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Human Trafficking

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3381. Intra- and Intercellular Trafficking of the Foamy Virus Auxiliary Bet Protein Full Text available with Trip Pro

Intra- and Intercellular Trafficking of the Foamy Virus Auxiliary Bet Protein The Bet protein of foamy viruses (FVs) is an auxiliary protein encoded by the 3' end of the viral genome. Although its function during the viral replication cycle is still unknown, Bet seems to play a key role in the establishment and/or maintenance of viral persistence, representing the predominant viral protein detected during chronic infection. To clarify the function of this viral protein, the subcellular (...) distribution of Bet from the prototypic human foamy virus (HFV) was examined. We report here that this protein is distributed in both the cytoplasm and the nucleus of HFV-infected or Bet-transfected cells. The nuclear targeting results from the presence of a bipartite nuclear localization signal at the C-terminal region, sufficient to direct heterologous reporter proteins to the nucleus. Since HFV Bet spreads between cells, we show here that the secreted protein targets the nuclei of recipient cells. HFV

2002 Journal of virology

3382. Distinct Trafficking Pathways Mediate Nef-Induced and Clathrin-Dependent Major Histocompatibility Complex Class I Down-Regulation Full Text available with Trip Pro

Distinct Trafficking Pathways Mediate Nef-Induced and Clathrin-Dependent Major Histocompatibility Complex Class I Down-Regulation The human immunodeficiency virus type 1 Nef protein alters the post-Golgi stages of major histocompatibility complex class I (MHC-I) biogenesis. Presumed mechanisms involve the disclosure of a cryptic tyrosine-based sorting signal (YSQA) located in the cytoplasmic tail of HLA-A and -B heavy chains. We changed this signal for a prototypic sorting motif (YSQI or YSQL (...) ). Modified HLA-A2 molecules, termed A2-endo, displayed constitutively low surface levels and accumulated in a region close to or within the Golgi apparatus, a behavior reminiscent of wild-type HLA-A2 in Nef-expressing cells. However, several lines of evidence indicate that the action of prototypic signals on MHC-I trafficking differs from that of Nef. Internalization of surface A2-endo was more rapid and was associated with efficient recycling to the surface. A transdominant-negative mutant of dynamin-1

2000 Journal of virology

3383. Trafficking of Varicella-Zoster Virus Glycoprotein gI: T338-Dependent Retention in the trans-Golgi Network, Secretion, and Mannose 6-Phosphate-Inhibitable Uptake of the Ectodomain Full Text available with Trip Pro

Trafficking of Varicella-Zoster Virus Glycoprotein gI: T338-Dependent Retention in the trans-Golgi Network, Secretion, and Mannose 6-Phosphate-Inhibitable Uptake of the Ectodomain The trans-Golgi network (TGN) is putatively the site where varicella-zoster virus is enveloped. gE is targeted to the TGN by selective retrieval from the plasmalemma in response to signaling sequences in its endodomain. gI lacks these sequences but forms a complex with gE. We now find that gI is targeted to the TGN (...) and plasma membrane when expressed in Cos-7 cells; nevertheless, surface labeling revealed that gI is not retrieved from the plasma membrane. TGN targeting of gI depended on the T(338) of its endodomain and was lost when T(338) was deleted or mutated to A, S, or D. The endodomain of gI was sufficient, if it contained T(338), to target a fusion protein containing the ectodomain of the human interleukin-2 receptor to the TGN. A truncated protein consisting only of the gI ectodomain was secreted and taken

2000 Journal of virology

3384. Intracellular Trafficking of Adeno-Associated Virus Vectors: Routing to the Late Endosomal Compartment and Proteasome Degradation Full Text available with Trip Pro

to the nucleus. Human cell lines were transduced with a recombinant AAV (rAAV) carrying a reporter gene (luciferase or green fluorescent protein) in the presence of agents that affect trafficking. The effects of bafilomycin A(1), brefeldin A, and MG-132 were measured. These drugs act at the level of endosome acidification, early-to-late endosome transition, and proteasome activity, respectively. We observed that the transducing virions needed to be routed as far as the late endosomal compartment (...) Intracellular Trafficking of Adeno-Associated Virus Vectors: Routing to the Late Endosomal Compartment and Proteasome Degradation The early steps of adeno-associated virus (AAV) infection involve attachment to a variety of cell surface receptors (heparan sulfate, integrins, and fibroblast growth factor receptor 1) followed by clathrin-dependent or independent internalization. Here we have studied the subsequent intracellular trafficking of AAV particles from the endosomal compartment

2001 Journal of virology

3385. Trafficking of Phosphatidylinositol 3-Phosphate from the trans-Golgi Network to the Lumen of the Central Vacuole in Plant Cells Full Text available with Trip Pro

Trafficking of Phosphatidylinositol 3-Phosphate from the trans-Golgi Network to the Lumen of the Central Vacuole in Plant Cells Very limited information is available on the role of phosphatidylinositol 3-phosphate (PI[3]P) in vesicle trafficking in plant cells. To investigate the role of PI(3)P during the vesicle trafficking in plant cells, we exploited the PI(3)P-specific binding property of the endosome binding domain (EBD) (amino acids 1257 to 1411) of human early endosome antigen 1, which (...) in addition to the zinc finger motif. Overexpression of GFP:EBD inhibited vacuolar trafficking of sporamin but not trafficking of H(+)-ATPase to the plasma membrane. On the basis of these results, we propose that the trafficking of GFP:EBD reflects that of PI(3)P and that PI(3)P synthesized at the trans-Golgi network is transported to the vacuole through the prevacuolar compartment for degradation in plant cells.

2001 The Plant cell

3386. Evidence of Rab3A Expression, Regulation of Vesicle Trafficking, and Cellular Secretion in Response to Heregulin in Mammary Epithelial Cells Full Text available with Trip Pro

Evidence of Rab3A Expression, Regulation of Vesicle Trafficking, and Cellular Secretion in Response to Heregulin in Mammary Epithelial Cells Heregulin beta1 (HRG), a combinatorial ligand for human growth factor receptors 3 and 4, is a regulatory polypeptide that promotes the differentiation of mammary epithelial cells into secretory lobuloalveoli. Emerging evidence suggests that the processes of secretory pathways, such as biogenesis and trafficking of vesicles in neurons and adipose cells (...) , are regulated by the Rab family of low-molecular-weight GTPases. In this study, we identified Rab3A as a gene product induced by HRG. Full-length Rab3A was cloned from a mammary gland cDNA library. We demonstrated that HRG stimulation of human breast cancer cells and normal breast epithelial cells induces the expression of Rab3A protein and mRNA in a cycloheximide-independent manner. HRG-mediated induction of Rab3A expression was blocked by an inhibitor of phosphatidylinositol 3-kinase but not by inhibitors

2000 Molecular and cellular biology

3387. Membrane trafficking and the cytoskeleton: an integrated view. ASCB/EMBO/Dudley Wright Summer Research Conference, Santa Maria Imbaro, Italy, June 26-30, 1999. Full Text available with Trip Pro

Membrane trafficking and the cytoskeleton: an integrated view. ASCB/EMBO/Dudley Wright Summer Research Conference, Santa Maria Imbaro, Italy, June 26-30, 1999. 10523289 1999 12 06 2018 12 01 0261-4189 18 20 1999 Oct 15 The EMBO journal EMBO J. Membrane trafficking and the cytoskeleton: an integrated view. ASCB/EMBO/Dudley Wright Summer Research Conference, Santa Maria Imbaro, Italy, June 26-30, 1999. 5447-52 Sloboda R D RD Department of Biological Sciences, Dartmouth College, Hanover, NH 03755 (...) and Marine Biological Laboratory, 7 Water Street, Woods Hole, MA 02543, USA. rds@dartmouth.edu eng Congress Research Support, Non-U.S. Gov't England EMBO J 8208664 0261-4189 0 Membrane Proteins 0 Molecular Motor Proteins IM EMBO J 1999 Nov 15;18(22):6582 Alzheimer Disease etiology Animals Cytoskeleton physiology Endocytosis physiology Europe Humans Intracellular Membranes physiology Italy Listeriosis etiology Membrane Proteins physiology Molecular Motor Proteins physiology Societies, Scientific United

1999 The EMBO journal

3388. In Vitro Studies on the Trafficking of Dendritic Cells Through Endothelial Cells and Extra-Cellular Matrix Full Text available with Trip Pro

lymphocytes takes place. Thus their correct functioning as APC involves localization in tissues and trafficking via the lymph or blood to lymphoid organs. In the present study we have investigated the ability of DC to interact in vitro with human vascular endothelial cells (EC) and extracellular matrix (ECM). DC are differentiated from monocytes by in vitro exposure to GM-CSF and IL-13 for 7 days. In adhesion assays a considerable proportion of DC binds to resting EC monolayers and this adhesion (...) In Vitro Studies on the Trafficking of Dendritic Cells Through Endothelial Cells and Extra-Cellular Matrix Dendritic cells (DC) are antigen presenting cells (APC) with the unique ability to initiate an immune response. Immature DC are localized in peripheral tissues where they exert a sentinel function for incoming antigens (Ag). After Ag capture and exposure to inflammatory stimuli DC undergo maturation and migrate to regional lymph nodes where the presentation of antigenic peptides to T

2000 Developmental immunology

3389. A tyrosine-based motif and a casein kinase II phosphorylation site regulate the intracellular trafficking of the varicella-zoster virus glycoprotein I, a protein localized in the trans-Golgi network. Full Text available with Trip Pro

A tyrosine-based motif and a casein kinase II phosphorylation site regulate the intracellular trafficking of the varicella-zoster virus glycoprotein I, a protein localized in the trans-Golgi network. We have studied the intracellular trafficking of the envelope glycoprotein I (gpI) of the varicella-zoster virus, a human herpes virus whose assembly is believed to occur in the trans-Golgi network (TGN) and/or in endocytic compartments. When expressed in HeLa cells in the absence of additional (...) intracellular compartments at steady-state, follow similar trafficking pathways and share similar sorting mechanisms.

1996 The EMBO journal

3390. Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells. Full Text available with Trip Pro

embryonic retina cells, and carp epithelial cells were fluorescently labeled under these conditions. GFP was distributed uniformly throughout the cytoplasm and nucleus independent of cell type examined. When GFP was fused to PML protooncogene product, fluorescence was detected in a unique nuclear organelle pattern indistinguishable from that of PML protein, showing the potential use of GFP as a fluorescent tag. To analyze both function and intracellular trafficking of proteins fused to GFP, a GFP-human (...) Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells. The localization, trafficking, and fluorescence of Aequorea green fluorescent protein (GFP) in cultured vertebrate cells transiently transfected with GFP cDNA were studied. Fluorescence of GFP in UV light was found to be strongest when cells were incubated at 30 degrees C but was barely visible at an incubation temperature of 37 degrees C. COS-1 cells, primary chicken

1995 Proceedings of the National Academy of Sciences of the United States of America

3391. Trafficking of lysosomal enzymes in normal and disease states. Full Text available with Trip Pro

Trafficking of lysosomal enzymes in normal and disease states. 3003148 1986 03 03 2018 11 13 0021-9738 77 1 1986 Jan The Journal of clinical investigation J. Clin. Invest. Trafficking of lysosomal enzymes in normal and disease states. 1-6 Kornfeld S S eng R01 CA 08759 CA NCI NIH HHS United States Journal Article Research Support, U.S. Gov't, P.H.S. Review United States J Clin Invest 7802877 0021-9738 0 Enzyme Precursors 0 Lectins, C-Type 0 Mannose-Binding Lectins 0 Mannosephosphates 0 (...) Oligosaccharides 0 Receptors, Cell Surface 0 Receptors, Immunologic 0 mannose receptor 3672-15-9 mannose-6-phosphate EC 2.7.- Phosphotransferases AIM IM Biological Transport, Active Endoplasmic Reticulum enzymology metabolism Enzyme Precursors biosynthesis Glycogen Storage Disease enzymology genetics metabolism Golgi Apparatus metabolism Histocytochemistry Humans Lectins, C-Type Lysosomes enzymology metabolism Mannose-Binding Lectins Mannosephosphates metabolism Oligosaccharides metabolism Phosphotransferases

1986 Journal of Clinical Investigation

3392. Pharmacoimmunodynamics of Methylprednisolone: Trafficking of Helper T Lymphocytes Full Text available with Trip Pro

Pharmacoimmunodynamics of Methylprednisolone: Trafficking of Helper T Lymphocytes A two-compartment closed model was used to characterize the cell trafficking behavior of helper T cells in response to various single doses of methylprednisolone. Steroids are assumed to inhibit the circadian-determined cell return from extravascular sites to blood in a classic inhibitory pattern reflected by an IC50. The rate of cell efflux from tissues is modeled with a cosine function having a period of 24 hr (...) and a maximum at about 1 AM. Nonlinear least-squares regression employing differential equations was used to analyze helper T-cell data from three human studies from our laboratory. The IC50 value of methylprednisolone of 12-19 ng/ml approximates receptor KD values. Simulations were performed to demonstrate the log-linear role of steroid dose or AUC on the integral of effect of helper T cells over a wide range of methylprednisolone doses. This pharmacodynamic model allows flexibility for characterizing any

1992 Journal of Pharmacokinetics and Biopharmaceutics

3393. Firearm injuries among Virginia juvenile drug traffickers, 1992 through 1994. Full Text available with Trip Pro

Firearm injuries among Virginia juvenile drug traffickers, 1992 through 1994. 8629738 1996 06 26 2018 11 13 0090-0036 86 5 1996 May American journal of public health Am J Public Health Firearm injuries among Virginia juvenile drug traffickers, 1992 through 1994. 751-2 McLaughlin C R CR Reiner S M SM Smith B W BW Waite D E DE Reams P N PN Joost T F TF Gervin A S AS eng Comparative Study Letter United States Am J Public Health 1254074 0090-0036 0 Street Drugs AIM IM Adolescent African Americans (...) Crime Firearms statistics & numerical data Humans Male Prevalence Retrospective Studies Risk Factors Street Drugs Virginia epidemiology Wounds, Gunshot epidemiology 1996 5 1 1996 5 1 0 1 1996 5 1 0 0 ppublish 8629738 PMC1380497 JAMA. 1992 Jun 10;267(22):3054-8 1514955 JAMA. 1992 Jun 10;267(22):3071-2 1588723 JAMA. 1995 Feb 8;273(6):477-82 7837366 J Adolesc Health. 1993 May;14(3):214-9 8323933 JAMA. 1992 Jun 10;267(22):3075-6 1290487

1996 American Journal of Public Health

3394. Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway. Full Text available with Trip Pro

Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway. Although Streptococcus pneumoniae is a major cause of meningitis in humans, the mechanisms underlying its traversal from the circulation across the blood-brain barrier (BBB) into the subarachnoid space are poorly understood. One mechanism might involve transcytosis through microvascular endothelial cells. In this study we investigated the ability of pneumococci to invade (...) and transmigrate through monolayers of rat and human brain microvascular endothelial cells (BMEC). Significant variability was found in the invasive capacity of clinical isolates. Phase variation to the transparent phenotype increased invasion as much as 6-fold and loss of capsule approximately 200-fold. Invasion of transparent pneumococci required choline in the pneumococcal cell wall, and invasion was partially inhibited by antagonists of the platelet-activating factor (PAF) receptor on the BMEC. Pneumococci

1998 Journal of Clinical Investigation

3395. Multiple signals regulate the intracellular trafficking of HLA-DM in B-lymphoblastoid cells. Full Text available with Trip Pro

Multiple signals regulate the intracellular trafficking of HLA-DM in B-lymphoblastoid cells. Peptide loading by major histocompatibility complex (MHC) class II molecules occurs in the endocytic pathway and is critically dependent upon the function of the class II-related molecule human leucocyte antigen-DM (HLA-DM). We have previously shown that a tyrosine-based lysosomal targeting signal present in the cytoplasmic tail of DMB has the capacity to target HLA-DM to peptide-loading compartments (...) ; and accessing lysosomal peptide-loading compartments. By transient transfection in HeLa cells we show that Ii is able to compensate for loss of DMB-encoded targeting information. These data imply that in cells expressing physiological levels of class II, Ii and DM, there is sufficient association with Ii to direct the majority of DM into the endocytic pathway. Thus MHC class II and HLA-DM may follow similar intracellular trafficking pathways on route to antigen-processing compartments.

1998 Immunology

3396. Sequence Analysis of LRPPRC and Its SEC1 Domain Interaction Partners Suggests Roles in Cytoskeletal Organization, Vesicular Trafficking, Nucleocytosolic Shuttling and Chromosome Activity Full Text available with Trip Pro

Sequence Analysis of LRPPRC and Its SEC1 Domain Interaction Partners Suggests Roles in Cytoskeletal Organization, Vesicular Trafficking, Nucleocytosolic Shuttling and Chromosome Activity LRPPRC (originally called LRP130) is an intracellular, 130-kD, leucine-rich protein that copurifies with the fibroblast growth factor receptor from liver cell extracts and has been detected in diverse multiprotein complexes from the cell membrane, cytoskeleton, and nucleus. Here we report results of a sequence (...) homology analysis of LRPPRC and its SEC1 domain interactive partners. We found that 23 copies of tandem repeats that are similar to pentatricopeptide, tetratricopeptide, and huntingtin-elongation A subunit-TOR repeats characterize the LRPPRC sequence. The amino terminus exhibits multiple copies of leucine-rich nuclear transport signals followed by ENTH, DUF28, and SEC1 homology domains. We used the SEC1 domain to trap interactive partners expressed from a human liver cDNA library. Interactive C19ORF5

2002 Genomics

3397. Kidney trafficking is "big business," says Council of Europe Full Text available with Trip Pro

Kidney trafficking is "big business," says Council of Europe 12896927 2003 08 22 2012 03 06 1756-1833 327 7409 2003 Aug 02 BMJ (Clinical research ed.) BMJ Kidney trafficking is "big business," says Council of Europe. 249 Kovac Carl C eng News England BMJ 8900488 0959-8138 AIM IM Europe Humans Kidney Transplantation economics Tissue and Organ Procurement economics 2003 8 5 5 0 2003 8 23 5 0 2003 8 5 5 0 ppublish 12896927 10.1136/bmj.327.7409.249-a 327/7409/249-a PMC1323242

2003 BMJ : British Medical Journal

3398. Correction of an enzyme trafficking defect in hereditary kidney stone disease in vitro. Full Text available with Trip Pro

Correction of an enzyme trafficking defect in hereditary kidney stone disease in vitro. In normal human hepatocytes, the intermediary-metabolic enzyme alanine:glyoxylate aminotransferase (AGT) is located within the peroxisomes. However, in approx. one-third of patients suffering from the hereditary kidney stone disease primary hyperoxaluria type 1, AGT is mistargeted to the mitochondria. AGT mistargeting results from the synergistic interaction between a common P11L (Pro11-->Leu) polymorphism (...) requirements of the two protein trafficking pathways and the formulation of possible treatment strategies for primary hyperoxaluria type 1.

2003 Biochemical Journal

3399. Police uncover large scale organ trafficking in Punjab Full Text available with Trip Pro

Police uncover large scale organ trafficking in Punjab 12543823 2003 02 20 2012 03 06 1756-1833 326 7382 2003 Jan 25 BMJ (Clinical research ed.) BMJ Police uncover large scale organ trafficking in Punjab. 180 Kumar Sanjay S eng News England BMJ 8900488 0959-8138 AIM E IM Commerce Crime Humans India Physician's Role Tissue and Organ Procurement economics statistics & numerical data 107645 Health Care and Public Health KIE Bib: fraud and misconduct; organ and tissue donation 2003 1 25 4 0 2003 2

2003 BMJ : British Medical Journal

3400. A copper treatable Menkes disease mutation associated with defective trafficking of a functional Menkes copper ATPase Full Text available with Trip Pro

A copper treatable Menkes disease mutation associated with defective trafficking of a functional Menkes copper ATPase 12676902 2003 04 17 2017 11 16 1468-6244 40 4 2003 Apr Journal of medical genetics J. Med. Genet. A copper treatable Menkes disease mutation associated with defective trafficking of a functional Menkes copper ATPase. 290-5 Kim B-E BE Smith K K Petris M J MJ eng DK59893 DK NIDDK NIH HHS United States Letter Research Support, U.S. Gov't, P.H.S. England J Med Genet 2985087R 0022 (...) -2593 0 Cation Transport Proteins 0 Recombinant Fusion Proteins 20350-15-6 Brefeldin A 789U1901C5 Copper EC 3.6.1.- Adenosine Triphosphatases EC 3.6.3.54 ATP7A protein, human EC 3.6.3.54 Copper-transporting ATPases IM Adenosine Triphosphatases genetics metabolism Biological Transport drug effects genetics Brefeldin A pharmacology Cation Transport Proteins genetics metabolism Cell Line Copper metabolism therapeutic use Copper-transporting ATPases Golgi Apparatus metabolism Humans Menkes Kinky Hair

2003 Journal of Medical Genetics

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