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Human Trafficking

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3321. Trafficking defects of the Southeast Asian ovalocytosis deletion mutant of anion exchanger 1 membrane proteins (Full text)

Trafficking defects of the Southeast Asian ovalocytosis deletion mutant of anion exchanger 1 membrane proteins Human AE1 (anion exchanger 1) is a membrane glycoprotein found in erythrocytes and as a truncated form (kAE1) in the BLM (basolateral membrane) of a-intercalated cells of the distal nephron, where they carry out electroneutral chloride/bicarbonate exchange. SAO (Southeast Asian ovalocytosis) is a dominant inherited haematological condition arising from deletion of Ala400-Ala408 in AE1 (...) , resulting in a misfolded and transport-inactive protein present in the ovalocyte membrane. Heterozygotes with SAO are able to acidify their urine, without symptoms of dRTA (distal renal tubular acidosis) that can be associated with mutations in kAE1. We examined the effect of the SAO deletion on stability and trafficking of AE1 and kAE1 in transfected HEK-293 (human embryonic kidney) cells and kAE1 in MDCK (Madin-Darby canine kidney) epithelial cells. In HEK-293 cells, expression levels and stabilities

2005 Biochemical Journal PubMed abstract

3322. Sequential Actions of Myotubularin Lipid Phosphatases Regulate Endosomal PI(3)P and Growth Factor Receptor Trafficking (Full text)

Sequential Actions of Myotubularin Lipid Phosphatases Regulate Endosomal PI(3)P and Growth Factor Receptor Trafficking Two different human diseases, X-linked myotubular myopathy and Charcot-Marie-Tooth disease, result from mutant MTM1 or MTMR2 lipid phosphatases. Although events involved in endosomal PI(3)P and PI(3,5)P(2) synthesis are well established and pivotal in receptor signaling and degradation, enzymes involved in phosphoinositide degradation and their roles in trafficking (...) providing a molecular rationale for related human myo- and neuropathies.

2008 Molecular biology of the cell PubMed abstract

3323. Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders (Full text)

Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders Ras-associated binding (Rab) proteins and Rab-associated proteins are key regulators of vesicle transport, which is essential for the delivery of proteins to specific intracellular locations. More than 60 human Rab proteins have been identified, and their function has been shown to depend on their interaction with different Rab-associated proteins regulating Rab activation, post (...) -translational modification and intracellular localization. The number of known inherited disorders of vesicle trafficking due to Rab cycle defects has increased substantially during the past decade. This review describes the important role played by Rab proteins in a number of rare monogenic diseases as well as common multifactorial human ones. Although the clinical phenotype in these monogenic inherited diseases is highly variable and dependent on the type of tissue in which the defective Rab or its

2008 European journal of pediatrics PubMed abstract

3324. Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development (Full text)

Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development Type I diabetes (TID) is an autoimmune disease resulting from destruction of the insulin-producing beta-cells by autoreactive T cells. Studies have shown that polymorphisms of chemokine CXCL12 gene are linked to TID in humans. In non-obese diabetic (NOD) mice, which are predisposed to develop the disease, reduction of CXCL12 level leads to significant (...) , mobilizes T cells and HSC from the bone marrow to the periphery, concomitantly inhibits insulitis and delays the onset of diabetes.These results suggest that the elevated CXCL12 expression promotes TID in NOD mice by altering T cell and hematopoietic stem cell trafficking. The findings highlight the potential usefulness of AMD3100 to treat or prevent TID in humans.

2008 BMC immunology PubMed abstract

3325. Internalization and trafficking of guanylyl (guanylate) cyclase/natriuretic peptide receptor A is regulated by an acidic tyrosine-based cytoplasmic motif GDAY (Full text)

Internalization and trafficking of guanylyl (guanylate) cyclase/natriuretic peptide receptor A is regulated by an acidic tyrosine-based cytoplasmic motif GDAY We have identified a GDAY motif in the C-terminal domain of guanylyl cyclase (guanylate cyclase)/NPRA (natriuretic peptide receptor A) sequence, which serves a dual role as an internalization signal and a recycling signal. To delineate the role of the GDAY motif in receptor internalization and sequestration, we mutated Gly920, Asp921 (...) and Tyr923 to alanine residues (GDAY/AAAA) in the NPRA cDNA sequence. The cDNAs encoding wild-type and mutant receptors were transfected in HEK-293 cells (human embryonic kidney 293 cells). The internalization studies of ligand-receptor complexes revealed that endocytosis of 125I-ANP by HEK-293 cells expressing G920A, Y923A or GDAY/AAAA mutant receptor was decreased by almost 50% (P<0.001) when compared with cells expressing the wild-type receptor. However, the effect of D921A mutation on receptor

2005 Biochemical Journal PubMed abstract

3326. Trafficking and health (Full text)

Trafficking and health 15178619 2004 06 18 2018 11 13 1756-1833 328 7452 2004 Jun 05 BMJ (Clinical research ed.) BMJ Trafficking and health. 1369-71 Busza Joanna J Centre for Population Studies, London School of Hygiene and Tropical Medicine, London WC1B 3DP. joanna.busza@lshtm.ac.uk Castle Sarah S Diarra Aisse A eng Journal Article England BMJ 8900488 0959-8138 AIM IM Cambodia Child Child Abuse Employment legislation & jurisprudence statistics & numerical data Female Health Policy Health (...) Status Humans Mali Risk-Taking Sex Work legislation & jurisprudence statistics & numerical data Transients and Migrants legislation & jurisprudence statistics & numerical data Vietnam 2004 6 5 5 0 2004 6 24 5 0 2004 6 5 5 0 ppublish 15178619 10.1136/bmj.328.7452.1369 328/7452/1369 PMC420297 Lancet. 2003 Jun 7;361(9373):1983 12801757 Reprod Health Matters. 2001 May;9(17):72-81 11468849

2004 BMJ : British Medical Journal PubMed abstract

3327. Trafficking in women: the Canadian perspective (Full text)

Trafficking in women: the Canadian perspective 15997036 2005 10 14 2008 11 20 1488-2329 173 1 2005 Jul 05 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Trafficking in women: the Canadian perspective. 25-6 Stewart Donna E DE Women's Health Program, University Health Network, University of Toronto, Ont. Gajic-Veljanoski Olga O eng Journal Article Canada CMAJ 9711805 0820-3946 AIM IM Adult Canada Child Child Welfare Commerce Crime Victims Education (...) Emigration and Immigration Female Human Rights Humans Public Policy Social Problems Women's Health 2005 7 6 9 0 2005 10 15 9 0 2005 7 6 9 0 ppublish 15997036 173/1/25 10.1503/cmaj.1041360 PMC1167803

2005 CMAJ : Canadian Medical Association Journal PubMed abstract

3328. Children are main victims of trafficking in Africa (Full text)

Children are main victims of trafficking in Africa 15117787 2004 05 19 2012 03 06 1756-1833 328 7447 2004 May 01 BMJ (Clinical research ed.) BMJ Children are main victims of trafficking in Africa. 1036 Fleck Fiona F eng News England BMJ 8900488 0959-8138 AIM IM Adolescent Africa Child Child Abuse Emigration and Immigration Humans Poverty Social Problems 2004 5 1 5 0 2004 5 20 5 0 2004 5 1 5 0 ppublish 15117787 10.1136/bmj.328.7447.1036-b 328/7447/1036-b PMC403882

2004 BMJ : British Medical Journal PubMed abstract

3329. Mutational analysis of the intramembranous H10 loop of yeast Nhx1 reveals a critical role in ion homoeostasis and vesicle trafficking (Full text)

Mutational analysis of the intramembranous H10 loop of yeast Nhx1 reveals a critical role in ion homoeostasis and vesicle trafficking Yeast Nhx1 [Na+(K+)/H+ exchanger 1] is an intracellular Na+(K+)/H+ exchanger, localizing to the late endosome where it is important for ion homoeostasis and vesicle trafficking. Phylogenetic analysis of NHE (Na+/H+ exchanger) sequences has identified orthologous proteins, including HsNHE6 (human NHE6), HsNHE7 and HsNHE9 of unknown physiological role. These appear (...) distinct from well-studied mammalian plasma membrane isoforms (NHE1-NHE5). To explore the differences between plasma membrane and intracellular NHEs and understand the link between ion homoeostasis and vesicle trafficking, we examined the consequence of replacing residues in the intramembranous H10 loop of Nhx1 between transmembrane segments 9 and 10. The critical role for the carboxy group of Glu355 in ion transport is consistent with the invariance of this residue in all NHEs. Surprisingly, residues

2006 Biochemical Journal PubMed abstract

3330. MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells (Full text)

MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells The hemopexin-like domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) enables MT1-MMP to form oligomers that facilitate the activation of pro-matrix metalloproteinase-2 (pro-MMP-2) at the cell surface. To investigate the role of the MT1-MMP hemopexin domain in the trafficking of MT1-MMP to the cell surface we have examined the activity of two MT1-MT4-MMP (...) chimaeras in which the hemopexin domain of MT1-MMP has been replaced with that of human or mouse MT4-MMP. We show that MT1-MMP bearing the hemopexin domain of MT4-MMP was incapable of activating pro-MMP-2 or degrading gelatin in cell based assays. Furthermore, cell surface biotinylation and indirect immunofluorescence show that transiently expressed MT1-MT4-MMP chimaeras failed to reach the plasma membrane and were retained in the endoplasmic reticulum. Functional activity could be restored by replacing

2006 Biochemical Journal PubMed abstract

3331. Policies to prevent firearm trafficking (Full text)

Policies to prevent firearm trafficking 17446245 2007 09 04 2018 11 13 1353-8047 13 2 2007 Apr Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention Inj. Prev. Policies to prevent firearm trafficking. 78-9 Vernick Jon S JS Johns Hopkins Center for Gun Policy and Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. jvernick@jhsph.edu Webster Daniel W DW eng Journal Article Review England Inj Prev 9510056 1353-8047 IM (...) Commerce legislation & jurisprudence Crime prevention & control Firearms legislation & jurisprudence Humans Licensure Public Policy United States 24 2007 4 21 9 0 2007 9 5 9 0 2007 4 21 9 0 ppublish 17446245 13/2/78 10.1136/ip.2007.015487 PMC2610592 J Urban Health. 2006 Sep;83(5):778-87 16937085 Inj Prev. 2006 Dec;12(6):365-72 17170183 J Law Med Ethics. 2006 Winter;34(4):765-75 17199819 Inj Prev. 1999 Dec;5(4):259-63 10628912 Inj Prev. 2006 Aug;12(4):225-30 16887943 Inj Prev. 2003 Jun;9(2):147-50

2007 Injury Prevention PubMed abstract

3332. Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways (Full text)

Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways Establishing a complete pathway which links occupancy of the insulin receptor to GLUT4 translocation has been particularly elusive because of the complexities involved in studying both signalling and membrane trafficking processes. However, Lienhard's group has now discovered two related molecules that could function in this linking role. These proteins, Tbc1d4 (also known as AS160) and now Tbc1d1, as reported (...) in this issue of the Biochemical Journal, have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt (protein kinase B) and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. The data from Leinhard and colleagues suggest that high levels of Rab GAP activity lead to suppression of GLUT4 translocation and this observation has wide significance and is likely to be relevant to the recent discovery that mutations in the Tbc1d1 gene lead

2007 Biochemical Journal PubMed abstract

3333. Israeli transplant surgeon is arrested for suspected organ trafficking (Full text)

Israeli transplant surgeon is arrested for suspected organ trafficking 17494004 2007 05 22 2012 03 06 1756-1833 334 7601 2007 May 12 BMJ (Clinical research ed.) BMJ Israeli transplant surgeon is arrested for suspected organ trafficking. 973 Sarig Merav M eng News England BMJ 8900488 0959-8138 AIM IM Humans Israel Kidney Transplantation legislation & jurisprudence Tissue and Organ Procurement legislation & jurisprudence 2007 5 12 9 0 2007 5 23 9 0 2007 5 12 9 0 ppublish 17494004 334/7601/973

2007 BMJ : British Medical Journal PubMed abstract

3334. Copper Trafficking and Extracellular Superoxide Dismutase Activity: Kinky Hair, Kinky Vessels (Full text)

Copper Trafficking and Extracellular Superoxide Dismutase Activity: Kinky Hair, Kinky Vessels 18768396 2008 11 13 2018 11 13 1524-4563 52 5 2008 Nov Hypertension (Dallas, Tex. : 1979) Hypertension Copper trafficking and extracellular superoxide dismutase activity: kinky hair, kinky vessels. 811-2 10.1161/HYPERTENSIONAHA.108.117770 Rudolph Volker V Rudolph Tanja K TK Freeman Bruce A BA eng R01 HL058115 HL NHLBI NIH HHS United States R01 HL064937 HL NHLBI NIH HHS United States HL58115 HL NHLBI (...) NIH HHS United States R01 HL64937 HL NHLBI NIH HHS United States Editorial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment 2008 09 02 United States Hypertension 7906255 0194-911X 0 Cation Transport Proteins 31C4KY9ESH Nitric Oxide 789U1901C5 Copper EC 1.15.1.1 Superoxide Dismutase EC 3.6.1.- Adenosine Triphosphatases EC 3.6.3.54 ATP7A protein, human EC 3.6.3.54 Copper-transporting ATPases IM Hypertension. 2008 Nov;52(5):945-51 18768397 Adenosine Triphosphatases

2008 Hypertension PubMed abstract

3335. Prolactin Activation of Srcs Accelerates Receptor Internalization, Modulating Trafficking and Signaling in Breast Cancer Cells. (Full text)

Prolactin Activation of Srcs Accelerates Receptor Internalization, Modulating Trafficking and Signaling in Breast Cancer Cells. Despite the growing body of evidence supporting prolactin (PRL) actions in human breast cancer, little is known regarding PRL regulation of its own receptor in these cells. Ligand-initiated endocytosis is a key process in the regulation of receptor availability and signaling cascades that may lead to oncogenic actions. Although exposure to exogenous PRL accelerates (...) for optimal phosphorylation of ERK1/2 and Akt, but not for Janus kinase 2 or signal transducer and activator of transcription 5, indicating that internalization selectively modulates signaling cascades. Together, these data indicate that SFKs are key mediators of ligand-initiated lPRLR internalization, down-regulation, and signal transduction in breast cancer cells, and underscore the importance of target cell context in receptor trafficking and signal transduction.

2008 Molecular Endocrinology PubMed abstract

3336. Phosphorylation-dependent interaction with 14-3-3 regulates Bad trafficking in retinal ganglion cells. (Full text)

Phosphorylation-dependent interaction with 14-3-3 regulates Bad trafficking in retinal ganglion cells. To focus on the proteomic analysis of 14-3-3 proteins and to determine their cellular localization and functional role during glaucomatous neurodegeneration.Complementary proteomic approaches were used to identify phosphorylated proteins in a chronic pressure-induced rat model of glaucoma. To detect interacting proteins, specific protein complexes were eluted using coimmunoprecipitation (...) and recombinant protein-based affinity pull-down for subsequent mass spectrometric analysis. Western blot analysis was performed for validation of the proteomic findings, and immunohistochemical analysis of rat eyes and human donor eyes determined the cellular localization of 14-3-3 proteins. In addition, in vivo treatment experiments were conducted using JNK and protein phosphatase inhibitors.Findings of mass spectrometry, Western blotting, and tissue immunolabeling revealed the presence of different 14-3-3

2008 Investigative Ophthalmology & Visual Science PubMed abstract

3337. Organ trafficking and transplant tourism: a commentary on the global realities. (Full text)

Organ trafficking and transplant tourism: a commentary on the global realities. The extent of organ sales from commercial living donors (CLDs) or vendors has now become evident. At the Second Global Consultation on Human Transplantation of the World Health Organization's (WHO) in March 2007, it was estimated that organ trafficking accounts for 5-10% of the kidney transplants performed annually throughout the world. Patients with sufficient resources in need of organs may travel from one country

2008 American Journal of Transplantation PubMed abstract

3338. Melanocytes derived from patients with Hermansky-Pudlak Syndrome types 1, 2, and 3 have distinct defects in cargo trafficking. (Full text)

unaffected in all three HPS genotypes. These data demonstrate that the three initially identified subtypes of human HPS exhibit distinct defects in the trafficking of various melanocyte-specific proteins. (...) Melanocytes derived from patients with Hermansky-Pudlak Syndrome types 1, 2, and 3 have distinct defects in cargo trafficking. Hermansky-Pudlak Syndrome (HPS) is a genetically heterogeneous disorder in which mutations in one of several genes interrupts biogenesis of melanosomes, platelet dense bodies, and lysosomes. Affected patients have oculocutaneous albinism, a bleeding diathesis, and sometimes develop granulomatous colitis or pulmonary fibrosis. In order to assess the role of HPS genes

2005 Journal of Investigative Dermatology PubMed abstract

3339. Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia. (Full text)

Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia. The hyperpolarization-activated nucleotide-gated channel--HCN4 plays a major role in the diastolic depolarization of sinus atrial node cells. Mutant HCN4 channels have been found to be associated with inherited sinus bradycardia.Sixteen members of a family with sinus bradycardia were evaluated. Evaluation included a clinical (...) mutation, G480R, in the ion channel pore domain in all affected family members. Function analysis, including expression of HCN4 wild-type and G480R in Xenopus oocytes and human embryonic kidney 293 cells, revealed that mutant channels were activated at more negative voltages compared with wild-type channels. Synthesis and expression of the wild-type and mutant HCN4 channel on the plasma membrane tested in human embryonic kidney 293 cells using biotinylation and Western blot analysis demonstrated

2007 Circulation PubMed abstract

3340. Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. (Full text)

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. The KCNH2 or human ether-a-go-go related gene (hERG) encodes the Kv11.1 alpha-subunit of the rapidly activating delayed rectifier K+ current (IKr) in the heart. Type 2 congenital long-QT syndrome (LQT2) results from KCNH2 mutations that cause loss of Kv11.1 channel function. Several mechanisms have been identified, including disruption of Kv11.1 channel synthesis (class 1), protein trafficking (...) (class 2), gating (class 3), or permeation (class 4). For a few class 2 LQT2-Kv11.1 channels, it is possible to increase surface membrane expression of Kv11.1 current (IKv11.1). We tested the hypotheses that (1) most LQT2 missense mutations generate trafficking-deficient Kv11.1 channels, and (2) their trafficking-deficient phenotype can be corrected.Wild-type (WT)-Kv11.1 channels and 34 missense LQT2-Kv11.1 channels were expressed in HEK293 cells. With Western blot analyses, 28 LQT2-Kv11.1 channels

2006 Circulation PubMed abstract

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