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Hyperaldosteronism

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2. Arterial Hypertension, Atrial Fibrillation And Hyperaldosteronism: The Triple Trouble Full Text available with Trip Pro

Arterial Hypertension, Atrial Fibrillation And Hyperaldosteronism: The Triple Trouble 28264920 2018 01 29 2019 02 22 1524-4563 69 4 2017 04 Hypertension (Dallas, Tex. : 1979) Hypertension Arterial Hypertension, Atrial Fibrillation, and Hyperaldosteronism: The Triple Trouble. 545-550 10.1161/HYPERTENSIONAHA.116.08956 Seccia Teresa M TM From the Clinica dell'Ipertensione Arteriosa, Department of Medicine-DIMED, University of Padua, Italy (T.M.S., B.C., G.M., M.C., G.P.R.); and Division (...) and Women's Hospital, Harvard Medical School, Boston, MA (G.K.A.). gianpaolo.rossi@unipd.it. eng K24 HL103845 HL NHLBI NIH HHS United States T32 HL007609 HL NHLBI NIH HHS United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review United States Hypertension 7906255 0194-911X IM Atrial Fibrillation complications physiopathology Humans Hyperaldosteronism complications physiopathology Hypertension complications physiopathology 2017 3 8 6 0 2018 1 30 6 0 2017 3 8

2017 Hypertension (Dallas, Tex. : 1979)

3. Effects of Eplerenone on Resistance to Antihypertensive Medication in Patients with Primary or Secondary Hyperaldosteronism Full Text available with Trip Pro

Effects of Eplerenone on Resistance to Antihypertensive Medication in Patients with Primary or Secondary Hyperaldosteronism Resistant hypertension is an important problem; nearly half of diagnosed hypertensives are not controlled to target blood pressure levels, and approximately 90% of strokes occur among patients with resistant hypertension. Primary aldosteronism accounts for approximately 20% of resistant hypertension, but the role of secondary hyperaldosteronism in resistant hypertension (...) -334.05 ± 21.73 on eplerenone (P = 0.0001), and the Diastolic Resistance Score increased by 1.28 ± 31.65 on placebo and declined by -40.74 ± 57.08 on eplerenone (P = 0.009).Eplerenone significantly reduced resistance to concomitant antihypertensive medication in both primary and secondary hyperaldosteronism.

2017 Journal of translational internal medicine Controlled trial quality: uncertain

4. PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy. (Abstract)

PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy. Accumulating evidences suggest a link between adrenocortical zona glomerulosa and parathyroid gland through mechanisms that remain unexplored.To test the hypothesis that in vivo Angiotensin (Ang) II blockade affects parathyroid hormone (PTH) secretion in hypertensive patients and that aldosterone and Ang II directly stimulate PTH secretion ex vivo.We investigated the changes of serum

2019 Journal of Clinical Endocrinology and Metabolism

5. A novel clinical nomogram to predict bilateral hyperaldosteronism in Chinese patients with primary aldosteronism. (Abstract)

A novel clinical nomogram to predict bilateral hyperaldosteronism in Chinese patients with primary aldosteronism. Adrenal venous sampling (AVS) is recommended as the gold standard for subtype classification in primary aldosteronism (PA); however, this approach has limited availability.We aimed to develop a novel clinical nomogram to predict PA subtype based on routine variables, thereby reducing the number of candidates for AVS.Patients were randomly divided into a training set (n = 185 (...) ) and a validation set (n = 79). Risk factors for idiopathic hyperaldosteronism (IHA) differentiating from aldosterone-producing adenoma (APA) were identified using logistic regression analysis. A nomogram was constructed to predict the probability of IHA. A receiver operating characteristic (ROC) curve and a calibration plot were applied to assess the predictive value. Then, 115 patients were prospectively enrolled, and a nomogram was used to predict the subtypes before AVS.Body mass index (BMI), serum

2019 Clinical endocrinology Controlled trial quality: uncertain

6. Latent autonomous cortisol secretion from apparently non-functioning adrenal tumor in non-lateralized hyperaldosteronism. (Abstract)

Latent autonomous cortisol secretion from apparently non-functioning adrenal tumor in non-lateralized hyperaldosteronism. Adrenal tumors (ATs), even those diagnosed as non-functioning, may cause metabolic disorders. Some primary aldosteronism (PA) patients with ATs are diagnosed with bilateral PA based on adrenal venous sampling (AVS), and their ATs are apparently non-functioning.To clarify the influence of apparently non-functioning ATs, we compared hormone levels and clinical complications

2019 Journal of Clinical Endocrinology and Metabolism

7. Obesity as a key factor underlying idiopathic hyperaldosteronism. Full Text available with Trip Pro

Obesity as a key factor underlying idiopathic hyperaldosteronism. Recently, the relationship between primary aldosteronism (PA) and various metabolic disorders, including obesity, diabetes mellitus, and dyslipidemia, has been discussed. However, in PA, aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) have different etiologies.Our objectives were to clarify differences in obesity and metabolic disorders between APA and IHA and to gain insight in the pathogenesis

2018 Journal of Clinical Endocrinology and Metabolism

8. ’Malignant’ hypertension from hyperaldosteronism: a case report Full Text available with Trip Pro

’Malignant’ hypertension from hyperaldosteronism: a case report Adrenocortical carcinomas (ACC) are rare with an incidence of 0.7-2 per million population per year and account for only 0.05%-2% of all malignant tumors. While majority of the functional ACC present as Cushing syndrome, recurrent hyperaldosteronism from metastatic ACC is exceedingly rare. We describe a 67-year old female presented with hypertensive urgency & hypokalemia as a result of hyperaldosteronism from an 8-cm right ACC (...) . She underwent a radical right nephrectomy with adrenalectomy that normalized her blood pressure. However, a few years later she presented again with resistant hypertension from hyperaldosteronism, raising the suspicion of recurrence of ACC. A contrast-enhanced CT scan showed a normal left adrenal gland but revealed pulmonary metastases of ACC based on a lung biopsy. Chemotherapy was complicated with side effects leading to refusal of further chemotherapy, henceforth requiring high dose

2018 The Pan African medical journal

9. CLCN2 chloride channel mutations in familial hyperaldosteronism type II. Full Text available with Trip Pro

CLCN2 chloride channel mutations in familial hyperaldosteronism type II. Primary aldosteronism, a common cause of severe hypertension 1 , features constitutive production of the adrenal steroid aldosterone. We analyzed a multiplex family with familial hyperaldosteronism type II (FH-II) 2 and 80 additional probands with unsolved early-onset primary aldosteronism. Eight probands had novel heterozygous variants in CLCN2, including two de novo mutations and four independent occurrences

2018 Nature Genetics

10. Long-term Blood Pressure Outcome After Unilateral Adrenalectomy for Primary Hyperaldosteronism

Long-term Blood Pressure Outcome After Unilateral Adrenalectomy for Primary Hyperaldosteronism Long-term Blood Pressure Outcome After Unilateral Adrenalectomy for Primary Hyperaldosteronism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Long-term Blood Pressure Outcome After Unilateral Adrenalectomy for Primary Hyperaldosteronism (Hyperaldo) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03648294 Recruitment Status : Completed First Posted : August 27, 2018 Last Update Posted : August 27, 2018

2018 Clinical Trials

11. Cellular and Genetic Causes of Idiopathic Hyperaldosteronism. Full Text available with Trip Pro

Cellular and Genetic Causes of Idiopathic Hyperaldosteronism. Primary aldosteronism affects ≈5% to 10% of hypertensive patients and has unilateral and bilateral forms. Most unilateral primary aldosteronism is caused by computed tomography-detectable aldosterone-producing adenomas, which express CYP11B2 (aldosterone synthase) and frequently harbor somatic mutations in aldosterone-regulating genes. The cause of the most common bilateral form of primary aldosteronism, idiopathic hyperaldosteronism

2018 Hypertension

12. Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study. Full Text available with Trip Pro

Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study. Primary aldosteronism is one of the most common cause of secondary hypertension. It is well known that the incidence of cardiovascular events is higher in patients with primary aldosteronism than in patients with essential hypertension. In a previous study, we showed that aldosterone-producing adenoma is associated (...) with vascular function and structure. The aim of this study was to evaluate the effects of eplerenone on vascular function in the macrovasculature and microvasculature, arterial stiffness and Rho-associated kinase (ROCK) activity in patients with idiopathic hyperaldosteronism (IHA).Vascular function, including reactive hyperemia index (RHI), flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID), arterial stiffness including brachial-ankle pulse wave velocity (baPWV) and brachial

2018 Journal of Hypertension

13. Somatic mutations in adrenocortical carcinoma with hyperaldosteronism. Full Text available with Trip Pro

Somatic mutations in adrenocortical carcinoma with hyperaldosteronism. Several somatic mutations specific to aldosterone-producing adenomas (APA) have been described. A small proportion of adrenocortical carcinomas (ACC) are associated with hyperaldosteronism, either primary aldosteronism or hyperreninemic hyperaldosteronism. However, it is unknown, whether they harbor mutations of the same spectrum as APAs. The objective of this study is to describe the clinical phenotype and molecular (...) genotype of ACCs with hyperaldosteronism, particularly the analysis for common APA-associated genetic changes. Patients were identified by retrospective chart review at a specialized referral center and by positive staining for CYP11B2 of tissue microarrays. 25 patients with ACC and hyperaldosteronism were initially identified by retrospective chart review and tissue for further analysis was available on 13 tumors. Seven patients were identified by positive staining for CYP11B2 in a tissue microarray

2018 Endocrine-Related Cancer

14. Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice Full Text available with Trip Pro

Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice We investigated the potential adverse effects of hyperaldosteronism and/or hypoestrogenism on cardiac phenotype, and examined their combined effects in female mice overexpressing cardiac aldosterone synthase (AS). We focused on some signaling cascades challenging defensive responses to adapt and/or to survive in the face of double deleterious stresses, such as Ca2+ -homeostasis, pro/anti-hypertrophic

2018 Physiological reports

15. Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism. Full Text available with Trip Pro

Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism. We report a rare case of a juxta-adrenal schwannoma that could not be discriminated from an adrenal tumor before surgical resection and was complicated by bilateral hyperaldosteronism. To the best of our knowledge, this is first case in which both a juxta-adrenal schwannoma and hyperaldosteronism co-existed.A 69-year-old male treated for hypertension was found to have a left supra-renal mass (5.8 (...) was indicated by AVS before the operation, the PRA, PAC and ARR values were within their respective reference ranges after resection of the unilateral tumor, suggesting that the slight increase in hormone secretion from the remaining right-sided lesion could not be detected after resection.A clinical and morphologic diagnosis of juxta-adrenal schwannoma is difficult, particularly in a case of hyperaldosteronism, as shown in this case. These data suggest the complexity and difficulty diagnosing adrenal

2017 BMC Endocrine Disorders

16. An unusual case of Takotsubo syndrome with hyperaldosteronism as the potential cause. Full Text available with Trip Pro

An unusual case of Takotsubo syndrome with hyperaldosteronism as the potential cause. Catecholamine-related factors are the most popular explanation for the occurrence of Takotsubo syndrome. An aldosterone-related mechanism, however, has not been proposed.A 45-year-old male patient presenting with ST-segment elevation myocardial infarction was diagnosed with primary aldosteronism, severe hypokalemia, and Takotsubo syndrome. After excluding the known conditions of apical ballooning (...) and the factors of vasospasm, primary aldosteronism is considered as the major contributor to the development of Takotsubo syndrome. The potential mechanisms are discussed.The case suggests a possible hyperaldosteronism-induced and vasoconstriction-mediated mechanism in the development of Takotsubo syndrome.Copyright © 2017 Endocrine Society

2017 Journal of Clinical Endocrinology and Metabolism

17. Renin angiotensin aldosterone system altered in resistant hypertension in Sub-Saharan African diabetes patients without evidence of primary hyperaldosteronism Full Text available with Trip Pro

Renin angiotensin aldosterone system altered in resistant hypertension in Sub-Saharan African diabetes patients without evidence of primary hyperaldosteronism The renin-angiotensin-aldosterone system may be altered in patients with resistant hypertension. This study aimed to evaluate the relation between renin-angiotensin-aldosterone system activity and resistant hypertension in Cameroonian diabetes patients with resistant hypertension.We carried out a case-control study including 19 diabetes (...) found a significant negative correlation between potassium ion and plasma aldosterone (ρ = -0.324; p = 0.047), the other correlations being weak and unsignificant.Although this study failed to show an association between RH and primary hyperaldosteronism in our context, there was a hyperactivity of renin-angiotensin-aldosterone system. Moreover, this study confirms the importance of potassium dosage when screening the renin-angiotensin-aldosterone system.

2017 JRSM cardiovascular disease

18. Anomalous adrenal vein anatomy complicating the evaluation of primary hyperaldosteronism Full Text available with Trip Pro

Anomalous adrenal vein anatomy complicating the evaluation of primary hyperaldosteronism Adrenal vein development in utero occurs concurrently with the development of the inferior vena cava, the renal veins, and the gonadal veins. The embryologic formation of these veins involves communication of various venous systems. Although the left adrenal-renal vein complex is most commonly described as a shared emptying of the left adrenal vein and the left inferior phrenic vein into the left renal vein

2017 Radiology Case Reports

19. Coexistence of Primary Hyperaldosteronism and Graves' Disease, a Rare Combination of Endocrine Disorders: Is It beyond a Coincidence—A Case Report and Review of the Literature Full Text available with Trip Pro

Coexistence of Primary Hyperaldosteronism and Graves' Disease, a Rare Combination of Endocrine Disorders: Is It beyond a Coincidence—A Case Report and Review of the Literature Primary hyperaldosteronism is a known cause for secondary hypertension. In addition to its effect on blood pressure, aldosterone exhibits proinflammatory actions and plays a role in immunomodulation/development of autoimmunity. Recent researches also suggest significant thyroid dysfunction among patients (...) with hyperaldosteronism, but exact causal relationship is not established. Autoimmune hyperthyroidism (Graves' disease) and primary hyperaldosteronism rarely coexist but underlying mechanisms associating the two are still unclear.A 32-year-old Sri Lankan female was evaluated for new onset hypertension in association with hypokalemia. She also had features of hyperthyroidism together with high TSH receptor antibodies suggestive of Graves' disease. On evaluation of persistent hypokalemia and hypertension, primary

2017 Case reports in endocrinology

20. On the effect of hyperaldosteronism-inducing mutations in Na/K pumps Full Text available with Trip Pro

On the effect of hyperaldosteronism-inducing mutations in Na/K pumps Primary aldosteronism, a condition in which too much aldosterone is produced and that leads to hypertension, is often initiated by an aldosterone-producing adenoma within the zona glomerulosa of the adrenal cortex. Somatic mutations of ATP1A1, encoding the Na/K pump α1 subunit, have been found in these adenomas. It has been proposed that a passive inward current transported by several of these mutant pumps is a "gain (...) . Electrophysiological characterization of another hyperaldosteronism-inducing mutation, G99R, reveals the absence of inward currents under many different conditions, including in the presence of the regulator FXYD1 as well as with mammalian ionic concentrations and body temperatures. Instead, we observe robust outward currents, but with significantly reduced affinities for intracellular Na+ and extracellular K+ Collectively, our results point to loss-of-function as the common mechanism for the hyperaldosteronism

2017 The Journal of general physiology

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