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Hyperpigmentation

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1. Laser Treatment of Gingival Hyperpigmentation Is More Effective at Providing a Stable Outcome Compared to Treatment with Conventional Techniques

Laser Treatment of Gingival Hyperpigmentation Is More Effective at Providing a Stable Outcome Compared to Treatment with Conventional Techniques UTCAT3116, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Laser Treatment of Gingival Hyperpigmentation Is More Effective at Providing a Stable Outcome Compared to Treatment with Conventional Techniques Clinical Question For a patient with gingival hyperpigmentation (...) , will treatment with a laser, as compared to conventional treatment (i.e., scalpel technique or bur abrasion), be effective in providing a stable outcome? Clinical Bottom Line Treatment of gingival hyperpigmentation with lasers is a viable alternative to conventional techniques and has shown stable, long-term results. Current data suggest that laser surgery is more effective at limiting re-pigmentation. Lasers also offer the benefits of reduced chair time and less post-operative discomfort. The initial cost

2016 UTHSCSA Dental School CAT Library

2. Deletion of a conserved transcript PG_RS02100 expressed during logarithmic growth in Porphyromonas gingivalis results in hyperpigmentation and increased tolerance to oxidative stress. Full Text available with Trip Pro

Deletion of a conserved transcript PG_RS02100 expressed during logarithmic growth in Porphyromonas gingivalis results in hyperpigmentation and increased tolerance to oxidative stress. The oral obligate anaerobe Porphyromonas gingivalis possesses a small conserved transcript PG_RS02100 of unknown function we previously identified using small RNA-seq analysis as expressed during logarithmic growth. In this study, we sought to determine if PG_RS02100 plays a role in P. gingivalis growth or stress

2018 PLoS ONE

3. Pharmacotherapy of post inflammatory hyperpigmentation: systematic review and meta analysis

Pharmacotherapy of post inflammatory hyperpigmentation: systematic review and meta analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

4. Efficacy and tolerability of using platelet-rich plasma versus chemical peeling in periorbital hyperpigmentation. (Abstract)

Efficacy and tolerability of using platelet-rich plasma versus chemical peeling in periorbital hyperpigmentation. Various therapeutic modalities for periorbital hyperpigmentation (POH) have been proposed.This study was designed to compare the efficacy and tolerability of autologous platelet-rich plasma (PRP) and chemical peeling in POH.Forty-two patients were enrolled in this study and randomly subdivided into two groups. Group A patients were assigned to receive four sessions of chemical

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

5. A Comparison of 940 nm Diode Laser and Cryosurgery With Liquid Nitrogen in the Treatment of Gingival Physiologic Hyperpigmentation Using Split Mouth Technique: 12 Months Follow Up. Full Text available with Trip Pro

A Comparison of 940 nm Diode Laser and Cryosurgery With Liquid Nitrogen in the Treatment of Gingival Physiologic Hyperpigmentation Using Split Mouth Technique: 12 Months Follow Up. Introduction: Gingival hyperpigmentation is excessive deposition of melanin pigments in the epithelium of gingiva which affects facial esthetics. Various surgical methods for gingival depigmentation have been used to treat the darkened color of pigmented gingiva. This study compared the use of 940 nm diode laser (...) and liquid nitrogen cryosurgery in the treatment of gingival physiologic hyperpigmentation in terms of gingival depigmentation, postoperative pain, healing duration, pigmentation recurrence, and patients' satisfaction. Methods: Fifteen systemically healthy patients (11 females and 4 males; 17-35 years of age) with bilateral gingival physiologic hyperpigmentation were enrolled in this split-mouth randomized study. Maxillary anterior labial gingiva of each patient was divided into left and right halves

2019 Journal of lasers in medical sciences Controlled trial quality: uncertain

6. A Prospective Randomized Controlled Study of Oral Tranexamic Acid for the Prevention of Postinflammatory Hyperpigmentation After Q-Switched 532-nm Nd:YAG Laser for Solar Lentigines. (Abstract)

A Prospective Randomized Controlled Study of Oral Tranexamic Acid for the Prevention of Postinflammatory Hyperpigmentation After Q-Switched 532-nm Nd:YAG Laser for Solar Lentigines. Q-switched (QS) 532-nm Nd:YAG laser is one of the treatment options for solar lentigines (SLs). However, the high incidence of postinflammatory hyperpigmentation (PIH) is concerning, especially in dark-complexioned skin. Tranexamic acid (TA) can decrease melanogenesis and has been used to treat melasma. The aim

2019 Lasers in surgery and medicine Controlled trial quality: uncertain

7. Contact sensitization to hair colors in acquired dermal macular hyperpigmentation: Results from a patch and photo patch-test study of 108 patients. (Abstract)

Contact sensitization to hair colors in acquired dermal macular hyperpigmentation: Results from a patch and photo patch-test study of 108 patients. Acquired dermal macular hyperpigmentation (ADMH) is an umbrella term including lichen planus pigmentosus, erythema dyschromicum perstans and pigmented contact/cosmetic dermatitis.To establish contact sensitization to hair colours as an aetiological factor for ADMH.Detailed clinical examination, skin biopsies, and patch and photo-patch testing (...) with Indian standard series and patient's own cosmetic products were performed.Thirty-nine (36.1%) patients were found to demonstrate a positive patch/photo-patch test with 35/39 reacting to their own products (all were hair colours) and 16/39 reacting to antigens from commercial series (commonly paraphenylenediamine). Fourteen patients developed delayed hyperpigmentation on positive patch-test sites at 1 month. Higher mean age, symptomatic pigmentation (pruritus, burning and photosensitivity), hair

2019 Journal of the European Academy of Dermatology and Venereology

8. The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study. (Abstract)

The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study. Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still limited.To evaluate the effects (...) of the topical EGF ointment on wound healing process and postinflammatory hyperpigmentation (PIH) prevention after fractional ablative laser resurfacing.This is a randomized split-face study. Nineteen healthy subjects were enrolled and completed follow up protocol. Patients received single treatment of fractional carbon dioxide laser on both cheeks. After randomization, each patient was assigned to apply one side of the face with topical EGF ointment and another side with petrolatum. Wound healing

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

9. Reliability assessment and validation of the Dermal Pigmentation Area and Severity Index (DPASI): A new scoring method for Acquired Dermal Macular Hyperpigmentation. (Abstract)

Reliability assessment and validation of the Dermal Pigmentation Area and Severity Index (DPASI): A new scoring method for Acquired Dermal Macular Hyperpigmentation. Dermal pigmentation area and severity score (DPASI), is a recently proposed scoring system for acquired dermal macular hyperpigmentation (ADMH) OBJECTIVE: To determine the reliability and validity of DPASI.After standardized training, three researchers independently rated 55 patients with ADMH on two consecutive days within one

2019 Journal of the European Academy of Dermatology and Venereology

10. Palladium causes bizarre skin hyperpigmentation in long-term dihydrocodeinone 'Braun' abusers. (Abstract)

Palladium causes bizarre skin hyperpigmentation in long-term dihydrocodeinone 'Braun' abusers. 'Braun' is an illegal injectable dihydrocodeinone-enriched drug mixture of semi-synthetic opioids. It is prepared by palladium-catalysed hydrogenation from codeine-containing tablets.We aimed to characterize the dermatologic consequences of long-term abuse of 'Braun'.Skin biopsies of two long-term 'Braun' abusers were evaluated histopathologically, immunohistochemically and ultrastructurally (...) . Palladium skin content was assessed by X-ray fluorescence (XRF) spectrometry.Both patients showed generalized diffuse dark blue-grey hyperpigmentation of the skin. In both, an abnormal population of cells containing intracytoplasmic brownish granular material was identified in the papillary dermis by light microscopy. Electron microscopy revealed a dense and minimally structured material that predominantly accumulated in macrophages, fibroblasts and vascular endothelial cells. XRF analysis confirmed

2019 Journal of the European Academy of Dermatology and Venereology

11. Insights on an in vivo model for postinflammatory hyperpigmentation. (Abstract)

Insights on an in vivo model for postinflammatory hyperpigmentation. Postinflammatory hyperpigmentation (PIH) can occur following a multitude of inflammatory skin conditions including acne vulgaris. It is more common in darker Fitzpatrick phototypes and represents a common skin complaint in dermatology offices. Despite its common occurrence, treatment options for PIH remain limited. Isedeh et al. published a validated in vivo model for PIH in which 35% trichloroacetic acid (TCA) solution

2019 British Journal of Dermatology

12. Acquired linear hyperpigmentation of the lips - a new entity? (Abstract)

Acquired linear hyperpigmentation of the lips - a new entity? 30719768 2019 03 15 1468-3083 2019 Feb 05 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Acquired linear hyperpigmentation of the lips - a new entity? 10.1111/jdv.15471 Almutairi A A Centre Hospitalier Universitaire Nice, Department of Dermatology, Université Nice Côte d'Azur, Nice, France. Claeys A A Private Dermatological Center, Grenoble, France. Bahadoran P P Centre Hospitalier

2019 Journal of the European Academy of Dermatology and Venereology

13. Polymyxin B-induced skin hyperpigmentation: a rare case report and literature review Full Text available with Trip Pro

Polymyxin B-induced skin hyperpigmentation: a rare case report and literature review Polymyxin B (PMB), which is regarded as the ultimate antibacterial treatment against some intractable gram-negative bacteria with its outstanding anti-bacterial activities, inflicts several adverse effects on patients. However, skin hyperpigmentaion (SH) induced by PMB is very rare. Here, we report a case of polymyxin B-induced skin hyperpigmentation (PMB-iSH) in a 21-year-old female. To the best of our

2018 BMC pharmacology & toxicology

14. A Severe Case of Minocycline-induced Hyperpigmentation of the Lower Extremities Full Text available with Trip Pro

A Severe Case of Minocycline-induced Hyperpigmentation of the Lower Extremities Drug reactions are a common cause of cutaneous eruptions. The authors present a case of shin hyperpigmentation resulting from long-term minocycline treatment. This case illustrates a severe example of minocycline-induced pigmentation and reminds clinicians who prescribe this commonly used antibiotic to remain vigilant of this rare adverse reaction.

2018 Cureus

15. A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine Full Text available with Trip Pro

A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine For years, clinical studies involving human volunteers and several known pre-clinical in vivo models (i.e., mice, guinea pigs) have demonstrated their reliability in evaluating the effectiveness of a number of depigmenting agents. Although these models have great advantages, they also suffer from several drawbacks, especially involving ethical issues regarding experimentation

2018 Medicina

16. Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment Full Text available with Trip Pro

Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment Kojic monooleate (KMO) is an ester derived from a fungal metabolite of kojic acid with monounsaturated fatty acid, oleic acid, which contains tyrosinase inhibitor to treat skin disorders such as hyperpigmentation. In this study, KMO was formulated in an oil-in-water nanoemulsion as a carrier for better penetration into the skin.The nanoemulsion was prepared by using high

2018 International journal of nanomedicine

17. The impact of acne and facial post-inflammatory hyperpigmentation on quality of life and self-esteem of newly admitted Nigerian undergraduates Full Text available with Trip Pro

The impact of acne and facial post-inflammatory hyperpigmentation on quality of life and self-esteem of newly admitted Nigerian undergraduates Acne and facial post-inflammatory hyperpigmentation are relatively common clinical conditions among adolescents and young adults, and inflict psychosocial injuries on sufferers.To document the psychosocial and self-esteem implications of acne and facial hyperpigmentation on newly admitted undergraduates.A cross-sectional survey was conducted among 200 (...) . Acne with facial hyperpigmentation, compared to acne without hyperpigmentation, was associated with significant level of anxiety in 30 participants (26.5% vs 10.3%, p=0.004) and emotional distress in 40 (35.4% vs 10.3%, p<0.001). Acne severity correlated with total CADI score but not with total RSES score. Quality of life (QoL) was significantly reduced among acne patients with facial hyperpigmentation (1.77±1.62, vs 1.07±1.02, p<0.001) compared to those without hyperpigmentation. Acne and facial

2018 Clinical, cosmetic and investigational dermatology

18. α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis Full Text available with Trip Pro

α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis Rationale: cAMP up-regulates microphthalmia-associated transcription factor subtype M (MITF-M) and tyrosinase (Tyro) in the generation of heavily pigmented melanosomes. Here, we communicate a therapeutic mechanism of hyperpigmented disorder by α-viniferin, an active constituent of Caragana sinica. Methods: We used cAMP-elevated melanocyte (...) with decreased melanin pigmentation. Conclusion: This study assigned PKA inactivation, a feedback termination in cAMP-induced facultative melanogenesis, as a putative target of α-viniferin in the treatment of melanocyte-specific hyperpigmented disorder. Finally, C. sinica containing α-viniferin was approved as an antimelanogenic agent with topical application in skin hyperpigmentation.

2018 Theranostics

19. Hyperpigmentation with Capecitabine: Part of Hand-Foot Syndrome or a Separate Entity? Full Text available with Trip Pro

Hyperpigmentation with Capecitabine: Part of Hand-Foot Syndrome or a Separate Entity? Capecitabine has several side effects, most common of which is Hand-Foot syndrome (HFS); however, less frequently reported is capecitabine-associated hyperpigmentation. The hyperpigmentation associated with this drug has been documented to involve the hands and feet and, less commonly, the mucous membranes of the mouth. To our knowledge, it has never been documented to involve the face. We report a case (...) of a patient with capecitabine-induced Hand-Foot Syndrome (HFS), who also presented with hyperpigmentation of the hands, feet, oral mucosa, and face.

2018 Cureus

20. Particular hyperpigmentation of the soft palate Full Text available with Trip Pro

Particular hyperpigmentation of the soft palate 30061965 2018 10 01 2018 10 01 1937-8688 29 2018 The Pan African medical journal Pan Afr Med J Particular hyperpigmentation of the soft palate. 187 10.11604/pamj.2018.29.187.15110 Casu Cinzia C Private Dental Practice, Cagliari, Italy. Viganò Luca L University of Milan, Department of Radiology, Milano, Italy. eng Case Reports Journal Article 2018 04 02 Uganda Pan Afr Med J 101517926 IM Female Humans Hyperpigmentation diagnosis pathology Middle

2018 The Pan African medical journal

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