenting complaints of darker-skinned racial ethnic groups when visiting a dermatologist. This is likely due

2011 American journal of clinical dermatology

204. Management of Gingival Hyperpigmentation by Semiconductor Diode Laser Full Text available with Trip Pro

Management of Gingival Hyperpigmentation by Semiconductor Diode Laser Gingival hyperpigmentation is caused by excessive deposition of melanin in the basal and suprabasal cell layers of the epithelium. Although melanin pigmentation of the gingiva is completely benign, cosmetic concerns are common, particularly in patients having a very high smile line (gummy smile). Various depigmentation techniques have been employed, such as scalpel surgery, gingivectomy, gingivectomy with free gingival

2011 Journal of cutaneous and aesthetic surgery

205. Commentary: use of oral therapy for the prevention of postinflammatory hyperpigmentation. (Abstract)

Commentary: use of oral therapy for the prevention of postinflammatory hyperpigmentation. 21518099 2011 07 26 2013 11 21 1524-4725 37 5 2011 May Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Use of oral therapy for the prevention of postinflammatory hyperpigmentation. 611 10.1111/j.1524-4725.2011.01958.x McDaniel David H DH Institute of Anti-Aging Research, Eastern Virginia Medical School, Virginia Beach, Virginia, USA. mail (...) @lsvcv.com eng Comment Journal Article United States Dermatol Surg 9504371 1076-0512 0 Antifibrinolytic Agents 6T84R30KC1 Tranexamic Acid IM Dermatol Surg. 2011 May;37(5):605-10 21457392 Administration, Oral Antifibrinolytic Agents administration & dosage therapeutic use Humans Hyperpigmentation etiology prevention & control Inflammation etiology prevention & control Japan Lasers adverse effects Tranexamic Acid administration & dosage therapeutic use 2011 4 27 6 0 2011 4 27 6 0 2011 7 27 6 0 ppublish

2011 Dermatologic Surgery

206. Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment Improves Amiodarone-Induced Hyperpigmentation. (Abstract)

Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment Improves Amiodarone-Induced Hyperpigmentation. 21707831 2012 01 05 2015 11 19 1524-4725 37 10 2011 Oct Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Long-pulse neodymium-doped yttrium aluminum garnet laser treatment improves amiodarone-induced hyperpigmentation. 1539-41 10.1111/j.1524-4725.2011.02083.x Bagheri Sepideh S Department of Dermatology, University (...) of California at Davis, Sacramento, California, USA. dbeisen@ucdavis.edu Eisen Daniel D eng Case Reports Journal Article 2011 06 24 United States Dermatol Surg 9504371 1076-0512 0 Anti-Arrhythmia Agents N3RQ532IUT Amiodarone IM Aged Amiodarone adverse effects Anti-Arrhythmia Agents adverse effects Face Humans Hyperpigmentation chemically induced radiotherapy Lasers, Solid-State therapeutic use Low-Level Light Therapy Male 2011 6 29 6 0 2011 6 29 6 0 2012 1 6 6 0 ppublish 21707831 10.1111/j.1524

2011 Dermatologic Surgery

207. Periorbital Hyperpigmentation in Asians: An Epidemiologic Study and a Proposed Classification. (Abstract)

Periorbital Hyperpigmentation in Asians: An Epidemiologic Study and a Proposed Classification. Periorbital hyperpigmentation (POH) presents with a dark area surrounding the eyelids. It is an ill-defined condition, and the pathogenesis can be multifactorial.This epidemiologic study was conducted to assess the prevalence of periorbital hyperpigmentation in Singapore in an attempt to propose a classification.One thousand consecutive patients attending the general dermatology clinic at the National (...) Skin Center were enrolled in the study to assess for POH, of whom 200 with POH were examined and investigated to define the cause of POH. The possible causes were determined according to a detailed history, clinical examination, and assessment by three dermatologists. The extent of the POH was measured using a mexameter.The commonest form of POH was the vascular type (41.8%), followed by constitutional (38.6%), postinflammatory hyperpigmentation (12%), and shadow effects (11.4%). The vascular type

2011 Dermatologic Surgery

208. Approach to reticulate hyperpigmentation. Full Text available with Trip Pro

Approach to reticulate hyperpigmentation. Reticulate hyperpigmentation is a feature of a number of conditions, which differ in age of onset and distribution of the lesions. Associated clinical findings (e.g. hair, nail, teeth, systemic involvement), are used to differentiate between the conditions. Histopathological examination is useful in some disorders. Diagnosing the disorders is important, because the underlying causes may be treatable, and some of the disorders are associated (...) with malignancies and life-threatening systemic involvement. In this review, I present a concise, systematic approach to the treatment of the patient with reticulate hyperpigmentation.© The Author(s). CED © 2011 British Association of Dermatologists.

2011 Clinical & Experimental Dermatology

209. Long-Term Follow-Up of a Case of Cheek Hyperpigmentation Associated with McCune-Albright Syndrome Treated with Q-Switched Ruby Laser. (Abstract)

Long-Term Follow-Up of a Case of Cheek Hyperpigmentation Associated with McCune-Albright Syndrome Treated with Q-Switched Ruby Laser. 21272121 2011 04 19 2015 11 19 1524-4725 37 2 2011 Feb Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Long-term follow-up of a case of cheek hyperpigmentation associated with McCune-Albright syndrome treated with Q-switched ruby laser. 263-6 10.1111/j.1524-4725.2010.01864.x Ozawa Toshiyuki T (...) Department of Plastic and Reconstructive Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan. Tateishi Chiharu C Shirakawa Makiko M Murakami Emi E Ishii Masamitsu M Harada Teruichi T eng Case Reports Journal Article 2011 01 27 United States Dermatol Surg 9504371 1076-0512 IM Cheek Child Female Fibrous Dysplasia, Polyostotic complications pathology Follow-Up Studies Humans Hyperpigmentation etiology pathology radiotherapy Lasers, Solid-State therapeutic use Low-Level Light Therapy

2011 Dermatologic Surgery

210. Non-ablative 1550 nm fractional laser therapy not effective for erythema dyschromicum perstans and postinflammatory hyperpigmentation: a pilot study. (Abstract)

Non-ablative 1550 nm fractional laser therapy not effective for erythema dyschromicum perstans and postinflammatory hyperpigmentation: a pilot study. Erythema dyschromicum perstans and postinflammatory hyperpigmentation (PIH) are characterized by papillary dermal pigmentation or pigment incontinence. To date, no standard treatment is available. Fractional laser therapy (FLT) was recently reported to improve different pigment disorders.To assess the efficacy and safety of non-ablative FLT (...) in the treatment of erythema dyschromicum perstans and PIH.Eight patients with erythema dyschromicum perstans and six patients with PIH were included. In each patient, two similar test regions were randomized to receive either five fractional laser treatments in combination with intermittent daily topical bleaching or the same intermittent regimen of topical bleaching alone. Three months after the last treatment, improvement of hyperpigmentation was assessed by melanin index, reflectance spectroscopy

2011 Journal of Dermatological Treatment Controlled trial quality: uncertain

212. Targeted intraoperative radiotherapy for early-stage breast cancer

beyond six months) • necrosis (Axxent ® : 0.1% at 1 month and 0 percent at 12 months; WB-EBRT: 2.1– 28.7%) • erythema (Axxent ® : 27.3% immediately post-surgery and 20.8% at 1 month; WB- EBRT: 66.5–85.0%) • dehiscence (Axxent ® : 1.3%; WB-EBRT: 1.9% at 6 months and 0.3% after 6months) • fibrosis (Axxent ® : 10.0% at 6months and 18.2% at 12 months; WB-EBRT: 11.2– 35.2%) • skin hyperpigmentation (Axxent®: 7.7% at 6 months; WB-EBRT: 10.2–20.1%) • breast pain (Axxent ® : 27.3% immediately post-surgery

2020 Medical Services Advisory Committee

213. Compression therapy for treating post-thrombotic syndrome. Full Text available with Trip Pro

Compression therapy for treating post-thrombotic syndrome. Post-thrombotic syndrome (PTS) is a long-term complication of deep vein thrombosis (DVT) characterised by chronic complaints such as oedema and skin changes including; venous ectasia, varicose veins, redness, eczema, hyperpigmentation, and in severe cases fibrosis of the subcutaneous adipose in the affected limb. These chronic complaints are the effects of venous outflow restriction that can cause symptoms such as heaviness, itching

2019 Cochrane

214. Epidermolysis bullosa

combination of milia, scarring, and dystrophic nails absence of milia, scarring, and dystrophic nails exuberant granulation tissue herpetiform blistering pseudosyndactyly enamel hypoplasia reticulate hyperpigmentation muscular dystrophy tracheolaryngeal stenosis or stricture severe upper airway disease onset in mid or late childhood inverse (intertriginous), acral, or centripetal distribution of skin involvement severe cardiomyopathy Family history of EB Diagnostic investigations immunofluorescence

2019 BMJ Best Practice

215. High-intensity focused ultrasound for symptomatic breast fibroadenoma

. A first-degree skin burn with hyperpigmentation visible after 6 months was reported in 1 woman of 7, who had more than 1 fibroadenoma, in the case series of 20 women treated by HIFU. 5.4 Hyperpigmentation of the skin was reported in 1 woman within days after the procedure in the case series of 42 women treated by HIFU. Hyperpigmentation of the skin was reported by 30% (6/20) of women treated by HIFU at 3 months and 20% (4/20) at 6 months in the non-randomised controlled study of 40 women. 5.5

2017 National Institute for Health and Clinical Excellence - Interventional Procedures

216. Radiation therapy for early Dupuytren's disease

weeks of follow-up. Erythema was reported in 2% (5/208) of patients in the case series of 135 patients at up to 1 year. 5.13 Weakness (subjective 10–20% reduction in strength) was reported in 3% (2/60) of sites in the case series of 33 patients within a median follow-up of 31 months. 5.14 Reduced nail health was reported in 3% (2/60) of sites in the case series of 33 patients within a median follow-up of 31 months. 5.15 Hyperpigmentation was reported in 3% (2/60) of sites in the case series of 33

2017 National Institute for Health and Clinical Excellence - Interventional Procedures

217. Diagnosis and Management of Acute Pulmonary Embolism Full Text available with Trip Pro

Plasminogen Activator for Occluded Coronary Arteries HAS-BLED Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly (>65 years), Drugs/alcohol concomitantly HERDOO2 Hyperpigmentation, Edema, or Redness in either leg; D-dimer level ≥250 μg/L; Obesity with body mass index ≥30 kg/m 2 ; or Older age, ≥65 years H-FABP Heart-type fatty acid-binding protein HIV Human immunodeficiency virus HR Hazard ratio INR International

2019 European Society of Cardiology

218. Hirsutism: Scenario: Management of hirsutism

Treatments that can be done in a domestic setting and offer temporary hair removal include: Shaving — an easily available technique. However, it needs to be repeated frequently and leads to stubble; the blunt tip of shaved hair may give the illusion of thicker hair. Waxing and plucking — these are effective techniques, but they can be painful and may cause scarring, folliculitis, and hyperpigmentation. Chemical depilatory agents — dissolve hair, but may be associated with irritant dermatitis (...) and hyperpigmentation. Bleaching — this can mask the appearance of unwanted hair especially on the face, but it may also lead to skin irritation and skin discolouration. Treatments carried out in specialist clinics may offer permanent hair reduction. They include: Electrolysis — this uses a small current of electricity to destroy the hair follicle. It is effective, but is time-consuming, can be painful, and is impractical for hair removal over large areas. Laser hair removal — can be used over larger areas. It can

2020 NICE Clinical Knowledge Summaries

219. Monkeypox

with: fever headache muscle aches backache swollen lymph nodes chills exhaustion Within 1 to 5 days after the appearance of fever, a rash develops, often beginning on the face then spreading to other parts of the body. The rash changes and goes through different stages before finally forming a scab which later falls off. Images of individual monkeypox lesions Notes areas of erythema and/or skin hyperpigmentation are often seen around discrete lesions lesions can vary in size and may be larger than those

2019 Public Health England

220. Pityriasis rosea: Scenario: Management

may worsen before it resolves, with new crops of skin lesions continuing to appear for up to 6 weeks. Reassure the person that: The rash will settle without treatment, usually within 2–3 months. No treatment is required apart from symptomatic treatment for itch. After the rash has disappeared, there may be some hyperpigmentation or hypopigmentation of the affected skin for several months, but there will be no scarring. The rash does not usually recur: about 1 in every 50 people with pityriasis

2020 NICE Clinical Knowledge Summaries

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>