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Hyperosmolar Hyperglycemic State

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3. Moderate-Intensity Insulin Therapy Is Associated With Reduced Length of Stay in Critically Ill Patients With Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State. (Abstract)

Moderate-Intensity Insulin Therapy Is Associated With Reduced Length of Stay in Critically Ill Patients With Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State. Insulin infusion therapy is commonly used in the hospital setting to manage diabetic ketoacidosis and hyperosmolar hyperglycemic state. Clinical evidence suggests both hypoglycemia and glycemic variability negatively impact patient outcomes. The hypothesis of this study was that moderate-intensity insulin therapy decreases (...) hospital length of stay and prevalence of hypoglycemia in patients with diabetic ketoacidosis and hyperosmolar hyperglycemic state.Pre-post study.Large academic medical center in the United States.Two-hundred one consecutive, nonpregnant, adult patients admitted for diabetic ketoacidosis and hyperosmolar hyperglycemic state between October 2010 and December 2014.High-intensity insulin therapy versus moderate-intensity insulin therapy. High-intensity insulin therapy was designed to rapidly normalize

2019 Critical Care Medicine

4. Treatment of Diabetic Ketoacidosis (DKA)/Hyperglycemic Hyperosmolar State (HHS): Novel Advances in the Management of Hyperglycemic Crises (UK Versus USA) Full Text available with Trip Pro

Treatment of Diabetic Ketoacidosis (DKA)/Hyperglycemic Hyperosmolar State (HHS): Novel Advances in the Management of Hyperglycemic Crises (UK Versus USA) Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are diabetic emergencies that cause high morbidity and mortality. Their treatment differs in the UK and USA. This review delineates the differences in diagnosis and treatment between the two countries.Large-scale studies to determine optimal management of DKA and HHS

2017 Current diabetes reports

5. Hyperosmolar hyperglycaemic state

. Kitabchi AE, Umpierrez GE, Murphy MB, et al. Management of hyperglycemic crises in patients with diabetes. Diabetes Care. 2001 Jan;24(1):131-53. http://care.diabetesjournals.org/content/24/1/131.long http://www.ncbi.nlm.nih.gov/pubmed/11194218?tool=bestpractice.com Wolfsdorf JI, Allgrove J, Craig ME, et al; International Society for Pediatric and Adolescent Diabetes. ISPAD clinical practice consensus guidelines 2014. Diabetic ketoacidosis and hyperglycemic hyperosmolar state. Pediatr Diabetes. 2014 Sep (...) Hyperosmolar hyperglycaemic state Hyperosmolar hyperglycaemic state - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Hyperosmolar hyperglycaemic state Last reviewed: February 2019 Last updated: October 2018 Summary Occurs most commonly in older people with type 2 diabetes. Contributes to less than 1% of all diabetes-related admissions. However, mortality is high (5% to 15%). Presents with polyuria, polydipsia

2018 BMJ Best Practice

6. Hyperosmolar hyperglycaemic state

. Kitabchi AE, Umpierrez GE, Murphy MB, et al. Management of hyperglycemic crises in patients with diabetes. Diabetes Care. 2001 Jan;24(1):131-53. http://care.diabetesjournals.org/content/24/1/131.long http://www.ncbi.nlm.nih.gov/pubmed/11194218?tool=bestpractice.com Wolfsdorf JI, Allgrove J, Craig ME, et al; International Society for Pediatric and Adolescent Diabetes. ISPAD clinical practice consensus guidelines 2014. Diabetic ketoacidosis and hyperglycemic hyperosmolar state. Pediatr Diabetes. 2014 Sep (...) Hyperosmolar hyperglycaemic state Hyperosmolar hyperglycaemic state - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Hyperosmolar hyperglycaemic state Last reviewed: February 2019 Last updated: October 2018 Summary Occurs most commonly in older people with type 2 diabetes. Contributes to less than 1% of all diabetes-related admissions. However, mortality is high (5% to 15%). Presents with polyuria, polydipsia

2018 BMJ Best Practice

7. Limb Ischemia in a Patient with Hyperosmolar Hyperglycemic State Full Text available with Trip Pro

Limb Ischemia in a Patient with Hyperosmolar Hyperglycemic State A 61-year-old male with a recent diagnosis of pemphigus vulgaris was brought to the emergency department for altered mental status. He had recently started taking prednisone to manage his autoimmune disease and had a progressive decline in his mental status along with decreased oral intake. Evaluation revealed hyperosmolar hyperglycemic state (HHS) and occlusive arterial thrombosis, a rare but known complication of HHS. He

2018 Clinical Practice and Cases in Emergency Medicine

8. Improvement in renal prognosis with prompt hemodialysis in hyperosmolar hyperglycemic state-related rhabdomyolysis: A case report. Full Text available with Trip Pro

Improvement in renal prognosis with prompt hemodialysis in hyperosmolar hyperglycemic state-related rhabdomyolysis: A case report. Acute kidney injury is common and correctable in patients with a hyperosmolar hyperglycemic state (HHS). Nevertheless, hyperglycemic crisis may also contribute to the development of rhabdomyolysis, which can worsen renal function and lead to high mortality in such patients.Herein, we report a case of hyperosmolar hyperglycemic state-related rhabdomyolysis and acute (...) renal failure with an excellent outcome.A 26-year-old Asian female with underlying paranoid schizophrenia presented with newly diagnosed type 2 diabetes mellitus complicated with HHS. Her renal function deteriorated rapidly in spite of standard management for hyperglycemic crisis. Rhabdomyolysis was subsequently diagnosed according to the high levels of serum creatine kinase (CK) (37,710 U/L, normal range: 20-180 U/L) and myoglobin (5167.7 ng/mL, normal range: 14.3-65.8 ng/mL).After treatment

2018 Medicine

9. Hyperglycemic Hyperosmolar State During Induction Chemotherapy for Acute Lymphoblastic Leukemia. (Abstract)

Hyperglycemic Hyperosmolar State During Induction Chemotherapy for Acute Lymphoblastic Leukemia. We present the case of a 16-year-old boy who presented with fatigue, polyuria, and polydipsia while on chemotherapy for his relapsed acute lymphoblastic leukemia (ALL). Blood gas examination confirmed the diagnosis of hyperosmolar hyperglycemic state. The etiology for his hyperglycemia was most likely a result of oral glucocorticoid therapy combined with asparaginase therapy-both are a cornerstone (...) of induction chemotherapy for ALL. The patient was aggressively rehydrated with saline, and medications were administered to correct his hyperkalemia. He was then slowly brought to euglycemia with a continuous infusion of insulin. Although hyperosmolar hyperglycemic state is rare during the treatment of ALL, frontline providers should be aware of this diagnosis because of the significant risk of hypovolemic shock and death if correction of hyperglycemia occurs prior to complete fluid resuscitation.

2017 Pediatric Emergency Care

10. Ascariasis and hyperosmolar hyperglycemic state: a surprising ultrasound finding in the emergency department Full Text available with Trip Pro

Ascariasis and hyperosmolar hyperglycemic state: a surprising ultrasound finding in the emergency department We report the ultrasound finding of ascariasis in a patient with hyperosmolar hyperglycemic state (HHS). Although ascariasis is common in low-resource settings, there has been no previous report associating ascariasis with HHS.A 26-year-old Rwandan man was admitted to the emergency department in coma, with a glycemia of 600 mg/dl. He was resuscitated with fluids, intubated and ventilated (...) , and treated with insulin and antibiotics. On day 3, an ascaris worm was passed via his nasogastric tube, and abdominal ultrasound revealed a heavy worm load. He was treated with albendazole and eventually made a full recovery.This is the first report of ascariasis as a potential cause of HHS, and we recommend that emergency practitioners consider early abdominal ultrasound in patients with hyperglycemic emergencies in areas with a high prevalence of ascariasis.

2017 International journal of emergency medicine

11. End-Stage Renal Disease Increases Rates of Adverse Glucose Events When Treating Diabetic Ketoacidosis or Hyperosmolar Hyperglycemic State Full Text available with Trip Pro

End-Stage Renal Disease Increases Rates of Adverse Glucose Events When Treating Diabetic Ketoacidosis or Hyperosmolar Hyperglycemic State IN BRIEF Treatment guidelines for diabetic emergencies are well described in patients with normal to moderately impaired kidney function. However, management of patients with end-stage renal disease (ESRD) is an ongoing challenge. This article describes a retrospective study comparing the rates of adverse glucose events (defined as hypoglycemia or a decrease (...) in glucose >200 mg/dL/h) between patients with ESRD and those with normal kidney function who were admitted with diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS). These results indicate that current treatment approaches to DKA or HHS in patients with ESRD are suboptimal and require further evaluation.

2017 Clinical diabetes : a publication of the American Diabetes Association

12. Central Diabetes Insipidus and Hyperglycemic Hyperosmolar State Following Accidental Carbon Monoxide Poisoning Full Text available with Trip Pro

Central Diabetes Insipidus and Hyperglycemic Hyperosmolar State Following Accidental Carbon Monoxide Poisoning Carbon monoxide poisoning is common and carries significant morbidity and mortality. The nervous system, particularly the brain, is frequently affected by it, owing to its high metabolic activity and oxygen requirements. Carbon monoxide damages the nervous system by both hypoxic and inflammatory mechanisms. Central diabetes insipidus is an extremely rare complication of carbon monoxide (...) poisoning. Herein, we report the case of a young lady, who developed this complication and severe hypernatremia after accidental carbon monoxide poisoning. She also developed a hyperglycemic hyperosmolar state during the treatment for hypernatremia. To the best of our knowledge, both these entities have not been reported together in association with carbon monoxide poisoning. The purpose of this article is to emphasize the anticipation and early recognition of central diabetes insipidus in carbon

2017 Cureus

13. Reversible splenial lesion syndrome with a hyperosmolar hyperglycemic state and neuroleptic malignant syndrome caused by olanzapine Full Text available with Trip Pro

Reversible splenial lesion syndrome with a hyperosmolar hyperglycemic state and neuroleptic malignant syndrome caused by olanzapine A 27-year-old woman with panic disorder taking 20 mg olanzapine daily for 4 months was admitted to Mito Kyodo General Hospital, Mito, Ibaraki, Japan, because of disturbed consciousness with fever, hyperglycemia, hyperosmolarity and elevated creatine phosphokinase. She was diagnosed with a hyperosmolar hyperglycemic state and neuroleptic malignant syndrome. Brain (...) mild encephalitis/encephalopathy with a reversible splenial lesion. The first case of mild encephalitis/encephalopathy with a reversible splenial lesion caused by olanzapine-induced hyperosmolar hyperglycemic state and neuroleptic malignant syndrome is reported.© 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

2017 Journal of Diabetes Investigation

14. A case report of hyperosmolar hyperglycemic state in a 7-year-old child: An unusual presentation of first appearance of type 1 diabetes mellitus. Full Text available with Trip Pro

A case report of hyperosmolar hyperglycemic state in a 7-year-old child: An unusual presentation of first appearance of type 1 diabetes mellitus. A hyperosmolar hyperglycemic state (HHS) is a rare presentation of a hyperglycemic crisis in children with diabetes mellitus. As this condition can be fatal and has high morbidity, early recognition and proper management are necessary for a better outcome. Here, we report a rare case of HHS as the first presentation of type 1 diabetes mellitus (T1DM

2017 Medicine

15. Practical Management of Hyperglycaemic Hyperosmolar State (HHS) in children

GE. Hyperosmolar hyperglycemic state: a historic review of the clinical presentation, diagnosis, and treatment. Diabetes care 2014;37:3124-31. Gouni-Berthold I, Krone W. Diabetic ketoacidosis and hyperosmolar hyperglycemic state. Medizinische Klinik (Munich, Germany : 1983) 2006;101 Suppl 1:100-5. Fourtner SH, Weinzimer SA, Levitt Katz LE. Hyperglycemic hyperosmolar non-ketotic syndrome in children with type 2 diabetes*. Pediatric diabetes 2005;6:129-35. Wolfsdorf JI, Allgrove J, Craig ME, et al (...) . ISPAD Clinical Practice Consensus Guidelines 2014. Diabetic ketoacidosis and hyperglycemic hyperosmolar state. Pediatric diabetes 2014;15 Suppl 20:154-79. Nyenwe EA, Kitabchi AE. Evidence-based management of hyperglycemic emergencies in diabetes mellitus. Diabetes research and clinical practice 2011;94:340-51. Rosenbloom AL. Hyperglycemic comas in children: new insights into pathophysiology and management. Reviews in endocrine & metabolic disorders 2005;6:297-306. Bagdure D, Rewers A, Campagna E

2018 British Society for Paediatric Endocrinology and Diabetes

16. Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State Hyperosmolar Hyperglycemic State Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperosmolar (...) Hyperglycemic State Hyperosmolar Hyperglycemic State Aka: Hyperosmolar Hyperglycemic State , Hyperosmolar Hyperglycemic Nonketotic Coma , Hyperglycemic Hyperosmolar Nonketotic Coma , Hyperglycemic Dehydration Syndrome , Hyperosmolar Nonketotic Diabetic Syndrome , Diabetic Hyperosmolar Non-Ketotic State From Related Chapters II. Pathophysiology Occurs in patients still able to produce (contrast with ) However, DKA and HHS findings coexist in the same patient presentation in up to one third of patients Very

2018 FP Notebook

17. Successful Treatment of Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Status in an Infant with KCNJ11-Related Neonatal Diabetes Mellitus via Continuous Renal Replacement Therapy Full Text available with Trip Pro

Successful Treatment of Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Status in an Infant with KCNJ11-Related Neonatal Diabetes Mellitus via Continuous Renal Replacement Therapy Neonatal diabetes mellitus (NDM) is a rare monogenic disorder presenting as uncontrolled hyperglycemia during the first 6 months of life. Hyperglycemic hyperosmolar state (HHS) is quite rare in NDM patients, and reported experience with this condition is limited. Continuous renal replacement therapy (CRRT

2018 Diabetes Therapy

18. Hyperglycemic hyperosmolar state associated with invasive rhino-orbital aspergillosis in a patient with end-stage renal disease Full Text available with Trip Pro

Hyperglycemic hyperosmolar state associated with invasive rhino-orbital aspergillosis in a patient with end-stage renal disease 26968192 2018 07 09 2018 11 13 2005-6648 32 5 2017 09 The Korean journal of internal medicine Korean J. Intern. Med. Hyperglycemic hyperosmolar state associated with invasive rhino-orbital aspergillosis in a patient with end-stage renal disease. 936-938 10.3904/kjim.2015.056 Seo Ju Hyun JH Division of Endocrinology and Metabolism, Department of Internal Medicine (...) , Korea. eng Case Reports Letter 2016 03 10 Korea (South) Korean J Intern Med 8712418 1226-3303 0 Antifungal Agents 0 Hypoglycemic Agents 0 Insulin IM Aged Antifungal Agents therapeutic use Aspergillosis complications diagnosis microbiology therapy Debridement Eye Infections, Fungal complications diagnosis microbiology therapy Humans Hyperglycemic Hyperosmolar Nonketotic Coma diagnosis drug therapy etiology Hypoglycemic Agents administration & dosage Infusions, Intravenous Insulin administration

2016 The Korean journal of internal medicine

19. Rhabdomyolysis in Pediatric Patients With Diabetic Ketoacidosis or Hyperglycemic Hyperosmolar State: A Case Series Full Text available with Trip Pro

Rhabdomyolysis in Pediatric Patients With Diabetic Ketoacidosis or Hyperglycemic Hyperosmolar State: A Case Series 28229089 2018 11 13 2333-794X 3 2016 Global pediatric health Glob Pediatr Health Rhabdomyolysis in Pediatric Patients With Diabetic Ketoacidosis or Hyperglycemic Hyperosmolar State: A Case Series. 2333794X16671391 10.1177/2333794X16671391 Mercer Shelly S University of Alabama at Birmingham, AL, USA. Hanks Lynae L University of Alabama at Birmingham, AL, USA. Ashraf Ambika (...) A University of Alabama at Birmingham, AL, USA. eng Journal Article 2016 11 30 United States Glob Pediatr Health 101670224 2333-794X Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 2016 08 16 2016 08 16 2017 2 24 6 0 2017 2 24 6 0 2017 2 24 6 1 epublish 28229089 10.1177/2333794X16671391 10.1177_2333794X16671391 PMC5308516 Am J Med. 1990 Jan;88(1):9-12 2294777 Intern Med. 2010;49(21

2016 Global pediatric health

20. Predictors of Recurrent Hospital Admission for Patients Presenting With Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State Full Text available with Trip Pro

Predictors of Recurrent Hospital Admission for Patients Presenting With Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are two serious, preventable complications of diabetes mellitus. Analysis of variables associated with recurrent DKA and HHS admission has the potential to improve patient outcomes by identifying possible areas for intervention. The aim of this study was to evaluate potential predictors

2016 Journal of clinical medicine research

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