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Human Trafficking

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61. Human Trafficking: The Role of Medicine in Interrupting the Cycle of Abuse and Violence. (Abstract)

Human Trafficking: The Role of Medicine in Interrupting the Cycle of Abuse and Violence. Human trafficking, a form of modern slavery, is an egregious violation of human rights with profound personal and public health implications. It includes forced labor and sexual exploitation of both U.S. and non-U.S. citizens and has been reported in all 50 states. Victims of human trafficking are currently among the most abused and disenfranchised persons in society, and they face a wide range of negative (...) health outcomes resulting from their subjugation and exploitation. Medicine has an important role to play in mitigating the devastating effects of human trafficking on individuals and society. Victims are cared for in emergency departments, primary care offices, urgent care centers, community health clinics, and reproductive health clinics. In addition, they are unknowingly being treated in hospital inpatient units. Injuries and illnesses requiring medical attention thus represent unique windows

2016 Annals of Internal Medicine

62. Human trafficking and health: a cross-sectional survey of NHS professionals' contact with victims of human trafficking. Full Text available with Trip Pro

Human trafficking and health: a cross-sectional survey of NHS professionals' contact with victims of human trafficking. (1) To estimate the proportion of National Health Service (NHS) professionals who have come into contact with trafficked people and (2) to measure NHS professionals' knowledge and confidence to respond to human trafficking.A cross-sectional survey.Face-to-face mandatory child protection and/or vulnerable adults training sessions at 10 secondary healthcare provider (...) organisations in England, and meetings of the UK College of Emergency Medicine.782/892 (84.4%) NHS professionals participated, including from emergency medicine, maternity, mental health, paediatrics and other clinical disciplines.Self-completed questionnaire developed by an expert panel. Questionnaire asks about prior training and contact with potential victims of trafficking, perceived and actual human trafficking knowledge, confidence in responding to human trafficking, and interest in future human

2015 BMJ open

63. Human Trafficking

Human Trafficking Human Trafficking Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Human Trafficking Human Trafficking Aka: Human (...) Trafficking , Human Sex Trafficking , Sex Trafficking , Forced Labor , Sexual Slavery , Slavery , Organ Trafficking From Related Chapters II. Definition Human Trafficking Persons forced or coerced into exploitation (e.g. Forced Labor, Sexual Slavery, Organ Trafficking) III. Epidemiology Affects more than 27 Million persons annually worldwide ($10-30 Billion global industry) U.N. estimates up to 20% of donors were coerced into organ donation via black market Affects at least 17,000 s brought to the United

2018 FP Notebook

64. Experiences of maternity care and pregnancy outcomes in women exposed to sexual violence and human trafficking: a qualitative meta-synthesis

Experiences of maternity care and pregnancy outcomes in women exposed to sexual violence and human trafficking: a qualitative meta-synthesis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2018 PROSPERO

65. A systematic review of interventions to support the mental health of survivors of modern slavery and human trafficking

A systematic review of interventions to support the mental health of survivors of modern slavery and human trafficking Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2018 PROSPERO

66. How effective and cost-effective are casework and client support interventions in improving health and social outcomes for victims of modern slavery and human trafficking, asylum seekers and refugees?

How effective and cost-effective are casework and client support interventions in improving health and social outcomes for victims of modern slavery and human trafficking, asylum seekers and refugees? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files

2018 PROSPERO

67. Cross?border Trafficking In Human Beings: Prevention and Intervention Strategies for Reducing Sexual Exploitation Full Text available with Trip Pro

Cross?border Trafficking In Human Beings: Prevention and Intervention Strategies for Reducing Sexual Exploitation Cross‐border Trafficking In Human Beings: Prevention and Intervention Strategies for Reducing Sexual Exploitation - Laan - 2011 - Campbell Systematic Reviews - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term SYSTEMATIC REVIEW Open Access Cross‐border Trafficking In Human Beings (...) )national conventions on human trafficking in the last decade as well as a vast increase in the number of publications on THB and on ways to prevent and suppress it ( ; ). 1.1 DEFINITION OF HUMAN TRAFFICKING In this systematic review cross‐border trafficking is operationalized by following the definition of the United Nations Protocol to Prevent, Suppress and Punish Trafficking in Persons especially Women and Children, supplementing the United Nations convention against Transnational Organized Crime

2011 Campbell Collaboration

68. Would you know human trafficking if you saw it?

Would you know human trafficking if you saw it? Would you know human trafficking if you saw it? Would you know human trafficking if you saw it? | | May 30, 2018 8 Shares He looked tired and worn down, more so than many of the other patients I had seen that day. He didn’t speak English and I did not speak his language, but I could feel his anxiety as it filled the exam room. One of my employees translated, in fact, what his “boss” was telling us. The boss was worried that he was more tired than (...) was too tired after his long day of work and his family was depending on him. He didn’t want to disappoint them. At the time, I didn’t realize it but he met the criteria for being considered a human trafficking victim. He had been brought from his country with the promise of a good job but rather found himself trapped in a situation that he could not walk away from. He was not paid what had been promised and the job he was given was far away from anything that had lured him to the US. From the time he

2018 KevinMD blog

69. Barcoding of GPCR Trafficking and Signaling Through the Various Trafficking Roadmaps by Compartmentalized Signaling Networks Full Text available with Trip Pro

itinerary of these GPCR. While endosomal SNX27, retromer/WASH complexes and actin were required for efficient sorting and budding of all these GPCR, additional proteins were required for GPCR sorting via the second "barcode". Here we will review recent developments in GPCR trafficking in general and the human β1-adrenergic receptor in particular across the various trafficking roadmaps. In addition, we will discuss the role of GPCR trafficking in regulating endosomal GPCR signaling, which promote (...) Barcoding of GPCR Trafficking and Signaling Through the Various Trafficking Roadmaps by Compartmentalized Signaling Networks Proper signaling by G protein coupled receptors (GPCR) is dependent on the specific repertoire of transducing, enzymatic and regulatory kinases and phosphatases that shape its signaling output. Activation and signaling of the GPCR through its cognate G protein is impacted by G protein-coupled receptor kinase (GRK)-imprinted "barcodes" that recruit β-arrestins to regulate

2017 Cellular signalling

70. Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor–mediated inflammatory responses Full Text available with Trip Pro

Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor–mediated inflammatory responses Subcellular compartmentalization of receptor signaling is an emerging principle in innate immunity. However, the functional integration of receptor signaling pathways into membrane trafficking routes and its physiological relevance for immune responses is still largely unclear. In this study, using Lyst-mutant beige mice, we show that lysosomal trafficking regulator Lyst links (...) maturation, resulting in a failure to form an activation-induced Rab7+ endosomal/phagosomal compartment. This specific Rab7+ compartment was further demonstrated to serve as a major site for active TRIF signaling events, thus linking phagosomal maturation to specific TLR signaling pathways. The immunoregulatory role of Lyst on TLR signaling pathways was confirmed in human cells by CRISPR/Cas9-mediated gene inactivation. As mutations in LYST cause human Chédiak-Higashi syndrome, a severe immunodeficiency

2017 The Journal of experimental medicine

71. Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. Full Text available with Trip Pro

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines. HERG channels are also expressed in a variety of cancer cells and control cell proliferation and apoptosis. Hypoxia, a common feature of tumors, alters gating properties of hERG currents in SH-SY5Y neuroblastoma cells. In the present study, we examined (...) the molecular mechanisms and physiological significance underlying hypoxia-altered hERG currents in SH-SY5Y neuroblastoma cells. Hypoxia reduced the surface expression of 150kDa form and increased 125kDa form of hERG protein expression in the endoplasmic reticulum (ER). The changes in protein expression were associated with ~50% decrease in hERG potassium conductance. ER retention of hERG 125kDa form by CH was due to defective trafficking and was rescued by exposing cells to hypoxia at low temperatures

2019 PLoS ONE

72. Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathies. Full Text available with Trip Pro

Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathies. Tauopathies represent a heterogeneous group of neurodegenerative disorders characterized by abnormal deposition of the hyperphosphorylated microtubule-associated protein tau. Chronic neuroinflammation in tauopathies is driven by glial cells that potentially trigger the disruption of the blood-brain barrier (BBB). Pro-inflammatory signaling molecules such as cytokines, chemokines (...) , VCAM-1, and selectins. We suggest that the compensation of BBB in the diseased brain represents a crucial factor in neurodegeneration of human tauopathies.

2019 PLoS ONE

73. Caring for trafficked and unidentified patients in the EHR shadows: Shining a light by sharing the data. Full Text available with Trip Pro

Caring for trafficked and unidentified patients in the EHR shadows: Shining a light by sharing the data. Healthcare providers have key roles in the prevention of, detection of, and interventions for human trafficking. Yet caring for trafficked persons is particularly challenging: patients whose identities are unknown, unreliable, or false could receive subpar care from providers delivering care in a vacuum of relevant information. The application of precision medicine principles and integration (...) -structured interviews with key informants, which informed a subsequent broad survey of physicians and registered nurses.Our findings support the perception that trafficked persons obtain care yet remain unnoticed or undocumented in the electronic health record. Our survey findings further reveal that healthcare providers remain largely unaware of human trafficking issues and are inadequately prepared to provide patient-centered care for trafficked and unidentified patients.Meaningful efforts to design

2019 PLoS ONE

74. An endothelial microRNA-1-regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis. Full Text available with Trip Pro

An endothelial microRNA-1-regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis. Airway eosinophilia is a prominent feature of asthma and chronic rhinosinusitis (CRS), and the endothelium plays a key role in eosinophil trafficking. To date, microRNA-1 (miR-1) is the only microRNA known to be regulated in the lung endothelium in asthma models.We sought to determine the role of endothelial miR-1 in allergic airway inflammation.We measured microRNA and mRNA (...) -selectin levels were measured by using flow cytometry.Serum miR-1 levels had inverse correlations with sputum eosinophilia, airway obstruction, and number of hospitalizations in asthmatic patients and sinonasal tissue eosinophilia in patients with CRS. IL-13 stimulation decreased miR-1 levels in human lung endothelium. Endothelium-specific overexpression of miR-1 reduced airway eosinophilia and asthma phenotypes in murine models and inhibited IL-13-induced eosinophil binding to endothelial cells. miR-1

2020 Journal of Allergy and Clinical Immunology

75. Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling. Full Text available with Trip Pro

caveolin vesicle-mediated trafficking of the IL1R1, which in turn determines the responsiveness to IL-1. Administration of antibodies (Ab) against the dimerisation domain of sdc4, thus, strongly reduces the expression IL1R1 on arthritic fibroblasts both in vitro and an animal model of human RA.Collectively, our data suggest that Ab that specifically inhibit sdc4 dimerisation may support anti-IL-1 strategies in diseases such as inflammatory arthritis.© Author(s) (or their employer(s)) 2020 (...) Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling. Syndecan-4 (sdc4) is a cell-anchored proteoglycan that consists of a transmembrane core protein and glucosaminoglycan (GAG) side chains. Binding of soluble factors to the GAG chains of sdc4 may result in the dimerisation of sdc4 and the initiation of downstream signalling cascades. However, the question of how sdc4 dimerisation and signalling affects the response of cells

2020 Annals of the rheumatic diseases

76. Review of Published Curriculum on Sex Trafficking for Undergraduate Medical Trainees. (Abstract)

of MEDLINE, PubMed, Embase, MedEdPORTAL, Google Scholar, and Google was conducted in December 2018 to January 2019 using the search terms: human trafficking OR sex traffic OR sex violence OR sex work OR sex exploitation OR child prostitution AND education, medical, undergraduate OR students, medical OR medical student or medical education OR education, medical. The inclusion criteria included informational educational materials for medical students on sex trafficking. Studies were excluded for: non (...) Review of Published Curriculum on Sex Trafficking for Undergraduate Medical Trainees. Educational councils and medical societies recommend that medical students learn to recognize and care for victims of sex trafficking. Previous research has found that healthcare providers are one of the few professionals to interact with sex trafficking victims during exploitation. This review evaluates currently published curricular and extracurricular U.S. medical education resources. A literature review

2020 American journal of preventive medicine

77. Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication Full Text available with Trip Pro

Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication Human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type 1 (HTLV-1) are complex retroviruses mainly infecting CD4(+) T lymphocytes. In addition, antigen-presenting cells such as dendritic cells (DCs) are targeted in vivo by both viruses, although to a lesser extent. Interaction (...) of HIV-1 with DCs plays a key role in viral dissemination from the mucosa to CD4(+) T lymphocytes present in lymphoid organs. While similar mechanisms may occur for HTLV-1 as well, most HTLV-1 data were obtained from T-cell studies, and little is known regarding the trafficking of this virus in DCs. We first compared the efficiency of cell-free versus cell-associated viral sources of both retroviruses at infecting DCs. We showed that both HIV-1 and HTLV-1 cell-free particles are poorly efficient

2016 Journal of virology

78. Disrupted ER‐to‐Golgi trafficking underlies anti‐HIV drugs and alcohol‐induced cellular stress and hepatic injury Full Text available with Trip Pro

Disrupted ER‐to‐Golgi trafficking underlies anti‐HIV drugs and alcohol‐induced cellular stress and hepatic injury Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) are involved in anti-human immunodeficiency virus (HIV) drugs and alcohol-induced liver disease in a significant number of patients infected with HIV. However, the precise mechanism by which the drugs and alcohol cause ER stress remains elusive. We found that ritonavir-boosted lopinavir (RL) activated two (...) dislocation and ER stress. Moreover, the coat protein complex II (COPII) complexes that mediate ER-to-Golgi trafficking accumulated in the RL-treated liver cells; this was not due to interference of RL with the initial assembly of the COPII complexes. RL also inhibited Golgi fragmentation and reassembly induced by short treatment and removal of brefeldin A.Our study indicates that ER-to-Golgi trafficking is disrupted by anti-HIV drugs and/or alcohol, and this contributes to subsequent ER stress

2017 Hepatology communications

79. Trafficking of Vietnamese women and girls for marriage in China Full Text available with Trip Pro

of individuals from five services in Vietnam were invited to be interviewed within the first 2 weeks of admission. It is part of a wider dataset for research on the health of men, women, and children in post-trafficking services in Cambodia, Thailand, and Vietnam, the largest study to date on human trafficking and health. We calculated proportions for all variables and conducted bivariate analyses using Fisher Exact Tests for their associations with mental health disorders symptoms.Before leaving home, 31 (...) Trafficking of Vietnamese women and girls for marriage in China Bride-trafficking has been a growing phenomenon in Southeast Asia, particularly in China, where one-child policies have resulted in demographic imbalances favoring males. Yet, empirical evidence about women and girls sold into marriage in China remains sparse.This study describes the experiences of 51 Vietnamese women and girls as young as 14 in post-trafficking services who were sold into marriage in China. A consecutive sample

2017 Global health research and policy

80. A specialized pathway for erythroid iron delivery through lysosomal trafficking of transferrin receptor 2 Full Text available with Trip Pro

A specialized pathway for erythroid iron delivery through lysosomal trafficking of transferrin receptor 2 Erythroid progenitors are the largest consumers of iron in the human body. In these cells, a high flux of iron must reach the mitochondrial matrix to form sufficient heme to support hemoglobinization. Canonical erythroid iron trafficking occurs via the first transferrin receptor (TfR1)-mediated endocytosis of diferric-transferrin into recycling endosomes, where ferric iron is released (...) in mitochondrial maintenance. Human TFR2 shares a lineage- and stage-specific expression pattern with MCOLN1, encoding a lysosomal iron channel, and MFN2, encoding a protein mediating organelle contacts. Functional studies reveal these latter factors to be involved in mitochondrial regulation and erythroid differentiation, with Mfn2 required for mitochondrial-lysosomal contacts. These findings identify a new pathway for erythroid iron trafficking involving TfR2-mediated lysosomal delivery followed

2017 Blood advances

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