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1. Hyperhidrosis

Hyperhidrosis Hyperhidrosis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Hyperhidrosis Last reviewed: February 2019 Last updated: March 2018 Summary An excess sweating condition beyond physiological need. Classified as primary and of unknown cause (idiopathic), or secondary due to an underlying condition (usually an infectious, endocrine, or neurological disorder). Primary hyperhidrosis may also be described (...) include direct axillary sweat gland removal and thoracoscopic sympathectomy. Definition A condition of excess sweating, beyond physiological need, which is frequently disabling for the patient, professionally and socially. It can be classified as primary and of unknown cause (idiopathic), or secondary due to an underlying condition (usually an infectious, endocrine, or neurological disorder). Primary hyperhidrosis may also be described as palmar, plantar, axillary, or craniofacial, each of which has

2018 BMJ Best Practice

2. Transcutaneous microwave ablation for severe primary axillary hyperhidrosis

or adolescence, but can happen at any age. It is usually life-long, although in a few people symptoms can spontaneously improve over time. Severe primary axillary hyperhidrosis can be defined as a score of 3 or 4 on the Hyperhidrosis Disease Severity Scale. Excessive sweating can have a profound effect on quality of life, interfering with daily activities and causing anxiety and embarrassment. 2.2 First-line management of primary axillary hyperhidrosis includes lifestyle measures such as avoiding known (...) Transcutaneous microwave ablation for severe primary axillary hyperhidrosis T T r ranscutaneous microwa anscutaneous microwav ve ablation for se e ablation for sev vere ere primary axillary h primary axillary hyperhidrosis yperhidrosis Interventional procedures guidance Published: 20 December 2017 nice.org.uk/guidance/ipg601 Y Y our responsibility our responsibility This guidance represents the view of NICE, arrived at after careful consideration of the evidence available. When exercising

2018 National Institute for Health and Clinical Excellence - Interventional Procedures

3. Medication Causes of Hyperhidrosis

Medication Causes of Hyperhidrosis Medication Causes of Hyperhidrosis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Medication (...) Causes of Hyperhidrosis Medication Causes of Hyperhidrosis Aka: Medication Causes of Hyperhidrosis , Drug Induced Excessive Sweating From Related Chapters II. Causes: Antidepressants s or (e.g. ) or (e.g. ) III. Causes: Cholinergic Agonists ( ) IV. Causes: Selective Estrogen Receptor Modulators (SERMs) ( ) V. Causes: Hypoglycemics s (e.g. ) s (e.g. ) VI. Causes: Miscellaneous ( ) ( ) VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2018 FP Notebook

4. Hyperhidrosis Causes

Hyperhidrosis Causes Hyperhidrosis Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperhidrosis Causes Hyperhidrosis Causes (...) Aka: Hyperhidrosis Causes , Causes of Excessive Sweating From Related Chapters II. Causes: Substances See exposure use , or other III. Causes: Endocrine or Hyperpituitarism IV. Causes: Neurologic Spinal cord injury V. Causes: Psychiatric Social Anxiety VI. Causes: Cardiopulmonary VII. Causes: Malignancy VIII. Causes: Miscellaneous See Spicy Foods Febrile Illness (and defervescence) IX. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2018 FP Notebook

5. Medication Causes of Hyperhidrosis

Medication Causes of Hyperhidrosis Medication Causes of Hyperhidrosis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Medication (...) Causes of Hyperhidrosis Medication Causes of Hyperhidrosis Aka: Medication Causes of Hyperhidrosis , Drug Induced Excessive Sweating From Related Chapters II. Causes: Antidepressants s or (e.g. ) or (e.g. ) III. Causes: Cholinergic Agonists ( ) IV. Causes: Selective Estrogen Receptor Modulators (SERMs) ( ) V. Causes: Hypoglycemics s (e.g. ) s (e.g. ) VI. Causes: Miscellaneous ( ) ( ) VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2018 FP Notebook

6. Hyperhidrosis Causes

Hyperhidrosis Causes Hyperhidrosis Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hyperhidrosis Causes Hyperhidrosis Causes (...) Aka: Hyperhidrosis Causes , Causes of Excessive Sweating From Related Chapters II. Causes: Substances See exposure use , or other III. Causes: Endocrine or Hyperpituitarism IV. Causes: Neurologic Spinal cord injury V. Causes: Psychiatric Social Anxiety VI. Causes: Cardiopulmonary VII. Causes: Malignancy VIII. Causes: Miscellaneous See Spicy Foods Febrile Illness (and defervescence) IX. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2018 FP Notebook

7. Impact of Thoracoscopic T2 Sympathectomy on Patients With Primary Palmar and Axillary Hyperhidrosis

Impact of Thoracoscopic T2 Sympathectomy on Patients With Primary Palmar and Axillary Hyperhidrosis There are different techniques for thoracoscopic sympathectomy for management of primary hyperhidrosis. Each technique has the advantage of giving good surgical results, but may cause complications, which depend on the level of sympathectomy used in each technique.From October 2012 to August 2016, a total number of 120 patients (of primary palmar and axillary hyperhidrosis) were enrolled

2018 EvidenceUpdates

8. The Etiology, Diagnosis and Management of Hyperhidrosis: A Comprehensive Review. Part I. Etiology and Clinical Work-Up. (PubMed)

The Etiology, Diagnosis and Management of Hyperhidrosis: A Comprehensive Review. Part I. Etiology and Clinical Work-Up. Hyperhidrosis (HH) is a dermatologic disorder defined by sweat production beyond the thermoregulatory requirements. Clinically, HH is diagnosed when excess sweating creates significant emotional, physical, or social discomfort, causing negative impact on the patient's quality of life. Existing data imply that this condition may affect at least 4.8% of the US population (...) and asymmetric distribution and is generated by various underlying diseases or medications. Secondary causes of HH need to be excluded prior to diagnosing primary HH.Copyright © 2019. Published by Elsevier Inc.

2019 Journal of American Academy of Dermatology

9. Long-Term Impact of Endoscopic Thoracic Sympathectomy for Primary Palmar Hyperhidrosis. (PubMed)

disruptive than preoperative hyperhidrosis.This study confirms that the benefits of ETS are maintained in the long term. Although CS is the main cause for discontent postoperatively, it is still preferred over the distress experienced from palmar or axillary hyperhidrosis and QOL is increased despite CS.Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. (...) Long-Term Impact of Endoscopic Thoracic Sympathectomy for Primary Palmar Hyperhidrosis. Endoscopic thoracic sympathectomy (ETS) is the gold standard treatment for primary hyperhidrosis, with excellent short-term results. The potential for adverse effects, particularly compensatory sweating (CS), may affect long-term satisfaction. In this retrospective review we aimed to examine long-term results and quality of life (QOL) after ETS in the management of primary, dominantly palmar, hyperhidrosis

2018 Annals of Thoracic Surgery

10. A Safety Study of BBI-4000 Gel in Patients With Axillary Hyperhidrosis

): Brickell Biotech, Inc. Study Details Study Description Go to Brief Summary: Hyperhidrosis is a disorder of abnormal excessive sweating. Primary hyperhidrosis (armpits, hands, and feet) affects approximately 4.8% of the US population and is believed to be caused by an overactive cholinergic response of the sweat glands. Current therapies have limited effectiveness, significant side effects, and can be invasive and costly. Sofpironium bromide (BBI-4000) is a novel soft-drug in development for the topical (...) effects (taken within the last 28 days), including dry mouth, blurred vision, may be allowed based on the Principal Investigator's assessment. NOTE: If anticholinergic side effect(s) are experienced on these medications prior to starting study medication; document the side effect(s) and severities in the source document and the eCRF. The doses of these agents should not be altered during the course of the study. Known causes of hyperhidrosis or known history of a condition that may cause hyperhidrosis

2018 Clinical Trials

11. Phenol With Fluoroscopy Guided Radiofrequency Ablation of T2-T3in Palmar Hyperhidrosis.

hyperhidrosis is a disorder characterized by excessive, chronic sweating in the absence of a sweating trigger. This condition must be differentiated from secondary hyperhidrosis, which is due to a lot of stimuli as infection, malignancy, drugs, anxiety, neurological and endocrine disorders. Primary hyperhidrosis is caused by hyperactivity of the sympathetic system. The etiology of the disease is unknown and appears simultaneously. It affects patients between 15 and 40 years of age and may cause serious (...) , inexpensive and done under sedation with local anaesthesia in an outpatient setting, but its success rate is still significantly lower than endoscopic sympathectomy. McCormack et al. concluded that there are anatomical variations in the position of sympathetic trunk which are thought to be one of the main causes of failure and patient dissatisfaction after thoracic sympathetic neurolysis in hyperhidrosis. Previous studies tried to increase the efficacy of radiofrequency ablation of T2, T3 sympathetic

2018 Clinical Trials

12. Hyperhidrosis and its impact on those living with it. (PubMed)

Hyperhidrosis and its impact on those living with it. Sweating plays a vital role for humans. However, excessive sweating, also called hyperhidrosis, is a condition resulting in sweating beyond what is physiologically necessary. The increased rate of sweating is not caused by external stimuli or temperature fluctuations, as with an individual without hyperhidrosis. Hyperhidrosis affects approximately 4.8% of Americans. Primary hyperhidrosis, a specific classification of the disease, primarily (...) affects younger adults aged 18 to 39 years, and it often has a genetic component. Living with hyperhidrosis presents many challenges and impacts numerous aspects of daily life. Patients with hyperhidrosis are impacted in their social and professional lifestyles, as well as their mental and emotional health. These negative effects, which have been studied, lead to a lower quality of life (QOL) in this population. Additionally, constant moisture from sweating can lead to skin maceration. This increases

2018 American Journal Of Managed Care

13. Examining hyperhidrosis: an update on new treatments. (PubMed)

Examining hyperhidrosis: an update on new treatments. Primary hyperhidrosis is a debilitating condition that causes significant distress and financial burden for affected patients, triggering them to seek medical care for their excessive sweating. Once a diagnosis of primary hyperhidrosis has been established, treatment is initiated to help control sweat production and increase quality of life. While there are no current guidelines in the United States for the treatment of primary hyperhidrosis (...) , there are International Hyperhidrosis Society guidelines that clinicians can use. Currently, a step-therapy approach with the least invasive treatments prioritized first is recommended; the patient's reported disability should also be taken into consideration when selecting a first-line treatment. This update will discuss new treatment modalities, surgical procedures, associated comorbidities, and the impact on managed care of hyperhidrosis, so clinicians can tailor therapy, improve outcomes, and increase patient

2018 American Journal Of Managed Care

14. A Confirmatory Safety and Efficacy Study of BBI-4000 in Subjects With Axillary Hyperhidrosis

of administration. Use of potent inhibitors of cytochrome P450 CYP3A and CYP2D6. Use of any cholinergic drug (e.g. bethanechol) within 30 days. Known cause of hyperhidrosis or known history of a condition that may cause hyperhidrosis (i.e., hyperhidrosis secondary to any known cause such hyperthyroidism, diabetes mellitus, medications, etc.). Subjects with unstable diabetes mellitus or thyroid disease, history of renal or hepatic impairment, malignancy glaucoma, intestinal obstructive or motility disease (...) A Confirmatory Safety and Efficacy Study of BBI-4000 in Subjects With Axillary Hyperhidrosis A Confirmatory Safety and Efficacy Study of BBI-4000 in Subjects With Axillary Hyperhidrosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

15. Fractional Micro-Needle Radiofrequency and I Botulinum Toxin A for Primary Axillary Hyperhidrosis

such as radical resection of sweat glands for primary axillary hyperhidrosis Currently being treated with intradermal botulinum toxin type A injection at axillary area for less than 12 months Currently being inserted the cardiac pace maker or any other internal electronic devices Secondary hyperhidrosis caused by hyperthyroidism, drug induced, abnormal autonomic or neurological disorder that affect sweat gland Allergy to botulinum toxin type A Known contact allergy to iodine Unable to follow and comply (...) Fractional Micro-Needle Radiofrequency and I Botulinum Toxin A for Primary Axillary Hyperhidrosis Fractional Micro-Needle Radiofrequency and I Botulinum Toxin A for Primary Axillary Hyperhidrosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2017 Clinical Trials

16. Exploratory Study to Assess the Efficacy and Safety of TC-5214 in the Treatment of Subjects With Palmar Hyperhidrosis

that can cause secondary hyperhidrosis or affect sweating. Subject has known history of Sjögren's syndrome or Sicca syndrome. Subject has used any of the following hyperhidrosis medications or therapies within the specified timeframe: Iontophoresis to the palms within four weeks prior to baseline visit; Botulinum toxin to the palms within one year prior to baseline visit; Prior surgical procedures to the palms (e.g., sympathectomy, debulking of sweat glands); Prior medical device treatment to the palms (...) Exploratory Study to Assess the Efficacy and Safety of TC-5214 in the Treatment of Subjects With Palmar Hyperhidrosis Exploratory Study to Assess the Efficacy and Safety of TC-5214 in the Treatment of Subjects With Palmar Hyperhidrosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

17. The Etiology of Primary Hyperhidrosis: A Systematic Review. (PubMed)

The Etiology of Primary Hyperhidrosis: A Systematic Review. Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Recently some differences between affected and non-affected people have been reported. The aim of this review is to summarize these new etiological data.Search of the literature was performed in the PubMed (...) /Medline Database and pertinent articles were retrieved and reviewed. Additional publications were obtained from the references of these articles.Some anatomical and pathophysiological characteristics (as well as enzymatic, metabolic, and neurological dysfunctions) have been observed in hyperhidrotic subjects; three main possible etiological factors predominate. A familial trait seems to exist, and genetic loci associated with hyperhidrosis have been identified. Histological differences were observed

2017 Clinical autonomic research : official journal of the Clinical Autonomic Research Society

18. Retroperitoneoscopic lumbar sympathectomy for plantar hyperhidrosis. (PubMed)

Retroperitoneoscopic lumbar sympathectomy for plantar hyperhidrosis. The objective of this study was to assess the reduction in quality of life (QoL) caused by the persistence of primary plantar hyperhidrosis (PPH) symptoms and the level of satisfaction in PPH patients after retroperitoneoscopic lumbar sympathectomy (RLS). The efficacy, safety, and procedure of bilateral RLS in both sexes are also described in this study.This is a longitudinal study of consecutive patients who sought specific (...) treatment from a private practitioner for severe PPH as classified on the Hyperhidrosis Disease Severity Scale (HDSS) from October 2005 to October 2014. The patients were asked to report the symptoms of PPH experienced in the immediate preoperative period and to complete a standardized QoL questionnaire developed by de Campos at least 12 months after RLS. Disease outcomes, recurrence of symptoms, and any adverse effects of surgery were evaluated after 30 days and at least 12 months after RLS.Lumbar

2017 Journal of Vascular Surgery

19. A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosis (PubMed)

A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosis Hyperhidrosis can cause dehydration and exercise intolerance. There are several case reports of extremely high sweat rates in athletes. We present as case report of a 17-year-old male with the highest sweat rate recorded in the literature (5.8 L/h). Our goal was to determine if glycopyrrolate, an anticholinergic medication with primarily anti-muscarinic effects that is known to decrease sweat production, would reduce (...) . However, the clinical effect of reducing the sweat rate was very strong. The improvement of the subject's sweat rate allowed him to successfully return to sport.Our findings suggest that low-dose glycopyrrolate may be a safe and effective method of controlling exertional hyperhidrosis.

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2017 SAGE Open Medical Case Reports

20. Clonidine is effective for the treatment of primary idiopathic hyperhidrosis and hot flushes: a case report (PubMed)

to a dermatology clinic with a complaint of generalized sweating, with heavier involvement of his inguinal region, axilla, and lower back. His complaint was associated with a transient hot sensation and erythema over the affected areas. He did not respond to topical antiperspirants containing aluminum chloride, topical aluminum chloride, or to botulinum toxin A injected in both inguinal areas. He was then referred to an endocrinology clinic to rule out secondary causes of hyperhidrosis and hot flushes (...) Clonidine is effective for the treatment of primary idiopathic hyperhidrosis and hot flushes: a case report While primary hyperhidrosis can be seen in men, accompanying hot flushes is rarely seen in men. Primary hyperhidrosis is thought to be related to overactivity of the sympathetic nervous system while hot flushes are believed to be related to altered peripheral vascular reactivity and a narrowed thermoregulatory zone.I report the case of a 29-year-old man of Arab origin who presented

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2017 Journal of medical case reports

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